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Dr Sunil Keswani
Dr Laksmi Vas
Dr Vandana Keswani
NATIONAL BURN CENTRE,
Airoli,
Mumbai

Dr. Sunil Keswani, National Burns Centre,
www.burns-india.com,
nbcairoli@gmail.com

1
Circumferential chest burns-pain restricts full
respiratory excursions ,atelectasis and pneumonias
 Pain prevents patients from eating well-nutrition
affected.
 Pain depresses the patient-psychosomatic
problems
 Pain contributory to Post burn psychosis
 Pain-poor compliance during physiotherapy-poor
rehabilitation-poor functional outcome


Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

2


PAIN IS A FORM OF STRESS AND PRODUCES ELEVATION IN
STRESS HORMONES AND CATECHOLAMINES.

PAIN RELIEF ADVANTAGES: LESSER CHEST INFECTIONS-better compliance in Physiotherapy
 LESS CATABOLISM AND ENDOCRINE DERANGEMENTS.
 FEWER THROMBOEMBOLIC COMPLICATIONS-Earlier mobilisation
 BETTER NUTRITION-Better appetite in absence of Pain
 BETTER PSYCOLOGICAL STATUS-No pain no depression and
positive outlook to healing and DESIRE TO LIVE.
 PAIN FREE DRESSINGS MAKE PATIENTS MORE COMFORTABLE
AND DECREASES THE MORBIDITY AND MORTALITY.
 SHORTER HOSPITAL STAY.
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

3
 Defined as an unpleasant sensory and

emotional experience associated with actual
or potential tissue damage or described in
terms of such damage.
 Acute pain < 6wks
 Surgery,Trauma or Acute illness

Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

4
 GRADE 1:Nonopioids +/- adjuvants
 GRADE 2:Opioids for mild to moderate +/-

nonopiods+/- adjuvant
 GRADE 3:Opioids for moderate to severe

pain+/- nonopoids+/- adjuvant
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

5


PAIN KILLERS e.g ULTRACET



ANTIDEPRESSANTS e.g TRYTOMER,FLUDAC.



PHENCYCLIDINE DERIVATIVEe.g KETAMINE



OPIOIDSe.g MORPHINE, HYDROMORPHONE
FENTANYL.



ROUTES OF ADMINSTRATION- ORAL OR
INTRAVENOUS THROUGH PATIENT CONTROLLED
ANALGESIA PUMPS (SYRINGE INFUSION PUMPS)
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

6
 Antidepressant & Serotonin-uptake inhibitor
 Dose-20 mg daily-for depression
 Other names-Fluchem, Fludawn, Flugen
 Availability-10 mg, 20 mg, 60 mg caps

Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

7
 Phenylpiperidine -analogue of codeine
 Mechanisim

 1) Activates opioids receptors

 2) Inhibits Neuronal uptakes of nor-

epineprhrine
 3) Potentiates release of serotonin
 4) Decending inhibition of nociception
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

8
 Names-Ketalar,Ketamax,Ketmin
 Profound analgesia
 Pharangeal & Laryngeal reflexes retained
 Dissociative Anaesthesia
 BP increases but returns back within 15 mins

after IV
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

9


Synthetic opioid

IV 75-125 times more potent than Morphine
Patch 30-40 times more potent than Morphine
Opioid profile of analgesia
Respiratory depression
 Muscle rigidity abolished by Naloxone
 CVS –hardly any effect
 Availability 50mcg/ml and 2,10ml
 Names-Fendrop,Fenlate,Trofentyl





Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

10
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

11
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

12
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

13
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

14
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

15
 FIRST DAY:-ON ADMISSION, ALL MEDICINES TO BE
GIVEN ORALLY.

 Body wt < 10KG

3mg midazolam+50mgketamine mix it with
fruit concentrate and give orally.
 Body wt. 10—15kgs—upto 2 years of age.

4.5mg midaz+75 mg of ketamine,
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

16
 ADULTS:-body wt-25-50kg—

10-15mg Midaz+175-250mg Ketamine
 ALL PATIENTS

Fludac
10mg in the morning
Tryptomer 10mg HS
. Pregabalin 75mg HS
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

17
MILD PAIN / MIXED BURNS / LESS%BURNS
Tab Ultracet 1tds for men .1/2 to1-1/2 for small
women and children.
 Tab Tryptomer 10 mg HS.
 Tab Fludac 10 mg in the morning.




ASSESS PAIN

Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

18
MOD PAIN /MIXED BURNS/HIGH % BURNS
Start Ketamine 100mg,Tramadol 100mg,&
Midazolam 10mg Infusion
 Set pump rate at 1ml/hour.For 60kg-1-2ml/hr.
 For 70kg- 1-4ml/hr.




ASSESS PAIN and TITRATE



If increasing give bolus of 1ml at a time assess,set
basal flow rate again.
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

19
 Starvation protocol as for anaesthesia
 6hours for solids & milk,2hours for juices &

water.
 Jonac suppository / IM Dynapar
 Start infusion of ketamine,tramadol,
midazolam.
 Dresssings soaked in 30cc 2%Xylocaine- in 500
cc saline for 15 mins and then removed
 Patient should be talking all the time.
 Patient should not become unconscious at any
time.
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

20
 Visual Analogue Scale
 McGill Pain Questionnaire

Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

21
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

22
.

(1) What Does Your Pain Feel Like?
(2) How Does Your Pain Change with Time?
(3) How Strong is Your Pain?

Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

23
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

24
 Interpretation:
 • minimum pain score: 0 (would not be seen

in a person with true pain)
 • maximum pain score: 78
 • The higher the pain score the greater the

pain.
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

25
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

26
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com,
nbcairoli@gmail.com

27
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

28
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

29
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

30
PHYSICAL DEPENDENCE:-PHYSIOLOGIC




ADAPTATION OF THE BODY TO THE PRESENCE OF AN
OPIOID. IT DEVELOPS IN ALL PATIENTS ON OPOIDS FOR
SEVERAL WEEKS.
THIS IS NOT ADDICTION.
WITHRAWAL CAN BE AVOIDED BY TAPERING THE DOSE
OF OPIOIDS.

TOLERANCE IS THE NEED FOR A HIGHER DOSE TO


PRODUCE THE SAME PHARMACOLOGIC EFFECT.
THIS TOO IS NOT ADDICTION.

Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

31
ADDICTION OR PSYCHOLOGICAL DEPENDENCE:CHARACTERISED BY COMPULSIVE BEHAVIOR
PATTERN INVOLVED IN ACQUIRING OPIOIDS FOR
NONMEDICAL REASONS AS OPPOSED TO PAIN
RELIEF.
INCIDENCE BEING 0.1%.
PSEUDO ADDICTION:-REPEATED REQUESTS FOR
OPIOIDS MAY MIMIC ADDICTION.
THIS IS DUE TO INADEQUATE PAIN RELIEF.
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

32
“The purpose of a physician is to

relieve pain and cure disease”

Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

33
THANK YOU
NATIONAL BURNS CENTRE

BURNS HELPLINE 027793333
www.burns-india.com
Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com

34

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Pain relief in burns by Dr. Sunil Keswani, National Burns Centre, Airoli

  • 1. Dr Sunil Keswani Dr Laksmi Vas Dr Vandana Keswani NATIONAL BURN CENTRE, Airoli, Mumbai Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 1
  • 2. Circumferential chest burns-pain restricts full respiratory excursions ,atelectasis and pneumonias  Pain prevents patients from eating well-nutrition affected.  Pain depresses the patient-psychosomatic problems  Pain contributory to Post burn psychosis  Pain-poor compliance during physiotherapy-poor rehabilitation-poor functional outcome  Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 2
  • 3.  PAIN IS A FORM OF STRESS AND PRODUCES ELEVATION IN STRESS HORMONES AND CATECHOLAMINES. PAIN RELIEF ADVANTAGES: LESSER CHEST INFECTIONS-better compliance in Physiotherapy  LESS CATABOLISM AND ENDOCRINE DERANGEMENTS.  FEWER THROMBOEMBOLIC COMPLICATIONS-Earlier mobilisation  BETTER NUTRITION-Better appetite in absence of Pain  BETTER PSYCOLOGICAL STATUS-No pain no depression and positive outlook to healing and DESIRE TO LIVE.  PAIN FREE DRESSINGS MAKE PATIENTS MORE COMFORTABLE AND DECREASES THE MORBIDITY AND MORTALITY.  SHORTER HOSPITAL STAY. Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 3
  • 4.  Defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage.  Acute pain < 6wks  Surgery,Trauma or Acute illness Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 4
  • 5.  GRADE 1:Nonopioids +/- adjuvants  GRADE 2:Opioids for mild to moderate +/- nonopiods+/- adjuvant  GRADE 3:Opioids for moderate to severe pain+/- nonopoids+/- adjuvant Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 5
  • 6.  PAIN KILLERS e.g ULTRACET  ANTIDEPRESSANTS e.g TRYTOMER,FLUDAC.  PHENCYCLIDINE DERIVATIVEe.g KETAMINE  OPIOIDSe.g MORPHINE, HYDROMORPHONE FENTANYL.  ROUTES OF ADMINSTRATION- ORAL OR INTRAVENOUS THROUGH PATIENT CONTROLLED ANALGESIA PUMPS (SYRINGE INFUSION PUMPS) Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 6
  • 7.  Antidepressant & Serotonin-uptake inhibitor  Dose-20 mg daily-for depression  Other names-Fluchem, Fludawn, Flugen  Availability-10 mg, 20 mg, 60 mg caps Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 7
  • 8.  Phenylpiperidine -analogue of codeine  Mechanisim  1) Activates opioids receptors  2) Inhibits Neuronal uptakes of nor- epineprhrine  3) Potentiates release of serotonin  4) Decending inhibition of nociception Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 8
  • 9.  Names-Ketalar,Ketamax,Ketmin  Profound analgesia  Pharangeal & Laryngeal reflexes retained  Dissociative Anaesthesia  BP increases but returns back within 15 mins after IV Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 9
  • 10.  Synthetic opioid IV 75-125 times more potent than Morphine Patch 30-40 times more potent than Morphine Opioid profile of analgesia Respiratory depression  Muscle rigidity abolished by Naloxone  CVS –hardly any effect  Availability 50mcg/ml and 2,10ml  Names-Fendrop,Fenlate,Trofentyl     Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 10
  • 11. Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 11
  • 12. Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 12
  • 13. Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 13
  • 14. Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 14
  • 15. Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 15
  • 16.  FIRST DAY:-ON ADMISSION, ALL MEDICINES TO BE GIVEN ORALLY.  Body wt < 10KG 3mg midazolam+50mgketamine mix it with fruit concentrate and give orally.  Body wt. 10—15kgs—upto 2 years of age. 4.5mg midaz+75 mg of ketamine, Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 16
  • 17.  ADULTS:-body wt-25-50kg— 10-15mg Midaz+175-250mg Ketamine  ALL PATIENTS Fludac 10mg in the morning Tryptomer 10mg HS . Pregabalin 75mg HS Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 17
  • 18. MILD PAIN / MIXED BURNS / LESS%BURNS Tab Ultracet 1tds for men .1/2 to1-1/2 for small women and children.  Tab Tryptomer 10 mg HS.  Tab Fludac 10 mg in the morning.   ASSESS PAIN Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 18
  • 19. MOD PAIN /MIXED BURNS/HIGH % BURNS Start Ketamine 100mg,Tramadol 100mg,& Midazolam 10mg Infusion  Set pump rate at 1ml/hour.For 60kg-1-2ml/hr.  For 70kg- 1-4ml/hr.   ASSESS PAIN and TITRATE  If increasing give bolus of 1ml at a time assess,set basal flow rate again. Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 19
  • 20.  Starvation protocol as for anaesthesia  6hours for solids & milk,2hours for juices & water.  Jonac suppository / IM Dynapar  Start infusion of ketamine,tramadol, midazolam.  Dresssings soaked in 30cc 2%Xylocaine- in 500 cc saline for 15 mins and then removed  Patient should be talking all the time.  Patient should not become unconscious at any time. Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 20
  • 21.  Visual Analogue Scale  McGill Pain Questionnaire Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 21
  • 22. Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 22
  • 23. . (1) What Does Your Pain Feel Like? (2) How Does Your Pain Change with Time? (3) How Strong is Your Pain? Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 23
  • 24. Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 24
  • 25.  Interpretation:  • minimum pain score: 0 (would not be seen in a person with true pain)  • maximum pain score: 78  • The higher the pain score the greater the pain. Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 25
  • 26. Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 26
  • 27. Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 27
  • 28. Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 28
  • 29. Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 29
  • 30. Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 30
  • 31. PHYSICAL DEPENDENCE:-PHYSIOLOGIC   ADAPTATION OF THE BODY TO THE PRESENCE OF AN OPIOID. IT DEVELOPS IN ALL PATIENTS ON OPOIDS FOR SEVERAL WEEKS. THIS IS NOT ADDICTION. WITHRAWAL CAN BE AVOIDED BY TAPERING THE DOSE OF OPIOIDS. TOLERANCE IS THE NEED FOR A HIGHER DOSE TO  PRODUCE THE SAME PHARMACOLOGIC EFFECT. THIS TOO IS NOT ADDICTION. Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 31
  • 32. ADDICTION OR PSYCHOLOGICAL DEPENDENCE:CHARACTERISED BY COMPULSIVE BEHAVIOR PATTERN INVOLVED IN ACQUIRING OPIOIDS FOR NONMEDICAL REASONS AS OPPOSED TO PAIN RELIEF. INCIDENCE BEING 0.1%. PSEUDO ADDICTION:-REPEATED REQUESTS FOR OPIOIDS MAY MIMIC ADDICTION. THIS IS DUE TO INADEQUATE PAIN RELIEF. Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 32
  • 33. “The purpose of a physician is to relieve pain and cure disease” Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 33
  • 34. THANK YOU NATIONAL BURNS CENTRE BURNS HELPLINE 027793333 www.burns-india.com Dr. Sunil Keswani, National Burns Centre, www.burns-india.com, nbcairoli@gmail.com 34