Pain definition, Pain pathways, pain modulation, the endorphin system, Types of Pain, current trend of Drugs used for pain management. New Drugs for pain
Pain definition, Pain pathways, pain modulation, the endorphin system, Types of Pain, current trend of Drugs used for pain management. New Drugs for pain
Pain is the common symptom in many chronic conditions such as cancers, neuropathies, and chronic disease. It is also experienced in trauma varying from mild to severe based on the location and degree of trauma. This presentation is a brief outline on types of pain, classification of pain, pain pathways and management of pain
Physiology of Pain, Characteristic of pain, Basic consideration of nervous system, Pain receptor, Mechanism of pain causation, Theories of pain, Pathways of pain, Pain Receptors
Pain is the common symptom in many chronic conditions such as cancers, neuropathies, and chronic disease. It is also experienced in trauma varying from mild to severe based on the location and degree of trauma. This presentation is a brief outline on types of pain, classification of pain, pain pathways and management of pain
Physiology of Pain, Characteristic of pain, Basic consideration of nervous system, Pain receptor, Mechanism of pain causation, Theories of pain, Pathways of pain, Pain Receptors
An introduction to the use of spinal cord stimulator therapy for chronic pain states as an adjunct and adjuvant
therapy. Spinal cord stimulators are meant for patients who have failed conservative modalities, medications, and even surgery. It is a modality to restore function and pain relief.
Definition n classification •Pathophysiologyof pain. •Physiological Effects of pain. •Pharmacological & non-pharmacological methods of analgesia. •Principles of pain management.METHODS OF CONTROLLING METHODS OF CONTROLLING
Non-pharmacological Preoperative counseling TENS Acupuncture
Pharmacological Opioids •Im •IV infusion •IV PCA Local anaesthetics: •Local Infiltration •Nerve Blocks •Epidural Blocks NSAIDS •IM •IV infusion •IV PCA
NON-PHARMACOLOGICAL METHODS PRE-OP COUNSELLING: Well informed patients about: •Nature of operation •Nature of post operative pain •Methods of analgesia available
Cope better with Post –op Pain
NON-PHARMACOLOGICAL METHODS TENS (Trans Cutaneous electric nerve stimulation)
Stimulates afferent myelinated (A-beta) nerve fibers at 70hz
Inhibitory circuits within sp cord activated
Nerve impulse transmission reduced
Maximum benefit in neurogenic pain
PHARMACOLOGICAL METHODS OPIODS •Activate opiodreceptors within the CNS •Reduce transmission of nerve impulses by modulation in the dorsal horn
PHARMACOLOGICAL METHODS
LOCAL ANAESTHETICS –Blocks the conduction of nerve impulses –Can be given with adrenaline because •Decreases absorption of L.A allowing larger doses •Also acts on alpha 2 receptors which potentiates analgesic effect
PHARMACOLOGICAL METHODS
NASIDS –Blocks synthesis of PG’s –Only suitable for miledto moderate pain
PRINCIPLE OF MANAGEMENT OF PAIN •Pre-emptive analgesia •Balanced or combination analgesia •Analgesia ladder
PHARMACOLOGICAL METHODS
Balanced Analgesia –NASID are used in conjunction with opioids. –Reduces amount of opioids –Reduces side affect of opioids,ASSESMENT OF PAIN •Observe the behaviour of the patient •Monitor analgesic requirement of the patient –Visual Analogue Score( VAS )
–Verbal Rating Score ( VRS ) •None •Mild •Moderate •severe
Endoscopic ultrasonography (EUS) is an outpatient procedure
During an EUS procedure, an upper gastrointestinal (GI) scope is inserted into the esophagus through the mouth to obtain ultrasonographic as well as endoluminal images of various upper gastrointestinal pathologies.
Background: Neck flexion by head elevation using an 8 to 10 cm thick pillow and head extension has been suggested to
align the laryngeal, pharyngeal and oral axis and facilitate tracheal intubation. Presently, the laryngeal view and discomfort
for tracheal intubation were evaluated according to two different degrees of head elevation in adult patients.
Methods: This prospective randomized, controlled study included 50 adult patients aged 18 to 90 years. After induction
of anesthesia, the Cormack Lehane grade was evaluated in 25 patients using a direct laryngoscope while the patient’s head
was elevated with a 4 cm pillow (4 cm group) and then an 8 cm pillow (8 cm group). In the other 25 patients, the grades
were evaluated in the opposite sequence and tracheal intubation was performed. The success rate and anesthesiologist’s
discomfort score for tracheal intubation, and laryngeal, pharyngeal and oral axes were assessed.
Results: There were no differences in the laryngeal view and success rate for tracheal intubation between the two groups.
The discomfort score during tracheal intubation was higher in the 8 cm group when the patient’s head was elevated 4 cm
first and then 8 cm. The alignment of laryngeal, pharyngeal and oral axes were not different between the two degrees of
head elevation.
Conclusions: A pillow of 8 cm height did not improve laryngeal view and alignment of airway axes but increased the anesthesiologist
discomfort, compared to a pillow of 4 cm height, during tracheal intubation in adult patients.
Key Words: Airway management, Intratracheal intubation, Laryngoscope, Vocal cords.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Ocular injury ppt Upendra pal optometrist upums saifai etawah
Pain anatomy and physiology
1. PAIN
ANATOMY&PHYSIOLOGY
Dr. M.ANEEQUE ALAM
Anesthesia Resident
Department of Anesthesiology
Patel Hospital
aneeque86@gmail.com
2. DEFINITION
Pain is unpleasant sensory and
emotional experience associated
with actual or potential tissue
damage, or described in terms of
such damage.
Ref: International Association for the Study of Pain(IASP)
o Pain is SUBJECTIVE phenomena
3. NOCICEPTION
Nocioception is a complex sequence of actions
between tissue damage and the perception of
pain.Its includes
Transduction
Transmission
Modulation
Perception
5. Transmission: Guidance of the pain – information
through the nervous system, including:
Ascending pathway
Primary afferent nerve-ends that go to the dorsal horn of
the spinal cord.
ascending (inter-) neurons that project their information
from the spinal cord to the brainstem and
the hypothalamus/thalamus
The thalamic-cortical pathways
6. Modulation: Modification of the nociceptive
transmission through a number of humoral and
neural effects
anti-nociceptive pathways
(descending pathway)
7. Perception: Observing the pain in
a conscious way. Integration of transduction,
transmission and modulation with the unique
psychology of the individual, resulting in a
subjective and emotional pain sensation
9. CLASSIFICATION
PAIN IS CLASSIFIED INTO NOCICEPTIVE, NEUROPATHIC AND
PSYCHOGENIC
1. Nociceptive is pain caused by tissue damage (inflammation)
which stimulate pain receptors (nociceptors).
2. Neuropathic: (pain due to injury of nerve pathway)
site of injury: Central Central pain (thalamic infarct).
Mixed Plexus avulsion, Post herpetic neuralgia.
Peripheral Neuroma, nerve compression, phantom, neuralgias.
character: burning, tingling, numbness, pressing, squeezing, itching, constant +/-
intermittent shooting, lancinating, electric.
3. Psychogenic: (difficult to differentiate whether secondary to or actual
cause of pain), anxiety, depression (30% of depressives complain of pain on initial
presentation).
10. Nociceptors are special receptors that
respond only to noxious stimuli and generate
nerve impulses which the brain interprets as “pain”
Free nerve endings
oNon adaptive it’s a
protective function
to keep the individual
trying to remove the
damaging stimulus or
to get away from it.
12. CHARACTERISTICS A DELTA FIBRES C-FIBRES
MYLENATION MYELINATED
LARGE DIAMETER
NON-MYLENATED
SMALL DIAMETER
CONDUCTION SPEED FAST(70-120 m/sec) SLOW(0.2-2 m/sec)
ONSET FIRST
FAST PAIN
SECOND
SLOW PAIN
DURATION BRIEF LONG
RECEPTIVE FIELD SMALL LARGE
LOCALIZATION PRECISE DIFFUSE
SENSORY QUALITY SHARP,PRICKING ACHING,DULL,
BURNING
CNS RESPONSE RELFEX,ANALYSIS EMOTIONAL,
SUFFERING
14. FAST PAIN SLOW PAIN
onset: during application of the stimulus Shortly after application if tissue damage
occurs
Duration: short duration Longer duration
Nature: pricking Burning
Afferent: A-delta fibers C-fibers
Neurotransmitter: glutamate Substance-P
Significance: * determine site & severity.
* Initiate withdrawal reflexes.
Associated with arousal, autonomic &
emotional reactions
Localization: well-localized Poorly-localized
15. THE NEUROCHEMICALS OF PAIN
• Glutamate - Central
• Substance P - Central
• Brandykinin - Peripheral
• Prostaglandins - Peripheral
PAIN
INITIATOR
• Serotinin
• Endorphins
• Enkephalins
• Dynorphin
PAIN
INHIBITOR
16. PAIN’S ASCENDING PATHWAY TO THE
BRAIN
THREE neurons from the receptor
to the cerebral cortex
First order neuron:
Cell body located in the
dorsal root ganglion.
Starts from free nerve ending
Ends at substantia gelatinosa
17. Second order neuron:
Has cell body in the
spinal cord or
medulla oblongata
• Starts from substantia
gelatinosa
Axon decussate &
Terminate on 3rd order
in thalamus
neuron following
Spinothalamic tract
Third order neuron:
Has cell body in thalamus
Axon terminates on
cerebral cortex ipsilaterally
18. The Descending Pathway
pain afferents stimulates the neurons in
periaqueductal gray (PAG) - gray matter
surrounding the cerebral aqueduct in the
midbrain results in activation of efferent anti-nociceptive
pathways
from there the impulses are transmitted
through the spinal cord to the dorsal horn
there thay inhibit or block transmission of
nociceptive signals at the level of dorsal horn
19.
20.
21. GATE THEORY
Melzack & Wall (1965)
. non-painful input closes
the "gates" to painful input
22. APPLICATIONS OF GATE THEORY
Stimulation of touch fibres for pain relief:
TENS (transcutaneous electrical nerve
stimulation)
Acupuncture
Massage
23.
24. PAIN TOLERANCE
It is the maximum intensity of pain can be tolerated by the
subject without obvious complaint.
Pain tolerance is affected by a number of factors:
- Anxiety, depression & fatigue ------> pain tolerance.
- rest, sever exercise & strong emotional excitement ------> pain tolerance.
25. Hyperalgesia
Increased pain from a stimulus that
normally provokes pain
Allodynia
Pain due to a stimulus that does not
normally provoke pain.
26. PAIN FELT AWAY FROM THE ORIGINAL SITE OF THE
PAINFUL STIMULUS.
27. PHANTOM LIMB
o sensations are described as
perceptions that an individual experiences
relating to a limb or an organ that is not
physically part of the body
o brain contains neuromatrix of the
body image –neurosignature like a
hologram