Download as PDF, PPTX
Uploaded byIsfahan University Of Medical science
Paget disease
This document provides information on Paget's disease, including: - It is a chronic bone disorder characterized by abnormal bone remodeling that can cause bone deformities and fractures. - The cause is unknown but may involve viruses or genetic factors. It most commonly affects older adults and bones like the pelvis and spine. - Symptoms can include bone pain, stiffness, fractures, and hearing loss. Lab tests show elevated alkaline phosphatase levels. Imaging like x-rays are used for diagnosis. - The disease involves abnormal bone breakdown and formation seen on imaging as thickened and misshapen bones. While often asymptomatic, treatment with medications may be used for painful symptoms.
More Related Content
Similar to Paget disease
Paget disease
- 1. PATHOLOGY.. Paget’s Disease Maryam Sharifian MScstudent In Isfahan University Of medical Sciences
- 2. INTRODUCTION Paget’s disease isa chronic condition of bone characterized by disorder of the normal bone remodeling process. Characterized by excessive breakdown of bone tissue followed by abnormal bone formation. Also known as Osteitis Deformans is a bone disease unknown cause. Affecting men twice as freaquently as women. Named after the England Surgeons Sir James Paget.
- 3. DISEASE CLASSIFICATION INFLAMMATORY DISEASE •Multifocal chronic skeletaldisease due to Chronic paramyxoviral Virus infection. •As a result, the bone that is formed is abnormal. CONGENTIAL •Certain of genes may Been associated with Paget’s disease, including The Sequestrosome 1 Gene On Chromosome 5.
- 4. ETIOLOGY The cause ofPaget’s disease is unknown Disease may be caused by a virus: Paramyxo virus Resulting in localized abnormal osteoclastic activity typical of paget’s disease. Also, a person’s genes may predispose them to developing paget’s disease.
- 5. Paget’s disease affectsskeletal older bone of adults There is also an extremely rare form of paget’s disease in children, referred to as Juvenile Paget’s disease In two of every three cases of Paget's disease, more than one bone is affected
- 6. Pathogenesis Hyper vascular/ Osteolytic phase Abnormalmatrix Persists but cellular Activity is nearly Absent. Exhaustive (burn out) stage Initial phase of Disorder involves Bone resorption by osteoclasts Paget’s disease Intermediate phase Osteolytic activity + Osteoblastic activity
- 7. MANIFESTATIONS - SYMPTOMS Paget’sdisease is more commonly asymptomatic, but may exhibit a variety of non-specific symptoms due to increased bone turnover. The bones that are move commonly affected include the pelvis, spine, skull, and the long bone. Individuals may experience any or a combination of the following symptoms; Bone pain fractures
- 8. symptoms … Pain Stiffness Difficulty movingyour affected joints Nerve damage Loss of balance bone fractures
- 9. Other symptoms … Hearingloss Headaches Osteoarthritis visual abnormalities Cardiac abnormalities Skeletal Deformities
- 10. SIGNIFICANT LAB TESTS Bloodchemistry (blood patient who have paget’s disease) results indicate very high alkaline phosphates levels with normal serum calcium and phosphorus. There is no known cure for this disease. Most cases are mild and asymptomatic no treatment is necessary in symptomatic cases medications.
- 11. IMAGING CONSIDERATION X-ray ofthe skull, spine, pelvis and long bone. CT scan MRI (Magnetic Resonance Imaging) Radionuclide bone scan or RNI (Radionuclide Imaging).
- 12. RADIOLOGICAL APPEARANCE Radionuclide bonescans readily detect Paget’s disease even in its very early stage. Radio graphically of the affected bone typically demonstrate cortical thickening, with a coarse, thickened trabecular pattern.
- 13. Paget’s disease…. Radiograph ofthe fibula and tibia of the patient in figure demonstrating the effect of advanced proliferative Paget’s disease on the fibula and tibia.
- 14. Paget’s disease onpelvis… Paget’s disease involving the left hemi pelvis and right, there is severe osteoarthritis of the left hip but a relatively normal joint space in the right hip.
- 15.
- 16. Treatment … Not everyonewith Paget's disease will require treatment. If treatment is needed, medication is most often used.
- 17.