This document discusses oxidation and various oxidizing agents. It begins by defining oxidation and reduction as the loss or gain of electrons, respectively. It then lists several common oxidizing agents including permanganates, dichromates, hypochlorous acid, chlorates, peroxides, and ozone. Specific details are provided about permanganates and how potassium permanganate can oxidize carbon atoms with pi-bonds, weak C-H bonds, and weak C-C bonds. Fuming sulfuric acid and chlorine dioxide are also discussed. The document concludes by covering liquid-phase oxidation using oxygen and examples of oxidations like acetaldehyde to acetic acid.
This is a report about Aldehydes. The content of this slideshow are as follows: What is an aldehyde, How to name aldehydes with IUPAC Nomenclature and Common Names, The Physical Properties of Aldehydes, and the examples of aldehyde and its uses. The main objective of this report is to widen the knowledge of the readers/learners concerning of the stated topic so that they can further understand the concept of aldehydes.
Report made by: Students of Sogod National High School STEM 9-Newton
Kyla Krystelle Salva
Krishia Belle Cambalon
Marycris Felicilda
Full power point presentation for Alcohol, Phenol and Ethers.
Hope will help very one whosoever will see.........
For school, college and job use.
Anyone can prefer to my ppt.
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Alkanes, Alkenes, Alkynes, Alkyl Halides, Alicyclic Hydrocarbons, Alcohols,
Ethers and Epoxides, Aldehydes and Ketones, Carboxylic Acids and their
Functional Derivatives
This is a report about Aldehydes. The content of this slideshow are as follows: What is an aldehyde, How to name aldehydes with IUPAC Nomenclature and Common Names, The Physical Properties of Aldehydes, and the examples of aldehyde and its uses. The main objective of this report is to widen the knowledge of the readers/learners concerning of the stated topic so that they can further understand the concept of aldehydes.
Report made by: Students of Sogod National High School STEM 9-Newton
Kyla Krystelle Salva
Krishia Belle Cambalon
Marycris Felicilda
Full power point presentation for Alcohol, Phenol and Ethers.
Hope will help very one whosoever will see.........
For school, college and job use.
Anyone can prefer to my ppt.
Hope every one will like it and support for making more for all.
Alkanes, Alkenes, Alkynes, Alkyl Halides, Alicyclic Hydrocarbons, Alcohols,
Ethers and Epoxides, Aldehydes and Ketones, Carboxylic Acids and their
Functional Derivatives
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
1. OXIDATION
Presenting by:
Mr. Purushotham KN
Assistant Professor
Department Of Pharmaceutical Chemistry
Sri Adichunchanagiri College Of Pharmacy,
B G Nagar
2022-2023
1
2. • Oxidation is loss of electrons
• Reduction is gain of electrons
–Oxidation is always accompanied by reduction
• The total number of electrons is kept constant
• Oxidizing agents oxidize and are themselves reduced
• Reducing agents reduce and are themselves oxidized
• Oxidation constitutes one of the most powerful tools used in the synthesis of chemical
compounds. The oxidation processes are many and varied.
2
4. Permanganates
• Solid salts of permanganic acid are powerful oxidizing agents.
–Calcium permanganate induces rapid oxidation of ethanol that may result acetic acid.
• Aqueous solutions of the permanganates also possess powerful oxidizing properties.
• These are common and most useful agents employed to oxidize a wide range of organic
molecules.
• It functions as an oxidizing agent of different strengths in alkaline, neutral, and acid
solutions.
4
5. • KMnO₄, is probably the most common, and also the most applicable.
• KMnO₄ can be utilized to oxidize a wide range of organic molecules.
• The products that are obtained can vary depending on the conditions, but because KMnO₄ is
such a strong oxidizing agent, the final products are often carboxylic acids.
• KMnO₄ is able to oxidize carbon atoms if they contain sufficiently weak bonds, including:
1. Carbon atoms with π-bonds, as in alkenes and alkynes
2. Carbon atoms with weak C-H bonds, such as
–C-H bonds in the alpha-positions of substituted aromatic rings
–C-H bonds in carbon atoms containing C-O bonds, including alcohols and aldehydes
5
6. 3. Carbons with exceptionally weak C-C bonds such as
–C-C bonds in a glycol
–C-C bonds next to an aromatic ring and an oxygen.
6
7. Fuming Sulfuric Acid (Oleum):
• Fuming sulfuric acid, H₂SO₄ + SO₂, in the Presence of mercury salts is a powerful
oxidizing agent.
• It was formerly used extensively in the oxidation of
–naphthalene to phthalic anhydride
–piperidine(tetrahydropyridine) may be oxidized to pyridine.
7
8. Sodium Chlorite and Chlorine Dioxide
• When reacted with chlorine, sodium chlorite (NaClO3)releases Chlorine dioxide (ClO2),
is a powerful oxidizing and bleaching agent; but because of its instability, it cannot be
produced and stored.
• Chlorine dioxide has also been found to have utility in bleaching and maturing flour,
treating water, checking blue mold in fruits, and bleaching textiles.
8
9. Chlorates:
• Chloric acid, HCIO3, is a powerful oxidizing agent. Oxidation of
–ethanol / ethyl ether to acetic acid,
–ethylene to glycol,
–allyl alcohol to glycerine,
–fumaric acid to racemic acid effected with Chloric acid
• However, since its aqueous solutions must be obtained by double decomposition from its
salts, its industrial usefulness is very limited, and it is more often used in the form of the
soluble salts.
9
10. Ozone (O3):
• Ozone is being promoted for use in the conversion of
–Tertiary amines to amine oxides
–α-pinene to pinonic and pinic acids.
• The powerful oxidizing potential of ozone has been made use
–in textile bleaching
–paper bleaching
–in limited ways for water purification.
10
11. Liquid-phase Oxidation with Oxidizing Compounds
• Oxidation in the gas/liquid phase often occurs in the production of basic and fine
chemicals.
• Very often, molecular oxygen is used here in the form of process air.
• The oxidation of aniline furnishes an example for comparison of a number of oxidizing
agents.
• Results obtained under conditions best suited for the particular agent are shown below:
11
12. The action of oxidizing agents on organic compounds depends not only upon the nature of
the agent or the compound but also upon such factors:
–Concentration of the reactants
–Temperature
–Hydrogen-ion concentration and
–Method of mixing
12
14. Aniline to Quinone
• Sodium or potassium dichromate may be used to oxidize aniline to quinone, but a low
temperature and slow addition of the oxidizing agent must be employed in order to
restrict the action.
• Although the high stability of the quinone structure toward further oxidation makes
possible the use of so powerful an oxidizing agent as sodium dichromate in acid solution,
care must still be exercised in order to prevent destructive reaction.
14
15. Oxidation of Toluene:
• The use of manganese dioxide for the oxidation of toluene to benzaldehyde and
benzoic acid was formerly extensive.
• With manganese dioxide, the principal product is benzaldehyde; for high yields of
benzoic acid, a stronger oxidizing agent such as chromic acid is required.
15
16. Liquid-phase Oxidation with Oxygen:
•The oxygen of the air is the cheapest available oxidizing agent but, at the same time it is
most difficult to control.
•Although atmospheric oxygen is constantly reacted with organic substances at ordinary
temperature, the rates of the reactions are too slow, generally, to be of any significance
(usefulness in chemical synthesis).
•To induce molecular oxygen to react at commercially useful rates, it is necessary to
provide a catalyst, to elevate the temperature, or to use a catalyst in conjunction with
elevated temperatures.
16
17. • In liquid-phase processes, catalysts may be either dissolved or suspended in finely
divided form to ensure contact with bubbles of gas containing oxygen which may be
caused to pass through the liquid undergoing oxidation.
• To speed up production, means must be provided for initially raising the temperature
and for later removing reaction heat.
17
18. Acetaldehyde to Acetic Acid
• The formation of acetic acid furnishes an excellent example of liquid-phase oxidation with
molecular oxygen.
• Acetic acid may be obtained by the direct oxidation of ethanol,
• but the concentrated acid is generally obtained by oxidation methods from acetaldehyde
that may have been formed by the hydration of acetylene or the oxidation of ethanol.
• The oxidation usually occurs in acetic acid solution in the presence of a catalyst and at
atmospheric or elevated pressures.
• Temperatures may range up to 100°C, depending upon conditions, but are usually lower.
18
19. • Ozonolysis has been used frequently in major drug synthesis such as indolizine 251F
and D,L-camptothecin, as well as in fine chemical synthesis such as L-
isoxazolylalanine and prostaglandin endoperoxides.
• Hydrogen peroxide in the presence of catalysts of the oxides of Cr or Mo also
oxidizes organic unsaturated compounds to glycols.
19
20. • Isoborneol to camphor: Nitric acid has been widely used in production of
synthetic camphor from turpentine. the commonly accepted general practice for
this manufacture involves the following steps:
• 1) Distillation of turpentine to obtain pinene,
• 2)Saturation with HCl gas to obtain bornyl chloride,
• 3) Hydrolyzing this to obtain camphene
• 4)Esterifying camphene to isobornyl acetate
• 5) Saponification to isoborneol
• 6)Oxidation to camphor.
20
21. Oxidizing agents Products
• Sodium chlorate in neutral solution with V₂O catalyst.........fumaric acid.
• Sodium chlorate in dilute acid with OsO₄ catalyst ……… mesotartaric acid.
• Caro’s acid, HO.O.SO₃H, a strong oxidizing agent………….succinic acid.
• Hydrogen peroxide in presence of ferrous salts………….hydroxy furfural.
• Bromine water at (100°C)………………………………….Mucobromic acid.
• Potassium permanganate(diluted solution)……………….Pyromucic acid.
21
Esterifying: process of combining an organic acid with an alcohol to form an ester and water.
Turpentines: are semifluid subs consisting of resins dissolved in a volatile oil.