The document discusses ovarian rejuvenation using platelet-rich plasma (PRP) injections. PRP is extracted from a patient's own blood and contains growth factors that may reawaken dormant follicles in the ovaries. The procedure involves extracting blood, centrifuging it to separate PRP from other blood components, and injecting the PRP into the ovaries under ultrasound guidance, usually once a month for three months. The goal is to stimulate egg maturation and development, helping patients conceive. Side effects are minimal and may include pain, fever, or internal bleeding. Follow-up monitors hormone levels to check for signs of improved ovarian function.
Uterus Transplantation Utx (obstetric and gynecology) D.A.B.M
Is the surgical procedure whereby a healthy uterus is transplanted into an organism of which the uterus is absent or diseased.
As part of normal mammalian sexual reproduction, a diseased or absent uterus does not allow normal embryonic implantation, effectively rendering the female infertile.
This phenomenon is known as Absolute Uterine Factor Infertility (AUFI).
Uterine transplant is a potential treatment for this form of infertility.
Uterus is a dynamic, complex organ. It is hugely blood-flow dependent.
More than 116,000 Number of men, women and children on the national transplant waiting list as of August 2017.
33,611 transplants were performed in 2016.
20 people die each day waiting for a transplant.
every 10 minutes another person is added to the waiting list.
Uterus Transplantation Utx (obstetric and gynecology) D.A.B.M
Is the surgical procedure whereby a healthy uterus is transplanted into an organism of which the uterus is absent or diseased.
As part of normal mammalian sexual reproduction, a diseased or absent uterus does not allow normal embryonic implantation, effectively rendering the female infertile.
This phenomenon is known as Absolute Uterine Factor Infertility (AUFI).
Uterine transplant is a potential treatment for this form of infertility.
Uterus is a dynamic, complex organ. It is hugely blood-flow dependent.
More than 116,000 Number of men, women and children on the national transplant waiting list as of August 2017.
33,611 transplants were performed in 2016.
20 people die each day waiting for a transplant.
every 10 minutes another person is added to the waiting list.
interest in stem cells is raising in different field of medicine. The question is : is it successful in Gynecology or it is still too early to say that. The present talk may help to explore this .
the objective is to clarify the problem of recurrent implantation failure , regarding the definition, the caused, diagnosis, and management in cases of IVF
OVERVIEW
Aim
Definition
Prerequisites
Individualisation of patient.
Ohss free IUI. Clinic
{Strict cancellation of cycle if OHSS is suspected}
Newer trends
Sucess Rates in IUI with COH
PROGNOTIC FACTORS to increase Pregnancy Rates..& discussion
Role of Stem Cells in Obstetrics and Gynecology PracticeAsha Jain
Role of Stem Cells in Obstetrics and Gynecology Practice
Talk delivered at 4th Biennial International ISCSGCON 2021
on Febuary 13,2021 by Dr. Asha Jain
Ovarian Reserve Testing in Infertility Dr. Jyoti Agarwal Dr. Sharda JainLifecare Centre
The Best Gametes
Give The Best Result
OVARIAN RESERVE
Plan fertility preservation
Fertility outcome
Response to ovarian stimulation
Predict pregnancy rate
Monitor fertility decline
Fertility after chemotherapy and cancer treatment
Invited Lecture delivered by Dr Sujoy Dasgupta in the Annual Conference of ISAR (Indian Society of Assisted Reproduction) held at Kolkata in November, 2019
Platelet-rich plasma (PRP) has become popular as a non operative treatment option for a broad spectrum of medical disorders. There are reasonable amount of data which warrant continued research in PRP but currently its role in clinical practice is not completely defined. Prior to its use, special consent is required after an honest and open discussion with the patient as well controlled human studies are lacking
interest in stem cells is raising in different field of medicine. The question is : is it successful in Gynecology or it is still too early to say that. The present talk may help to explore this .
the objective is to clarify the problem of recurrent implantation failure , regarding the definition, the caused, diagnosis, and management in cases of IVF
OVERVIEW
Aim
Definition
Prerequisites
Individualisation of patient.
Ohss free IUI. Clinic
{Strict cancellation of cycle if OHSS is suspected}
Newer trends
Sucess Rates in IUI with COH
PROGNOTIC FACTORS to increase Pregnancy Rates..& discussion
Role of Stem Cells in Obstetrics and Gynecology PracticeAsha Jain
Role of Stem Cells in Obstetrics and Gynecology Practice
Talk delivered at 4th Biennial International ISCSGCON 2021
on Febuary 13,2021 by Dr. Asha Jain
Ovarian Reserve Testing in Infertility Dr. Jyoti Agarwal Dr. Sharda JainLifecare Centre
The Best Gametes
Give The Best Result
OVARIAN RESERVE
Plan fertility preservation
Fertility outcome
Response to ovarian stimulation
Predict pregnancy rate
Monitor fertility decline
Fertility after chemotherapy and cancer treatment
Invited Lecture delivered by Dr Sujoy Dasgupta in the Annual Conference of ISAR (Indian Society of Assisted Reproduction) held at Kolkata in November, 2019
Platelet-rich plasma (PRP) has become popular as a non operative treatment option for a broad spectrum of medical disorders. There are reasonable amount of data which warrant continued research in PRP but currently its role in clinical practice is not completely defined. Prior to its use, special consent is required after an honest and open discussion with the patient as well controlled human studies are lacking
Intrauterine insemination versus fallopian tube sperm perfusion in non tubal ...Internet Medical Journal
Background: Controlled ovarian hyper stimulation (COH) combined with intrauterine insemination (IUI), using a volume of 0.5 mail of inseminate is commonly offered to couples with non tubal infertility. Another method is Fallopian tube sperm perfusion (FSP) which is based on a pressure injection of 4 ml of sperm suspension while attempting to seal the cervix to prevent semen reflux. This technique ensures the presence of higher sperm density in the fallopian tubes at the time of ovulation than standard IUI. The aim of this study was to compare the efficiency of IUI and FSP in the treatment of infertility.
Methods: 200 consecutive patients with infertility in 404 stimulated cycles were included in the study. Those randomized to standard IUI included 100 patients in 184 cycles [158 Clomiphene citrate/human menopausal gonadotrophin cycles and 26 Letrozole/FSH cycles exclusively for polycystic ovarian disease patients] (group A). Patients subjected to FSP included 100 patients in 220 cycles (193 Clomiphene citrate/human menopausal gonadotrophin cycles and 27 Letrozole/FSH cycles exclusively for polycystic ovarian disease patients] (group B). Swim up semen preparation technique was used in all cases. Insemination was performed in both groups 34-37 hours after hCG administration. Standard IUI was performed using 0.5 ml of inseminate. In FSP 4ml inseminate was used.
Results: In group A (184 IUI cycles in 100 patients), 22 clinical pregnancies (presence of gestational sac with fetal cardiac activity) occurred (11.95% per cycle over four cycles). In group B, (220 cycles of FSP in 100 patients), 48 clinical pregnancies occurred (21.81%per cycle over four cycles) and this difference was statistically significant (p<0.05).
Conclusions: For non-tubal sub fertility, the results indicate clear benefit for FSP (Fallopian tube sperm perfusion) over IUI (Intrauterine insemination).
Key Words: Intrauterine insemination, Fallopian tube sperm perfusion, Non-tubal infertility.
Authors: Dr. Col (Retd) G S Shekhawat, MD(Obst & Gyn) * (Corresponding. Author), Dr Priyanka S, MBBS+
Women with benign heavy menstrual bleeding have the choice of a number of medical treatment options to reduce their blood loss and improve quality of life.
HEAVY MENSTRUAL BLEEDING IN ADOLESCENTS DR. Sharda Jain , Dr. Meenakshi Dr. M...DGFPublicAwareness
CAUSES: Anovulatory bleeding :
Early menarche earlier is the commonest cause to cycles become ovulatory: if menarche 13 year it takes 4,5 year for cycle to become ovulatory due to unopposed estrogen thick endometrium thin stromal layer causes AUB in adolescence
Dr Sujoy Dasgupta moderated a panel in “Milan”, the conference of all of the Obstetric and Gynaecological Societies of West Bengal, held in Kolkata in February, 2022
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
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OVARIAN REJUVENATION - ROLE OF PLATELET RICH PLASMA THERAPY BY DR SHASHWAT JANI
1. Ovarian Rejuvenation
( Role Of PRP )
Dr Shashwat Jani
M.S. ( OBS - GYN ), F.I.A.O.G.
Diploma in Advanced Endoscopy.
Assistant Professor, Sheth V. S. General hospital.
Smt. N.H.L. Municipal Medical College, Ahmedabad.
Mobile : +91 99099 44160.
E- mail : drshashwatjani@gmail.com
104-Dec-18
3. Ovarian
Rejuvenation
(a brighter side towards all lost hopes)
A procedure intended
to re-awake egg
maturation and
development within
the ovary by
activating dormant
follicles.
3
4. Process by which the
production of eggs is
artificially stimulated,
giving women the
chance to produce more
eggs than they would
naturally have been able
to, and therefore giving
them the chance to
conceive using their own
genetic material .
Helping patient to
conceive.
Ovarian
Rejuvenation
(A Brighter Side Towards
All Lost Hopes)
4
5. Back to basics . . .
Women are born with about 2 million eggs.
About 11,000 of them are lost EVERY MONTH prior
to puberty.
At puberty she is left with about 400,000 eggs.
After this, every month a woman continues to lose
about 1000 eggs.
This loss is irrespective of medicines, oral
contraceptives, pregnancy, health issues, nutritional
status etc.
The number of eggs a woman is born with will
determine at what rate she loses her eggs.
5
6. • Over the last 20 years or so, we are finding
rapid decline in the ovarian reserve.
• More and more women are suffering from
poor ovarian reserve (POR) at an earlier age.
• This could be a result of environmental
pollution, toxic substances or fertilizers in our
food or maybe the stressful situations we live in.
• Whatever maybe the reason, the fact
remains that fertility is going down rapidly.
6
7. Indications
Menopausal or Perimenopausal women <50 years.
Infertile women , over the age of 35 years having
low egg reserve and low AMH levels.
Women <35yrs with low egg reserve and low AMH
levels.
Women with premature ovarian failure
Primary ovarian Insufficiency
Loss of ovarian function due to chemotherapy
Ovarian dysfunction
04-Dec-18
Dr Shashwat Jani.
+91 99099 44160.
7
8. Platelet Rich Plasma ( PRP )
• The theory behind this modality of treatment
was derived from natural healing process as
the body's first response to tissue injury is to
deliver platelets to the injured area.
• Platelets promote healing and attract stem
cells to the site of injury.
04-Dec-18
Dr Shashwat Jani.
+91 99099 44160.
8
9. • Autologous PRP is derived from whole
blood of the same individual centrifuged
to remove RBCs.
• The remaining plasma has a higher
concentration of growth factors 5-10
folds greater than whole blood. Cocktail
of growth factors.
04-Dec-18
Dr Shashwat Jani.
+91 99099 44160.
9
11. Preparation of PRP is an office
procedure that involves withdrawal of
blood, preparation of the PRP, and then
injection into diseased area by the
following steps:
04-Dec-18
Dr Shashwat Jani.
+91 99099 44160.
11
12. PRP Classification
• Types of PRP preparations
1. After centrifugation of whole blood,
2. Four preparations can be obtained.
3. These types or classifications were proposed
by Ehrenfest et al. (2009), depending on
their cell content and fibrin density
04-Dec-18
Dr Shashwat Jani.
+91 99099 44160.
12
13. Ehrenfest et al. (2009) Classification
04-Dec-18
Dr Shashwat Jani.
+91 99099 44160.
13
15. Procedure
PRP is extracted using a specially designed
centrifuge machine and a special conical tube.
About 15 ml of venous blood is taken from the
patient, injected into the conical tube and
centrifuged. (21-24degree Celsius ) @1200 rpm
for 12 minutes
Blood separates in 3 layers :
1. Upper : platelets and WBC
2. middle buffy coat (rich in WBC)
3. lower: RBCs. Dr Shashwat Jani.
+91 99099 44160.
15
17. • The upper and intermediate Buffy layers are
transferred to an empty sterile tube.
• The plasma is centrifuged again @ 3300 rpm
for 7 min to help in formation of soft pellets at
the bottom of the tube.
• Discard the upper 2/3 portions of plasma as
this volume is PPP (Platelet Poor Plasma).
• Pellets are homogenized in lower 1/3rd to
create PRP ( Platelet Rich Plasma ).
04-Dec-18
Dr Shashwat Jani.
+91 99099 44160.
17
19. Infusion Procedure
Call the patient at the end of the periods,
before the follicles begin to grow on the empty
stomach
Withdraw blood for PRP preparation.
30 ml of venous blood yields 3-5 ml of PRP.
Inject PRP in both the ovaries as done for
the egg pickup under USG guidance.
The patient can go home 1-2 hours.
04-Dec-18
Dr Shashwat Jani.
+91 99099 44160.
19
20. The process is to be repeated every
month for three months.
In few centers , Laparoscopy done for
injection in B/L Ovaries
If required, The PRP can be infused in
to the uterus for thin endometrial
thickening.
04-Dec-18
Dr Shashwat Jani.
+91 99099 44160.
20
21. Follow Up…
• AMH , FSH, LH and Estradiol levels are
measured at monthly intervals in women who
do not menstruate, and during the menstrual
flow in menstruating women for a period of
six months.
• If the AMH levels rise,
• while the FSH, LH, and estradiol levels become
lower, there is objective evidence of ovarian
rejuvenation is demonstrated.
04-Dec-18
Dr Shashwat Jani.
+91 99099 44160.
21
31. Future....
Apart from ovarian rejuvenation , researches are
going into oocyte vitrification, a process which
rapidly slows the aging process in eggs.
This means that women may put off trying for a
baby for longer, without the fear of decreased
fertility and poorer quality eggs.
This is also a great option for women who need
to undergo treatments for cancer, and who now
have the chance to preserve their fertility.