This document compares and contrasts single-celled and multi-celled organisms. Single-celled organisms like bacteria and amoebas consist of only one cell, while multi-celled organisms like plants and animals are made of many cells that work together. Examples of single-celled organisms are given as algae, amoeba and paramecium. Multi-celled organisms develop from a single cell and then organize into tissues and organs, as in the case of humans who start as a single cell and differentiate into three germ layers that form the major body systems.