This document discusses model dependent approaches for drug release testing of controlled drug delivery systems. It provides an overview of various mathematical models that can be used to describe drug release kinetics, including zero-order, first-order, Higuchi, Korsmeyer-Peppas, Hixson-Crowell, Baker-Lonsdale, and Weibull models. It explains the equations and mechanisms of drug release for each model. The document also discusses how to select the best-fitting model by comparing the coefficient of determination and other statistical parameters between models. The overall aim is to predict drug release profiles and optimize controlled drug delivery system performance using appropriate kinetic models.