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THE HIGUCHI AND PEPPAS PLOT
Presented By
Simran
M.Pharmacy 1st year
GGSCOP, YNR
The Higuchi Plot
• In 1961 Higuchi developed a mathematical model for the study of the release
of drugs from its matrix.
• For studying the release of water-soluble and poorly soluble drugs from a
variety of matrices, including semisolid and solids.
• Initial drug concentration in the matrix is much higher.
• As the drug is released, the distance for diffusion progressively increases.
• Drug is leached out polymer matrix by the entrance of medium.
• The Equation Of Higuchi model:
Q= [D(2A-Cs)Cs x t]1/2 or
Q=(2ADCst)¹/2
• By differentiating the above equation we get,
dQ/dt=(ADCs/2t)1/2
• Release of the drug is proportional to the square root of time.
• The Drug release from the granular matrix is given by
Applications of Higuchi Plot
• Higuchi describes the drug release as a diffusion process based on Fick's law,
square root time dependent.
• This model is useful for studying the release of water-soluble and poorly
soluble drugs from a variety of matrices, including solids and semi-solids.
Korsmeyer’s-Peppa’s model
• A simple relationship that described drug release from a polymeric system
equation was derived by Korsmeyer-Peppa in 1983.
• To understand the mechanism of drug release and to compare the release
profile differences among these matrix formulations , the percent drug
released time versus time were fitted using this equation:
• The n value characterizes different releases from matrix and specify release
mechanisms as shown below:
Release Exponent (n) Drug transport mechanism
0.5 Fickian diffusion
0.5<n=0.89 Non Fickian transport
0.89 Case II transport
Higher than 0.89 Super case II transport
• To study release kinetic data obtained plotted as log cumulative % drug
release versus time.
Applications of Peppas Plot
• This equation has been used for the linearization of release data from several
formulations of microcapsules or microspheres.
• Use to analyze the release of pharmaceutical polymeric dosage form.
• When the release mechanism is not known or when more than one type of
release phenomena could be involved.
• To study the modified release dosage form and release phenomenon of drugs.
Thank You…!!!

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Higuchi And Peppas Plot

  • 1. THE HIGUCHI AND PEPPAS PLOT Presented By Simran M.Pharmacy 1st year GGSCOP, YNR
  • 2. The Higuchi Plot • In 1961 Higuchi developed a mathematical model for the study of the release of drugs from its matrix. • For studying the release of water-soluble and poorly soluble drugs from a variety of matrices, including semisolid and solids. • Initial drug concentration in the matrix is much higher. • As the drug is released, the distance for diffusion progressively increases. • Drug is leached out polymer matrix by the entrance of medium.
  • 3. • The Equation Of Higuchi model: Q= [D(2A-Cs)Cs x t]1/2 or Q=(2ADCst)¹/2 • By differentiating the above equation we get, dQ/dt=(ADCs/2t)1/2 • Release of the drug is proportional to the square root of time. • The Drug release from the granular matrix is given by
  • 4. Applications of Higuchi Plot • Higuchi describes the drug release as a diffusion process based on Fick's law, square root time dependent. • This model is useful for studying the release of water-soluble and poorly soluble drugs from a variety of matrices, including solids and semi-solids.
  • 5. Korsmeyer’s-Peppa’s model • A simple relationship that described drug release from a polymeric system equation was derived by Korsmeyer-Peppa in 1983. • To understand the mechanism of drug release and to compare the release profile differences among these matrix formulations , the percent drug released time versus time were fitted using this equation:
  • 6. • The n value characterizes different releases from matrix and specify release mechanisms as shown below: Release Exponent (n) Drug transport mechanism 0.5 Fickian diffusion 0.5<n=0.89 Non Fickian transport 0.89 Case II transport Higher than 0.89 Super case II transport
  • 7. • To study release kinetic data obtained plotted as log cumulative % drug release versus time.
  • 8. Applications of Peppas Plot • This equation has been used for the linearization of release data from several formulations of microcapsules or microspheres. • Use to analyze the release of pharmaceutical polymeric dosage form. • When the release mechanism is not known or when more than one type of release phenomena could be involved. • To study the modified release dosage form and release phenomenon of drugs.