The document discusses new developments in understanding migraine, including evidence that migraine is caused by electrical hyperactivity in the brainstem rather than being a vascular disorder. It proposes that migraine is due to mutations in ion channel genes that cause increased excitability of neurons and astrocytes in the brainstem. Symptoms of migraine like nausea and facial congestion are believed to involve cross-activation of other brainstem nuclei from the hyperactive brainstem center.