This document summarizes a review on the irrational use of antibiotics leading to antibiotic resistance. It introduces that antibiotic resistance emerged shortly after penicillin was introduced and has become a major public health concern. The primary cause of antimicrobial resistance is the irrational use of antibiotics, which results in a rapid increase in resistance. The review aims to study how irrational antibiotic use develops resistance and reduces drug efficacy, determine the causes of irrational medication use, examine which antibiotics are used and by whom, and identify factors influencing antibiotic use patterns and the costs and benefits of changing use.