The perspective of antibiotic resistanceLimon Mirza
Antibiotic, Antibiotic resistance, Causes of antibiotic resistance, History of antibiotic, Bangladesh perspective of antibiotic resistance, Prevention & Control of antibiotic resistance
Future impacts of antibiotic resistance
Antibiotic resistance poses serious risks to global public health in the future, including the potential for 10 million deaths per year by 2050 from currently treatable infections and diseases becoming deadly again without effective treatments. Recognition of these future impacts is important for emphasizing the urgent need to change antibiotic prescription and usage. If antibiotic resistance continues to grow, global health systems will lose control over infectious diseases and see increased rates of severe infection, hospitalization, disability and death. Many medical procedures may also become riskier as common postoperative infections become difficult or impossible to treat.
First World Antibiotic Awareness Week and awareness campaigns on prudent antibiotic use extended throughout the WHO European Region - presentation delivered by Dr Zsuzsanna Jakab, Regional Director, WHO Regional Office for Europe, on 16 November 2015
The document summarizes a group presentation on antibiotic resistance. It begins with an introduction that defines antibiotic resistance and outlines the presentation topics. These include a brief history of antibiotics, factors contributing to resistance, examples of resistant bacteria, and mechanisms of resistance. It then discusses the concerns of physicians regarding resistant infections and strategies for managing resistance, such as prudent antibiotic use, development of new drugs, and controlling spread. It concludes that human overuse of antibiotics has led to widespread resistance and that improved hygiene and isolation can help control spread.
Antibiotic resistance is a growing public health problem caused by the overuse and misuse of antibiotics. The document discusses the various mechanisms by which bacteria develop resistance, including intrinsic, acquired, and gene transfer-related resistance. It emphasizes the need for prudent antibiotic use to slow resistance, such as only using antibiotics when necessary, completing full treatment courses, and developing new drug classes. All healthcare providers, including physicians, pharmacists and microbiologists, must work together using treatment guidelines to optimize antibiotic prescribing and containment of resistance.
Antibiotic Resistance as a development and aid issueSidaresearch
1) The document discusses the global threat of antibiotic resistance, noting it is a development and aid issue.
2) Key factors that have contributed to the rise of antibiotic resistance include overuse of antibiotics in agriculture, overprescription by doctors, lack of access to diagnostics in developing countries, and global travel and trade.
3) Addressing antibiotic resistance requires strengthening surveillance, rationalizing antibiotic use, securing access to effective antibiotics globally, developing new diagnostics and treatment guidelines, and reframing antibiotic resistance as a global health and development priority.
Mechanistic View of Antibiotic Resistance
1. Antibiotic resistance occurs when bacteria no longer respond to antibiotics designed to kill them, allowing them to continue growing. 2. Resistance can be intrinsic, through natural mechanisms like efflux pumps, or acquired through genetic mutations or transfer of genes. 3. Acquired resistance is a concern as it can lead to treatment failure, increased mortality, and spread in communities.
Impact of antimicrobial resistance (AMR) in developing countries.Robin Barmon
This document is a research paper submitted by Parth Protim Barmon to Professor Tahera Ahmed on antimicrobial resistance in developing countries. It provides background information on antimicrobial resistance as resistance of microorganisms to antimicrobial medicines. It discusses how antimicrobial resistance is a growing global problem, but has a greater impact in developing countries due to factors like poverty and limited access to healthcare. The paper aims to study the risk factors for antimicrobial resistance in developing countries, including socio-demographic factors, why developing countries are more vulnerable, the role of poverty, and the disease burden.
The perspective of antibiotic resistanceLimon Mirza
Antibiotic, Antibiotic resistance, Causes of antibiotic resistance, History of antibiotic, Bangladesh perspective of antibiotic resistance, Prevention & Control of antibiotic resistance
Future impacts of antibiotic resistance
Antibiotic resistance poses serious risks to global public health in the future, including the potential for 10 million deaths per year by 2050 from currently treatable infections and diseases becoming deadly again without effective treatments. Recognition of these future impacts is important for emphasizing the urgent need to change antibiotic prescription and usage. If antibiotic resistance continues to grow, global health systems will lose control over infectious diseases and see increased rates of severe infection, hospitalization, disability and death. Many medical procedures may also become riskier as common postoperative infections become difficult or impossible to treat.
First World Antibiotic Awareness Week and awareness campaigns on prudent antibiotic use extended throughout the WHO European Region - presentation delivered by Dr Zsuzsanna Jakab, Regional Director, WHO Regional Office for Europe, on 16 November 2015
The document summarizes a group presentation on antibiotic resistance. It begins with an introduction that defines antibiotic resistance and outlines the presentation topics. These include a brief history of antibiotics, factors contributing to resistance, examples of resistant bacteria, and mechanisms of resistance. It then discusses the concerns of physicians regarding resistant infections and strategies for managing resistance, such as prudent antibiotic use, development of new drugs, and controlling spread. It concludes that human overuse of antibiotics has led to widespread resistance and that improved hygiene and isolation can help control spread.
Antibiotic resistance is a growing public health problem caused by the overuse and misuse of antibiotics. The document discusses the various mechanisms by which bacteria develop resistance, including intrinsic, acquired, and gene transfer-related resistance. It emphasizes the need for prudent antibiotic use to slow resistance, such as only using antibiotics when necessary, completing full treatment courses, and developing new drug classes. All healthcare providers, including physicians, pharmacists and microbiologists, must work together using treatment guidelines to optimize antibiotic prescribing and containment of resistance.
Antibiotic Resistance as a development and aid issueSidaresearch
1) The document discusses the global threat of antibiotic resistance, noting it is a development and aid issue.
2) Key factors that have contributed to the rise of antibiotic resistance include overuse of antibiotics in agriculture, overprescription by doctors, lack of access to diagnostics in developing countries, and global travel and trade.
3) Addressing antibiotic resistance requires strengthening surveillance, rationalizing antibiotic use, securing access to effective antibiotics globally, developing new diagnostics and treatment guidelines, and reframing antibiotic resistance as a global health and development priority.
Mechanistic View of Antibiotic Resistance
1. Antibiotic resistance occurs when bacteria no longer respond to antibiotics designed to kill them, allowing them to continue growing. 2. Resistance can be intrinsic, through natural mechanisms like efflux pumps, or acquired through genetic mutations or transfer of genes. 3. Acquired resistance is a concern as it can lead to treatment failure, increased mortality, and spread in communities.
Impact of antimicrobial resistance (AMR) in developing countries.Robin Barmon
This document is a research paper submitted by Parth Protim Barmon to Professor Tahera Ahmed on antimicrobial resistance in developing countries. It provides background information on antimicrobial resistance as resistance of microorganisms to antimicrobial medicines. It discusses how antimicrobial resistance is a growing global problem, but has a greater impact in developing countries due to factors like poverty and limited access to healthcare. The paper aims to study the risk factors for antimicrobial resistance in developing countries, including socio-demographic factors, why developing countries are more vulnerable, the role of poverty, and the disease burden.
The document provides an overview of antibiotic resistance, including definitions of antibiotics and antibiotic resistance. It discusses mechanisms of antibiotic resistance such as enzyme modification, altered target sites, efflux pumps, and decreased membrane permeability. Causes of resistance include overuse and misuse of antibiotics in humans, agriculture, and health care settings. Management of resistance involves prudent antibiotic use, infection control, developing new antibiotics, and global cooperation. National action plans aim to combat resistance through improved awareness, surveillance, optimal antibiotic use, and investments in research.
This document discusses antimicrobial resistance and antibiotic use. It defines antibiotics and their classifications including site of action, mode of action, and spectrum of activity. It discusses the misuse of antibiotics and factors that can lead to drug resistance. Antimicrobial resistance has reached crisis levels and is linked to overuse of antibiotics. The document recommends educating healthcare professionals, hospitals, pharmacists, students and patients about appropriate antibiotic usage to curb rising antimicrobial resistance.
Antibiotic resistance occurs when bacteria change in response to antibiotic use, making infections harder to treat. Bacteria, not humans or animals, become resistant. This leads to higher medical costs, prolonged hospital stays, and increased deaths. Antibiotic resistance threatens global health and can affect anyone, of any age, in any country. It occurs naturally but also because of misuse of antibiotics in humans and farm animals. This is making many infections like pneumonia, tuberculosis, and gonorrhea more difficult to treat.
a research presentation done by Augustine Mwaawaaru Level 400) and Matthew Frimpong Antwi (Level 300) students of( Presbyterian University College-Ghana on Antimicrobial resistance and the way foeward in Ghana. contact 0261825262
More than half of all hospital patients are treated with antibiotics and prescribing practices vary widely, even within hospitals. Efforts to rationalize antibiotic use have been stymied by delays in obtaining specific diagnoses, by the volume of prescriptions written each day and by the difficulty of extracting meaningful data from scattered clinical, laboratory and pharmacy records. But the push is on – from the White House, the CDC, infectious disease specialists, the industry – for more judicious use of antibiotics through antibiotic stewardship programs.
Hear how leading health care institutions have moved from education to active surveillance to intervention, reducing infections and lowering costs.
FLOW OF THE SEMINAR
1. Definition – antibiotic resistance, Multi-resistance, cross-resistance in antibiotics
2. Evolution of resistance
3. Impact of resistance
4. The scenario of resistance: Global, India
5. Factors causing resistance
6. Mechanisms of resistance: Intrinsic and Acquired
7. Acquired mechanism of resistance
8. Quorum sensing
9. Mechanism of resistance in commonly used antibiotics
10. Methods for determining the resistance
11. Strategies to contain resistance
12. Antibiotic stewardship
13. Role of Pharmacologist
14. Initiatives undertaken by India to control resistance
ANTIBIOTIC AWARENESS - BE PART OF THE SOLUTIONAnkush Biswas
This document discusses antibiotic resistance and provides information to help prevent its spread. It defines antibiotic resistance as bacteria becoming resistant to antibiotics they were once sensitive to. It notes that resistance is a concern as it can lead to treatment failure and spread of resistant bacteria. The document outlines how resistance has developed from overuse and misuse of antibiotics. It explains how resistance spreads during hospitalization or travel. It provides India-specific information on resistance issues and recommendations for healthcare professionals and the public to help prevent further resistance, such as only taking antibiotics as prescribed.
This document provides an overview of antimicrobial resistance (AMR) and recent advances in combating it. It discusses the classification and mechanisms of drug resistance. The global scenario of increasing AMR is presented, along with the situation in Nepal. Recent strategies discussed include leveraging the role of the human microbiome, developing vaccines against resistant pathogens, interrupting bacterial conjugation through bioconjugation techniques, and interfering with quorum sensing pathways. The document also reviews Nepal's national policy and action plan related to AMR containment. Prevention strategies are proposed for individuals, policymakers, and health professionals.
The document discusses antibiotics, their development and success, as well as the rise of antibiotic resistance. It notes that Alexander Fleming discovered penicillin in 1928, but others were able to mass produce it starting in the 1940s. While antibiotics were initially very effective, overuse and misuse has led to increasing antibiotic resistance in bacteria. The document outlines factors that promote resistance, such as antibiotic use in agriculture and overprescription, and stresses the need for monitoring resistance through programs like WHONET to track resistance trends and guide appropriate antibiotic use.
This document discusses antimicrobial resistance and provides information on various related topics. It begins with definitions of antimicrobials and antimicrobial resistance. It then explains why antimicrobial resistance is a concern due to increased mortality, treatment failure, and selection pressure. The document categorizes resistance into intrinsic and acquired resistance and describes various mechanisms of resistance including drug impermeable, drug destroying, and drug tolerant mechanisms. It also discusses cross-resistance and provides examples of antibiotic resistant bacteria. Finally, it introduces phage therapy as an alternative treatment approach to address antimicrobial resistance issues.
Growing antimicrobial resistance – meeting the challengesNeha Sharma
Growing antimicrobial resistance poses a serious threat as many bacteria are now resistant to existing antibiotics. This could lead to a "post-antibiotic era" with high mortality from infectious diseases. Rational antibiotic use at all levels is needed to slow resistance. Prompt diagnosis and targeted treatment are important, as is continuing research to develop new antibiotics. Improving hygiene, immunization rates, and antibiotic stewardship can help address this looming crisis.
Antibiotic stewardship programme hiht final 3nov2012Vikas Kesarwani
The document discusses antimicrobial stewardship and its importance. It provides 3 key goals of antimicrobial stewardship programs: [1] Ensuring each patient receives the most appropriate antimicrobial, [2] Preventing overuse, misuse and abuse of antimicrobials, and [3] Minimizing the development of resistance. It also outlines some core strategies for antimicrobial stewardship programs, including formulary restrictions, preauthorization requirements, and prospective audit and feedback of antimicrobial usage.
This document discusses antimicrobial resistance in Libya. It finds resistance is a serious problem that is increasing, including emerging resistance to newer drugs. Many bacteria isolated from clinical and other sources in Libya show high resistance percentages to various antibiotics. Resistance appears related to easy over-the-counter antibiotic access without prescription, improper hospital usage, and uncontrolled animal antibiotic use. Urgent action is needed to regulate antibiotic sales and usage, educate on proper clinical use, control hospital infections, and regulate non-human antibiotic use to address this growing resistance issue in Libya.
Drug resistance has increased significantly over the past decades as various resistance mechanisms have emerged and spread globally. The document discusses the history of drug resistance beginning with penicillin in the 1940s and the subsequent emergence of resistance to various classes of antibiotics. It describes several factors that have led to increased resistance such as inappropriate antibiotic use in medicine, agriculture, and genetically modified crops. Common resistance mechanisms involve production of antibiotic-modifying enzymes like beta-lactamases, altered antibiotic targets, decreased antibiotic permeability, and active efflux of antibiotics. Detection methods for various resistance enzymes and phenotypes like ESBLs and AmpC beta-lactamases are also summarized.
Mechanism Antibiotic Resistance
Intrinsic (Natural)
Acquired
Chromosomal
Extra chromosomal
Intrinsic Resistance
Lack target : No cell wall; innately resistant to penicillin
2. Drug inactivation: Cephalosporinase in Klebsiella
3. Innate efflux pumps:
It is an active transport mechanism. It requires ATP.
Eg. E. coli, P. aeruginosa
Altered target sites
PBP alteration
Ribosomal target alteration
Decreased affinity by target modification
Beta-lactamase
Beta-lactamases are enzymes produced by bacteria that provide resistance to β-lactam antibiotics such as penicillins, cephamycins, and carbapenems
Major resistant Pathogen
1. PRSP- Penicillin resistant Streptococcus pneumoniae2. MRSA/ORSA- Methicillin-resistant Staphylococcus Aureus (Super bug)3. VRE -Vancomycin-Resistant Enterococci4. Carbapenem resistant pseudomonas aeruginosa5. Carbapenem resistant Carbapenem resistant 6. Extended spectrum beta-lactamase (ESBL)-producing bacteria
The document summarizes a presentation on antimicrobial drug resistance given by Dr. Manas Kr. Nath. It discusses the objectives of the presentation, which were to introduce antimicrobial drug resistance, define it, discuss its timeline and factors, mechanisms of resistance, control strategies, and conclusions. The presentation covered intrinsic and acquired resistance, genetic and biochemical mechanisms of resistance such as mutations, plasmids, conjugation, transduction, transformation, transposons, integrons, and production of antibiotic inactivating enzymes. It emphasized that antimicrobial resistance is a major global health concern.
Antibiotics are drugs which have saved and still saving hundreds of thousands of lives every year. Antibiotics are possibly the most vital advancement in the history of medicine and undoubtedly; they are among medicine's most prevailing sector. But the other side of the coin offers us “antibiotic resistance” which is a serious and one of the most threatening healthcare problems worldwide
Dr. Sachin Verma is a young, diligent and dynamic physician. He did his graduation from IGMC Shimla and MD in Internal Medicine from GSVM Medical College Kanpur. Then he did his Fellowship in Intensive Care Medicine (FICM) from Apollo Hospital Delhi. He has done fellowship in infectious diseases by Infectious Disease Society of America (IDSA). He has also done FCCS course and is certified Advance Cardiac Life support (ACLS) and Basic Life Support (BLS) provider by American Heart Association. He has also done a course in Cardiology by American College of Cardiology and a course in Diabetology by International Diabetes Centre. He specializes in the management of Infections, Multiorgan Dysfunctions and Critically ill patients and has many publications and presentations in various national conferences under his belt. He is currently working in NABH Approved Ivy super-specialty Hospital Mohali as Consultant Intensivists and Physician.
Multifaceted approaches are needed to combat antimicrobial resistance (AMR). AMR occurs when microbes evolve to resist antimicrobial drugs like antibiotics. It threatens modern medicine by reducing treatment effectiveness. Factors driving AMR include overuse and misuse of antibiotics in humans, agriculture, and poor infection control. Solutions require action at individual, policy, health professional, and industry levels through improved stewardship, surveillance, education, and investment in new drugs. Coordinated global efforts like the WHO's action plan aim to strengthen awareness, research, infection prevention and optimize antibiotic use to slow the emergence and spread of drug-resistant infections.
Antibiotic resistance is one of the biggest threats to global health today. When bacteria become resistant to antibiotics, common infections become harder to treat and even deadly. The overuse and misuse of antibiotics is accelerating this problem. Urgent action is needed across all sectors including changes in how antibiotics are prescribed and used by individuals, farmers, health systems and policymakers to preserve the effectiveness of antibiotics and reduce the spread of resistant infections. The WHO has created a global action plan with initiatives to improve awareness, surveillance, infection prevention and optimize antibiotic use to tackle this growing public health crisis.
The document provides an overview of antibiotic resistance, including definitions of antibiotics and antibiotic resistance. It discusses mechanisms of antibiotic resistance such as enzyme modification, altered target sites, efflux pumps, and decreased membrane permeability. Causes of resistance include overuse and misuse of antibiotics in humans, agriculture, and health care settings. Management of resistance involves prudent antibiotic use, infection control, developing new antibiotics, and global cooperation. National action plans aim to combat resistance through improved awareness, surveillance, optimal antibiotic use, and investments in research.
This document discusses antimicrobial resistance and antibiotic use. It defines antibiotics and their classifications including site of action, mode of action, and spectrum of activity. It discusses the misuse of antibiotics and factors that can lead to drug resistance. Antimicrobial resistance has reached crisis levels and is linked to overuse of antibiotics. The document recommends educating healthcare professionals, hospitals, pharmacists, students and patients about appropriate antibiotic usage to curb rising antimicrobial resistance.
Antibiotic resistance occurs when bacteria change in response to antibiotic use, making infections harder to treat. Bacteria, not humans or animals, become resistant. This leads to higher medical costs, prolonged hospital stays, and increased deaths. Antibiotic resistance threatens global health and can affect anyone, of any age, in any country. It occurs naturally but also because of misuse of antibiotics in humans and farm animals. This is making many infections like pneumonia, tuberculosis, and gonorrhea more difficult to treat.
a research presentation done by Augustine Mwaawaaru Level 400) and Matthew Frimpong Antwi (Level 300) students of( Presbyterian University College-Ghana on Antimicrobial resistance and the way foeward in Ghana. contact 0261825262
More than half of all hospital patients are treated with antibiotics and prescribing practices vary widely, even within hospitals. Efforts to rationalize antibiotic use have been stymied by delays in obtaining specific diagnoses, by the volume of prescriptions written each day and by the difficulty of extracting meaningful data from scattered clinical, laboratory and pharmacy records. But the push is on – from the White House, the CDC, infectious disease specialists, the industry – for more judicious use of antibiotics through antibiotic stewardship programs.
Hear how leading health care institutions have moved from education to active surveillance to intervention, reducing infections and lowering costs.
FLOW OF THE SEMINAR
1. Definition – antibiotic resistance, Multi-resistance, cross-resistance in antibiotics
2. Evolution of resistance
3. Impact of resistance
4. The scenario of resistance: Global, India
5. Factors causing resistance
6. Mechanisms of resistance: Intrinsic and Acquired
7. Acquired mechanism of resistance
8. Quorum sensing
9. Mechanism of resistance in commonly used antibiotics
10. Methods for determining the resistance
11. Strategies to contain resistance
12. Antibiotic stewardship
13. Role of Pharmacologist
14. Initiatives undertaken by India to control resistance
ANTIBIOTIC AWARENESS - BE PART OF THE SOLUTIONAnkush Biswas
This document discusses antibiotic resistance and provides information to help prevent its spread. It defines antibiotic resistance as bacteria becoming resistant to antibiotics they were once sensitive to. It notes that resistance is a concern as it can lead to treatment failure and spread of resistant bacteria. The document outlines how resistance has developed from overuse and misuse of antibiotics. It explains how resistance spreads during hospitalization or travel. It provides India-specific information on resistance issues and recommendations for healthcare professionals and the public to help prevent further resistance, such as only taking antibiotics as prescribed.
This document provides an overview of antimicrobial resistance (AMR) and recent advances in combating it. It discusses the classification and mechanisms of drug resistance. The global scenario of increasing AMR is presented, along with the situation in Nepal. Recent strategies discussed include leveraging the role of the human microbiome, developing vaccines against resistant pathogens, interrupting bacterial conjugation through bioconjugation techniques, and interfering with quorum sensing pathways. The document also reviews Nepal's national policy and action plan related to AMR containment. Prevention strategies are proposed for individuals, policymakers, and health professionals.
The document discusses antibiotics, their development and success, as well as the rise of antibiotic resistance. It notes that Alexander Fleming discovered penicillin in 1928, but others were able to mass produce it starting in the 1940s. While antibiotics were initially very effective, overuse and misuse has led to increasing antibiotic resistance in bacteria. The document outlines factors that promote resistance, such as antibiotic use in agriculture and overprescription, and stresses the need for monitoring resistance through programs like WHONET to track resistance trends and guide appropriate antibiotic use.
This document discusses antimicrobial resistance and provides information on various related topics. It begins with definitions of antimicrobials and antimicrobial resistance. It then explains why antimicrobial resistance is a concern due to increased mortality, treatment failure, and selection pressure. The document categorizes resistance into intrinsic and acquired resistance and describes various mechanisms of resistance including drug impermeable, drug destroying, and drug tolerant mechanisms. It also discusses cross-resistance and provides examples of antibiotic resistant bacteria. Finally, it introduces phage therapy as an alternative treatment approach to address antimicrobial resistance issues.
Growing antimicrobial resistance – meeting the challengesNeha Sharma
Growing antimicrobial resistance poses a serious threat as many bacteria are now resistant to existing antibiotics. This could lead to a "post-antibiotic era" with high mortality from infectious diseases. Rational antibiotic use at all levels is needed to slow resistance. Prompt diagnosis and targeted treatment are important, as is continuing research to develop new antibiotics. Improving hygiene, immunization rates, and antibiotic stewardship can help address this looming crisis.
Antibiotic stewardship programme hiht final 3nov2012Vikas Kesarwani
The document discusses antimicrobial stewardship and its importance. It provides 3 key goals of antimicrobial stewardship programs: [1] Ensuring each patient receives the most appropriate antimicrobial, [2] Preventing overuse, misuse and abuse of antimicrobials, and [3] Minimizing the development of resistance. It also outlines some core strategies for antimicrobial stewardship programs, including formulary restrictions, preauthorization requirements, and prospective audit and feedback of antimicrobial usage.
This document discusses antimicrobial resistance in Libya. It finds resistance is a serious problem that is increasing, including emerging resistance to newer drugs. Many bacteria isolated from clinical and other sources in Libya show high resistance percentages to various antibiotics. Resistance appears related to easy over-the-counter antibiotic access without prescription, improper hospital usage, and uncontrolled animal antibiotic use. Urgent action is needed to regulate antibiotic sales and usage, educate on proper clinical use, control hospital infections, and regulate non-human antibiotic use to address this growing resistance issue in Libya.
Drug resistance has increased significantly over the past decades as various resistance mechanisms have emerged and spread globally. The document discusses the history of drug resistance beginning with penicillin in the 1940s and the subsequent emergence of resistance to various classes of antibiotics. It describes several factors that have led to increased resistance such as inappropriate antibiotic use in medicine, agriculture, and genetically modified crops. Common resistance mechanisms involve production of antibiotic-modifying enzymes like beta-lactamases, altered antibiotic targets, decreased antibiotic permeability, and active efflux of antibiotics. Detection methods for various resistance enzymes and phenotypes like ESBLs and AmpC beta-lactamases are also summarized.
Mechanism Antibiotic Resistance
Intrinsic (Natural)
Acquired
Chromosomal
Extra chromosomal
Intrinsic Resistance
Lack target : No cell wall; innately resistant to penicillin
2. Drug inactivation: Cephalosporinase in Klebsiella
3. Innate efflux pumps:
It is an active transport mechanism. It requires ATP.
Eg. E. coli, P. aeruginosa
Altered target sites
PBP alteration
Ribosomal target alteration
Decreased affinity by target modification
Beta-lactamase
Beta-lactamases are enzymes produced by bacteria that provide resistance to β-lactam antibiotics such as penicillins, cephamycins, and carbapenems
Major resistant Pathogen
1. PRSP- Penicillin resistant Streptococcus pneumoniae2. MRSA/ORSA- Methicillin-resistant Staphylococcus Aureus (Super bug)3. VRE -Vancomycin-Resistant Enterococci4. Carbapenem resistant pseudomonas aeruginosa5. Carbapenem resistant Carbapenem resistant 6. Extended spectrum beta-lactamase (ESBL)-producing bacteria
The document summarizes a presentation on antimicrobial drug resistance given by Dr. Manas Kr. Nath. It discusses the objectives of the presentation, which were to introduce antimicrobial drug resistance, define it, discuss its timeline and factors, mechanisms of resistance, control strategies, and conclusions. The presentation covered intrinsic and acquired resistance, genetic and biochemical mechanisms of resistance such as mutations, plasmids, conjugation, transduction, transformation, transposons, integrons, and production of antibiotic inactivating enzymes. It emphasized that antimicrobial resistance is a major global health concern.
Antibiotics are drugs which have saved and still saving hundreds of thousands of lives every year. Antibiotics are possibly the most vital advancement in the history of medicine and undoubtedly; they are among medicine's most prevailing sector. But the other side of the coin offers us “antibiotic resistance” which is a serious and one of the most threatening healthcare problems worldwide
Dr. Sachin Verma is a young, diligent and dynamic physician. He did his graduation from IGMC Shimla and MD in Internal Medicine from GSVM Medical College Kanpur. Then he did his Fellowship in Intensive Care Medicine (FICM) from Apollo Hospital Delhi. He has done fellowship in infectious diseases by Infectious Disease Society of America (IDSA). He has also done FCCS course and is certified Advance Cardiac Life support (ACLS) and Basic Life Support (BLS) provider by American Heart Association. He has also done a course in Cardiology by American College of Cardiology and a course in Diabetology by International Diabetes Centre. He specializes in the management of Infections, Multiorgan Dysfunctions and Critically ill patients and has many publications and presentations in various national conferences under his belt. He is currently working in NABH Approved Ivy super-specialty Hospital Mohali as Consultant Intensivists and Physician.
Multifaceted approaches are needed to combat antimicrobial resistance (AMR). AMR occurs when microbes evolve to resist antimicrobial drugs like antibiotics. It threatens modern medicine by reducing treatment effectiveness. Factors driving AMR include overuse and misuse of antibiotics in humans, agriculture, and poor infection control. Solutions require action at individual, policy, health professional, and industry levels through improved stewardship, surveillance, education, and investment in new drugs. Coordinated global efforts like the WHO's action plan aim to strengthen awareness, research, infection prevention and optimize antibiotic use to slow the emergence and spread of drug-resistant infections.
Antibiotic resistance is one of the biggest threats to global health today. When bacteria become resistant to antibiotics, common infections become harder to treat and even deadly. The overuse and misuse of antibiotics is accelerating this problem. Urgent action is needed across all sectors including changes in how antibiotics are prescribed and used by individuals, farmers, health systems and policymakers to preserve the effectiveness of antibiotics and reduce the spread of resistant infections. The WHO has created a global action plan with initiatives to improve awareness, surveillance, infection prevention and optimize antibiotic use to tackle this growing public health crisis.
Antimicrobial resistance (AMR) occurs when microorganisms become resistant to antimicrobial drugs that were previously able to treat infections. AMR arises through natural mutation and genetic transfer between microbes and is accelerated by misuse and overuse of antimicrobials. If not addressed, AMR could lead to increased mortality and healthcare costs as resistant organisms cause treatment failure. To combat AMR, proper antimicrobial use, hygiene, and surveillance are needed at the patient, clinical, agricultural, and policy levels. Education is also key to promoting appropriate antimicrobial usage.
Antibiotic resistance occurs when bacteria evolve and develop the ability to survive exposure to antibiotics that were designed to kill them. This document discusses the causes of antibiotic resistance including overuse and misuse of antibiotics as well as their use in agriculture. It describes "superbugs" which are strains resistant to multiple antibiotics and outlines some of the most dangerous ones. Complications of antibiotic resistance include treatment failure and increased spread of resistant infections. Prevention strategies target appropriate antibiotic use by individuals, health professionals, and the healthcare industry.
Role and Responsibilties of ICD IN abx.pptxShahnazAlman2
Infection prevention and control (IP&C) practices are important in maintaining a safe environment for everyone by reducing the risk of the potential spread of disease.
Antibiotic Resistance: Global Threat to Public Health.pptxSudnyankaKandge1
Antibiotics are medicines used to prevent and treat bacterial infections. Antibiotic resistance occurs when bacteria change in response to the use of these medicines.
Bacteria, not humans or animals, become antibiotic-resistant. These bacteria may infect humans and animals, and the infections they cause are harder to treat than those caused by non-resistant bacteria.
Antibiotic resistance leads to higher medical costs, prolonged hospital stays, and increased mortality.
Antibiotic Guardian Birmingham Workshop4 All of Us
Antibiotic resistance is one of the biggest threats facing us today!
European Antibiotic Awareness Day (EAAD) is part of the UK 5 Year Antimicrobial Resistance Strategy 2013 to 2018, which focuses on antibiotics and sets out actions to slow the development and spread of antimicrobial resistance.
This year, to run in line with EAAD; Public Health England has established the Antibiotic Guardian pledge campaign. It calls on everyone in the UK, the public and healthcare community to become antibiotics guardian by choosing one simple pledge about how they will make better use of these vital medicines.
To ensure that the information and knowledge on Antibiotic Stewardship is disseminated to those practising healthcare across the nation, a series of awareness and educational events have been developed. These educational workshop events, to be held in Leeds, Birmingham and London, will provide guidance, resources and information for practitioners on topics associated with antibiotic awareness. The events will provide an opportunity to understand how you and your organisation can support combat the global challenge faced by antibiotic resistance whilst gaining advice, support and resources to inform patients and staff.
1. Antibiotics are drugs that kill or slow the growth of bacteria. They work through various mechanisms like inhibiting cell wall synthesis or interfering with bacterial DNA/RNA.
2. Antibiotic resistance occurs when bacteria no longer respond to antibiotics. Bacteria develop resistance through mechanisms like producing drug-inactivating enzymes or modifying antibiotic target sites.
3. The spread of antibiotic resistance is a major global concern as it could lead us back to a pre-antibiotic era where many infections were untreatable. Factors driving resistance include overuse and misuse of antibiotics in humans and animals.
In India, bacteria that cause common infections, such as urinary tract and bloodstream infections, are becoming resistant to nearly all antibiotics. This resistance is due to a combination of factors: uncontrolled access to antibiotics, gaps in infection prevention and control (IPC) practices, and high rates of communicable diseases. Antibiotic resistance, or AR, is a serious problem throughout the country, and threatens to reduce the usefulness of antibiotics both in India and around the world.
Because of this emerging threat, India is committed to slowing the spread of AR. Two institutions within India’s Ministry of Health – the Indian Council of Medical Research and National Centre for Disease Control – each developed national networks of public and private hospitals to measure AR trends, prevent healthcare-associated infections (HAIs), and enhance appropriate use of antibiotics. The All India Institute of Medical Sciences is coordinating HAI measurement and prevention efforts in both networks. In addition, efforts in the state of Tamil Nadu focus on building district-level IPC capacity to prevent HAIs, focusing on maternal and neonatal patients.
The Indian Governamnet is is working closely with partners at the national and state level to:
Detect AR pathogens, including novel strains, by developing lab networks and lab expertise.
Use standardized surveillance to monitor and track AR infections in healthcare to learn how often these infections occur and to help develop strategies to prevent them.
Implement focused IPC activities and training.
Optimize use and reduce misuse of critical antibiotics through antibiotic stewardship programs.
Drug resistance occurs through several mechanisms: mutation, selective pressure, and gene transfer allow microbes to develop resistance. Strategies to combat resistance include international collaboration on surveillance and incentives for new drugs, national treatment guidelines and education programs, and community efforts like rational antibiotic use and hygiene. Genetic changes allow microbes to develop resistance through various mechanisms like mutation, selective pressure, and horizontal gene transfer between microbes.
This document discusses rational antibiotic use and antibiotic resistance. It defines rational antibiotic use as patients receiving appropriate medications for their clinical needs in adequate doses and durations at the lowest cost. Antibiotic overuse and misuse can lead to antibiotic resistance where infections become difficult or impossible to treat. The emergence of multidrug-resistant bacteria is a major public health threat. Hospitals should establish antibiotic policies and guidelines to promote appropriate antibiotic prescribing and prevent the spread of resistance.
This document discusses rational antibiotic use and antibiotic resistance. It defines rational antibiotic use as patients receiving appropriate medications for their clinical needs in optimal doses and durations. Inappropriate uses include unnecessary prescriptions, broad-spectrum antibiotics when narrow ones suffice, and improper dosing. This can lead to antibiotic resistance where resistant bacteria survive and spread. The document advocates for antibiotic policies to promote appropriate use and preserve antibiotic effectiveness through guidelines, committees, and surveillance.
The document discusses rational antibiotic use and antibiotic resistance. It defines rational antibiotic use as patients receiving appropriate medications for their clinical needs in adequate doses and durations at the lowest cost. Antibiotic overuse and misuse can lead to resistance, which is a major public health problem. Hospitals should establish antibiotic policies and antimicrobial stewardship programs to optimize antibiotic use and slow resistance by ensuring appropriate prescribing and monitoring of antibiotic use and resistance patterns.
Antibiotic resistance is a complex issue that requires coordinated efforts between healthcare providers, patients, governments, and industries. Key problems contributing to resistance include overuse and misuse of antibiotics in both humans and animals, lack of tools to monitor resistance, and lack of coordination between stakeholders. Coordinated actions are needed such as educational campaigns to optimize antibiotic use, regulation of antibiotic use, development of new diagnostic tests and antibiotics, and improved global collaboration and data sharing. The WHO and countries like the US are developing plans to combat resistance through various prevention and research efforts.
Antibiotic resistance occurs when bacteria evolve and adapt to antibiotics, making the drugs less effective at killing the bacteria. Many factors can contribute to the rise and spread of antibiotic resistance, including improper use of antibiotics in humans, agriculture, hospitals, and the environment. To address this growing problem, guidelines for antibiotic prescription and public awareness of appropriate antibiotic use need to be improved. Surveillance of antibiotic resistance patterns and infection control practices are also important for monitoring and containing the spread of resistant bacteria.
Antimicrobial resistance is caused by overuse and misuse of antibiotics and other antimicrobial drugs in humans, animals, and agriculture. This threatens modern medicine by rendering many lifesaving drugs ineffective. A global action plan was adopted with five objectives: improving awareness, strengthening surveillance and research, reducing infections through hygiene, optimizing antimicrobial use, and increasing investment in new treatments. Coordinated action across all sectors of society is needed to tackle this growing crisis.
This document discusses rational antibiotic use and antibiotic resistance. It defines rational antibiotic use as patients receiving appropriate medications for their clinical needs in adequate doses and durations at lowest cost. Inappropriate uses include unnecessary prescriptions, improper dosing, and not following treatment plans. This can lead to antibiotic overuse and resistance. As resistance spreads, infections become harder to treat, resulting in increased costs, length of stay, morbidity and mortality. The document outlines an antibiotic policy framework including guidelines, stewardship, surveillance and an antibiotic committee to optimize use and slow resistance.
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Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
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antibiotics resistance
1. Antibiotic resistance
Presented by:
Noor Abu-zuhair
Shahzenan Al-azzawi
Objective: public health intervention
Method: group approach
Education method: lecture
Audiance: first year medical students
10. Individuals
To prevent and control the spread of antibiotic resistance,
individuals can:
• Only use antibiotics when prescribed by a certified health
professional.
• Never demand antibiotics if your health worker says you don’t need
them.
• Always follow your health worker’s advice when using antibiotics.
• Never share or use leftover antibiotics.
• Prevent infections by regularly washing hands,
preparing food hygienically, avoiding close contact with sick
people, practising safer sex, and keeping vaccinations up to
date.
• Prepare food hygienically, following the WHO Five Keys
to Safer Food (keep clean, separate raw and cooked, cook
thoroughly, keep food at safe temperatures, use safe water
and raw materials) and choose foods that have been
produced without the use of antibiotics for growth
promotion or disease prevention in healthy animals.
11. Policy makers
To prevent and control the spread of antibiotic resistance, policy
makers can:
• Ensure a robust national action plan to tackle antibiotic
resistance is in place.
• Improve surveillance of antibiotic-resistant infections.
• Strengthen policies, programmes, and implementation of
infection prevention and control measures.
• Regulate and
promote the
appropriate use and
disposal of quality
medicines.
• Make information
available on the
impact of antibiotic
resistance.
12. Health professionals
To prevent and control the spread of antibiotic resistance, health
professionals can:
• Prevent infections by ensuring your hands, instruments, and
environment are clean.
• Only prescribe and dispense antibiotics when they are needed,
according to current guidelines.
• Report antibiotic-resistant infections to
surveillance teams.
• Talk to your patients about how to take
antibiotics correctly, antibiotic resistance
and the dangers of misuse.
• Talk to your patients about preventing
infections.
13. Healthcare industry
To prevent and control the spread of antibiotic resistance, the
health industry can:
• Invest in research and development of new antibiotics,
vaccines, diagnostics and other tools.
14. Agriculture sector
To prevent and control the spread of antibiotic resistance, the
agriculture sector can:
• Only give antibiotics to animals under veterinary
supervision.
• Not use antibiotics for growth promotion or to prevent
diseases in healthy animals.
• Vaccinate animals to reduce the need for antibiotics and
use alternatives to antibiotics when available.
• Promote and apply good practices at all steps of production
and processing of foods from animal and plant sources.
• Improve biosecurity on farms and prevent infections
through improved hygiene and animal welfare.
15. WHO response
A global action plan on antimicrobial resistance, including
antibiotic resistance, was endorsed at the World Health Assembly
in May 2015. The global action plan aims to ensure prevention
and treatment of infectious diseases with safe and effective
medicines.
The “Global action plan on antimicrobial resistance” has 5
strategic objectives:
• To improve awareness and understanding of
antimicrobial resistance.
• To strengthen surveillance and research.
• To reduce the incidence of infection.
• To optimize the use of antimicrobial medicines.
• To ensure sustainable investment in countering
antimicrobial resistance.
16. WHO response
WHO has been leading multiple initiatives to address antimicrobial
resistance:
•World Antibiotic Awareness Week
•The Global Antimicrobial Resistance Surveillance System
(GLASS)
•Global Antibiotic Research and Development Partnership
(GARDP)
•Interagency Coordination Group on Antimicrobial Resistance
(IACG)
bacteria are among the oldest living things on this planet, the smallest thing we still consider life. they are masters of survival and can be found everywhere——————
most bacteria are harmless to us, your body hosts trillions of them and they help you to survive but others can invade your body spread quickly and kill you ——————-
millions of people used to die as a result of bacterial infections until we developed a super weapon called the antibiotics——————-
together with vaccinations antibiotics revolutionized medicine and saved millions of lives————— antibiotics kill the vast majority of susceptible bacteria fairly quickly leaving only a small group of survivors that our immune system then deals with easily
how do antibiotics do this?
Antibiotic kill bacteria by interfering their metabolism or attacking the Genetic material of the bacteria. All without bothering body cells.
The rise of antibiotic resistant bacteria occur according to the Motto “What doesn’t kill you make you stronger”
As a minority of bacteria manages to “evolve” into rather more powerful bacteria
These super bacteria have an ability to resist the antibiotic and thereby can’t be killed by it anymore.
a few immune bacteria are not that big a deal because the immune system can take care of them but if they escape they might spread their immunity and the problem Arise
How can bacteria spread immunity?
first of all bacteria have two kinds of DNA, the chromosome and small free-floating parts called plasmids, the bacteria hug each other and exchange those plasmids to exchange useful abilities.
this way immunity can be spread quickly through a population or in a process called transformation
The super bacteria can harvest other bacteria species genetic material and become immune to multiple antibiotics.
another serious problem is antibiotic use in meat production
at any particular point in time humanity holds between 20 and 30 billion animals as livestock to make meat cheaper
many animals are held in horrible conditions in very tight spaces and in unhygienic conditions the perfect breeding ground for a disease,, so many animals are given antibiotics to kill as many bacteria as possible and prevent them from getting sick because a cheeseburger has to cost a dollar
unsurprisingly as a result of this system we have created more and more bacteria that are resistant to antibiotics
With increased flights numbers connecting the world, we built the infrastructure for a dangerous pandemic.
We need to take some steps to avoid the antibiotic resistance from spreading.