A 46-year-old male presented with sudden onset of chest pain radiating to the left arm and shortness of breath. He has risk factors of smoking but no other medical history. On examination, his vitals were stable and heart and lung sounds were normal. The document discusses the arterial supply of the heart and how electrocardiogram leads correspond to different areas of the heart muscle. It provides detailed descriptions of ST segment changes that would indicate occlusions or blocks in different coronary arteries and the regions of the heart affected.
Aortic insufficiency (AI), also known as aortic regurgitation (AR), is the leaking of the aortic valve of the heart that causes blood to flow in the reverse direction
Aortic insufficiency (AI), also known as aortic regurgitation (AR), is the leaking of the aortic valve of the heart that causes blood to flow in the reverse direction
Pulmonary atresia with intact interventricular septum management Ramachandra Barik
The goals of early palliation of pulmonary atresia with intact ventricular septum (PA-IVS) include the relief of cyanosis and ductal dependence by providing a reliable source of pulmonary blood flow, and the relief of right ventricular outflow tract (RVOT) obstruction to encourage forward flow and growth of right-sided
Wolff–Parkinson–White syndrome (WPW) is one of several disorders of the conduction system of the heart that are commonly referred to as pre-excitation syndromes. WPW is caused by the presence of an abnormal accessory electrical conduction pathway between the atria and the ventricles. Electrical signals traveling down this abnormal pathway (known as the bundle of Kent) may stimulate the ventricles to contract prematurely, resulting in a unique type of supra-ventricular tachycardia referred to as an atrio-ventricular reciprocating tachycardia.
Pulmonary atresia with intact interventricular septum management Ramachandra Barik
The goals of early palliation of pulmonary atresia with intact ventricular septum (PA-IVS) include the relief of cyanosis and ductal dependence by providing a reliable source of pulmonary blood flow, and the relief of right ventricular outflow tract (RVOT) obstruction to encourage forward flow and growth of right-sided
Wolff–Parkinson–White syndrome (WPW) is one of several disorders of the conduction system of the heart that are commonly referred to as pre-excitation syndromes. WPW is caused by the presence of an abnormal accessory electrical conduction pathway between the atria and the ventricles. Electrical signals traveling down this abnormal pathway (known as the bundle of Kent) may stimulate the ventricles to contract prematurely, resulting in a unique type of supra-ventricular tachycardia referred to as an atrio-ventricular reciprocating tachycardia.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
2. A 46 Years old male presented with complaints of sudden onset of chest pain which
is retrosternal, compressive type radiating to left side of the chest and left arm for
the past 1 hour
C/o shortness of breath present
C/o excessive sweating present
C/o dizziness
No other complaints
Not a k/c/o DM,HTN,CAD,CKD,TB,BA,Epilepsy,other illness
Chronic smoker
Vitals – PR- 70/Mt BP- 114/70 mm of Hg Spo2- 96% in RA
CVS-s1s2 heard, no murmur
RS- bilateral air entry present, no added sounds
Abdomen- soft, no organomegaly
CNS- NFND
6. Arterial supply of the heart
Heart receives its blood supply from coronary arteries.
Right coronary artery
Left main coronary artery –
Left anterior descending artery
left circumflex artery
7. Left anterior descending artery
Supplies the most of the anterior, anteroseptal and anterolateral wall of the
left ventricle (leads v1 – v6, Lead 1,aVL)
Left Circumflex artery
Supplies the anterolateral (leads v5,v6,lead1,aVL) and posterolateral (lead
v7,v8,v9) wall of left ventricle
In 10-15% population it supplies the inferior wall (leads 2,3,aVF)
Right coronary artery
Supplies the inferior wall (lead 2,3,aVF) and often posterolateral wall (lead
v7,v8,v9) of left ventricle
Only artery supplies the right ventricle( leads v3R-v6R)
8. ECG leads representation on heart
Lead v1,v2 – ventricular septum
Lead v2-v4 – anterior wall of the left ventricle
Lead v5,v6,1,aVL - lateral wall of the left ventricle
Lead 2,3,aVF – inferior wall of left ventricle
Lead v7-v9 (special leads) – posterolateral wall of left ventricle
Lead v3R-v6R (special right pre cordial leads) – right ventricle
12. Left anterior descending artery
Proximal occlusion
First diagonal branch
First septal branch
Distal occlusion
13. Proximal occlusion of LAD – Extensive Anterior
wall MI
ST elevation lead v1- v6,aVL , lead 1
Reciprocal ST depression In lead 3,aVF
14. LAD occlusion – first diagonal branch
high lateral wall MI
ST elevation in lead 1,Avl
Reciprocal ST depression in lead 3,aVF
15. LAD occlusion – distal to first diagonal
branch(Proximal to first septal)
ST elevation in lead v1-V4
New onset RBBB
16. LAD occlusion – distal to first diagonal &
first septal branch (Apical MI)
ST elevation in lead v2-v4 but not lead v1
17. LAD Wrap around occlusion
ST elevation & Q wave in lead 2,3,Avf in addition to lead V2-V4
18. Left circumflex artery occlusion –
anterolateral MI
ST segment elevation in lead v5,v6,lead1,Avl
Reciprocal ST depression in Lead 3,aVF
19. Left circumflex artery occlusion –
posterolateral MI
ST depression with tall R wave in lead v1-v3
ST elevation in lead v5,v6
ST elevation in posterior leads(v7-v9)
20. Left circumflex artery occlusion vs right
coronary artery occlusion
Inferior wall MI due to left circumflex artery occlusion
ST elevation in lead 2,3 avF (Lead 2 > lead 3)
ST Segment isoelectric or elevated in lead 1,Avl
Reciprocal ST depression in lead v2,v3
Inferior wall MI due to right coronary artery occlusion
ST segment elevation in lead 3 > lead 2
Reciprocal ST depression in lead Avl > lead 1
Features suggestive of Right ventricle MI(Proximal RCA occlusion) like ST
elevation in lead v1, V3r – v6R, AV nodal block
21. Right coronary artery occlusion- inferior
wall MI
ST elevation in lead 2,lead 3,Avf
Reciprocal ST depression in lead 1,Avl
22. Right coronary artery- inferolateral wall MI
ST elevation in lead 2,lead 3,Avf with ST elevation in lead v5,v6
23. Right coronary artery occlusion –
inferoposterior wall MI
ST elevation in lead 2, lead 3, Avf
Reciprocal ST depression with or without tall R wave in lead v1-v3
ST Elevation in lead v7-v9
25. Proximal Right coronary artery occlusion –
Inferior and right ventricular MI
ST elevation in lead 2,lead 3,Avf & Lead v1
Reciprocal ST depression in lead 1,aVL
26. Proximal Right coronary artery occlusion –
Inferior wall and right ventricular MI
ST elevation in lead 2, lead3, Avf
ST elevation in lead V3r,V4r,V5r,v6R
27. ST depression in lead v1- v3
Posterior wall MI vs Sub endocardial ischemia of anterior wall
Necessity of thrombolysis
Confirm with posterior leads( leads v7-v9)
In Some people left circumflex artery is small and its occlusion does not cause any
changes in ECG( bio markers & angiography needed)
