metastatik meme kanserinde doğal seyir-olgu sunumları
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metastatik meme kanserinde doğal seyir-olgu sunumları
- 1. METASTATİK MEME KANSERİ Dr Dilek Dinçol Ankara Tıp T. Onkoloji B.D.
- 7. CANCER Principles and Practice, 7th edition, DeVita VT, Hellman S, Rosenberg SA
- 9. Metastatik Meme Kanserinde Metastazların Lokalizasyon Dağılımı CANCER Principles and Practice, 7th edition, DeVita VT, Hellman S, Rosenberg SA 31-49 - Adrenal bezler 18 - Barsak 19-21 - Perikard 9-20 <5 Beyin 56-65 3-10 Karaciğer 23-51 5-15 Plevra 59-69 5-15 Akciğer 7-39 15-40 Lokorejyonal 44-71 40-75 Kemik Otopsi serileri % İlk nüks odağı % Lokalizasyon
- 12. 10- and 15-year OSRafor Connecticut and San Francisco-Oakland registry for 1981–1985 and 1991–1995 cohorts with 95% confidence intervals in brackets (SEER data) Tai P, BMC Cancer 2004;4:60 N.A. 2.4 (1.2-3.6) 15 yıl 8.8 (5.7-11.9) 4.6 (2.8-6.4) 10 yıl San Fransisco-Oakland N.A. 3.2 (2.0-4.4) 15 yıl 7.2 (3.7-10.7) 6.4 (4.6-8.2) 10 yıl Connecticut 1991-1995 OSR (%) 1981-1985 OSR (%)
- 14. Primer Tm ile Metastatik ve Lokal Rekürrens Arasında Diskordans Idirisinghe PK, Am J Clin Pathol 133:416-29,2010 % 2 % 7 erbB2 P=.017 % 33 % 42 PR % 13 % 18 ER Met veya lokal nüks Primer Tm
- 15. Broom RJ, Anticancer Res 29:1557, 2009 Primer Tm ile Metastatik ve Lokal Rekürrens Arasında Diskordans % 37.3 PR % 8 ER- -> ER+ % 9.7 ER+ -> ER- % 17.7 ER Diskordans Reseptör
- 23. A: HR negatif grup B: HR pozitif grup Dawood S, JCO 28;20-28:2010
- 32. Lower EE , Breast Cancer Res Treat 113:301-6,2009 erbB2 Durumuna Göre Hastalar % 14.1 % 9.2 % 25 %51.6 PR % 16.1 % 9.1 % 36 % 49.7 ER +/+ -/+ +/- -/- % 35.7 - Prediktif - - 205 % 84.6 + Prediktif + + 50 % 60.4 Spes + - 37 % 57.5 Sens - + 90 Metastatik Tm Primer tm erbB N
- 33. Lower EE , Breast Cancer Res Treat 113:301-6,2009 Fig. 1 Kaplan Meier curves showing probability of survival from the time of original diagnosis versus four groups based on HER/2 neu status in primary and metastatic lesion: Group 1 (negative/negative); Group 2 (positive/negative); Group 3 (negative/positive); Group 4 (positive/positive). This difference between the groups was significant (χ2 = 13.03, P < 0.005)
- 34. Fig. 2 Kaplan Meier curves showing probability of survival from the time of first diagnosis of metastases versus four groups based on HER/2 neu status in primary and metastatic lesion: Group 1 (negative/negative); Group 2 (positive/negative); Group 3 (negative/positive); Group 4 (positive/positive). There was no significant difference between groups (χ2 = 5.76, P > 0.05) Lower EE , Breast Cancer Res Treat 113:301-6,2009