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TheCarringtoneventof1859hasbeenthestrongestsolarflareintheobservationalhistory.ItplaysacrucialroleinsheddinglightonthefrequencyandimpactsofthepastandfutureSolarEnergeticParticle(SEP)eventsonhumansocieties.WeaddresstheimpactoftheCarringtoneventbymeasuringtree‐ring14Cwithmultiplereplicationsfromhigh‐latitudelocationsaroundtheeventandbycomparingthemwithmid‐latitudemeasurements.Atransientoffsetin14Cfollowingtheeventisobservedwithhighstatisticalsignificance.Ourstate‐of‐the‐art14Cproductionandtransportmodeldoesnotreproducetheobservationalfinding,suggestingfeaturesbeyondpresentunderstanding.Particularly,ourobservationwouldrequirepartiallyfasttransportof14Cbetweenthestratosphereandtroposphereathighlatitudes.TheobservationisconsistentwiththepreviousfindingswiththeSEPeventsof774and993CEforwhichfasterintegrationof14Cintotreeringsisobservedathighlatitudes

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HIV (human immunodeficiency virus) is a virus that attacks cells that help the body fight infection, making a person more vulnerable to other infections and diseases. It is spread by contact with certain bodily fluids of a person with HIV, most commonly during unprotected sex (sex without a condom or HIV medicine to prevent or treat HIV), or through sharing injection drug equipment. Seasonal influenza (the flu) is an acute respiratory infection caused by influenza viruses. It is common in all parts of the world. Most people recover without treatment. Influenza spreads easily between people when they cough or sneeze. Vaccination is the best way to prevent the disease. Symptoms of influenza include acute onset of fever, cough, sore throat, body aches and fatigue. Treatment should aim to relieve symptoms. People with the flu should rest and drink plenty of liquids. Most people will recover on their own within a week. Medical care may be needed in severe cases and for people with risk factors. There are 4 types of influenza viruses, types A, B, C and D. Influenza A and B viruses circulate and cause seasonal epidemics of disease. Influenza A viruses are further classified into subtypes according to the combinations of the proteins on the surface of the virus. Currently circulating in humans are subtype A(H1N1) and A(H3N2) influenza viruses. The A(H1N1) is also written as A(H1N1)pdm09 as it caused the pandemic in 2009 and replaced the previous A(H1N1) virus which had circulated prior to 2009. Only influenza type A viruses are known to have caused pandemics. Influenza B viruses are not classified into subtypes but can be broken down into lineages. Influenza type B viruses belong to either B/Yamagata or B/Victoria lineage. Influenza C virus is detected less frequently and usually causes mild infections, thus does not present public health importance. Influenza D viruses primarily affect cattle and are not known to infect or cause illness in people.

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The efficient delivery of therapeutic agents to tumor sites remains a significant challenge in cancer treatment. Nano-carriers have emerged as promising vehicles for targeted drug delivery due to their ability to enhance drug solubility, prolong circulation time, and minimize systemic toxicity. This review provides a comprehensive overview of active and passive targeting strategies employed to improve the efficiency of nano-carriers in reaching and accumulating at tumor sites. Active targeting utilizes ligands or antibodies to specifically bind to receptors overexpressed on tumor cells, while passive targeting exploits the unique characteristics of the tumor microenvironment, such as leaky vasculature and impaired lymphatic drainage, to enhance accumulation. The synergistic combination of active and passive targeting strategies holds great potential for optimizing drug delivery to tumors while minimizing off-target effects. In-depth understanding of these strategies is crucial for the rational design and development of nano-carriers tailored for enhanced efficacy in cancer therapy. Keywords: Nano-carriers, tumor targeting, active targeting, passive targeting, drug delivery, cancer therapy

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