This document discusses the challenges of improving hand hygiene compliance in healthcare settings. It notes that while hand hygiene is clearly important for reducing infections, achieving high compliance is difficult due to issues with behavior, culture and leadership. One way to improve compliance is through strong leadership that prioritizes hand hygiene, collects data on compliance regularly, provides feedback, and supports initiatives to make hand hygiene easier like ensuring adequate hand washing supplies are available. Examples are given of hospitals that have achieved over 95% compliance through this approach and have seen reductions in infection rates.