This document presents two case reports of maxillary second molars that each had an extra canal (MB2) identified in the mesiobuccal root. In the first case, careful visualization with magnifying loupes revealed a groove indicating the presence of an MB2 canal, which was located using an ultrasonic tip. In the second case, an incomplete access cavity was modified and exploration uncovered an extra mesiobuccal canal. Both cases were treated with biomechanical preparation and obturation of all canals. Failure to locate and treat extra canals such as MB2 is a common reason for endodontic treatment failure.