SlideShare a Scribd company logo
Malaria
By; Asma’u Abdullahi Ribadu
Infectious Disease Clerkship
What is malaria?
 Malaria is a life threatening disease caused by
plasmodium protozoa which is transmitted via bites of
an infected mosquito.
 Parasites infect RBC’s.
 It has an excellent prognosis if diagnosed and treated
early.
 Malaria is caused by a parasite which is carried by a
mosquito
 Only female anopheles mosquitoes can transmit
malaria.
Epidemiology
 40% of the world’s population lives in endemic areas.
 300 – 500 million new clinical cases per year.
 2 – 3 million deaths
It is an increasing problem because;
1) Resurgence
2) Drug resistance
Causative Agents
 1) Plasmodium falciparum; most severe type
 2) Plasmodium vivax; most commonly seen
 3) Plasmodium ovale
 4) Plasmodium malariae
 5) Plasmodium knowlesi
 The above plasmodium protozoan species are carried
by female anopheles mosquitoes
Life Cycle
1) Asexual cycle;
 exoerythrocytic schizony (liver stage)
 erythrocytic schizony (blood stage)
2) Sexual cycle
Sporogony.
Exoerythrocytic Schizony
 Sporozoites enters the hepatocytes and become
merozoites . Merozoites replicates asexually forming
a schizont which eventually bursts.
 In p. ovale and p. vivax, some sporozoites do not
undergo asexual replication and enter a dormant phase
known as hypnozoites which reactivate later resulting
in a relapse.
Erythrocytic Schizony
 Merozoites release from hepatocytes invade
erythrocytes, undergoes a trophic period then
replicates in it asexually.
 It later bursts releasing merozoites which infect more
cells.
 The release of merozoites is what causes malarial
paroxyms.
Sporogony
 Trophozites in RBC’s undergo a sexual cycle which
differentiates into gametocytes and are then ingested
by a mosquito.
 In the mosquito:
Gametocytes become gametes which fuse to become a
zygote in the mosquitos gut which then develops into an
ookinete then into an oocyte.
The oocyte divides asexually, ruptures and releases
sporozoites which infects the salivary gland and is what is
injected into the host.
Malaria
By; Asma’u Abdullahi Ribadu
Life Cycle
Incubation Period
 It is usually 7 to 30 days.
 Reduced in p. falciparum
 Increased in p. malariae
Clinical Features
 Malarial paroxyms; acute febrile attacks.
- periodic fever episodes alternating with symptom free
periods
Ususally synchronizes with merozite release.
Note: p. falciparum doesn’t exibit classic paroxyms.
 Tertian malaria;
fever on every third day. 48hrs cycle.
Benign in p. vivax
Malignant in p. falciparum
 Quartan malaria;
72hrs cycle. Fever on every fourth day.
Signs and Symptoms
 Symptoms are exclusively during asexual erythrocytic
phase.
 Fever > 40 degrees
 Chills and sweating
 Anemia
 Jaundice
 Splenomegaly
 Hepatomegaly
 Myalgia
 Headache
 Tiredness
 More sever symptoms;
 Malaria nephropathy
 Black water fever; due to massive intravascular
hemolysis. Hemoglobinuria, increased bilirubin, acute
tubular necrosis, hb casts, dark coloured urine can be
seen.
 Cerebral malaria
 If left untreated, leads to coma and death.
Malignant Malaria
 Caused by p. falciparum. It is the most severe form of
malaria.
 It has high parasitemia.
 Manifestations include; cerebral malaria, bwf, acute
respiratory distress syndrome, GI symptoms, renal
failure, shock, death.
 Uncomplicated malaria;
there’s no signs of vital organ dysfunction.
 Complicated malaria;
Organ dysfuction ie the severe symptoms plus convulsions,
bleedings, impaired conciousness etc
Labs; hypoglycemia, hyperlactemia, hyperparasitemia, severe
anemia, acidosis, renal dysfunction.
Diagnosis
1) Malarial parasites in blood films under microscope;
thick and thin films.
2) Antigen detection tests: dip sticks and cassettes. Not
sensitive. >100 parasites/100ml blood
3) Serology; IFA and ELISA
4) Molecular dx using pcr
Treatment
 Antimalerials;
 1) Atresunate
 2) Chloroquine
 3) Primaquine (hypnozoites)
 4) Artemether + Lumefantrine
 Fluid therapy for rehydration
 Blood transfusion in severe anemia
Prevention
 Avoid mosquito bites: using mosquito repellants,
insectides, using mosquito nets, wearing long sleeves
and trousers and window screens.
 Prophylaxis for travellers and pregnant women.
Malaria presentation

More Related Content

What's hot

Malaria
MalariaMalaria
Malaria
home
 
4) Malaria
4) Malaria4) Malaria
4) Malaria
Fuyuki Shimoto
 
Plasmodium malariae
Plasmodium malariaePlasmodium malariae
Plasmodium malariae
Ramya S
 
Malaria powerpoint
Malaria powerpointMalaria powerpoint
Malaria powerpoint
Hawkesdale P12 College
 
Malaria
MalariaMalaria
Malaria
Jack Frost
 
Malaria
MalariaMalaria
Plasmodium species
Plasmodium speciesPlasmodium species
Plasmodium species
Prbn Shah
 
Malaria.
Malaria.Malaria.
Malaria
MalariaMalaria
Malaria
yuyuricci
 
Malaria
MalariaMalaria
Malaria
Eneutron
 
Malaria
MalariaMalaria
Malaria
MalariaMalaria
Malaria
KULDEEP VYAS
 
Malaria (Everything about it)
Malaria (Everything about it)Malaria (Everything about it)
Malaria (Everything about it)
Arwa H. Al-Onayzan
 
seminar on Malaria
seminar on Malaria seminar on Malaria
seminar on Malaria
Dr Praman Kushwah
 
Malaria
MalariaMalaria
Malaria based on medical microbiology
Malaria based on medical microbiologyMalaria based on medical microbiology
Malaria based on medical microbiology
KAVIN6369950450
 
Malaria 19
Malaria 19Malaria 19
Malaria 19
rupesh giri
 
14 malaria
14  malaria14  malaria
14 malaria
Sumit Prajapati
 
Malaria by Dr. Aryan
Malaria by Dr. AryanMalaria by Dr. Aryan
Malaria by Dr. Aryan
Dr. Aryan (Anish Dhakal)
 
Malaria
MalariaMalaria

What's hot (20)

Malaria
MalariaMalaria
Malaria
 
4) Malaria
4) Malaria4) Malaria
4) Malaria
 
Plasmodium malariae
Plasmodium malariaePlasmodium malariae
Plasmodium malariae
 
Malaria powerpoint
Malaria powerpointMalaria powerpoint
Malaria powerpoint
 
Malaria
MalariaMalaria
Malaria
 
Malaria
MalariaMalaria
Malaria
 
Plasmodium species
Plasmodium speciesPlasmodium species
Plasmodium species
 
Malaria.
Malaria.Malaria.
Malaria.
 
Malaria
MalariaMalaria
Malaria
 
Malaria
MalariaMalaria
Malaria
 
Malaria
MalariaMalaria
Malaria
 
Malaria
MalariaMalaria
Malaria
 
Malaria (Everything about it)
Malaria (Everything about it)Malaria (Everything about it)
Malaria (Everything about it)
 
seminar on Malaria
seminar on Malaria seminar on Malaria
seminar on Malaria
 
Malaria
MalariaMalaria
Malaria
 
Malaria based on medical microbiology
Malaria based on medical microbiologyMalaria based on medical microbiology
Malaria based on medical microbiology
 
Malaria 19
Malaria 19Malaria 19
Malaria 19
 
14 malaria
14  malaria14  malaria
14 malaria
 
Malaria by Dr. Aryan
Malaria by Dr. AryanMalaria by Dr. Aryan
Malaria by Dr. Aryan
 
Malaria
MalariaMalaria
Malaria
 

Similar to Malaria presentation

Malaria
Malaria Malaria
Malaria
Sudhir Dev
 
Malaria
MalariaMalaria
Malaria and bebesia
Malaria and bebesiaMalaria and bebesia
Malaria and bebesia
فاتن عبده
 
Lesson 12 - MALARIA.pptx
Lesson 12 - MALARIA.pptxLesson 12 - MALARIA.pptx
Lesson 12 - MALARIA.pptx
sergeipee
 
Malaria
MalariaMalaria
Malaria
Toni Effs
 
malaria-180315092718.pdf parasitology zoology
malaria-180315092718.pdf parasitology zoologymalaria-180315092718.pdf parasitology zoology
malaria-180315092718.pdf parasitology zoology
ssuser4d911a
 
Lesson 12 - MALARIA.pptx
Lesson 12 - MALARIA.pptxLesson 12 - MALARIA.pptx
Lesson 12 - MALARIA.pptx
sergeipee
 
Malaria
MalariaMalaria
Malaria
raghunathp
 
Malaria
MalariaMalaria
malariappt-150708064913-lva1-app6892.pdf
malariappt-150708064913-lva1-app6892.pdfmalariappt-150708064913-lva1-app6892.pdf
malariappt-150708064913-lva1-app6892.pdf
Covidpetamburan
 
Malaria ppt
Malaria pptMalaria ppt
Malaria ppt
Jegon Varakala
 
Malaria
MalariaMalaria
Malaria
MalariaMalaria
malariappt-150708064913-lva1-app6892 (1).pptx
malariappt-150708064913-lva1-app6892 (1).pptxmalariappt-150708064913-lva1-app6892 (1).pptx
malariappt-150708064913-lva1-app6892 (1).pptx
kalsoom42
 
Malaria ppt _Dr Sumit Khetarpal.pptx
Malaria ppt _Dr Sumit Khetarpal.pptxMalaria ppt _Dr Sumit Khetarpal.pptx
Malaria ppt _Dr Sumit Khetarpal.pptx
MaxReports
 
6 malaria, toxoplasmosis
6 malaria, toxoplasmosis6 malaria, toxoplasmosis
6 malaria, toxoplasmosis
shakeel mushtaque
 
Malaria
MalariaMalaria
Malaria
NiranjanaES
 
Malaria
MalariaMalaria
Malaria
Urmila Aswar
 
Malaria
MalariaMalaria
Malaria
mahamed adam
 
MALARIA by Rohan.pptx
MALARIA by Rohan.pptxMALARIA by Rohan.pptx
MALARIA by Rohan.pptx
SheikWaseem
 

Similar to Malaria presentation (20)

Malaria
Malaria Malaria
Malaria
 
Malaria
MalariaMalaria
Malaria
 
Malaria and bebesia
Malaria and bebesiaMalaria and bebesia
Malaria and bebesia
 
Lesson 12 - MALARIA.pptx
Lesson 12 - MALARIA.pptxLesson 12 - MALARIA.pptx
Lesson 12 - MALARIA.pptx
 
Malaria
MalariaMalaria
Malaria
 
malaria-180315092718.pdf parasitology zoology
malaria-180315092718.pdf parasitology zoologymalaria-180315092718.pdf parasitology zoology
malaria-180315092718.pdf parasitology zoology
 
Lesson 12 - MALARIA.pptx
Lesson 12 - MALARIA.pptxLesson 12 - MALARIA.pptx
Lesson 12 - MALARIA.pptx
 
Malaria
MalariaMalaria
Malaria
 
Malaria
MalariaMalaria
Malaria
 
malariappt-150708064913-lva1-app6892.pdf
malariappt-150708064913-lva1-app6892.pdfmalariappt-150708064913-lva1-app6892.pdf
malariappt-150708064913-lva1-app6892.pdf
 
Malaria ppt
Malaria pptMalaria ppt
Malaria ppt
 
Malaria
MalariaMalaria
Malaria
 
Malaria
MalariaMalaria
Malaria
 
malariappt-150708064913-lva1-app6892 (1).pptx
malariappt-150708064913-lva1-app6892 (1).pptxmalariappt-150708064913-lva1-app6892 (1).pptx
malariappt-150708064913-lva1-app6892 (1).pptx
 
Malaria ppt _Dr Sumit Khetarpal.pptx
Malaria ppt _Dr Sumit Khetarpal.pptxMalaria ppt _Dr Sumit Khetarpal.pptx
Malaria ppt _Dr Sumit Khetarpal.pptx
 
6 malaria, toxoplasmosis
6 malaria, toxoplasmosis6 malaria, toxoplasmosis
6 malaria, toxoplasmosis
 
Malaria
MalariaMalaria
Malaria
 
Malaria
MalariaMalaria
Malaria
 
Malaria
MalariaMalaria
Malaria
 
MALARIA by Rohan.pptx
MALARIA by Rohan.pptxMALARIA by Rohan.pptx
MALARIA by Rohan.pptx
 

Recently uploaded

Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxDoes Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
walterHu5
 
THERAPEUTIC ANTISENSE MOLECULES .pptx
THERAPEUTIC ANTISENSE MOLECULES    .pptxTHERAPEUTIC ANTISENSE MOLECULES    .pptx
THERAPEUTIC ANTISENSE MOLECULES .pptx
70KRISHPATEL
 
Osteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdfOsteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdf
Jim Jacob Roy
 
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdfCHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
rishi2789
 
Cardiac Assessment for B.sc Nursing Student.pdf
Cardiac Assessment for B.sc Nursing Student.pdfCardiac Assessment for B.sc Nursing Student.pdf
Cardiac Assessment for B.sc Nursing Student.pdf
shivalingatalekar1
 
The Best Ayurvedic Antacid Tablets in India
The Best Ayurvedic Antacid Tablets in IndiaThe Best Ayurvedic Antacid Tablets in India
The Best Ayurvedic Antacid Tablets in India
Swastik Ayurveda
 
CBL Seminar 2024_Preliminary Program.pdf
CBL Seminar 2024_Preliminary Program.pdfCBL Seminar 2024_Preliminary Program.pdf
CBL Seminar 2024_Preliminary Program.pdf
suvadeepdas911
 
Chapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptxChapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptx
Earlene McNair
 
Efficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in AyurvedaEfficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in Ayurveda
Dr. Jyothirmai Paindla
 
Aortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 BernAortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 Bern
suvadeepdas911
 
Abortion PG Seminar Power point presentation
Abortion PG Seminar Power point presentationAbortion PG Seminar Power point presentation
Abortion PG Seminar Power point presentation
AksshayaRajanbabu
 
CHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdfCHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdf
rishi2789
 
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kol...
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kol...TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kol...
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kol...
rightmanforbloodline
 
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptxREGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
LaniyaNasrink
 
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.GawadHemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
NephroTube - Dr.Gawad
 
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
Donc Test
 
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptx
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptxMuscles of Mastication by Dr. Rabia Inam Gandapore.pptx
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptx
Dr. Rabia Inam Gandapore
 
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấuK CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
HongBiThi1
 
share - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptxshare - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptx
Tina Purnat
 
Artificial Intelligence Symposium (THAIS)
Artificial Intelligence Symposium (THAIS)Artificial Intelligence Symposium (THAIS)
Artificial Intelligence Symposium (THAIS)
Josep Vidal-Alaball
 

Recently uploaded (20)

Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxDoes Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
 
THERAPEUTIC ANTISENSE MOLECULES .pptx
THERAPEUTIC ANTISENSE MOLECULES    .pptxTHERAPEUTIC ANTISENSE MOLECULES    .pptx
THERAPEUTIC ANTISENSE MOLECULES .pptx
 
Osteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdfOsteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdf
 
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdfCHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
 
Cardiac Assessment for B.sc Nursing Student.pdf
Cardiac Assessment for B.sc Nursing Student.pdfCardiac Assessment for B.sc Nursing Student.pdf
Cardiac Assessment for B.sc Nursing Student.pdf
 
The Best Ayurvedic Antacid Tablets in India
The Best Ayurvedic Antacid Tablets in IndiaThe Best Ayurvedic Antacid Tablets in India
The Best Ayurvedic Antacid Tablets in India
 
CBL Seminar 2024_Preliminary Program.pdf
CBL Seminar 2024_Preliminary Program.pdfCBL Seminar 2024_Preliminary Program.pdf
CBL Seminar 2024_Preliminary Program.pdf
 
Chapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptxChapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptx
 
Efficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in AyurvedaEfficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in Ayurveda
 
Aortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 BernAortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 Bern
 
Abortion PG Seminar Power point presentation
Abortion PG Seminar Power point presentationAbortion PG Seminar Power point presentation
Abortion PG Seminar Power point presentation
 
CHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdfCHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdf
 
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kol...
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kol...TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kol...
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kol...
 
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptxREGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
 
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.GawadHemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
 
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
 
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptx
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptxMuscles of Mastication by Dr. Rabia Inam Gandapore.pptx
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptx
 
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấuK CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
 
share - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptxshare - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptx
 
Artificial Intelligence Symposium (THAIS)
Artificial Intelligence Symposium (THAIS)Artificial Intelligence Symposium (THAIS)
Artificial Intelligence Symposium (THAIS)
 

Malaria presentation

  • 1. Malaria By; Asma’u Abdullahi Ribadu Infectious Disease Clerkship
  • 2. What is malaria?  Malaria is a life threatening disease caused by plasmodium protozoa which is transmitted via bites of an infected mosquito.  Parasites infect RBC’s.  It has an excellent prognosis if diagnosed and treated early.
  • 3.  Malaria is caused by a parasite which is carried by a mosquito  Only female anopheles mosquitoes can transmit malaria.
  • 4. Epidemiology  40% of the world’s population lives in endemic areas.  300 – 500 million new clinical cases per year.  2 – 3 million deaths It is an increasing problem because; 1) Resurgence 2) Drug resistance
  • 5.
  • 6. Causative Agents  1) Plasmodium falciparum; most severe type  2) Plasmodium vivax; most commonly seen  3) Plasmodium ovale  4) Plasmodium malariae  5) Plasmodium knowlesi  The above plasmodium protozoan species are carried by female anopheles mosquitoes
  • 7. Life Cycle 1) Asexual cycle;  exoerythrocytic schizony (liver stage)  erythrocytic schizony (blood stage) 2) Sexual cycle Sporogony.
  • 8. Exoerythrocytic Schizony  Sporozoites enters the hepatocytes and become merozoites . Merozoites replicates asexually forming a schizont which eventually bursts.  In p. ovale and p. vivax, some sporozoites do not undergo asexual replication and enter a dormant phase known as hypnozoites which reactivate later resulting in a relapse.
  • 9. Erythrocytic Schizony  Merozoites release from hepatocytes invade erythrocytes, undergoes a trophic period then replicates in it asexually.  It later bursts releasing merozoites which infect more cells.  The release of merozoites is what causes malarial paroxyms.
  • 10. Sporogony  Trophozites in RBC’s undergo a sexual cycle which differentiates into gametocytes and are then ingested by a mosquito.  In the mosquito: Gametocytes become gametes which fuse to become a zygote in the mosquitos gut which then develops into an ookinete then into an oocyte. The oocyte divides asexually, ruptures and releases sporozoites which infects the salivary gland and is what is injected into the host.
  • 11.
  • 14. Incubation Period  It is usually 7 to 30 days.  Reduced in p. falciparum  Increased in p. malariae
  • 15. Clinical Features  Malarial paroxyms; acute febrile attacks. - periodic fever episodes alternating with symptom free periods Ususally synchronizes with merozite release. Note: p. falciparum doesn’t exibit classic paroxyms.
  • 16.  Tertian malaria; fever on every third day. 48hrs cycle. Benign in p. vivax Malignant in p. falciparum  Quartan malaria; 72hrs cycle. Fever on every fourth day.
  • 17.
  • 18. Signs and Symptoms  Symptoms are exclusively during asexual erythrocytic phase.  Fever > 40 degrees  Chills and sweating  Anemia  Jaundice  Splenomegaly  Hepatomegaly
  • 20.  More sever symptoms;  Malaria nephropathy  Black water fever; due to massive intravascular hemolysis. Hemoglobinuria, increased bilirubin, acute tubular necrosis, hb casts, dark coloured urine can be seen.  Cerebral malaria  If left untreated, leads to coma and death.
  • 21. Malignant Malaria  Caused by p. falciparum. It is the most severe form of malaria.  It has high parasitemia.  Manifestations include; cerebral malaria, bwf, acute respiratory distress syndrome, GI symptoms, renal failure, shock, death.
  • 22.  Uncomplicated malaria; there’s no signs of vital organ dysfunction.  Complicated malaria; Organ dysfuction ie the severe symptoms plus convulsions, bleedings, impaired conciousness etc Labs; hypoglycemia, hyperlactemia, hyperparasitemia, severe anemia, acidosis, renal dysfunction.
  • 23. Diagnosis 1) Malarial parasites in blood films under microscope; thick and thin films. 2) Antigen detection tests: dip sticks and cassettes. Not sensitive. >100 parasites/100ml blood 3) Serology; IFA and ELISA 4) Molecular dx using pcr
  • 24.
  • 25. Treatment  Antimalerials;  1) Atresunate  2) Chloroquine  3) Primaquine (hypnozoites)  4) Artemether + Lumefantrine  Fluid therapy for rehydration  Blood transfusion in severe anemia
  • 26. Prevention  Avoid mosquito bites: using mosquito repellants, insectides, using mosquito nets, wearing long sleeves and trousers and window screens.  Prophylaxis for travellers and pregnant women.