Lower eyelid reconstruction aims to re-establish a functional eyelid with adequate protection of the eyeball and reasonable cosmesis. Direct closure can be used for up to 30-40% defects in younger patients with eyelid laxity. The Hughes procedure uses a tarso-conjunctival flap to reconstruct large posterior lamella defects but requires a second stage for anterior lamella coverage. The Tenzel slide uses a semicircular musculocutaneous flap to reconstruct large anterior lamella defects but requires posterior lamella coverage. Free tarsal grafts can be used to replace the posterior lamella while the anterior lamella is covered with a myocutaneous advancement flap.
In this talk , we discuss the assessment and evaluation for patients presenting for cosmetic upper and lower lid blepharoplasty along with surgical technique.
In this talk , we discuss the assessment and evaluation for patients presenting for cosmetic upper and lower lid blepharoplasty along with surgical technique.
Eyelid laceration repair with defects.pptxSHAYRI PILLAI
PRINCIPLES OF EYELID REPAIR
Wounds should be copiously irrigated and explored, with the removal of any foreign material after local anesthesia
Reconstruction should be done in layers as per correct anatomical orientation
Wounds should not be extended to explore structures unless the exploration is for suspected foreign body
The orbital septum if damaged should never be repaired-result incompromised eyelid excursion and even lagophthalmos
This is a CME article that appears in Plastic and Reconstructive Surgery, the gold standard of publications within the field. Reconstructing the eyelid can be difficult and complicated. This article discusses the various approaches to defects caused by cancer.
Head and neck cancer reconstruction is arguably the
most challenging area of reconstruction for the reconstructive
surgeon. A clear understanding of the principles of use of local flaps and a comprehensive understanding of the anatomy of these flaps provides the head and neck surgeon with a plethora of local and regional options for primary and secondary reconstruction.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
2. Anatomy
Eyelid is traditionally described as a bilaminar
structure.
Anterior lamella-skin and orbicularis muscle.
Posterior lamella-tarsal plate, medial and
lateral canthal tendons, capsulapalpebral
fascia, lid retractors and conjunctiva.
5. Skin
Thinnest in the body, measuring about 0.3mm
in some areas.
Surgical incisions within the skin of the eyelid
generally heal with almost imperceptible
scarring.
6. Orbicularis oculi muscles
They lie behind the skin.
Encircles the periorbital region.
Originated from the medial canthus and the bone
of medial orbit and inserted at the lateral canthus
and lateral orbital rim.
Divided into palpebral & orbital regions
Palpebral region subdivided into pretarsal &
preseptal parts.
Responsible for lid closure
7. Orbital Septum
Fascial membrane which separates the eyelid
structures from the deep orbital structures
– Underlies posterior orbicularis fascia
– Defines anterior extent of orbit and posterior
extent of eyelid
Barrier that helps prevent the spread of
hemorrhages, infection, inflammation.
8. Orbital Septum
Upper lid: OS inserts
into the levator
aponeurosis 2-5mm
above the superior
portion of the tarsus.
Lower lid: OS inserts
into the lower edge
of the tarsus
9. Tarsal plate
Thin elongated plates of connective tissue
Contribute to form and support the eyelids
Closely related to the LPS, medial, lateral canthal
structures
Superior tarsus 8-10mm tapering to the sides.
Inferior tarsus 4 mm
The tarsal plate are attached by the medial and
lateral canthal ligament
The meibomian glands are approximately 20 in
each lid within the substance opening in a row of
tiny dots corresponding to the Grey line –
mucocutaneous junction
10. Capsulopalpebr
al fascia is a
condensation of
fibroelastic
tissue anterior
to lockwood’s
ligament, which
joins with the
inferior tarsus.
They serves as a
lower lid
retractor.
11. Conjunctiva
• Mucosal layer adjacent to the surface of the
eye.
• Palpebral portion lines inner surface of eyelid.
• Bulbar portion lines sclera
19. Requirements
Smooth mucous membrane internal lining to
maintain lubrication of the ocular surface and
avoid corneal irritation.
Skeletal support to provide adequate lid
rigidity and shape.
Proper fixation of the medial & lateral canthal
attachments of the lids for eyelid stability &
orientation.
20. In the reconstruction of both anterior &
posterior lamellae, at least one must have its
own blood supply
Techniques would depend on the size,
location, configuration, & depth of the defect
Superficial defect: only anterior lamella needs
to be repaired
Full thickness defect: needs reconstruction of
both layers
24. Direct Closure
• 30% defects in young patients
• Up to 40% in older patients with more eyelid
laxity
• Lateral cantholysis provides additional 5 mm
• Tarsal defect should be squared
• Temporal slant to musculocutaneous layer
25. Lateral Cantholysis
• Split upper and
lower canthal
tendons
• Detach lower limb
(upper limb)
• Angle skin incision
superiorly
• Anchor muscle layer
to periosteum after
closure of defect
27. Hughes
Flap
• Large, shallow
posterior lamella
defects of the
entire lid
• Vertical upper lid
to lower lid
sharing
• Anterior lamella
reconstruction
– Advancement
musculocutaneo
us flap
– Free skin graft
• Requires 2nd
stage procedure
28. Advantages
• Reconstruction of large
posterior lamella defects
• Composite flap (tarsus and
conjunctiva)
• Requires anterior lamella
coverage.
• Two stage procedure.
Disadvantages
29. Tenzel Slide
• Semicircular
musculocutaneous flap
• Flap must arch upward
• Fixation of muscle to
periosteum superior to
• canthal attachment avoids
droop of lid
• Additional support of
lateral lid can be
• achieved with periosteal
strip from lateral orbital
rim
30. Advantages
Reconstruction of large
anterior lamella defects
Disadvantages
No lash restoration.
Requires posterior lamella
coverage.
31. Tripier Flap
• Anterior lamella defects
up to 100% of lower lid.
• Medially, Laterally or
Bipedicle.
• Thin donor skin.
• Two stage.
• Requires posterior
lamella coverage
33. Mustarde Rotation Cheek Flap
• Good for very large defects
• Advantage – single stage procedure
• Preferable for patients with:
– Monocular vision
– Children with amblyopia
– Active corneal disease
– Glaucoma
• Disadvantages – lacks orbicularis, sagging, thick
donor skin, lower lid malposition, posterior
lamella coverage.
34.
35. Fricke flap (Temporal)
Advantages
• Large anterior lamella
reconstruction.
Disadvantages
• Two stages procedure
• Donor skin very thick
• Risk of frontal branch
lesion
41. Take home message
Upto 30% of the lower lid can be closed primarily.
Lateral canthotomy or cantholysis can allow
primary closure of larger defects.
Skin only defect can frequently be reconstructed
with contralateral eyelid skin.
Conjunctival defect best reconstructed by
advancement of adjacent conjunctiva or buccal
mucosa or nasal mucosal graft.
Tarsal defects are best reconstructed by palatal
graft,conchal cartilage,nasal septal cartilage.
Prevention of tension with proper anchoring is
critical to prevention ectropion.