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The naked mole rat is the longest-living rodent known, and can live up to 16x longer than regular rats. But that's just the tip of the iceberg. They are immune to environmental chemicals, they don't feel pain when being burnt with acid and in their natural habitats they are immune to cancer.
If you enjoy this show please like, subscribe and share it with people you love to help spread the word. Click the following link to see the show notes: https://endalldisease.com/episode8
All of my videos, podcasts and articles are and will always be free. If you enjoyed this video and want to support my work, you can do so by donating, buying one of my bestselling books or red light therapy devices below.
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well, dis z again another ppt on molecular biology..
I know dis kinda luks boring bt pretty informative
thanks
let me know wat you think abt dis
don't forget to comment
Charles Overton was the first one to suggest that cell membrane is made up of lipids. In the last years of the 19th century Overton did experimental work, allowing the distinction to be drawn between the cell wall of plants and their cytoplasmic membrane.He studied the permeability of a range of biological
materials to around 500 chemical compounds. In 1900, Overton proposed a biomembrane model "Overton Biomembrane Model" which stated that biomembranes are made up of lipids. He gave this statement on the basis of observation of transport of lipid soluble substances across the biomembranes.
This presentation deals with the ‘Central Dogma’ which is briefly the process by which the instructions in DNA are converted into a functional product. It was first proposed in 1958 by Francis Crick, discoverer of the structure of DNA.
The urinary system includes the kidneys and the ducts that carry away their product, urine. The genital system includes the gonads and their ducts that carry away the products they form, sperm or eggs. Embryologically, urinary and reproductive organs arise from the same or
adjacent tissues and maintain close anatomical association
throughout the organism’s life.
The cell wall that surrounded bacteria and many types of eukaryotic cell (fungi, algae an higher plant) determine cell shapes and prevent cell from and bursting as a osmotic pressure.
The cell wall of bacteria and eukaryotes are structurally very different because Bacteria cell wall consist polysaccharides cross linked by short peptide.
Cell wall consist of polysaccharides embedded in gel like matrix
well, dis z again another ppt on molecular biology..
I know dis kinda luks boring bt pretty informative
thanks
let me know wat you think abt dis
don't forget to comment
Charles Overton was the first one to suggest that cell membrane is made up of lipids. In the last years of the 19th century Overton did experimental work, allowing the distinction to be drawn between the cell wall of plants and their cytoplasmic membrane.He studied the permeability of a range of biological
materials to around 500 chemical compounds. In 1900, Overton proposed a biomembrane model "Overton Biomembrane Model" which stated that biomembranes are made up of lipids. He gave this statement on the basis of observation of transport of lipid soluble substances across the biomembranes.
This presentation deals with the ‘Central Dogma’ which is briefly the process by which the instructions in DNA are converted into a functional product. It was first proposed in 1958 by Francis Crick, discoverer of the structure of DNA.
The urinary system includes the kidneys and the ducts that carry away their product, urine. The genital system includes the gonads and their ducts that carry away the products they form, sperm or eggs. Embryologically, urinary and reproductive organs arise from the same or
adjacent tissues and maintain close anatomical association
throughout the organism’s life.
The cell wall that surrounded bacteria and many types of eukaryotic cell (fungi, algae an higher plant) determine cell shapes and prevent cell from and bursting as a osmotic pressure.
The cell wall of bacteria and eukaryotes are structurally very different because Bacteria cell wall consist polysaccharides cross linked by short peptide.
Cell wall consist of polysaccharides embedded in gel like matrix
1- "Jell-O" hearing
2- Tiny capillaries
3-Stop drinking water
4- New organ
5- Tiny lizard-like muscles
6-World's oldest people
7-Brain efficiency
8- Immune cell X
9- Tongues can smell
10- Limit to human endurance
The Human Microbiome in Sports Performance and Healthctorgan
Because our knowledge of the human microbiome is moving so rapidly, we turned our presentation at this conference into a discussion session so experts in the audience could share their professional knowledge and personal experience. By the end of the session, it was clear that we had barely scratched the surface of the importance of our microscopic kin to our health, to sports performance, and to how we need to think about designing research studies. A list of recommended resources is available at: www.caroltorgan.com/microbiome-sports/. We welcome your input!
This talk was given as a guest lecture in the undergraduate "Comparative Animal Physiology" course at the University of Texas at Austin. The talk has three parts: 1) a very brief personal introduciton about me and my thesis research, 2) an overview of some brain regions and genes that regulate social behaviors in birds, frogs, fish, reptiles, and mammals, 3) a discussion of a study looking at neuromolecular differences between closely related with with different mating systems.
1
CHAPTER 1 Microbiology: Then and Now
CHAPTER 2 The Chemical Building Blocks of Life
CHAPTER 3 Concepts and Tools for Studying Microorganisms
CHAPTER 4 Cell Structure and Function in the Bacteria and Archaea
CHAPTER 5 Microbial Growth and Nutrition
CHAPTER 6 Metabolism of Microorganisms
CHAPTER 7 Control of Microorganisms: Physical and Chemical Methods
1 Foundations of Microbiology
P A R T
n 1676, a century before the Declaration of Independence, a Dutch
merchant named Antony van Leeuwenhoek sent a noteworthy let-
ter to the Royal Society of London. Writing in the vernacular of his
home in the United Netherlands, Leeuwenhoek described how he used a simple
microscope to observe vast populations of minute, living creatures. His reports
opened a chapter of science that would evolve into the study of microscopic
organisms and the discipline of microbiology. At that time, few people, including
Leeuwenhoek, attached any practical significance to the microorganisms, but
during the next three centuries, scientists would discover how profoundly these
organisms influence the quality of our lives and the environment around us.
We begin our study of the microorganisms by exploring the grassroot devel-
opments that led to the establishment of microbiology as a science. These devel-
opments are surveyed in Chapter 1, where we focus on some of the individuals
who stood at the forefront of discovery. Today we are in the midst of a third Golden Age of microbiology and our
understanding of microorganisms continues to grow even as you read this book. Chapter 1, therefore, is an important
introduction to microbiology then and now.
Part 1 also contains a chapter on basic chemistry, inasmuch as microbial growth, metabolism, and diversity
are grounded in the molecules and macromolecules these organisms contain and in the biological processes they
undergo. The third chapter in Part 1 sets down some basic concepts and describes one of the major tools for study-
ing microorganisms. Much as the alphabet applies to word development, in succeeding chapters we will formulate
words into sentences and sentences into ideas as we survey the different groups of microorganisms and concentrate
on their importance to public health and human welfare.
Although most microorganisms are harmless—or even beneficial, some cause infectious disease. We will concentrate
on the bacterial organisms in Chapter 4, where we survey their structural frameworks. In Chapter 5, we build on these
frameworks by examining microbial growth patterns and nutritional requirements. Chapter 6 describes the metabolism
of microbial cells, including those chemical reactions that produce energy and use energy. Part 1 concludes by consider-
ing the physical and chemical methods used to control microbial growth and metabolism (Chapter 7).
I
Cells of Vibrio cholerae, transmitted to
humans in contaminated water and food, are
the cause of cholera.
62582_CH01_001_034.pdf 162582.
The Science of Zoology
Zoology As Part of Biology
Branches of Zoology
Branches of Zoology related to the medical science
Importance in daily life
The Importance of Animals in Biomedical Research
This is an introductory presentation about zoology. It gives you insight into what's in this field and how to tackle it.
The lecture can be accessed
https://youtu.be/qhXqXaTlMPk
Similar to Longevity Secrets of the Naked Mole Rat (20)
The ROOT Cause of Hair Loss & Baldness - Can Red Light Therapy Help?MarkSloan21
If you suffer from hair loss and wish there was a way to reverse your baldness so you can feel confident again, then this episode is for you.
Hair loss or alopecia affects more than half of the entire population worldwide; that’s more than 3.5 billion people who are losing their hair.[1] And despite this, the medical industry has come up with only two approved drug treatment options, both of which can have devastating side effects and it’s questionable whether or not they even work.
Can red light therapy – a powerful treatment with no side effects – restore hair growth on a balding scalp?
In this presentation, you’ll learn the mainstream theory of hair loss, mainstream medical treatment options and some horror stories of people whose lives have been ruined by them. Then you’ll learn what actually causes hair loss and whether or not red light therapy can help you restore hair growth.
For the show notes visit:
http://endalldisease.com/episode23
If you haven't already, check out my bestselling books and red light therapy devices below.
Check out our red light therapy store:
https://endalldisease.com/store
Read my books:
https://endalldisease.com/books
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Thanks for watching! Don't forget to subscribe, will see you in the next episode.
Rejuvenate Your Skin With Red Light Therapy - Before and After PicturesMarkSloan21
Red and near-infrared light therapies are among the safest and most effective anti-aging skincare treatments in the world today – and they are increasingly being used by dermatologists and skincare professionals alike to rejuvenate skin and treat many skin conditions including wrinkles, acne, psoriasis, scars and to heal injuries.
In this presentation you’ll learn how red light therapy works to benefit the skin and how you can begin using it today to help energize and rejuvenate your skin for a younger, healthier, more youthful appearance.
For the show notes visit:
https://endalldisease.com/episode21
If you haven't already, check out my bestselling books and red light therapy devices below.
Check out our red light therapy store:
https://endalldisease.com/store
Read my books:
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Thanks for watching! Don't forget to subscribe, will see you in the next episode.
Red Light Therapy for Diabetes and Insulin ResistanceMarkSloan21
For the Show Notes and to sign up for our free monthly newsletter visit: https://endalldisease.com/episode20
Over 30 million people in the United States have been diagnosed with diabetes, all of whom were told they have a terminal disease that cannot be cured. They’re told that all they can do is manage their symptoms by eating less sugar and getting regular insulin injections. However, as you’re about to find out, the root cause of diabetes and how to reverse it has been known scientifically for over 70 years. Obviously, profiting from selling insulin is far more important to the medical industry than reducing humanity’s suffering.
In 1947, a Nobel Prize-winning scientist discovered that overconsumption of polyunsaturated fatty acids can cause diabetes. This means that every time you eat a large amount of polyunsaturated fats like vegetable oil you’re becoming temporarily diabetic and insulin resistant. And if you enough of these fats, the diabetes metabolism will become chronic.
In the decades since this landmark study, researchers have shown in both animals and in humans that eating a diet low in polyunsaturated fat can completely reverse diabetes.
In 2001, a paper in the New England Journal of Medicine admitted that “Type 2 diabetes can be prevented by changes in the lifestyles of high-risk subjects”[1] so contrary to popular belief, diabetes is a metabolic disease not a genetic one and it can be completely reversed.
In this video, you’ll learn what causes diabetes and how to use treatments like red light therapy and dietary changes to help you safely and effectively prevent or reverse the disease.
For the show notes visit:
https://endalldisease.com/episode20
If you liked this video and want to support my work, you can do so by donating, or by buying one of my bestselling books or red light therapy devices below.
Check out our red light therapy store:
https://endalldisease.com/store
Read my books:
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Donate :
►Paypal:
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Thanks for listening! Don't forget to subscribe, will see you in the next episode.
How to Build Muscle with Red Light Therapy | BodybuildingMarkSloan21
If you want to pack on 10 to 20 pounds of muscle but don’t want to have to go through the trouble or pain of injecting yourself with testosterone and other anabolic steroids, then this presentation is for you. This presentation is also for you if you’re a professional bodybuilder who is looking for a secret weapon that will give you the edge over your competition.
In this presentation we’re going to find out if red light therapy can help you build bigger muscles and the body you want - whether it’s to help you win that upcoming bodybuilding competition or to boost your confidence and overall health.
For the show notes visit:
https://endalldisease.com/episode15
All of my videos, podcasts and articles are and will always be free. If you enjoyed this video and want to support my work, you can do so by donating, buying one of my bestselling books or red light therapy devices below.
Check out our red light therapy store:
https://endalldisease.com/store
Read my books:
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Donate :
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How to Increase Strength, Speed and Athletic Performance with Red Light TherapyMarkSloan21
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In this video you’re going to learn how near-infrared and red light therapies before exercise can enhance every aspect of your physical performance including strength, speed, endurance, muscle size, and overall athletic performance.
Red light therapy is so effective at athletic performance enhancement that in recent years, athletic associations worldwide have considered banning it, calling it “light doping.”
For the show notes, go to:
https://endalldisease.com/episode14
All of my videos, podcasts and articles are and will always be free. If you enjoyed this video and want to support my work, you can do so by donating, buying one of my bestselling books or red light therapy devices below.
Check out our red light therapy store:
https://endalldisease.com/store
Read my books:
https://endalldisease.com/books
Donate :
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https://www.paypal.me/endalldisease
How to Reverse Hearing Loss and Tinnitus with Red Light TherapyMarkSloan21
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In this presentation, you’re going to learn how hearing works, the root cause of hearing loss and how hearing loss can be prevented and maybe even reversed using red light therapy and antioxidant therapy.
Be sure to stick around until the end and I’ll tell you about some of the most important nutrients for hearing as well as the specific foods most rich in these nutrients. That way you can eat them and ensure your hearing is as good as it can be for your entire life.
For the show notes, go to:
https://endalldisease.com/episode13
All of my videos, podcasts and articles are and will always be free. If you enjoyed this video and want to support my work, you can do so by donating, buying one of my bestselling books or red light therapy devices below.
Check out our red light therapy store:
https://endalldisease.com/store
Read my books:
https://endalldisease.com/books
Donate :
►Paypal:
https://www.paypal.me/endalldisease
Is Cancer a Genetic Disease? | The Cancer Genome Atlas Project ResultsMarkSloan21
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Today we’re going to put the genetic theory of cancer to the test to find out once-and-for-all if cancer is a genetic disease. From studies on frog egg tumor transplants, to cybrids to the cancer genome atlas project, we're going to look deep into the evidence and see what we find.
For the show notes, go to:
http://www.endalldisease.com/episode11
All of my videos, podcasts and articles are and will always be free. If you enjoyed this video and want to support my work, you can do so by donating, buying one of my bestselling books or red light therapy devices below.
Check out our red light therapy store:
https://endalldisease.com/store
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How to Improve Your Eyesight with Red Light TherapyMarkSloan21
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In this video you'll learn about how you can treat vision loss, improve your eyesight and other vision problems such as amblyopia and age-related macular degeneration using red light therapy.
We'll also answer the questions that I get most often, which are:
Can red light therapy damage my eyes? Do I need to use eye protection during red light therapy treatment?
After that we will explore the mechanisms behind the incredible vision boosting benefits of red light therapy. If you enjoy the show, please review us on iTunes and share it with everybody you love on social media.
For the show notes, go to:
https://endalldisease.com/episode10
All of my videos, podcasts and articles are and will always be free. If you enjoyed this video and want to support my work, you can do so by donating, buying one of my bestselling books or red light therapy devices below.
Check out our red light therapy store:
https://endalldisease.com/store
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https://endalldisease.com/books
Donate :
https://www.paypal.me/endalldisease
Red Light vs Liposuction for Weight Loss & ObesityMarkSloan21
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In this episode you'll learn about the dangers of liposuction, three of the most outrageous products for fat loss and how red light therapy can help you burn up to 3 inches of fat in just two weeks.
If you enjoy the show, please share it with everybody you love on social media.
All of my videos, podcasts and articles are and will always be free. If you enjoyed this video and want to support my work, you can do so by donating, buying one of my bestselling books or red light therapy devices below.
Check out our red light therapy store:
https://endalldisease.com/store
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https://endalldisease.com/books
Donate :
https://www.paypal.me/endalldisease
Get 3 FREE ebooks for signing up to our newsletter: https://endalldisease.com/subscribe
Get ready for the jawdropping history of Cancer Surgery, detailing how carving out tumors from cancer patients has gained public acceptance over the past 500 years.
In addition, you'll learn about 4 of the most gruesome cancer surgeries ever developed. I hope this information inspires you to ask your doctor for evidence before accepting any operations from them.
All of my videos, podcasts and articles are and will always be free. If you enjoyed this video and want to support my work, you can do so by donating, buying one of my bestselling books or red light therapy devices below.
Check out our red light therapy store:
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Raw meat vs Cooked Meat - Which is Healthier?MarkSloan21
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Aajonus Vonderplanitz, American actor, author and nutritionist who died in 2013, was famous for eating a diet consisting of raw meat and sometimes rotten animal foods which he called The Primal Diet. He claimed raw meat and other animal foods eaten raw were healthier than when cooked and he even credited this diet for curing him of multiple terminal cancers.
For decades, a number of movie stars and bodybuilders have been eating raw eggs as part of their diets, based on the belief that raw eggs are healthier and easier to digest.
It’s time to settle the debate once and for all by using anthropological and scientific evidence to answer the question: Are meat, eggs and other animal proteins healthier when eaten raw or are they healthier when cooked?
Show notes can be found at: https://endalldisease.com/episode5
All of my videos, podcasts and articles are and will always be free. If you enjoyed this video and want to support my work, you can do so by donating, buying one of my bestselling books or red light therapy devices below.
Check out our red light therapy store:
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The Health Benefits of Altitude | Elevation, Cancer, UFC, Michael PhelpsMarkSloan21
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Did you know that living at elevation can reduce your risk of cancer, heart disease, diabetes and ALL diseases? In this episode, we discuss the remarkable health benefits of living or vacationing in the mountains, high up above sea level at elevation. You'll also learn the mechanism underlying the physiological benefits from altitude on the human body and how you can use this information to improve your health today.
Show notes can be found at: https://endalldisease.com/episode4
All of my videos, podcasts and articles are and will always be free. If you enjoyed this video and want to support my work, you can do so by donating, buying one of my bestselling books or red light therapy devices below.
Check out our red light therapy store:
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Donate :
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My NoFap Success Story | The Porn EpidemicMarkSloan21
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In this presentation, Mark shares his 22-year history of porn addiction and what he did to finally overcome the burden on his life. You'll also learn the science behind porn addiction, potential side effects, and how to reduce withdrawal symptoms using red light therapy.
All of my videos, podcasts and articles are and will always be free. If you enjoyed this video and want to support my work, you can do so by donating, buying one of my bestselling books or red light therapy devices below.
Check out our exclusive red light therapy devices:
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History of Red Light Therapy | PhototherapyMarkSloan21
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Did you know red light therapy was first used by the Ancient Egyptians using colored glass solariums? In this video you'll learn the exciting history of red light therapy and how we've gone from using colored glass and sunshine to electric light baths to laser therapy to small yet powerful LED red light phototherapy devices.
All of my videos, podcasts and articles are and will always be free. My goal is to create a better world for everyone alive. If you enjoyed this video, support my work by clicking one of the links below.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. The Naked Mole Rat
• The naked mole rat is a type of rodent found
naturally in the hot, arid regions of eastern Africa,
which spends its entire existence underground, or
subterranean.
• They live in colonies with about 75 other rats, but
their colonies can be as large as 300 mole rats.
• Their large, protruding teeth are used to dig, and
their mouths are sealed just behind their teeth so
their mouths don’t fill with soil while they’re digging.
• They can move backwards as quickly as they
can move forwards.
• They eat primarily large tubers that they find
underground through their mining operations.
• And their tunnel systems can stretch from
three to five kilometres (2–3 miles) in
cumulative length.
4. They Reproduce From Birth
to The Grave
(Edrey YH. et al, 2011)
• Humans tend to believe that men have
the capacity to reproduce their entire
lives, but women can only reproduce
until menopause.
• Is menopause inevitable?
• Not for naked mole rats, who can
reproduce for their entire lifespans.
If we can figure out what is conferring their lifelong reproduction, perhaps
humans can gain the same benefit.
1
5. (Smith ES. et al, 2011)
The naked mole rat “is exceptional in its acid insensitivity,” wrote
scientist ES Smith and his colleagues in a 2011 study published in the
journal Science.
Their theory explaining why was a
species-specific gene modification
that allowed acid sensors to not be
activated upon contact with acid.
They Don’t Feel Pain After Being
Burnt with Acid
2
Studies testing pain threshhold of
naked mole rats found that they
registered no pain after being burnt
with acid.
6. (Larson J. et al, 2009)
Mammalian brains typically suffer irreversible
damage after brief periods of oxygen deprivation,
for example, during a stroke or cardiac arrest.
A 2009 study published in Neuroreport found that
“brain tissue from naked-mole rats, rodents that
live in a chronically low-oxygen environment, is
remarkably resistant to hypoxia.”
Their theory explaining why was that brain
tolerance to hypoxia “may result from slowed or
arrested brain development.”
Their Brains Can Survive Long
Periods Without Oxygen
3
7. Compared with mice, naked mole rat cells have a
remarkable resistance to many harmful insults including,
• Paraquat
• High temperature
• Heavy metals
• DNA damaging agents
• Harmful foreign materials
Naked mole rats have the ability to resist damage at the
cellular level over the course of their lives. And as
researchers in a 2016 study admitted, “the underlying
mechanisms are unclear.”
(Orr. et al, 2016)
They Are Immune to Damage from
Toxins and other Stressors
4
8. Interestingly, in 2016, a report was published claiming that two naked mole rats developed
cancer. However, as it turns out, both naked mole rats in this case were born and living in
captivity at zoos, which is a much different environment then their subterranean burrows.
(Delaney MA, et al. 2016)
• Cancer has never been
observed in naked mole rats
living in their natural habitats
underground.
• Something about their
natural environment makes
them immune to cancer.
(Liang S, et al, 2010)
They Are Immune To Cancer
5
9. • Rats typically live only 2 to 2.5
years maximum.
• And yet the longest lived naked
mole rat ever observed was 32
years old.
• That’s a 16x increase in lifespan.
• The naked mole rat is the longest-living
rodent known.
• The exceptional longevity and disease
resistance of the naked mole rat have
researchers calling it “a true ‘supermodel’ for
aging research and resistance to chronic
age-associated diseases.”
(Edrey YH. et al, 2011)
They Live 16x Longer Than Normal
Rats
6
10. • Unlike all other mammals studied to date, a
naked mole rat’s risk of death does no go up as
it gets older, wrote scientists in a study from
January 2018.
• “This absence of hazard increase with age, in
defiance with Gompertz’s law, [a mathematical
equation that describes aging] uniquely
identifies the naked mole-rat as a non-aging
mammal,” they continued.
“It goes against everything we know in terms of mammalian biology.”
• “After they reached sexual maturity at 6 months of age, each naked mole rat’s daily chance of
dying was a little more than one in 10,000. It stayed the same the rest of their lives and even
went down a little,” reported scientist Buffenstein.
(Ruby JG. et al. 2018)
Naked Mole Rats Don’t Age
7
11. Scientists are Baffled!
What is the Mechanism for
the astounding features of
the Naked Mole Rat?
• Mainstream scientists have a number of theories, some of which we touched upon.
• However, ultimately, in even the most recent studies, they admit that they haven’t
figured it out yet; to the mainstream, the longevity secrets of the naked mole rat remain
a mystery.
12. Mainstream Medicine Funds
Genetic-Based Research ONLY
A friend of mine and fellow researcher emailed one of the reknowned scientists working with naked
mole rats asking them to study the metabolism of naked mole rats.
“No way in hell I am going to check metabolism. I got 3 grants from NIH [The
National Institutes of Health] decoding the naked mole rat genome so I have
no time for this metabolic nonsense.”
Mainstream medicine is not interested in metabolic research, because it would lead to cures for
diseases. By focusing (and funding) studies solely on genetics, the answers, like the explanations for
the outstanding features of the naked mole rat, are never found.
But they can’t control all research…
The reason why scientists haven’t figured it out yet is that mainstream scientific research is focused
almost entirely on genetics, and as it turns out genetics have virtually nothing to do with the naked mole
rat’s outstanding health.
The scientist replied,
13. The Naked Mole Rat EXPLAINED
“They live in burrows that are kept closed, so the
percentage of oxygen is lower than in the outside
air, and the percentage of carbon dioxide ranges
from 0.2% to 5%,” explains Dr. Raymond Peat.
A 2005 study by Israeli scientists investigated the
oxygen and carbon dioxide content in burrows of
three species of subterranean mole rats and found
that maximal CO2 levels were 6.1% and minimal
O2 levels were 7.2%.
Carbon dioxide Oxygen
Air onEarth 0.04% 20.95%
Mole Rat Burrow Up to 6.1% As low as 7.2%
In the 2016 study that documented cancer in two naked mole rats living at the zoo, they
lived in an environment with 21% atmospheric oxygen compared to their natural 7%, and
CO2 was 0.04% compared to their natural 6%.
(Shams I. et al, 2005)
153x 2.9x
14. Similar Effects to Elevation
At Elevation
Naked Mole Rat Burrow
CO2 = 0.04%
O2 = 20.95% (Reduced pressure)
CO2 = 6%
O2 = 7%
Inside the Body
CO2 O2
Inside the Body
CO2 O2
(Increased concentration)
(Reduced concentration)
15. Highly Saturated Tissue
Phospholipids
• In a 2004 study, researchers investigated
longevity in mammals by looking at the type of
fatty acids contained within their cell
membranes.
• The study found, “The degree of unsaturation of
tissue fatty acids also correlates inversely with
maximum longevity.”
(Barja G, et al. 2004)
• “Animals that naturally have a relatively low
level of highly unsaturated fats in their tissues
have the greatest longevity.”
- Dr. Raymond Peat, PhD
The Key to Maximum Longevity Cell Membranes of Naked Mole Rats
• A 2006 study investigated tissue phospholipids
in mice compared to naked mole rats.
• “Both species had similar amounts of
membrane total unsaturated fatty acids,
however, mice had 9 times more
decosahexaenoic acid (DHA).”
• “Because this n-3 PUFA is more susceptible to
lipid peroxidation, mole rat membranes are
substantially more resistant to oxidative stress
than are mice membranes.”
(Hulbert AJ, et al. 2006)
“DHA-containing phospholipids represent 27-57% of all phospholipids in
mice but only 2-6% in naked mole-rats.”
(Mitchell TW, et al. 2007)
16. Study Shocks Researchers
Synopsis:
In 2010, Researchers at the College of
Staten Island in New York re-created the
environmental conditions of a naked
mole-rat burrow (lower oxygen and
increased carbon dioxide) in their
laboratory and examined its effects on
naked mole rat activity levels, memory
and social interaction.
Hypothesis:
They hypothesized that the environment
would have a negative impact on the
activity, memory and social interaction of
the rats.
Results:
When the rats were put into an
environment of decreased oxygen
(“hypoxic”) and increased carbon dioxide
(“hypercapnic”)…
17. They became more social
They had significantly improved memory
scores
Their overall movements increased by
76.8%
(Berkovits R. et al, 2017)
Conclusion:
“Results did not support the original hypothesis that activity, memory and social interaction
levels would decrease under hypercapnic hypoxia.”
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22. References
• Edrey YH, park TJ, kang H, biney A, buffenstein R. Endocrine function and neurobiology of the longest-living rodent, the naked mole-rat.
Exp gerontol. 2011;46(2-3):116-23.
• Smith ES, omerbašić D, lechner SG, anirudhan G, lapatsina L, lewin GR. The molecular basis of acid insensitivity in the african naked
mole-rat. Science. 2011;334(6062):1557-60.
• Larson J, park TJ. Extreme hypoxia tolerance of naked mole-rat brain. Neuroreport. 2009;20(18):1634-7.
• Liang S, mele J, wu Y, buffenstein R, hornsby PJ. Resistance to experimental tumorigenesis in cells of a long-lived mammal, the naked
mole-rat (heterocephalus glaber). Aging cell. 2010;9(4):626-35.
• Buffenstein R. The naked mole-rat: a new long-living model for human aging research. J gerontol A biol sci med sci. 2005;60(11):1369-77.
• O'connor tp, lee a, jarvis ju, buffenstein r. Prolonged longevity in naked mole-rats: age-related changes in metabolism, body composition
and gastrointestinal function. Comp biochem physiol, part A mol integr physiol. 2002;133(3):835-42.
• Csiszar A, labinskyy N, orosz Z, xiangmin Z, buffenstein R, ungvari Z. Vascular aging in the longest-living rodent, the naked mole rat. Am J
physiol heart circ physiol. 2007;293(2):h919-27.
• Orr ME, Garbarino VR, Salinas A, Buffenstein R. Extended postnatal brain development in the longest-lived rodent: prolonged maintenance
of neotenous traits in the naked mole-rat brain. Front Neurosci. 2016;10:504.
• Gorbunova V, Seluanov A, Zhang Z, Gladyshev VN, Vijg J. Comparative genetics of longevity and cancer: insights from long-lived
rodents. Nat Rev Genet. 2014;15:531–540.
• Delaney MA, Ward JM, Walsh TF, Chinnadurai SK, Kerns K, Kinsel MJ, Treuting PM (May 2016). "Initial Case Reports of Cancer in Naked
Mole-rats (Heterocephalus glaber)". Veterinary Pathology. 53 (3): 691–6.
• Ruby JG, Smith M, Buffenstein R. Naked Mole-Rat mortality rates defy gompertzian laws by not increasing with age. Elife. 2018;7.
• Lewis KN, mele J, hornsby PJ, buffenstein R. Stress resistance in the naked mole-rat: the bare essentials - a mini-review. Gerontology.
2012;58(5):453-62.
• Kim eb, fang x, fushan aa, et al. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature.
2011;479(7372):223-7.
• Lewis kn, andziak b, yang t, buffenstein r. The naked mole-rat response to oxidative stress: just deal with it. Antioxid redox signal.
2013;19(12):1388-99.
• Shams I, avivi A, nevo E. Oxygen and carbon dioxide fluctuations in burrows of subterranean blind mole rats indicate tolerance to hypoxic-
hypercapnic stresses. Comp biochem physiol, part A mol integr physiol. 2005;142(3):376-82.
• Berkovits R, boffa N, deluca V. The effects of hypercapnic hypoxia on naked mole rat activity levels, memory, and social interaction. 2010.
Available: https://macaulay.Cuny.Edu/eportfolios/newyorkcityonthebrain/files/2010/12/nmr-poster.Pdf [february 15, 2017].
• Barja G. Free radicals and aging. Trends Neurosci. 2004;27(10):595-600.
• Mitchell TW, Buffenstein R, Hulbert AJ. Membrane phospholipid composition may contribute to exceptional longevity of the naked mole-rat
(Heterocephalus glaber): a comparative study using shotgun lipidomics. Exp Gerontol. 2007;42(11):1053-62.
• Hulbert AJ, Faulks SC, Buffenstein R. Oxidation-resistant membrane phospholipids can explain longevity differences among the longest-
living rodents and similarly-sized mice. J Gerontol A Biol Sci Med Sci. 2006;61(10):1009-18.