Samia Sultana Anny, a 40-year-old housewife, presented with watering and purulent discharge from her left eye for 4 years and 1 year, respectively. Examination revealed matted eyelashes, full lacus lacrimalis, and a positive regurgitation test on the left side, indicating chronic dacryocystitis. Investigations and management with left dacryocystorhinostomy and intubation were planned. Differential diagnoses included acute dacryocystitis and punctum stenosis.
A 27-year-old male with bilateral red eyes.pptxAsAadHabib2
The patient presented with bilateral red eyes with chronic discharge from both eyes and a history of chalazion surgery. We did necessary investigations and treated him with topical fortified ceftazidime and systemic antibiotics. But later similar presentations were seen. We again did all the available and necessary investigations yet nothing significant was found. As our country is an endemic zone for TB we started empirical anti TB drugs. The rest is on the presentation.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
2. Particulars of the patient:
Name- Samia Sultana Anny
Age- 40 years
Sex- female
Religion- Islam
Marital status-Married
Occupation- Housewife
Address- Hatirpul,pukurpar mosjid,Dhaka.
Date of examination- 12/10/2021
4. History of present illness:
According to the statement of the patient, she was quite well 4 years
back since she developed watering from left eye which was initially
associated with painless swelling of the left eye. She gave no history
of ocular trauma ,nasal pathology, redness or any visual disturbance.
With these problems she visited doctors in her locality and was
prescribed with some eye drops, name of which she could not
mention.
5. History of present illness:
After using those medication her condition improved a bit but again
symptoms aggravated when she stopped medications. Initially
watering was scanty in amount but gradually it increased and
purulent discharge was associated with it for last 1 year. 9/10/2021
she again visited doctor and was advised Moxibac(Moxifloxacin)
eyedrop.
6. History of present illness:
With these complaints she came into BSMMU , Department of
Community Ophthalmology through OPD for better management.
She is non diabetic , normotensive and non asthmatic.
7. History of past illness:
No history of trauma, surgery or any significant systemic illness in
the past.
8. Family History:
None of her family member is suffering from same type of
problem.
She has a daughter.
All of them are healthy.
9. Drug History:
She used some eye drops earlier name of which she could not
mention and from 9/10/2021 she started using
Moxibac(Moxifloxacin) eyedrop.
11. Socio-economic History:
The patient belongs to a middle class family.
She lives in concrete house with proper water supply and sanitary
facilities.
13. General Examination:
Appearance- Normal
Co operation-Co-operative
Body built- Average
Nutrition-Good
Decubitus- On choice
Anaemia- Absent
Jaundice-Absent
Cyanosis- Absent
Oedema-Absent
15. Local Examination:
On inspection-
Head position is normal
No facial asymmetry
Eyelids: Normal in both side
Eye lashes: Matted in left side , normal in right side.
Lid margin is normal in both sides.
Punctum : both upper and lower puncta are normal in position both sides
16. Local Examination:
Lacus lacrimalis was full of water in left side.
Nasal cavity-normal in both sides , there is no deviation of septum ,polyps or
tumor . Nasal mucosa is normal.
Oral cavity- normal .
19. Ocular examination:
Ocular Examination Right eye Left eye
Visual acuity-distant vision 6/6, unaided 6/6,unaided
with pinhole 6/6 6/6
near Vision N6 with +1.00D N6 with +1.00D
Pupillary light reflex- Direct
Consensual
Brisk
Present
Brisk
Present
Hirschberg reflex Central Central
RAPD Absent Absent
Ocular motility Full in all gaze Full in all gaze
Color Vision Trichromatic Trichromatic
20. Slit lamp findings:
Right eye Left eye
EYE LIDS Normal Normal
EYE LASHES Normal Matted. Lacus lacrimalis full of water.
Marginal tear stripes height increased
CONJUNCTIVA Not congested Not congested
CORNEA Transparent Transparent
ANTERIOR CHAMBER Normal in depth both in centre and
periphery
Normal in depth both in centre and
periphery
IRIS Normal in color and pattern Normal in color and pattern
PUPIL Round regular and Reacting to light Round regular and Reacting to light
LENS
IOP(by GAT at 12/10/2021 @ 1.06pm)
Transparent
14 mm of Hg
Transparent
14mm of Hg
21. Fundus examination:
Fundus examination (Direct
ophthalmoscopy)
Right eye Left eye
Media Clear Clear
Optic disc-Color Pink Pink
Margin Well defined Well defined
Shape Circular Circular
CD ratio 0.3 0.3
Blood vessels Normal in number and distribution Normal in number and distribution
Background fundus Normal Normal
Macula Healthy, Foveal reflex present Healthy, Foveal reflex present
22. Special ocular examination:
Sac patency test-
On right side- Fluid easily pass into the nose and naso-pharynx
indicates the lacrimal drainage system is patent.
On left side- Cloudy fluid come out through the upper punctum
indicates block into the nasolacrimal duct.
30. Examination of the cardiovascular
system:
Inspection –
Shape of the chest-normal.
Anaemia , cyanosis , clubbing , coldness of extremities , pyrexia , oedema
absent.
Arterial pulse- 76 beats/min
Blood pressure- 110/70 mm of Hg
31. Examination of the cardiovascular
system:
Palpation-
Apex beat-present in left 5th intercostal space just medial to the mid clavicular
line.There was no thrill.
Percussion-area of superficial cardiac dullness normal.
Auscultation-
The first and second heart sounds were audible .
There is no added sound.
32. Examination of the Respiratory
System:
Inspection-Nasal cavity-normal
Nasopharynx-NAD
Oral cavity-NAD
Oropharynx-NAD
Respiratory rate-16 breaths/min
Shape of the chest-normal ,bilaterally symmetrical
Palpation-position of the trachea central.
Percussion-resonant
Auscultation-vesicular breath sound
33. Alimentary system:
Inspection : Size and Shape – Normal
Position of the Umbilicus – central
Palpation : Temperature is normal.
There is no tenderness, rigidity or swelling.
Percussion : Tympanitic
Auscultation : Bowel sound present.
35. Examination of the Nervous
System:
Higher cerebral function- intact
Patient is conscious and oriented , gait normal.
All cranial nerves-intact
Motor function-There is no muscle wasting ,bulk and tone of muscle
is normal in both upper and lower limbs .
Reflexes- are intact and normal.
Sensory function-Temperature ,touch , pain and vibration and position sense
intact.
Cerebellar function- intact
Signs of meningeal irritation -absent
36. Salient feature:
Mrs. Samia Sultana Anny 40 years old normotensive and non diabetic housewife
hailing from Hatirpool,Dhaka came into the department of community
ophthalmology,BSMMU on 12.10.2021 with the complaints of watering from left eye
for 4 years and purulent discharge from left eye for 1 year.
On Slit lamp examination left eye reveals that eye lashes were matted, lacus
lacrimalis was full of water, lower tear film meniscus height was increased and
regurgitation test –positive on left side .Sac patency test reveals NLD block of left
side.
Other ocular, general and systemic examination were within normal limit.