Liver function tests (LFT) measure various substances, including serum bilirubin, to evaluate liver health and detect conditions like jaundice and liver diseases. Key factors in bilirubin metabolism include its production from old red blood cells, conjugation processes, and defects associated with conditions such as Gilbert’s disease and Crigler-Najjar syndrome. The document also discusses the significance of normal bilirubin levels and potential disorders impacting bilirubin clearance and secretion.

1. LIVER FUNCTION TESTS (LFT)

2. Liver Function Tests :
1. Serum Bilirubin :
OLD R.B.C / IMMATURE CELLS
HAEMOGLOBIN
GLOBIN MYOGLOBIN
CYTOCHROMES
HEME
Fe3+ RES
M.H.O.S
BILIVERDIN
REDUCTION
BILIRUBIN 300mg
BILIRUBIN – ALBUMIN PLASMA
RE
system
i.e.
Spleen
Bone
Marrow

3. Bilirubin - Albumin PLASMA
Bilirubin – Ligandin
UDPGT 2UDPGA
2UDP
BDG
Secretion Defect
Dubin Johnson syndrome
Rotor syndrome
LIVER
GILBERT’S DISEASE x Uptake defect
Conjugation defect in
1. Neonatal jaundice
2. Toxic jaundice
3. Crigler najjar
syndrome
4. Gilberts disease

4. Bilirubin diglucuronide (BDG)
Bacterial enzymes
Glucuronides Betaglucuronidases Intestine
Reduction
Urobilinogens
Urine 1-4mg
Enterohepatic
Circulation
Feces 300mg

9. (Inhibits elastase)
20 to 40mg/dl
< 25 μg/L

10. Acute Viral Hepatitis

11. Obstructive Jaundice
ALP

12. Alcoholic Hepatitis

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