LEO Commercialization: Space-based Research and Development and Manufacturing
•
1 like•1,534 views
This document discusses a panel discussion on commercializing space-based research and development and manufacturing. The panelists included the president of a company called iXpressGenes, an associate director from the National Center for Advancing Translational Sciences, and the president of Made In Space. The panel, moderated by a writer from Fast Company, focused on using the microgravity environment of low Earth orbit to conduct protein crystal growth for drug development, perform tissue-on-chip experiments to study human disease, and develop advanced manufacturing techniques. The goal is to utilize the International Space Station and find sustainable business opportunities to further space commercialization and translation.
Report
Share
Report
Share
Recommended
Introduction of Research by Utilizing Kibo Internal Facilities
This presentation provides an overview of research being conducted utilizing the internal facilities of the Kibo Pressurized Module on the International Space Station. It aims to inspire potential users and encourage US researchers to participate. Several types of ongoing research are highlighted, including rodent research comparing microgravity and artificial gravity conditions; aquatic biology research using medaka and zebrafish; high-quality protein crystallization for structural analysis; high-temperature material property measurements using an electrostatic levitation furnace; and various other experimental equipment in the module. The speaker concludes by presenting typical laboratory equipment available and related experiments to maximize utilization of the Kibo Pressurized Module facilities.
Kibo Utilization Achievements
JAXA has pursued a new policy since 2015 to maximize outcomes from utilization of the ISS and Kibo facility. The policy includes:
1. Identifying and prioritizing prospective utilization areas as "platforms" to make available to various users, such as supporting research on new drug design, aging-like phenomena, small satellite deployment, and various uses of the Kibo Exposed Facility.
2. Implementing a new collaborative framework called the JP-US Open Platform Partnership Program between Japan and the US to enhance cooperation and mutual utilization of experiment facilities.
3. Increasing both the quantity and quality of Kibo utilization services to maximize outcomes and benefit scientific research and society. Examples of obtained results that
New Space Environment Utilization with Kibo Unique Exposed Facility
1) The document discusses maximizing utilization of the International Space Station (ISS) and the Japanese Experiment Module (Kibo) through new collaborations between JAXA and NASA.
2) Kibo has a unique exposed facility with an airlock and robotic arm, allowing it to exchange experimental equipment and deploy small satellites in unique ways compared to other ISS modules.
3) JAXA hopes to further collaboration with NASA under the new Japan-US Open Platform Partnership Program to increase utilization of ISS/Kibo resources and technologies.
Lecture at University of Wisconsin, Madison - April 2, 2018
Large SPEs, especially when the shielding is inadequate, not only increase the risk of cancer, but also the possibility of occurrence of acute radiation syndrome (ARS). As physical shielding alone cannot solve current space radiation problems, in 2003 we introduced the adaptive response as an efficient model of biological protection. The development of this model is discussed in our recent publications. A recently published paper, authored by 30 scientists from countries such as US, UK, Russia, and Belgium has confirmed the need for selection of astronauts based on their adaptive response (this paper cites our reports on how AR helps choosing the astronauts for a deep space mission). Moreover, A NASA report published in 2016 has cited our early report on the importance of radioadaptive response in space missions and states that cells can be expected to be exposed to multiple hits of protons before being traversed by an HZE particle. However, substantial evidence showing that SPEs are a real concern, indicate that our proposed model is more applicable and evidence-based. Regarding the risk of infection, change of the virulence (ability to cause disease) of microorganisms and astronauts’ dysregulated immune system, significantly increases the infection risk in deep space missions.
HIGH-FIELD MRS methods to Study Human Body ZOOM MRSI 2-hg 2-hydroxyglutarate...
This document discusses the use of high field MRI methods to study the human body. It provides background on how MRS has evolved from obtaining phosphate spectra in the 1970s to playing a pivotal role in human brain mapping. It describes comparative histories of automobile and smartphone societies from 2001-2012. Methods discussed include 1H MRS at high fields to study cancer metabolism, detect biomarkers for precision medicine in gliomas, and measure neurochemical profiles from childhood to adulthood. Ongoing work includes using ZOOM-MRSI, MRS-fMRI, and ultra-high field sodium and UTE imaging to study the brain, kidneys, cartilage and lungs.
Strategies for reducing the risk of radiation for astronauts in space mission...
Exposure to high levels of space radiation and microgravity are two important concerns which need to be addressed before any long-term manned space mission. There are also reports showing that microgravity, through a synergistic effect, increases the radiation susceptibility of living organisms. Other researchers as well as our team have conducted some experiments on design and fabrication of appropriate radiation shields for spacecrafts. However, due to some cardinal barriers such as weight limitations and extreme inadequacy of current physical shields during extravehicular activity, we strongly believe that the physical shielding alone cannot solve the problem of potential exposure to high levels of radiation in a long-term space mission.
Therefore, over the past several years, we focused on two solutions; radioadaptive response and other biological-based radiation protection methods. Adaptive response, that is the increased radioresistance in cells or living organisms pre-exposed to a low adapting dose and then exposed to a high challenging dose, was firstly proposed by our team in 2003 as an effective method. This novel idea later formed the basis of many space radiation biology projects around the world.
Furthermore, conventional radioprotectors cannot efficiently be used in space due to limitations such as their considerable toxicity and the very narrow time window for their effective use (radioprotectors should be used before or at the time of exposure, while astronauts cannot estimate their doses before a solar particle event). Therefore, we focused on introducing natural radiation mitigators which could be efficiently used several hours after exposure (e.g. when a solar particle event subsides and astronauts are able to estimate their doses). In these experiments, radiation mitigators were introduced by our team which could be used even 24 hours after exposure to high levels of radiation caused by unpredictable sources such as SPEs.
Finally, some of our recent experiments were aimed at finding methods which could lead to boosting the immune system of astronauts during long-term missions. We investigated the effect of RF-EMFs-induced adaptive responses on immune system modulation in a mouse model of hindlimb unloading (HU). Hindlimb unloading rodent model is widely accepted by the scientific community as the model of choice for simulating spaceflight. In this study, serum levels of T helper cytokines were determined in HU mice, RF-EMF treated mice and HU mice pre-exposed to RF-EMF compared to those of untreated controls. The findings of this study will be published soon.
Fillerup - SOARD Research Portfolio - Spring Review 2013
James Fillerup, PE, Director, presents an overview of his program, SOARD Research Portfolio, at the AFOSR 2013 Spring Review. At this review, Program Officers from AFOSR Technical Divisions will present briefings that highlight basic research programs beneficial to the Air Force.
Zen 362 group 2 effects of disaster fukushima
ZEN 362 assignment: Effects of disasters. In this presentation we looked at a study conducted by Yamashiro et al. (2013) about the effects of radioactive caesium on bull testes after the Fukushima nuclear plant accident.
Recommended
Introduction of Research by Utilizing Kibo Internal Facilities
This presentation provides an overview of research being conducted utilizing the internal facilities of the Kibo Pressurized Module on the International Space Station. It aims to inspire potential users and encourage US researchers to participate. Several types of ongoing research are highlighted, including rodent research comparing microgravity and artificial gravity conditions; aquatic biology research using medaka and zebrafish; high-quality protein crystallization for structural analysis; high-temperature material property measurements using an electrostatic levitation furnace; and various other experimental equipment in the module. The speaker concludes by presenting typical laboratory equipment available and related experiments to maximize utilization of the Kibo Pressurized Module facilities.
Kibo Utilization Achievements
JAXA has pursued a new policy since 2015 to maximize outcomes from utilization of the ISS and Kibo facility. The policy includes:
1. Identifying and prioritizing prospective utilization areas as "platforms" to make available to various users, such as supporting research on new drug design, aging-like phenomena, small satellite deployment, and various uses of the Kibo Exposed Facility.
2. Implementing a new collaborative framework called the JP-US Open Platform Partnership Program between Japan and the US to enhance cooperation and mutual utilization of experiment facilities.
3. Increasing both the quantity and quality of Kibo utilization services to maximize outcomes and benefit scientific research and society. Examples of obtained results that
New Space Environment Utilization with Kibo Unique Exposed Facility
1) The document discusses maximizing utilization of the International Space Station (ISS) and the Japanese Experiment Module (Kibo) through new collaborations between JAXA and NASA.
2) Kibo has a unique exposed facility with an airlock and robotic arm, allowing it to exchange experimental equipment and deploy small satellites in unique ways compared to other ISS modules.
3) JAXA hopes to further collaboration with NASA under the new Japan-US Open Platform Partnership Program to increase utilization of ISS/Kibo resources and technologies.
Lecture at University of Wisconsin, Madison - April 2, 2018
Large SPEs, especially when the shielding is inadequate, not only increase the risk of cancer, but also the possibility of occurrence of acute radiation syndrome (ARS). As physical shielding alone cannot solve current space radiation problems, in 2003 we introduced the adaptive response as an efficient model of biological protection. The development of this model is discussed in our recent publications. A recently published paper, authored by 30 scientists from countries such as US, UK, Russia, and Belgium has confirmed the need for selection of astronauts based on their adaptive response (this paper cites our reports on how AR helps choosing the astronauts for a deep space mission). Moreover, A NASA report published in 2016 has cited our early report on the importance of radioadaptive response in space missions and states that cells can be expected to be exposed to multiple hits of protons before being traversed by an HZE particle. However, substantial evidence showing that SPEs are a real concern, indicate that our proposed model is more applicable and evidence-based. Regarding the risk of infection, change of the virulence (ability to cause disease) of microorganisms and astronauts’ dysregulated immune system, significantly increases the infection risk in deep space missions.
HIGH-FIELD MRS methods to Study Human Body ZOOM MRSI 2-hg 2-hydroxyglutarate...
This document discusses the use of high field MRI methods to study the human body. It provides background on how MRS has evolved from obtaining phosphate spectra in the 1970s to playing a pivotal role in human brain mapping. It describes comparative histories of automobile and smartphone societies from 2001-2012. Methods discussed include 1H MRS at high fields to study cancer metabolism, detect biomarkers for precision medicine in gliomas, and measure neurochemical profiles from childhood to adulthood. Ongoing work includes using ZOOM-MRSI, MRS-fMRI, and ultra-high field sodium and UTE imaging to study the brain, kidneys, cartilage and lungs.
Strategies for reducing the risk of radiation for astronauts in space mission...
Exposure to high levels of space radiation and microgravity are two important concerns which need to be addressed before any long-term manned space mission. There are also reports showing that microgravity, through a synergistic effect, increases the radiation susceptibility of living organisms. Other researchers as well as our team have conducted some experiments on design and fabrication of appropriate radiation shields for spacecrafts. However, due to some cardinal barriers such as weight limitations and extreme inadequacy of current physical shields during extravehicular activity, we strongly believe that the physical shielding alone cannot solve the problem of potential exposure to high levels of radiation in a long-term space mission.
Therefore, over the past several years, we focused on two solutions; radioadaptive response and other biological-based radiation protection methods. Adaptive response, that is the increased radioresistance in cells or living organisms pre-exposed to a low adapting dose and then exposed to a high challenging dose, was firstly proposed by our team in 2003 as an effective method. This novel idea later formed the basis of many space radiation biology projects around the world.
Furthermore, conventional radioprotectors cannot efficiently be used in space due to limitations such as their considerable toxicity and the very narrow time window for their effective use (radioprotectors should be used before or at the time of exposure, while astronauts cannot estimate their doses before a solar particle event). Therefore, we focused on introducing natural radiation mitigators which could be efficiently used several hours after exposure (e.g. when a solar particle event subsides and astronauts are able to estimate their doses). In these experiments, radiation mitigators were introduced by our team which could be used even 24 hours after exposure to high levels of radiation caused by unpredictable sources such as SPEs.
Finally, some of our recent experiments were aimed at finding methods which could lead to boosting the immune system of astronauts during long-term missions. We investigated the effect of RF-EMFs-induced adaptive responses on immune system modulation in a mouse model of hindlimb unloading (HU). Hindlimb unloading rodent model is widely accepted by the scientific community as the model of choice for simulating spaceflight. In this study, serum levels of T helper cytokines were determined in HU mice, RF-EMF treated mice and HU mice pre-exposed to RF-EMF compared to those of untreated controls. The findings of this study will be published soon.
Fillerup - SOARD Research Portfolio - Spring Review 2013
James Fillerup, PE, Director, presents an overview of his program, SOARD Research Portfolio, at the AFOSR 2013 Spring Review. At this review, Program Officers from AFOSR Technical Divisions will present briefings that highlight basic research programs beneficial to the Air Force.
Zen 362 group 2 effects of disaster fukushima
ZEN 362 assignment: Effects of disasters. In this presentation we looked at a study conducted by Yamashiro et al. (2013) about the effects of radioactive caesium on bull testes after the Fukushima nuclear plant accident.
Genes In Space: A National STEM Competition Launching DNA Experiments to the ISS
The Genes in Space competition challenges students in 7-12th grades to design an experiment that can solve a space exploration problem through DNA analysis. This session will present the results from last year's winning experiment that tested the polymerase chain reaction to study epigenetic changes aboard the ISS.
ISS and Beyond: Habs, Labs, and Platforms, from LEO to Deep Space
This session will consider and discuss the role played by the International Space Station as an exploration testbed and in creating markets that extend beyond low Earth orbit (LEO). The ISS is a critical technical testbed for deep-space exploration system and subsystem development and as a testbed for the development of business in space that might be sustained in LEO or beyond, once the ISS is gone. Panelists will consider international partnerships; the development of specialized equipment or facilities; customer expectations; and the development of human-operated, human-tended, autonomous or passive platforms in LEO or in Cislunar space.
Markets in Motion: Developing Markets in Low Earth Orbit
This document summarizes a panel discussion on developing markets in low Earth orbit. The panel included representatives from Sierra Nevada Corporation, Kentucky Space, Planet Labs, Alpha Space, and Blue Origin. They discussed current and potential commercial activities and markets in LEO, including materials testing on the International Space Station, Earth observation from small satellites, and plans for commercial suborbital and orbital transportation systems.
International Space Station as the Gateway for Humankind's Future in Space an...
This session will highlight the active work of students and young professionals on the ISS. These next-generation researchers will discuss their experiences in translating their ground studies into spaceflight experiments, the benefits of microgravity research, and the overall impact of their research endeavors
ISS Research to Advance Health on Earth
In an era of increasing human longevity, it is becoming ever more critical to prioritize no only improved treatment of disease but also approaches for maintaining wellness to preserve the quality of life for aging adults. Spaceflight-induced physiological changes represent deviations from this state of wellness, with some changes serving as accelerated models of Earth-based conditions, including musculoskeletal disease, immune dysfunction, and delayed wound healing. This session will highlight research onboard the ISS National Lab that seeks to exploit these spaceflight-induced physiological effects to improve human health on Earth through studies that advance the prevention, detection, and treatment of disease. In parallel, spaceflight research and development efforts also seek to improve the human condition by employing the space environment to advance diagnostic tools and drug discovery, development and delivery systems.
Viewpoints: Leveraging ISS to Enable LEO Commercialization
The document discusses leveraging the International Space Station (ISS) to enable commercialization in low Earth orbit (LEO). Several speakers provide their perspectives. Jeff Bingham outlines the legislative history that designated the US segment of the ISS as a national lab and mandated its operation through at least 2024. Sam Sciame discusses leveraging remaining ISS time to enable demand for LEO services. Orbital ATK, Boeing, NanoRacks and Teledyne Brown Engineering describe commercial activities and plans to increase commercial utilization of the ISS and support a LEO economy beyond the ISS.
The Evolving ISS Lab: Improvements to Enable New Research & Utilization
The document discusses improvements being made to enable new research and utilization of the International Space Station (ISS). It summarizes four presentations:
1. Marybeth Edeen discusses ISS integration process improvements to better support customers.
2. Ryan Prouty discusses revolutionizing ISS for science and exploration through a customer-focused culture and more efficient processes.
3. Dana Weigel outlines enhanced ISS capabilities for research, including new facilities, payloads, and vehicle upgrades.
4. Mike Read discusses fostering commerce in space through public-private partnerships and treating commercial partners as customers to stimulate demand for services in low Earth orbit.
STEM on the ISS: How the ISS National Lab is Influencing Students and Teacher...
The document discusses how the ISS National Lab is influencing STEM education through various programs. It describes three specific STEM education projects on the ISS: the Student Spaceflight Experiments Program, a plant growth experiment from Duchesne Academy, and the NASA HUNCH Hydrofuge Project from Lakewood High School. For each project, it provides details on the student teams, experiment designs, goals and impacts on inspiring interest in STEM careers. It emphasizes how the ISS is being used as a platform to engage students and teachers in real-world science and research.
Materials Science Research: Testing and Manufacturing in Space
This document discusses materials science research related to testing and manufacturing in space, with a focus on growing indium iodide (InI) crystals. It includes:
1) Details on previous experiments growing tellurium and zinc-doped indium antimonide crystals on the International Space Station in 2002 using SUBSA hardware.
2) An overview of why InI is a promising room temperature radiation detector material due to its properties such as bandgap and atomic number.
3) Details of experiments growing InI crystals in microgravity using SUBSA and the challenges of high vapor pressure detector materials.
Can Humans Survive 1000 Days in Space?
The document discusses the challenges of long-duration human spaceflight and the need to understand human health risks over periods of 1000 days in space. The NASA Human Research Program aims to provide countermeasures, knowledge, and tools to enable safe space exploration by minimizing risks to human health and performance from hazards like altered gravity, isolation, closed environments, and distance from Earth. While six-month ISS missions provide some data, longer missions are needed to assess physiological and behavioral changes over time and validate countermeasures for medical conditions, deconditioning, and performance issues over multi-year missions like a journey to Mars.
Functional Analysis & Screening Technologies Congress
Join us in Boston this coming Fall to attend Cambridge Healthtech Institute's (CHI) 2nd Annual FAST: Functional Analysis & Screening Technologies Congress on November 17-19, 2014 and meet with a community of 250+ biologists, screening managers, assay developers, engineers and pharmacologists dedicated to improving in vitro cell models and phenotypic screening to advance drug discovery and development at 6 conferences: Phenotypic Drug Discovery (Part I & II), Engineering Functional 3D Models, Screening and Functional Analysis of 3D Models, Organotypic Culture Models for Toxicology and Physiologically-Relevant Cellular Tumor Models for Drug Discovery. Delegates have the opportunity to share insights in interactive panel discussions and connect during networking breaks. View innovative technologies and scientific research revolutionizing early-stage drug discovery in the exhibit/poster hall.
Microtask crowdsourcing for annotating diseases in PubMed abstracts (ASHG 2014)
Presentation on "Microtask crowdsourcing for annotating diseases in PubMed abstracts" at ASHG14 session on "Cloudy with a chance of big data".
dkNET Webinar: The Human BioMolecular Atlas Program (HuBMAP) 10/14/2022
Abstract
HuBMAP aims to catalyze the development of an open, global framework for comprehensively mapping the human body at cellular resolution. HuBMAP goals include: (1) Accelerate the development of the next generation of tools and techniques for constructing high resolution spatial tissue maps. (2) Generate foundational 3D tissue atlases. (3) Establish an open data platform. (4) Coordinate and collaborate with other funding agencies, programs, and the biomedical research community. (5) Support projects that demonstrate the value of the resources developed by the program. The HuBMAP Portal can be found at https://portal.hubmapconsortium.org and the Visible Human MOOC describes the compilation and coverage of HuBMAP data, demonstrates new single-cell analysis and mapping techniques, and introduces major features of the HuBMAP portal.
The top 3 key questions that HuBMAP can answer:
1. What assay types are best to map the human body in 3D and across scales?
2. What Common Coordinate System (CCF) is best to construct the Human Reference Atlas?
3. How can others help construct and/or use the Human Reference Atlas?
Presenters:
Katy Börner, PhD, Victor H. Yngve Distinguished Professor of Engineering and Information Science, Department of Intelligent Systems Engineering and Information Science, Indiana University
Jeffrey Spraggins, PhD, Assistant Professor, Department of Cell and Developmental Biology, Vanderbilt University
Upcoming webinars schedule: https://dknet.org/about/webinar
Quantitative Medicine Feb 2009
1) Quantitative medicine uses large amounts of medical data and advanced analytics to determine the most effective treatment for individual patients based on their specific clinical profile and biomarkers. This approach can help reduce healthcare costs and improve outcomes compared to the traditional one-size-fits-all model.
2) However, realizing the promise of quantitative personalized medicine is challenging due to the huge quantities of diverse medical data located in dispersed systems, lack of computing capabilities, and barriers to data sharing.
3) Grid and service-oriented computing approaches are helping to address these challenges by enabling federated querying, analysis, and sharing of medical data and services across organizations through virtual integration rather than true consolidation.
UNMSymposium2014
This document discusses optimizing cancer genomics pipelines on parallel supercomputers. It describes using a custom-built pipeline of open-source genomics codes to analyze RNA-Seq data from Adenoid Cystic Carcinoma tumor samples. Preliminary results show parallelizing the pipeline on a supercomputer by splitting the input data and running parts in parallel reduced processing time compared to running on a single node. Further optimization of the pipeline and testing on more data is planned.
Exomedicine[1]
This document discusses the potential benefits of conducting biomedical research under microgravity conditions in space. Microgravity allows scientists to grow better protein crystals and observe cell and tissue cultures in a way that is not possible on Earth. The International Space Station provides an environment for experiments in areas like cancer research, stem cells, tissue engineering and infectious diseases. Previous space-based experiments have yielded new insights, such as discovering a more effective crystal structure of an interferon drug. Continued microgravity research could advance understanding of human health and lead to new medical treatments and commercial applications.
mHealth Israel_Ryo Kosaka_AIST_National Institute of Advanced Industrial Scie...
Presentation by Ryo Kosaka, Senior Research Scientist, Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST). Includes an overview of priority strategies in Life Sciences and Biotech and description of the organization of the Life Sciences and Biotech department. Recent projects include a Portable System for High-Speed DNA Quantification, Application of a cell microarray chip for clinical diagnosis and single cell analysis, Safe and Secure Artificial Heart, New diagnosis for liver fibrosis utilizing glycans, AIST ventures from the department of Life Science & Biotech as well as International cooperation.
Processing Amplicon Sequence Data for the Analysis of Microbial Communities
This document provides an overview of next-generation sequencing (NGS) technologies and their usefulness for analyzing microorganisms associated with plants. It discusses how NGS methods allow addressing previously impossible questions about the composition, function, and interactions of microbial communities in environments like the rhizosphere and phyllosphere. While powerful, NGS platforms have limitations that can introduce errors or biases, but methods exist to overcome these issues. The review highlights applications of NGS in metagenomic studies of plant-associated microbiomes and how these new techniques are transforming the field.
Big Data at Golden Helix: Scaling to Meet the Demand of Clinical and Research...
This document summarizes Golden Helix's capabilities for handling big data in genomics. It discusses how Golden Helix's software tools like VarSeq and the Variant Storage Warehouse can scale to handle large volumes of genomic and clinical data from whole genome sequencing, exome sequencing, and large population studies. It provides examples of how these tools have been used for clinical and research applications like variant filtering, annotation, and analysis of rare variants. The presentation concludes with a demonstration of the software.
Advancing Convergence and Innovation in Cancer Research
Describes NCI's Center for Strategic Scientific Initiatives activities (2005 - 2017) as well as data and technology activities of the 2016 White House Cancer Moonshot Task Force (2016 - 2017).
Trends In Genomics
The flood of nextgen sequencing data is changing the landscape of computation biology, pushing the need for more robust infrastructures, tools, and visualization techniques.
acs talk open source drug discovery
This document discusses the Collaborative Drug Discovery (CDD) platform, which aims to facilitate drug discovery collaborations through secure data sharing. Key points:
- CDD provides a secure web-based platform (CDD Vault) for researchers to store private data and selectively share subsets with collaborators. It also hosts over 3 million public compounds.
- The platform allows users to simultaneously query private, collaborator, and public data. It has been used by thousands of scientists for projects like accelerating tuberculosis drug discovery.
- Analysis of data contributions to the platform found it follows a power law distribution, indicating most users only contribute a small amount but a long tail of more engaged users help maximize data sharing
More Related Content
Viewers also liked
Genes In Space: A National STEM Competition Launching DNA Experiments to the ISS
The Genes in Space competition challenges students in 7-12th grades to design an experiment that can solve a space exploration problem through DNA analysis. This session will present the results from last year's winning experiment that tested the polymerase chain reaction to study epigenetic changes aboard the ISS.
ISS and Beyond: Habs, Labs, and Platforms, from LEO to Deep Space
This session will consider and discuss the role played by the International Space Station as an exploration testbed and in creating markets that extend beyond low Earth orbit (LEO). The ISS is a critical technical testbed for deep-space exploration system and subsystem development and as a testbed for the development of business in space that might be sustained in LEO or beyond, once the ISS is gone. Panelists will consider international partnerships; the development of specialized equipment or facilities; customer expectations; and the development of human-operated, human-tended, autonomous or passive platforms in LEO or in Cislunar space.
Markets in Motion: Developing Markets in Low Earth Orbit
This document summarizes a panel discussion on developing markets in low Earth orbit. The panel included representatives from Sierra Nevada Corporation, Kentucky Space, Planet Labs, Alpha Space, and Blue Origin. They discussed current and potential commercial activities and markets in LEO, including materials testing on the International Space Station, Earth observation from small satellites, and plans for commercial suborbital and orbital transportation systems.
International Space Station as the Gateway for Humankind's Future in Space an...
This session will highlight the active work of students and young professionals on the ISS. These next-generation researchers will discuss their experiences in translating their ground studies into spaceflight experiments, the benefits of microgravity research, and the overall impact of their research endeavors
ISS Research to Advance Health on Earth
In an era of increasing human longevity, it is becoming ever more critical to prioritize no only improved treatment of disease but also approaches for maintaining wellness to preserve the quality of life for aging adults. Spaceflight-induced physiological changes represent deviations from this state of wellness, with some changes serving as accelerated models of Earth-based conditions, including musculoskeletal disease, immune dysfunction, and delayed wound healing. This session will highlight research onboard the ISS National Lab that seeks to exploit these spaceflight-induced physiological effects to improve human health on Earth through studies that advance the prevention, detection, and treatment of disease. In parallel, spaceflight research and development efforts also seek to improve the human condition by employing the space environment to advance diagnostic tools and drug discovery, development and delivery systems.
Viewpoints: Leveraging ISS to Enable LEO Commercialization
The document discusses leveraging the International Space Station (ISS) to enable commercialization in low Earth orbit (LEO). Several speakers provide their perspectives. Jeff Bingham outlines the legislative history that designated the US segment of the ISS as a national lab and mandated its operation through at least 2024. Sam Sciame discusses leveraging remaining ISS time to enable demand for LEO services. Orbital ATK, Boeing, NanoRacks and Teledyne Brown Engineering describe commercial activities and plans to increase commercial utilization of the ISS and support a LEO economy beyond the ISS.
The Evolving ISS Lab: Improvements to Enable New Research & Utilization
The document discusses improvements being made to enable new research and utilization of the International Space Station (ISS). It summarizes four presentations:
1. Marybeth Edeen discusses ISS integration process improvements to better support customers.
2. Ryan Prouty discusses revolutionizing ISS for science and exploration through a customer-focused culture and more efficient processes.
3. Dana Weigel outlines enhanced ISS capabilities for research, including new facilities, payloads, and vehicle upgrades.
4. Mike Read discusses fostering commerce in space through public-private partnerships and treating commercial partners as customers to stimulate demand for services in low Earth orbit.
STEM on the ISS: How the ISS National Lab is Influencing Students and Teacher...
The document discusses how the ISS National Lab is influencing STEM education through various programs. It describes three specific STEM education projects on the ISS: the Student Spaceflight Experiments Program, a plant growth experiment from Duchesne Academy, and the NASA HUNCH Hydrofuge Project from Lakewood High School. For each project, it provides details on the student teams, experiment designs, goals and impacts on inspiring interest in STEM careers. It emphasizes how the ISS is being used as a platform to engage students and teachers in real-world science and research.
Materials Science Research: Testing and Manufacturing in Space
This document discusses materials science research related to testing and manufacturing in space, with a focus on growing indium iodide (InI) crystals. It includes:
1) Details on previous experiments growing tellurium and zinc-doped indium antimonide crystals on the International Space Station in 2002 using SUBSA hardware.
2) An overview of why InI is a promising room temperature radiation detector material due to its properties such as bandgap and atomic number.
3) Details of experiments growing InI crystals in microgravity using SUBSA and the challenges of high vapor pressure detector materials.
Can Humans Survive 1000 Days in Space?
The document discusses the challenges of long-duration human spaceflight and the need to understand human health risks over periods of 1000 days in space. The NASA Human Research Program aims to provide countermeasures, knowledge, and tools to enable safe space exploration by minimizing risks to human health and performance from hazards like altered gravity, isolation, closed environments, and distance from Earth. While six-month ISS missions provide some data, longer missions are needed to assess physiological and behavioral changes over time and validate countermeasures for medical conditions, deconditioning, and performance issues over multi-year missions like a journey to Mars.
Viewers also liked (10)
Genes In Space: A National STEM Competition Launching DNA Experiments to the ISS
Genes In Space: A National STEM Competition Launching DNA Experiments to the ISS
ISS and Beyond: Habs, Labs, and Platforms, from LEO to Deep Space
ISS and Beyond: Habs, Labs, and Platforms, from LEO to Deep Space
Markets in Motion: Developing Markets in Low Earth Orbit
Markets in Motion: Developing Markets in Low Earth Orbit
International Space Station as the Gateway for Humankind's Future in Space an...
International Space Station as the Gateway for Humankind's Future in Space an...
Viewpoints: Leveraging ISS to Enable LEO Commercialization
Viewpoints: Leveraging ISS to Enable LEO Commercialization
The Evolving ISS Lab: Improvements to Enable New Research & Utilization
The Evolving ISS Lab: Improvements to Enable New Research & Utilization
STEM on the ISS: How the ISS National Lab is Influencing Students and Teacher...
STEM on the ISS: How the ISS National Lab is Influencing Students and Teacher...
Materials Science Research: Testing and Manufacturing in Space
Materials Science Research: Testing and Manufacturing in Space
Similar to LEO Commercialization: Space-based Research and Development and Manufacturing
Functional Analysis & Screening Technologies Congress
Join us in Boston this coming Fall to attend Cambridge Healthtech Institute's (CHI) 2nd Annual FAST: Functional Analysis & Screening Technologies Congress on November 17-19, 2014 and meet with a community of 250+ biologists, screening managers, assay developers, engineers and pharmacologists dedicated to improving in vitro cell models and phenotypic screening to advance drug discovery and development at 6 conferences: Phenotypic Drug Discovery (Part I & II), Engineering Functional 3D Models, Screening and Functional Analysis of 3D Models, Organotypic Culture Models for Toxicology and Physiologically-Relevant Cellular Tumor Models for Drug Discovery. Delegates have the opportunity to share insights in interactive panel discussions and connect during networking breaks. View innovative technologies and scientific research revolutionizing early-stage drug discovery in the exhibit/poster hall.
Microtask crowdsourcing for annotating diseases in PubMed abstracts (ASHG 2014)
Presentation on "Microtask crowdsourcing for annotating diseases in PubMed abstracts" at ASHG14 session on "Cloudy with a chance of big data".
dkNET Webinar: The Human BioMolecular Atlas Program (HuBMAP) 10/14/2022
Abstract
HuBMAP aims to catalyze the development of an open, global framework for comprehensively mapping the human body at cellular resolution. HuBMAP goals include: (1) Accelerate the development of the next generation of tools and techniques for constructing high resolution spatial tissue maps. (2) Generate foundational 3D tissue atlases. (3) Establish an open data platform. (4) Coordinate and collaborate with other funding agencies, programs, and the biomedical research community. (5) Support projects that demonstrate the value of the resources developed by the program. The HuBMAP Portal can be found at https://portal.hubmapconsortium.org and the Visible Human MOOC describes the compilation and coverage of HuBMAP data, demonstrates new single-cell analysis and mapping techniques, and introduces major features of the HuBMAP portal.
The top 3 key questions that HuBMAP can answer:
1. What assay types are best to map the human body in 3D and across scales?
2. What Common Coordinate System (CCF) is best to construct the Human Reference Atlas?
3. How can others help construct and/or use the Human Reference Atlas?
Presenters:
Katy Börner, PhD, Victor H. Yngve Distinguished Professor of Engineering and Information Science, Department of Intelligent Systems Engineering and Information Science, Indiana University
Jeffrey Spraggins, PhD, Assistant Professor, Department of Cell and Developmental Biology, Vanderbilt University
Upcoming webinars schedule: https://dknet.org/about/webinar
Quantitative Medicine Feb 2009
1) Quantitative medicine uses large amounts of medical data and advanced analytics to determine the most effective treatment for individual patients based on their specific clinical profile and biomarkers. This approach can help reduce healthcare costs and improve outcomes compared to the traditional one-size-fits-all model.
2) However, realizing the promise of quantitative personalized medicine is challenging due to the huge quantities of diverse medical data located in dispersed systems, lack of computing capabilities, and barriers to data sharing.
3) Grid and service-oriented computing approaches are helping to address these challenges by enabling federated querying, analysis, and sharing of medical data and services across organizations through virtual integration rather than true consolidation.
UNMSymposium2014
This document discusses optimizing cancer genomics pipelines on parallel supercomputers. It describes using a custom-built pipeline of open-source genomics codes to analyze RNA-Seq data from Adenoid Cystic Carcinoma tumor samples. Preliminary results show parallelizing the pipeline on a supercomputer by splitting the input data and running parts in parallel reduced processing time compared to running on a single node. Further optimization of the pipeline and testing on more data is planned.
Exomedicine[1]
This document discusses the potential benefits of conducting biomedical research under microgravity conditions in space. Microgravity allows scientists to grow better protein crystals and observe cell and tissue cultures in a way that is not possible on Earth. The International Space Station provides an environment for experiments in areas like cancer research, stem cells, tissue engineering and infectious diseases. Previous space-based experiments have yielded new insights, such as discovering a more effective crystal structure of an interferon drug. Continued microgravity research could advance understanding of human health and lead to new medical treatments and commercial applications.
mHealth Israel_Ryo Kosaka_AIST_National Institute of Advanced Industrial Scie...
Presentation by Ryo Kosaka, Senior Research Scientist, Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST). Includes an overview of priority strategies in Life Sciences and Biotech and description of the organization of the Life Sciences and Biotech department. Recent projects include a Portable System for High-Speed DNA Quantification, Application of a cell microarray chip for clinical diagnosis and single cell analysis, Safe and Secure Artificial Heart, New diagnosis for liver fibrosis utilizing glycans, AIST ventures from the department of Life Science & Biotech as well as International cooperation.
Processing Amplicon Sequence Data for the Analysis of Microbial Communities
This document provides an overview of next-generation sequencing (NGS) technologies and their usefulness for analyzing microorganisms associated with plants. It discusses how NGS methods allow addressing previously impossible questions about the composition, function, and interactions of microbial communities in environments like the rhizosphere and phyllosphere. While powerful, NGS platforms have limitations that can introduce errors or biases, but methods exist to overcome these issues. The review highlights applications of NGS in metagenomic studies of plant-associated microbiomes and how these new techniques are transforming the field.
Big Data at Golden Helix: Scaling to Meet the Demand of Clinical and Research...
This document summarizes Golden Helix's capabilities for handling big data in genomics. It discusses how Golden Helix's software tools like VarSeq and the Variant Storage Warehouse can scale to handle large volumes of genomic and clinical data from whole genome sequencing, exome sequencing, and large population studies. It provides examples of how these tools have been used for clinical and research applications like variant filtering, annotation, and analysis of rare variants. The presentation concludes with a demonstration of the software.
Advancing Convergence and Innovation in Cancer Research
Describes NCI's Center for Strategic Scientific Initiatives activities (2005 - 2017) as well as data and technology activities of the 2016 White House Cancer Moonshot Task Force (2016 - 2017).
Trends In Genomics
The flood of nextgen sequencing data is changing the landscape of computation biology, pushing the need for more robust infrastructures, tools, and visualization techniques.
acs talk open source drug discovery
This document discusses the Collaborative Drug Discovery (CDD) platform, which aims to facilitate drug discovery collaborations through secure data sharing. Key points:
- CDD provides a secure web-based platform (CDD Vault) for researchers to store private data and selectively share subsets with collaborators. It also hosts over 3 million public compounds.
- The platform allows users to simultaneously query private, collaborator, and public data. It has been used by thousands of scientists for projects like accelerating tuberculosis drug discovery.
- Analysis of data contributions to the platform found it follows a power law distribution, indicating most users only contribute a small amount but a long tail of more engaged users help maximize data sharing
JALANov2000
This document provides an overview of the November 2000 issue of JALA (Journal of Analytical Laboratories Automation). It describes the development of a novel robotic system for the New York Cancer Project biorepository in collaboration with the Medical Automation Research Center. The biorepository receives 50-100 blood samples per day which are processed robotically to extract, quantify, aliquot and store DNA, plasma and RNA to be accessible to investigators. The robotic system aims to provide rapid random access to the hundreds of thousands of DNA samples stored for high-throughput analysis in studies of gene-environment interactions and cancer risk.
Human genome project
The document summarizes the Human Genome Project (HGP), which had the goals of identifying all human genes, determining the sequences of DNA base pairs that make up human DNA, storing this information in databases, and addressing ethical issues. Key milestones included completing a working draft in 2000 and fully sequencing the genome in 2003, two years ahead of schedule. The HGP and a private company collaborated to obtain the DNA sequence.
Rozen 2016-10-05-ieee-cibcb-big-genome-data-to-share
Steve Rozen's keynote talk at IEEE CIBCB 2016
Big Genome Data Sheds Light on Cancer Causes
Steven G. Rozen, PhD
Professor, Cancer & Stem Cell Programme, Duke-NUS Medical School, Singapore
Director, Duke-NUS Centre for Computational Biology
The last eight years have see a revolution in the availability of DNA sequencing data. This revolution has been driven by costs that have plummeted from US$ 10 million per human genome in 2008 to US $1,200 today. Abundant sequencing data brings with it a previously unimaginable range of research possibilities in all areas of biomedical research. Naturally, these research possibilities make heavy demands on computation and data storage, because costs of sequencing are falling much faster than Moore's law. In this talk I will present a high level overview of these computational demands. I will then go into detail on a few of the cancer-related big data projects my lab is working on. One of these is "mutation signature analysis", which has important applications in cancer prevention and epidemiology and in research into the fundamental processes by which cancers arise. One example of the importance of this approach is the recent finding that a highly mutagenic herbal remedy is implicated in many more geographical regions and types of cancer than suspected a few years ago.
Oncoset symposium kibbe 201704
The document discusses precision medicine in cancer and the National Cancer Institute's (NCI) Molecular Analysis for Therapy Choice (NCI MATCH) trial and the Beau Biden Cancer Moonshot initiative. It provides background on cancer statistics and tumor biology. It describes the NCI MATCH trial which matches patients to targeted therapies based on genomic testing of their tumors. It outlines the 30 treatment arms in MATCH. It discusses observations from MATCH so far and notes that precision oncology requires understanding biology, genomics, imaging, and clinical data. It provides an overview of the goals and recommendations of the Beau Biden Cancer Moonshot, including establishing a national cancer data ecosystem to share data.
Cancer moonshot and data sharing
Precision Medicine and the Cancer Moonshot. Given on May 25, 2017 at the National Cancer Center Hospital in Japan
eb2015_Kidney_FINAL
- The 3D renal tissues recapitulate key morphological and functional aspects of the human proximal tubule, including polarization of renal epithelial cells, endothelial cell networks, and stable expression of GGT over two weeks.
- Histological analysis shows the tissues contain an organized interstitial layer with collagen deposition supporting the renal epithelium.
- The 3D renal tissues may be useful for preclinical assessment of nephrotoxicity and drug-induced fibrosis since they model the tubule-interstitial interface and maintain renal epithelial function.
FDA NGS and Big Data Conference September 2014
The document discusses the National Cancer Institute's efforts to address challenges in cancer data access and analysis through the development of the NCI Genomics Data Commons and NCI Cloud Pilots. The NCI Genomics Data Commons will provide integrated genomic and clinical cancer data from projects like TCGA to researchers. The NCI Cloud Pilots aim to explore cloud-based models for analyzing large cancer genomics datasets without having to download the full datasets locally, helping to enable more widespread data access and analysis. The goal is to build a national learning health system for cancer clinical genomics through open data sharing and cloud-based approaches.
Advancing Convergence and Innovation in Cancer Research: Seminar at Universit...
Since 2003, the National Cancer Institute’s Center for Strategic Scientific Initiatives (CSSI) has worked to develop the resources and infrastructures investigators need to surmount roadblocks in cancer research. CSSI manages programs that promote technology development and cross-disciplinary collaboration and provide support for investigators in nascent and challenging research fields. This support includes funding opportunities, shared reagent and database resources, and assistance in the development of standards and protocols. CSSI also provides a network of partners in industry and government that can help NCI-funded researchers advance their technologies toward commercialization and translation. This presentation will highlight technologies including single-cell isolation and analysis techniques that have been supported through various CSSI mechanisms from proof-of-concept to translation into the clinic.
Similar to LEO Commercialization: Space-based Research and Development and Manufacturing (20)
Functional Analysis & Screening Technologies Congress
Functional Analysis & Screening Technologies Congress
Microtask crowdsourcing for annotating diseases in PubMed abstracts (ASHG 2014)
Microtask crowdsourcing for annotating diseases in PubMed abstracts (ASHG 2014)
dkNET Webinar: The Human BioMolecular Atlas Program (HuBMAP) 10/14/2022
dkNET Webinar: The Human BioMolecular Atlas Program (HuBMAP) 10/14/2022
mHealth Israel_Ryo Kosaka_AIST_National Institute of Advanced Industrial Scie...
mHealth Israel_Ryo Kosaka_AIST_National Institute of Advanced Industrial Scie...
Processing Amplicon Sequence Data for the Analysis of Microbial Communities
Processing Amplicon Sequence Data for the Analysis of Microbial Communities
Big Data at Golden Helix: Scaling to Meet the Demand of Clinical and Research...
Big Data at Golden Helix: Scaling to Meet the Demand of Clinical and Research...
Advancing Convergence and Innovation in Cancer Research
Advancing Convergence and Innovation in Cancer Research
Rozen 2016-10-05-ieee-cibcb-big-genome-data-to-share
Rozen 2016-10-05-ieee-cibcb-big-genome-data-to-share
Advancing Convergence and Innovation in Cancer Research: Seminar at Universit...
Advancing Convergence and Innovation in Cancer Research: Seminar at Universit...
Recently uploaded
Compexometric titration/Chelatorphy titration/chelating titration
Classification
Metal ion ion indicators
Masking and demasking reagents
Estimation of Magnisium sulphate
Calcium gluconate
Complexometric Titration/ chelatometry titration/chelating titration, introduction, Types-
1.Direct Titration
2.Back Titration
3.Replacement Titration
4.Indirect Titration
Masking agent, Demasking agents
formation of complex
comparition between masking and demasking agents,
Indicators/Metal ion indicators/ Metallochromic indicators/pM indicators,
Visual Technique,PM indicators (metallochromic), Indicators of pH, Redox Indicators
Instrumental Techniques-Photometry
Potentiometry
Miscellaneous methods.
Complex titration with EDTA.
Immersive Learning That Works: Research Grounding and Paths Forward
We will metaverse into the essence of immersive learning, into its three dimensions and conceptual models. This approach encompasses elements from teaching methodologies to social involvement, through organizational concerns and technologies. Challenging the perception of learning as knowledge transfer, we introduce a 'Uses, Practices & Strategies' model operationalized by the 'Immersive Learning Brain' and ‘Immersion Cube’ frameworks. This approach offers a comprehensive guide through the intricacies of immersive educational experiences and spotlighting research frontiers, along the immersion dimensions of system, narrative, and agency. Our discourse extends to stakeholders beyond the academic sphere, addressing the interests of technologists, instructional designers, and policymakers. We span various contexts, from formal education to organizational transformation to the new horizon of an AI-pervasive society. This keynote aims to unite the iLRN community in a collaborative journey towards a future where immersive learning research and practice coalesce, paving the way for innovative educational research and practice landscapes.
ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...
ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...Advanced-Concepts-Team
Presentation in the Science Coffee of the Advanced Concepts Team of the European Space Agency on the 07.06.2024.
Speaker: Diego Blas (IFAE/ICREA)
Title: Gravitational wave detection with orbital motion of Moon and artificial
Abstract:
In this talk I will describe some recent ideas to find gravitational waves from supermassive black holes or of primordial origin by studying their secular effect on the orbital motion of the Moon or satellites that are laser ranged.Authoring a personal GPT for your research and practice: How we created the Q...
Thematic analysis in qualitative research is a time-consuming and systematic task, typically done using teams. Team members must ground their activities on common understandings of the major concepts underlying the thematic analysis, and define criteria for its development. However, conceptual misunderstandings, equivocations, and lack of adherence to criteria are challenges to the quality and speed of this process. Given the distributed and uncertain nature of this process, we wondered if the tasks in thematic analysis could be supported by readily available artificial intelligence chatbots. Our early efforts point to potential benefits: not just saving time in the coding process but better adherence to criteria and grounding, by increasing triangulation between humans and artificial intelligence. This tutorial will provide a description and demonstration of the process we followed, as two academic researchers, to develop a custom ChatGPT to assist with qualitative coding in the thematic data analysis process of immersive learning accounts in a survey of the academic literature: QUAL-E Immersive Learning Thematic Analysis Helper. In the hands-on time, participants will try out QUAL-E and develop their ideas for their own qualitative coding ChatGPT. Participants that have the paid ChatGPT Plus subscription can create a draft of their assistants. The organizers will provide course materials and slide deck that participants will be able to utilize to continue development of their custom GPT. The paid subscription to ChatGPT Plus is not required to participate in this workshop, just for trying out personal GPTs during it.
Candidate young stellar objects in the S-cluster: Kinematic analysis of a sub...
Context. The observation of several L-band emission sources in the S cluster has led to a rich discussion of their nature. However, a definitive answer to the classification of the dusty objects requires an explanation for the detection of compact Doppler-shifted Brγ emission. The ionized hydrogen in combination with the observation of mid-infrared L-band continuum emission suggests that most of these sources are embedded in a dusty envelope. These embedded sources are part of the S-cluster, and their relationship to the S-stars is still under debate. To date, the question of the origin of these two populations has been vague, although all explanations favor migration processes for the individual cluster members. Aims. This work revisits the S-cluster and its dusty members orbiting the supermassive black hole SgrA* on bound Keplerian orbits from a kinematic perspective. The aim is to explore the Keplerian parameters for patterns that might imply a nonrandom distribution of the sample. Additionally, various analytical aspects are considered to address the nature of the dusty sources. Methods. Based on the photometric analysis, we estimated the individual H−K and K−L colors for the source sample and compared the results to known cluster members. The classification revealed a noticeable contrast between the S-stars and the dusty sources. To fit the flux-density distribution, we utilized the radiative transfer code HYPERION and implemented a young stellar object Class I model. We obtained the position angle from the Keplerian fit results; additionally, we analyzed the distribution of the inclinations and the longitudes of the ascending node. Results. The colors of the dusty sources suggest a stellar nature consistent with the spectral energy distribution in the near and midinfrared domains. Furthermore, the evaporation timescales of dusty and gaseous clumps in the vicinity of SgrA* are much shorter ( 2yr) than the epochs covered by the observations (≈15yr). In addition to the strong evidence for the stellar classification of the D-sources, we also find a clear disk-like pattern following the arrangements of S-stars proposed in the literature. Furthermore, we find a global intrinsic inclination for all dusty sources of 60 ± 20◦, implying a common formation process. Conclusions. The pattern of the dusty sources manifested in the distribution of the position angles, inclinations, and longitudes of the ascending node strongly suggests two different scenarios: the main-sequence stars and the dusty stellar S-cluster sources share a common formation history or migrated with a similar formation channel in the vicinity of SgrA*. Alternatively, the gravitational influence of SgrA* in combination with a massive perturber, such as a putative intermediate mass black hole in the IRS 13 cluster, forces the dusty objects and S-stars to follow a particular orbital arrangement. Key words. stars: black holes– stars: formation– Galaxy: center– galaxies: star formation
快速办理(UAM毕业证书)马德里自治大学毕业证学位证一模一样
学校原件一模一样【微信：741003700 】《(UAM毕业证书)马德里自治大学毕业证学位证》【微信：741003700 】学位证，留信认证（真实可查，永久存档）原件一模一样纸张工艺/offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
本公司拥有海外各大学样板无数，能完美还原。
1:1完美还原海外各大学毕业材料上的工艺：水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠。文字图案浮雕、激光镭射、紫外荧光、温感、复印防伪等防伪工艺。材料咨询办理、认证咨询办理请加学历顾问Q/微741003700
【主营项目】
一.毕业证【q微741003700】成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！
二.真实使馆公证(即留学回国人员证明,不成功不收费)
三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）
四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
如果您处于以下几种情况：
◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【q/微741003700】
◇面对父母的压力，希望尽快拿到；
◇不清楚认证流程以及材料该如何准备；
◇回国时间很长，忘记办理；
◇回国马上就要找工作，办给用人单位看；
◇企事业单位必须要求办理的
◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
8.Isolation of pure cultures and preservation of cultures.pdf
Isolation of pure culture, its various method.
Gadgets for management of stored product pests_Dr.UPR.pdf
Insectsplayamajorroleinthedeteriorationoffoodgrainscausingbothquantitativeandqualitativelosses
Wellprovedthatnogranariescanbefilledwithgrainswithoutinsectsastheharvestedproducecontainegg(or)larvae(or)pupae(or)adultinsectinthembecauseoffieldcarryoverinfestationwhichcannotbeavoidedindevelopingcountrieslikeIndia
Simpletechnologiesfortimelydetectionofinsectsinthestoredproduceandtherebyplantimelycontrolmeasures
(June 12, 2024) Webinar: Development of PET theranostics targeting the molecu...
(June 12, 2024) Webinar: Development of PET theranostics targeting the molecu...Scintica Instrumentation
Targeting Hsp90 and its pathogen Orthologs with Tethered Inhibitors as a Diagnostic and Therapeutic Strategy for cancer and infectious diseases with Dr. Timothy Haystead.在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样
学校原件一模一样【微信：741003700 】《(salfor毕业证书)索尔福德大学毕业证》【微信：741003700 】学位证，留信认证（真实可查，永久存档）原件一模一样纸张工艺/offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
本公司拥有海外各大学样板无数，能完美还原。
1:1完美还原海外各大学毕业材料上的工艺：水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠。文字图案浮雕、激光镭射、紫外荧光、温感、复印防伪等防伪工艺。材料咨询办理、认证咨询办理请加学历顾问Q/微741003700
【主营项目】
一.毕业证【q微741003700】成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！
二.真实使馆公证(即留学回国人员证明,不成功不收费)
三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）
四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
如果您处于以下几种情况：
◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【q/微741003700】
◇面对父母的压力，希望尽快拿到；
◇不清楚认证流程以及材料该如何准备；
◇回国时间很长，忘记办理；
◇回国马上就要找工作，办给用人单位看；
◇企事业单位必须要求办理的
◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
The cost of acquiring information by natural selection
This is a short talk that I gave at the Banff International Research Station workshop on Modeling and Theory in Population Biology. The idea is to try to understand how the burden of natural selection relates to the amount of information that selection puts into the genome.
It's based on the first part of this research paper:
The cost of information acquisition by natural selection
Ryan Seamus McGee, Olivia Kosterlitz, Artem Kaznatcheev, Benjamin Kerr, Carl T. Bergstrom
bioRxiv 2022.07.02.498577; doi: https://doi.org/10.1101/2022.07.02.498577
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
Current descriptions of immersive learning cases are often difficult or impossible to compare. This is due to a myriad of different options on what details to include, which aspects are relevant, and on the descriptive approaches employed. Also, these aspects often combine very specific details with more general guidelines or indicate intents and rationales without clarifying their implementation. In this paper we provide a method to describe immersive learning cases that is structured to enable comparisons, yet flexible enough to allow researchers and practitioners to decide which aspects to include. This method leverages a taxonomy that classifies educational aspects at three levels (uses, practices, and strategies) and then utilizes two frameworks, the Immersive Learning Brain and the Immersion Cube, to enable a structured description and interpretation of immersive learning cases. The method is then demonstrated on a published immersive learning case on training for wind turbine maintenance using virtual reality. Applying the method results in a structured artifact, the Immersive Learning Case Sheet, that tags the case with its proximal uses, practices, and strategies, and refines the free text case description to ensure that matching details are included. This contribution is thus a case description method in support of future comparative research of immersive learning cases. We then discuss how the resulting description and interpretation can be leveraged to change immersion learning cases, by enriching them (considering low-effort changes or additions) or innovating (exploring more challenging avenues of transformation). The method holds significant promise to support better-grounded research in immersive learning.
Direct Seeded Rice - Climate Smart Agriculture
Direct Seeded Rice - Climate Smart AgricultureInternational Food Policy Research Institute- South Asia Office
PPT on Direct Seeded Rice presented at the three-day 'Training and Validation Workshop on Modules of Climate Smart Agriculture (CSA) Technologies in South Asia' workshop on April 22, 2024.
MICROBIAL INTERACTION PPT/ MICROBIAL INTERACTION AND THEIR TYPES // PLANT MIC...
MICROBIAL INTERACTION PPT/ MICROBIAL INTERACTION AND THEIR TYPES // PLANT MIC...ABHISHEK SONI NIMT INSTITUTE OF MEDICAL AND PARAMEDCIAL SCIENCES , GOVT PG COLLEGE NOIDA
Microbial interaction
Microorganisms interacts with each other and can be physically associated with another organisms in a variety of ways.
One organism can be located on the surface of another organism as an ectobiont or located within another organism as endobiont.
Microbial interaction may be positive such as mutualism, proto-cooperation, commensalism or may be negative such as parasitism, predation or competition
Types of microbial interaction
Positive interaction: mutualism, proto-cooperation, commensalism
Negative interaction: Ammensalism (antagonism), parasitism, predation, competition
I. Mutualism:
It is defined as the relationship in which each organism in interaction gets benefits from association. It is an obligatory relationship in which mutualist and host are metabolically dependent on each other.
Mutualistic relationship is very specific where one member of association cannot be replaced by another species.
Mutualism require close physical contact between interacting organisms.
Relationship of mutualism allows organisms to exist in habitat that could not occupied by either species alone.
Mutualistic relationship between organisms allows them to act as a single organism.
Examples of mutualism:
i. Lichens:
Lichens are excellent example of mutualism.
They are the association of specific fungi and certain genus of algae. In lichen, fungal partner is called mycobiont and algal partner is called
II. Syntrophism:
It is an association in which the growth of one organism either depends on or improved by the substrate provided by another organism.
In syntrophism both organism in association gets benefits.
Compound A
Utilized by population 1
Compound B
Utilized by population 2
Compound C
utilized by both Population 1+2
Products
In this theoretical example of syntrophism, population 1 is able to utilize and metabolize compound A, forming compound B but cannot metabolize beyond compound B without co-operation of population 2. Population 2is unable to utilize compound A but it can metabolize compound B forming compound C. Then both population 1 and 2 are able to carry out metabolic reaction which leads to formation of end product that neither population could produce alone.
Examples of syntrophism:
i. Methanogenic ecosystem in sludge digester
Methane produced by methanogenic bacteria depends upon interspecies hydrogen transfer by other fermentative bacteria.
Anaerobic fermentative bacteria generate CO2 and H2 utilizing carbohydrates which is then utilized by methanogenic bacteria (Methanobacter) to produce methane.
ii. Lactobacillus arobinosus and Enterococcus faecalis:
In the minimal media, Lactobacillus arobinosus and Enterococcus faecalis are able to grow together but not alone.
The synergistic relationship between E. faecalis and L. arobinosus occurs in which E. faecalis require folic acid
Mending Clothing to Support Sustainable Fashion_CIMaR 2024.pdf
Ozturkcan, S., Berndt, A., & Angelakis, A. (2024). Mending clothing to support sustainable fashion. Presented at the 31st Annual Conference by the Consortium for International Marketing Research (CIMaR), 10-13 Jun 2024, University of Gävle, Sweden.
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
Context. With a mass exceeding several 104 M⊙ and a rich and dense population of massive stars, supermassive young star clusters
represent the most massive star-forming environment that is dominated by the feedback from massive stars and gravitational interactions
among stars.
Aims. In this paper we present the Extended Westerlund 1 and 2 Open Clusters Survey (EWOCS) project, which aims to investigate
the influence of the starburst environment on the formation of stars and planets, and on the evolution of both low and high mass stars.
The primary targets of this project are Westerlund 1 and 2, the closest supermassive star clusters to the Sun.
Methods. The project is based primarily on recent observations conducted with the Chandra and JWST observatories. Specifically,
the Chandra survey of Westerlund 1 consists of 36 new ACIS-I observations, nearly co-pointed, for a total exposure time of 1 Msec.
Additionally, we included 8 archival Chandra/ACIS-S observations. This paper presents the resulting catalog of X-ray sources within
and around Westerlund 1. Sources were detected by combining various existing methods, and photon extraction and source validation
were carried out using the ACIS-Extract software.
Results. The EWOCS X-ray catalog comprises 5963 validated sources out of the 9420 initially provided to ACIS-Extract, reaching a
photon flux threshold of approximately 2 × 10−8 photons cm−2
s
−1
. The X-ray sources exhibit a highly concentrated spatial distribution,
with 1075 sources located within the central 1 arcmin. We have successfully detected X-ray emissions from 126 out of the 166 known
massive stars of the cluster, and we have collected over 71 000 photons from the magnetar CXO J164710.20-455217.
The debris of the ‘last major merger’ is dynamically young
The Milky Way’s (MW) inner stellar halo contains an [Fe/H]-rich component with highly eccentric orbits, often referred to as the
‘last major merger.’ Hypotheses for the origin of this component include Gaia-Sausage/Enceladus (GSE), where the progenitor
collided with the MW proto-disc 8–11 Gyr ago, and the Virgo Radial Merger (VRM), where the progenitor collided with the
MW disc within the last 3 Gyr. These two scenarios make different predictions about observable structure in local phase space,
because the morphology of debris depends on how long it has had to phase mix. The recently identified phase-space folds in Gaia
DR3 have positive caustic velocities, making them fundamentally different than the phase-mixed chevrons found in simulations
at late times. Roughly 20 per cent of the stars in the prograde local stellar halo are associated with the observed caustics. Based
on a simple phase-mixing model, the observed number of caustics are consistent with a merger that occurred 1–2 Gyr ago.
We also compare the observed phase-space distribution to FIRE-2 Latte simulations of GSE-like mergers, using a quantitative
measurement of phase mixing (2D causticality). The observed local phase-space distribution best matches the simulated data
1–2 Gyr after collision, and certainly not later than 3 Gyr. This is further evidence that the progenitor of the ‘last major merger’
did not collide with the MW proto-disc at early times, as is thought for the GSE, but instead collided with the MW disc within
the last few Gyr, consistent with the body of work surrounding the VRM.
Farming systems analysis: what have we learnt?.pptx
Presentation given at the official farewell of Prof Ken Gillet at Wageningen on 13 June 2024
Recently uploaded (20)
Compexometric titration/Chelatorphy titration/chelating titration
Compexometric titration/Chelatorphy titration/chelating titration
Immersive Learning That Works: Research Grounding and Paths Forward
Immersive Learning That Works: Research Grounding and Paths Forward
ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...
ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...
Authoring a personal GPT for your research and practice: How we created the Q...
Authoring a personal GPT for your research and practice: How we created the Q...
Candidate young stellar objects in the S-cluster: Kinematic analysis of a sub...
Candidate young stellar objects in the S-cluster: Kinematic analysis of a sub...
8.Isolation of pure cultures and preservation of cultures.pdf
8.Isolation of pure cultures and preservation of cultures.pdf
Gadgets for management of stored product pests_Dr.UPR.pdf
Gadgets for management of stored product pests_Dr.UPR.pdf
(June 12, 2024) Webinar: Development of PET theranostics targeting the molecu...
(June 12, 2024) Webinar: Development of PET theranostics targeting the molecu...
The cost of acquiring information by natural selection
The cost of acquiring information by natural selection
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
Tissue fluids_etiology_volume regulation_pressure.pptx
Tissue fluids_etiology_volume regulation_pressure.pptx
MICROBIAL INTERACTION PPT/ MICROBIAL INTERACTION AND THEIR TYPES // PLANT MIC...
MICROBIAL INTERACTION PPT/ MICROBIAL INTERACTION AND THEIR TYPES // PLANT MIC...
Mending Clothing to Support Sustainable Fashion_CIMaR 2024.pdf
Mending Clothing to Support Sustainable Fashion_CIMaR 2024.pdf
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
The debris of the ‘last major merger’ is dynamically young
The debris of the ‘last major merger’ is dynamically young
Farming systems analysis: what have we learnt?.pptx
Farming systems analysis: what have we learnt?.pptx
LEO Commercialization: Space-based Research and Development and Manufacturing
- 1. LEO Commercialization: Space-Based Research and Development and Manufacturing • ADAM BLUESTEIN, CONTRIBUTING INNOVATION WRITER, FAST COMPANY (MODERATOR) • DR. JOSEPH NG, PRESIDENT, IXPRESSGENES; ASSOCIATE PROFESSOR, UNIVERSITY OF ALABAMA-HUNTSVILLE • DR. DANILO TAGLE, ASSOCIATE DIRECTOR, SPECIAL INITIATIVES, NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES, NATIONAL INSTITUTES OF HEALTH • ANDREW RUSH, PRESIDENT, MADE IN SPACE SPEAKERS:
- 2. Large-volume protein crystal growth for neutron macromolecular crystallography Joseph D. Ng University of Alabama in Huntsville ngj@uah.edu iXpressGenes Inc
- 3. Disease Target Identification/ Bioinformtics Protein Sequence Structure-based Drug Design Process Protein Production Crystals X-ray/Neutron Crystallography StructureLead Structure Chemoinformatics Biochemical Assays Cell-based Assays Animal Tests Clinical Trials Drug
- 4. Structure-based Drug Design Process StructureLead Structure Chemoinformatics Biochemical Assays Cell-based Assays Animal Tests Clinical Trials Drug Experiment Typical cost per compound ($) Computer modeling $10 Biochemical assay $400 Cell culture assay $4,000 Rat acute toxicity $120,000 Animal efficacy trial $300,000 Rat 2-year chronic oral toxcity $800,000 Human clinical trial $500,000,000 Young, D.C. (2009). Computational Drug Design: A guide for computational and medicinal chemists. Wiley & Sons, Inc. Publications
- 5. 107,324 As of Thursday 30 June, 2016 <100 Structures determined by neutron diffraction (<0.08% of total)
- 6. 50% Of the atoms in a protein are hydrogen and the majority of the proteins do not have structural placement and biological function for hydrogen atoms. The role of hydrogen atoms in protein structures is severely understudied. Why is protein Neutron Crystallography important?????
- 7. Munshi et al. (2012). Rapid visualization of hydrogen positions in protein neutron crystallographic structure. Acta Cryst. Section D 68:35-41
- 9. Granada crystallization box(GCB) and facility (GCF). Counter diffusion crystallization can be performed in capillary filled with protein solution set to equilibrate with a precipitant that slowly
- 10. A B C D E F G 1 2 3 1 2 3
- 12. Ground Microgravity A B IPPase + Mg+2 (Acetate) Length of capillary = 70mm; Inner diameter = 2mm Original sample code: 6C
- 13. Ground Microgravity A B IPPase + Mg+2 (Acetate) Length of capillary = 70mm; Inner diameter = 2mm Original sample code: 5C
- 19. H2O H2O H2O H2O H2O D2O D2O D2O D2O D2O Ca2+ Ca2+ Tyr56 Tyr56 Lys105 Lys105 H2O H2O H2O H2O H2O D2O D2O D2O D2O D2O Ca2+ Ca2+ Tyr56 Tyr56 Asp71 Glu22 Glu22 Lys105 Glu22 Glu22 Tyr56Lys105 Asp71 Lys35 Lys35 Asp71 Tyr56 8 44 PDB ID: 3Q3L,3Q9MPDB ID: 3Q3L,3R5V
- 20. NIH and CASIS Partnership on Microphysiological Systems for Translational Research in Space Danilo A. Tagle, Ph.D. Associate Director for Special Initiatives National Center for Advancing Translational Sciences, NIH
- 22. NIH-CASIS Coordinated Program in Tissue-on-Chips Systems for Translational Research in Space • Goal: NCATS has established a MOU with the Center for the Advancement of Science in Space (CASIS) to deploy and further develop tissue chip technology platforms for biomedical research at the International Space Station (ISS) that will lead to a better understanding of the molecular basis of human disease and/or the effectiveness of diagnostic markers and therapeutic interventions. • Expected outcome: Among the areas of research encouraged in this program is translational research examining the mechanisms that underlie the effects of diseases or conditions associated with bone and cartilage, skeletal muscle, brain, gastrointestinal tract, lung, liver, skin, microvasculature, or other tissues, as well as research designed to improve the translation of existing knowledge of strategies for the prevention and treatment of such diseases or conditions.
- 23. NIH-CASIS Coordinated Program in Tissue-on-Chips Systems for Translational Research in Space • Potential impact: Understanding of the effects of microgravity on human organ systems. It could provide better insight into the molecular basis, including epigenome changes, for many human conditions in space and provide information for novel drug targets for use on Earth. • Key Dates: – Estimated Publication Date of Funding Opportunity Announcement: September 2016 – Application Due Date: December 2016 – Earliest Estimated Award Date: July 2017 – Earliest Estimated Project Start Date: August 2017 • http://www.casistissuechip.blogspot.com
- 24. W HERE W E’VE BEEN
- 25. THE NEAR TERM FUTURE OF THE SPACE INDUSTRY IS LEO COMMERCIALIZATION NASA and other government agencies have been incredible partners to get us to LEO, and will continue to be so as we stay there and push beyond, but it is time we begin finding sustainable business reasons to be on orbit.
- 26. FIBER