This document discusses the use of high field MRI methods to study the human body. It provides background on how MRS has evolved from obtaining phosphate spectra in the 1970s to playing a pivotal role in human brain mapping. It describes comparative histories of automobile and smartphone societies from 2001-2012. Methods discussed include 1H MRS at high fields to study cancer metabolism, detect biomarkers for precision medicine in gliomas, and measure neurochemical profiles from childhood to adulthood. Ongoing work includes using ZOOM-MRSI, MRS-fMRI, and ultra-high field sodium and UTE imaging to study the brain, kidneys, cartilage and lungs.
The MRL/MpJ Mouse Strain Is Not Protected From Muscle Atrophy And Weakness Af...InsideScientific
Analyzing whether MRL mouse strain has any enhanced healing ability after injury in skeletal muscle. This strain has been touted as a "superhealer" although different tissues have previously displayed different levels of healing ability. We sought to test that ability in skeletal muscle.
The MRL/MpJ Mouse Strain Is Not Protected From Muscle Atrophy And Weakness Af...InsideScientific
Analyzing whether MRL mouse strain has any enhanced healing ability after injury in skeletal muscle. This strain has been touted as a "superhealer" although different tissues have previously displayed different levels of healing ability. We sought to test that ability in skeletal muscle.
Latest updates concerning the general nuclear physics, indications, uses and side effects of Radium223 for patients with prostate cancer and symptomatic bone metastasis.
Managing Health and Disease Using Omics and Big DataLaura Berry
Presented at the NGS Tech and Applications Congress: USA. To find out more, visit:
www.global-engage.com
Michael Snyder is a Professor, Chair of Genetics and Director of the Stanford Center for Genomics and Personalized Medicine at Stanford University. In this presentation Michael discusses using omics and big data to predict disease risk and catch early disease onset.
Nanotechnology and its Application in Cancer TreatmentHasnat Tariq
Nanotechnology
Nanomaterials
Nanostructures
Nanoparticles
Unexpected Optical Properties of Nanoparticles
Synthesis of Nanoparticles
Nanotechnology in Cancer Treatment
Role of Sulfur NPs in Cancer Treatment
Human Tumour Cell Lines Used in Research
Ehrlich ascites carcinoma (EAC)
Sulfur Nanoparticles Preparation
MTT Assay
Sulphorhodamine-B (SRB) Assay
Median lethal dose (LD 50)
Experimental design
FT-IR Characterization of Sulfur Nanoparticles
SEM Characterization of Sulfur Nanoparticles
EDS Characterization of Sulfur Nanoparticles
XRD Characterization of Sulfur Nanoparticles
Chemical Studies on Sulfur Nanoparticles In Vitro
Biochemical investigations
Conclusion
Applications of Nanoparticles in cancer treatment
Nanoshells
Nano X-Ray therapy
Drug Delivery by Nanoparticles
Louis Stodieck, BioServe Space Technologies, University of Colorado at Boulder: "AMGEN Countermeasures for Bone and Muscle Loss in Space and on Earth." Presented at the 2013 International Space Station Research and Development Conference, http://www.astronautical.org/issrdc/2013.
Our YOUNG RESEARCH SCHOLAR (YRS) of International Conference on Biotechnology, Bio Informatics, Bio Medical Sciences and Stem Cell Applications (B3SC), Singapore
11-12 November 2016
Name: Mohd Anas Shamsi
Affiiation: Aligarh muslim university, India
Magnetic Resonance Spectroscopy and MetabolomicsUzay Emir
Magnetic Resonance Spectroscopy, MRI, Human Connectome, 2-HG, 2-hydroxyglutarate, zoom, zoom MRSI, reduced field of View, rFOV, Cerebellum, High-resolution, IDH, Isocitrate, IDH1, IDH2, Cancer, Glioma, Parcellation, Macro Anatomical
Functional
Myeloarchitectonic
CYTO- AND RECEPTOR ARCHITECTONIC MAPPING OF THE HUMAN BRAIN
MR Spectroscopy Study Group
Latest updates concerning the general nuclear physics, indications, uses and side effects of Radium223 for patients with prostate cancer and symptomatic bone metastasis.
Managing Health and Disease Using Omics and Big DataLaura Berry
Presented at the NGS Tech and Applications Congress: USA. To find out more, visit:
www.global-engage.com
Michael Snyder is a Professor, Chair of Genetics and Director of the Stanford Center for Genomics and Personalized Medicine at Stanford University. In this presentation Michael discusses using omics and big data to predict disease risk and catch early disease onset.
Nanotechnology and its Application in Cancer TreatmentHasnat Tariq
Nanotechnology
Nanomaterials
Nanostructures
Nanoparticles
Unexpected Optical Properties of Nanoparticles
Synthesis of Nanoparticles
Nanotechnology in Cancer Treatment
Role of Sulfur NPs in Cancer Treatment
Human Tumour Cell Lines Used in Research
Ehrlich ascites carcinoma (EAC)
Sulfur Nanoparticles Preparation
MTT Assay
Sulphorhodamine-B (SRB) Assay
Median lethal dose (LD 50)
Experimental design
FT-IR Characterization of Sulfur Nanoparticles
SEM Characterization of Sulfur Nanoparticles
EDS Characterization of Sulfur Nanoparticles
XRD Characterization of Sulfur Nanoparticles
Chemical Studies on Sulfur Nanoparticles In Vitro
Biochemical investigations
Conclusion
Applications of Nanoparticles in cancer treatment
Nanoshells
Nano X-Ray therapy
Drug Delivery by Nanoparticles
Louis Stodieck, BioServe Space Technologies, University of Colorado at Boulder: "AMGEN Countermeasures for Bone and Muscle Loss in Space and on Earth." Presented at the 2013 International Space Station Research and Development Conference, http://www.astronautical.org/issrdc/2013.
Our YOUNG RESEARCH SCHOLAR (YRS) of International Conference on Biotechnology, Bio Informatics, Bio Medical Sciences and Stem Cell Applications (B3SC), Singapore
11-12 November 2016
Name: Mohd Anas Shamsi
Affiiation: Aligarh muslim university, India
Magnetic Resonance Spectroscopy and MetabolomicsUzay Emir
Magnetic Resonance Spectroscopy, MRI, Human Connectome, 2-HG, 2-hydroxyglutarate, zoom, zoom MRSI, reduced field of View, rFOV, Cerebellum, High-resolution, IDH, Isocitrate, IDH1, IDH2, Cancer, Glioma, Parcellation, Macro Anatomical
Functional
Myeloarchitectonic
CYTO- AND RECEPTOR ARCHITECTONIC MAPPING OF THE HUMAN BRAIN
MR Spectroscopy Study Group
On April 5, 2014 the MRF partnered with Seattle Cancer Care Alliance and Fred Hutchinson Cancer Research Center to provide a free educational event dedicated to melanoma patients and the people who support them.
This webinar is part of a 2-hour monthly series hosted by the Neurotechnology Innovation Network: https://ktn-uk.org/health/neurotechnology/
Each webinar features expert speakers and focusses on a new development in a different technology area.
The third topic in this series is Dementia treatment using a biodesign approach. Dementia can have enormous effects, not only to those suffering but also family members and others
caring for them, but there are currently no effective therapies available. Neurotechnology offers a new way of treating dementia.
There is growing evidence that technologies such as deep brain stimulation and transcranial magnetic stimulation could help treat some of the effects of dementia and brain-computer interfaces are now able to detect the first signs of dementia years before symptoms appear.
In collaboration with UK Dementia Research Institute this webinar explores novel neurotechnologies to treat dementia, discuss barriers to adoption and new opportunities in the field.
Multimodality Molecular Imaging – An Overview With Special Focus on PET/CTApollo Hospitals
Imaging capabilities have evolved from those that provide anatomical pictures to those that capture functional information and, more recently, molecular information (nuclear medicine, PET, SPECT, PET/CT, SPECT/CT, MRS, contrast-enhanced ultrasound, fluorescence and bioluminescence imaging). Multimodality imaging has emerged as a technology that utilizes the strengths of different modalities and yields a hybrid imaging platform with benefits superior to those of any of its individual components, considered alone. Leading edge hybrid imaging (combining multiple, complementary imaging technologies such as PET and CT) offer unique opportunities to “view” the molecular biology of disease, and the use of this equipment is on the rise.
Microdialysis is an integral part of preclinical research to determine extracellular fluid and blood concentrations of metabolites, hormones, drugs, etc, and is often used in quantifying the biochemistry of brain and peripheral tissues. However, it is a molecular-only technique and other imaging modalities are needed to provide the researcher with functional and anatomical information of the animal in vivo.
Turn Away from Traditional Tethering and Towards a Better Method for Data Col...InsideScientific
Experts discuss the use of a novel movement responsive rodent caging system as a means to minimize animal stress and enable unique discovery in many research applications, namely neuroscience, animal behaviour, drug discovery and cardiometabolic disease.
Investigations & Evaluation of Male partner after 2 IUI failureSujoy Dasgupta
Invited lecture by Dr Sujoy Dasgupta in a Webinar on Practical Approach in Infertility by ISAR (Indian Society for Assisted Reproduction), held in August, 2020
Our first webinar in the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at the target landscape for Complex Medicine.
Dr Duygu Yilmaz, Medicines Discovery Catapult
Side Effects of I-131: Preventive Measures and Management When Side Effects O...Mark Tulchinsky
Presented at the 2017 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging in Denver, CO
Date: Saturday, June 10, 2017
Session: Update and Controversies in Radioiodine Theranostics
In this work, we demonstrate the sodium magnetic resonance imaging (MRI) capabilities of a three-dimensional (3D) dual-echo ultrashort echo time (UTE) sequence with a novel rosette petal trajectory (PETALUTE), in comparison to the 3D density-adapted (DA) radial spokes UTE sequence. #mri #ismrm #msk
3D UTE 31P-MRSI with modified rosette k-space (PETALUTE): Comparison with con...Uzay Emir
Phosphorus-31 magnetic resonance spectroscopic imaging (31P-MRSI) provides valuable non-invasive in vivo information on tissue metabolism but is burdened by poor sensitivity and prolonged scan duration. Ultra-short echo time (UTE) acquisitions minimize signal loss when probing signals with relatively short spin-spin relaxation time (T2), while also preventing first-order dephasing. Here, a three-dimensional (3D) UTE sequence with a rosette k-space trajectory is applied to 31P-MRSI at 3T. Conventional chemical shift imaging (CSI) employs highly regular Cartesian k-space sampling, susceptible to substantial artifacts when accelerated via undersampling. In contrast, this novel sequence’s “petal-like” pattern offers incoherent sampling more suitable for compressed sensing (CS). These results showcase the competitive performance of UTE rosette 31P-MRSI against conventional weighted CSI with simulation, phantom, and in vivo leg muscle comparisons.
Modified Rosette PETALUTE for preclinical imagingUzay Emir
We have demonstrated a sequence, PETALUTE, for clinical and preclinical high (3T) and ultra-high fields (>7T) scanners.
The modified Rosette kspace dual-echo Acquisition/ PETALUTE strategy could further enhance integrated and translational research studies to understand human and non-human complex structures and physiologies better.
While Phosphorous (31P) MRS (I) has been promising in experimental and clinical settings since the early 70s, it has been beset by prohibitively lower sensitivity, limited spectral-spatial resolution, and prolonged acquisition. This manuscript and proceedings of the annual scientific meeting of ISMRM in 2022 (REF1) and 2023 (REF2) demonstrate that our novel acquisition strategy, the novel Rosette Trajectory for fast and flexible MR(S)I contrast (Shen et al. 2023 (REF3), later we renamed it as PETALUTE after the translation to the preclinical scanners of 7T and 9.4T), enables operator-independent (1) rapid acquisition (~7 minutes), (2) reconstruction, and (3) processing pipeline, resulting in phosphorous metabolite ratio maps (10 x 10 x 10 mm3) of the whole brain.
In response to the “Repeat it with Me” challenge organized by the Reproducible Research study group of ISMRM, we demonstrated the power of this technique in 5 healthy volunteers at three different institutions with different experimental setups (2nd Place: UTE 31P 3D Rosette MRSI Reproducibility Team, REF4). Since the proposed acquisition/reconstruction/processing pipeline was operator/scanner/coil-independent, the Reproducer sub-teams successfully replicated the findings of the original proceeding in 2022 (REF1). As part of this challenge, we provided some MATLAB scripts and k-space data to reproduce some of the results described in this manuscript. The software and data can be downloaded from https://purr.purdue.edu/projects/ismrm31pmrsi.
These results will likely be of broad interest across clinical settings since the proposed acquisition strategy is not specific to any region, nuclei, or magnetic field and is operator-independent. This study's resolution and signal-to-noise ratios permit the metabolite maps in an experimentally and clinically feasible timeframe at 3 Tesla and 7T.
REF1 Bozymski B, Shen X, Ozen AC, Ibey S, Chiew M, Thomas A, Dydak U, Emir UE. Ultra-Short Echo Time 31P 3D MRSI at 3T with Novel Rosette k-space Trajectory. Proceedings 30th Scientific Meeting, International Society for Magnetic Resonance in Medicine, 2022.
REF2 Farley N, Bozymski B, Dydak U, Emir UE*. Fast 3D 31P MRSI Using Novel Rosette Petal Trajectory at 3T with x4 Accelerated Compressed Sensing. Proceedings 31st Scientific Meeting, International Society for Magnetic Resonance in Medicine, 2023.
REF3 Shen X, Özen AC, Sunjar A, Ilbey S, Sawiak S, Shi R, Chiew M, Emir UE. Ultrashort T2 components imaging of the whole brain using 3D dual-echo UTE MRI with rosette k-space pattern. Magnetic Resonance in Medicine. 2023;89(2):508–521.
REF4 https://challenge.ismrm.org/2023-24-reproducibility-challenge/results-22-23/
Rosette Applications (MRI and MRSI) at UHF human (7T) and animal scanners (9....Uzay Emir
MRI
MRSI
LEAF
PETAL
EGG
ROSETTE
MRI
siemens
bruker
his study aimed to develop a new 3D dual-echo rosette k-space trajectory, specifically for applications of ultra-short echo time (UTE) magnetic resonance imaging (MRI). The direct imaging of the myelin bilayer, which has ultra-short transverse relaxation time (uT2), was acquired to test the performance of the proposed UTE sequence.
Theory and Methods The rosette trajectory was developed based on rotations of a ‘petal-like’ pattern in the kx-ky plane, with oscillated extensions in kz-direction for 3D coverage. Five healthy volunteers were recruited and underwent ten dual-echo rosette UTE scans with varied echo times (TEs). Dual-exponential model fitting was performed to separate uT2 signals, with the output of uT2 fraction, uT2 value and long T2 value.
Results The reconstructed images’ signal contrast between white matter (WM) and grey matter (GM) increased with longer TEs. The WM regions had higher uT2 fraction values than GM (10.9%±1.9% vs. 5.7%±2.4%). The uT2 value was about 0.12 milliseconds in WM.
Conclusion The higher uT2 fraction value in WM compared to GM demonstrated the ability of the proposed sequence to capture rapidly decaying signals.
UTE 31P 3D Rosette MRSI reproducibility Team has demonstrated the Reproducibility of the method. The method has been challenged on #siemenshealthineers PET-MRI (mMR) and Prisma 3T scanners.ISMRM #spectroscopy ISMRM ChallengeISMRM RAPID Biomedical
https://lnkd.in/gnjCHtu2
Submillimeter fMRI Acquisition using a dual-echo Rosette kspace trajectory at 3TUzay Emir
n this study, we overcome the technological barrier against acquiring submillimeter resolution (~ 0.5 mm) fMRI data at 3T via a novel dual-echo Rosette k-space design. This design results in the fine representation of activation maps in two different functional tasks and might be a springboard in neuroimaging by providing very high-resolution spatiotemporal dynamics of neural networks. The method will be further evolved with the feedback from the MRI community via the GitHub platform as such for further acceleration, inflow saturation, and 3D coverage via 3D sampling and/or multiband approaches.
3D-UTE Rosette MRI and MRSI at UHF human (7T) and animal scanners (9.4T) usin...Uzay Emir
#ismrm #ISMRM2022 #ISMRM22
3D-UTE Rosette Applications (MRI and MRSI) at UHF human (7T) and animal scanners (9.4T) using The Berkeley Advanced Reconstruction Toolbox (BART) toolbox
Uzay Emir
Afternoon Tea with BART
Time: 15:45-16:45
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...University of Maribor
Slides from talk:
Aleš Zamuda: Remote Sensing and Computational, Evolutionary, Supercomputing, and Intelligent Systems.
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Inter-Society Networking Panel GRSS/MTT-S/CIS Panel Session: Promoting Connection and Cooperation
https://www.etran.rs/2024/en/home-english/
Toxic effects of heavy metals : Lead and Arsenicsanjana502982
Heavy metals are naturally occuring metallic chemical elements that have relatively high density, and are toxic at even low concentrations. All toxic metals are termed as heavy metals irrespective of their atomic mass and density, eg. arsenic, lead, mercury, cadmium, thallium, chromium, etc.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
HIGH-FIELD MRS methods to Study Human Body ZOOM MRSI 2-hg 2-hydroxyglutarate IDH mutation 7 Tesla
1. HIGH FIELD
MRI METHODS
TO STUDY
HUMAN BODY
SCHOOL OF HEALTH SCIENCES AND WELDON SCHOOL OF BIOMEDICAL ENGINEERING
PURDUE UNIVERSITY, WEST LAFAYETTE, IN, UNITED STATES
UEMIR@PURDUE.EDU
3. MULTI-OMICS ERA
• NMR spectra were obtained from
phosphate containing metabolites in
early 70s
• Metabolomics ?
• The fMRI, a newbie compared to
MRS, has evolved in practice,
sophistication, range of applications,
and impacts.
• Notably, it has been playing a
pivotal role in human brain
mapping, one of the significant
scientific challenges of the 21st
century.
• Connectomics
Saykin et al, Alzheimers Dement. 2015 Jul;11(7):792-814.
4. COMPARATIVE
HISTORY
• Comparative history is the comparison of
different societies which existed during
the same time period.
• Automobile Society
• Smartphone Society
• 1H MRS @high field
8. “Violent hierarchy”
"IT’S UNFAIR TO BLAME THE TOOL.
IT’S LIKE BLAMING A TELESCOPE WHEN SOMEBODY’S WRONG ABOUT [IDENTIFYING] A PLANET.
IT’S NOT THE TELESCOPE’S FAULT.” Rebecca Saxe at MIT
“There are questions … is good at answering and questions it is bad at answering.
There are right ways to use …., and there are irresponsible ways to use it.” Brian Resnick @B_resnick brian@vox.com
Question Tool
9. METHODS HAS TO BE CLINICALLY PRACTICAL
• Methods has to be simple to run without requiring any
manipulation from the user
• Results have to be easy to interpret if possible during the scan
time
2012
2021
https://www.youtube.com/watch?v=QN-eLHdwClM
https://www.cmrr.umn.edu/spectro/nc-
cms/content/upload/sLASER_VDVE.pdf
14. 2-HG and cancer metabolism
metabolic reprogramming
IDH-mutants
undergo
metabolic
reprogramming2,
3
1H-MRS (7T)
Potential to gain more integrated in
vivo information from other metabolites
(Gly, GSH, Lac, Glu, Gln)
1Kalinina et al. (2012)
3Tateishi K et al. (2015)
2Viswanath P et al. (2016)
21. THE NEED FOR
ULTRA-HIGH-
FIELD MRS
A Prognostic Precision
Medicine Biomarker Detection
System
Precision medicine strategies
• Tailoring therapies,
• Delivering more effective treatments,
whilst avoiding or reducing adverse
outcomes
Identify
Stratifying,
Monitoring IDH1 and IDH2 mutant
glioma patients
22. INCREASE IN SENSITIVITY
ALLOWS THE HIGHEST
RESOLUTION 2-HG MAP
AT 3T
SEMI-LASER
TE = 110 MS
VOI = 5 X 5 X 10 MM3
TA=4 MINUTES
=
SEMI-LASER
TE = 110 MS
VOI = 10 X 10 X 10 MM3
TA= 1 MINUTE
23. PSYCHOACTIVE DRUG
TRIALS (EBSELEN TRIAL)
• Mood stabilizers
• classically -> Lithium
• Inositol-depletion hypothesis (Harwood, Molecular Psychiatry, 2005)
• Inhibition of the enzyme inositol-1 (or 4)-monophosphatase (IMPase)
• However, undesirable side effects
• reduced urinary concentrating ability,
• hypothyroidism, hyperparathyroidism
• Weight gain
• Novel -> ebselen
• Bioavailable antioxidant drug
• Clinical trials for cardiovascular diseases, arthritis, stroke, atherosclerosis,
and cancer (Azad et al., Mol Biol Rep, 2014)
• Inhibition of IMPase (Singh et al., Nat. Commun, 2014)
29. POPULATION BASED STUDY
MAGNETIC RESONANCE IMAGING IN
A CROSS-SECTIONAL SAMPLE
SPANNING FROM CHILDHOOD
TO ADULTHOOD
• Cross-sectional sample spanning
from childhood to adulthood which
was reassessed in 1.5 years (N =
293).
• 3T Siemens MAGNETOM Prisma
MRI System
• Spectra were measured by semi-
adiabatic localization using an
adiabatic selective refocusing (semi-
LASER) sequence (TE = 32 ms; TR =
3.5 s; 32 averages;). Total
acquisition less than minutes
• 20 Neurochemicals were reported
37. make good use of all the
information of acquisitions
from multiple coils
Generate different phase
modulation in different slices
MUTLI-BAND ZOOM-MRSI
https://www.biorxiv.org/content/10.1101/628594v1.full
3 ZOOM-MRSI
slices with a 62.5 μL
resolution in 4.5
minutes
40. ZOOM-MRSI FOR
SODIUM IMAGING
• 2.5 × 2.5 × 20 mm3 (nominal resolution = 0.125 mL)
• TE = 0.55 ms
• total acquisition time (TA) of 15 min and 24 s.
Alhulail, AA, Xia, P, Shen, X, et al. Magn Reson Med. 2021; 85: 1783– 1794.
44. MRS OR MRI
Question Tool
• Methods has to be simple to run without requiring any
manipulation from the user
• Results have to be easy to interpret if possible during the
scan time
45. THANK YOU SO MUCH
Purdue
• Ulrike Dydak
• Sean Lane
• Xin Shen
• Nicholas Farley
• Pingyu Xia
• Ahmad Al-Hulail
UCLA
• Albert Thomas
MGH
• Matthew Rosen
• Neha Koonjoo
UNIVERSITÄTSKLINIKUM FREIBURG
• Ali Caglar Ozen
The study was supported by the Indiana CTSI and
funded in part by grant #UL1TR001108 from the the
National Institutes of Health (NIH), National Center for
Advancing Translational Sciences (NCATS) Clinical
and Translational Science Awards (CTSA)
Showalter Trust Purdue MRI Facility
Editor's Notes
The multi-slice SENSE reconstruction model is from Alan Chu’s multiband fmri paper. X is the image domain signal of different slices, and s is the signal from all the channels, c is the sensitivity, Q is NUFFT, and M is the phase modulation pattern, which will be explained later. In order to get signal from multiple slices simultaneously, just replace the z-direction single band pulse with multiband pulse and achieve simultaneous excitation.
In our case, we acquire three slices simultaneously, and there is concentric ring in the x-y plane, and three points in kz direction. It will start from kz plane, repeating on the first ring and record the FID, and then go to a positive kz, acquiring a ring with different radius, then go to negative kz, go back to zero plane, and repeat this process, For the corresponding single band pulse sequence, there won’t be encoding in the z direction, so it goes backs to 2D k-space with three sets of interleaves. In the parallel imaging scenario, the kz can be interpreted as gradient inducing phase modulation, which is a similar concept as blip CAIPI. So when kz=0, no phase modulation, kz 1/6, in our case, top slice will be phased by 120, and bottom slice will be phased by -120. It is similar when kz=-1/6 Now you can see the different phase modulation pattern of the three slices, which will induce FOV shift in case of cartesian k-space, but here it will induce image transformation9