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Online Bioscience Course for IT Professionals Spring 2010
Class Mechanics… ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Lecture 1: Biosciences Overview
Take Homes: ,[object Object],[object Object],[object Object],[object Object],[object Object]
http:// www.youtube.com/watch?v =zKNZjP9BdCw The “Big Picture”-an Overview
What is Life?: Dictionary.com  Unabridged (v 1.1)  -  Cite This Source  -  Share This   life            laɪf/  Pronunciation Key  -  Show Spelled  Pronunciation [lahyf]  Pronunciation Key  -  Show IPA Pronunciation   noun, plural lives          laɪvz/  Pronunciation Key  -  Show Spelled  Pronunciation [lahyvz]  Pronunciation Key  -  Show IPA Pronunciation ,  adjective  – noun  1.the condition that distinguishes organisms from inorganic objects and dead organisms, being manifested by growth through metabolism, reproduction, and the power of adaptation to environment through changes originating internally.  2.the sum of the distinguishing phenomena of organisms, esp. metabolism, growth, reproduction, and adaptation to environment.
Problems?: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
http://www.youtube.com/watch?v=aqGztEExN4Y The Andromeda Strain: It’s a Crystal!
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],For our Purposes:
Take Home I ,[object Object],Terrestrial living systems are all based on carbon compounds and use liquid water.  They are self-contained, use macromolecules such as nucleic acids and proteins to function, and react to and adapt to their environment over the short-term (movement) and also over the long-term (evolution).
The Basic Unit of Life on Earth is the Cell-and there are Two Types: Prokaryote Eukaryote plant animal
Prokaryotic Cell Structure Prokaryote=no nucleus
Eukaryotic Animal Cell Structure Eukaryote=has a nucleus
Eukaryotic Plant Cell Structure
http:// www.youtube.com/watch?v =MMrvmZ2i1sE The “Inner Life” of a Eukaryotic Cell
Size-Eukaryotes are Generally Bigger than Prokaryotes
Prokaryotes & Eukaryotes have  Different Genetic Structures as  Well…
Take Home II ,[object Object],There are two types of cells, prokaryotes and eukaryotes, each of which have very different structures, genetic mechanisms and behaviors yet are composed of mostly the same kinds of biomolecules and have very similar genetic codes…
from  Doolittle, W. Ford (1997) Proc. Natl. Acad. Sci. USA 94, 12751-12753 The Tree of Life:
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Model Organisms:
Take Home III ,[object Object],All organisms on earth are related by evolution from a common ancestor which existed on Earth about 4-3.5 billion years ago…this fact allows us to use studies of a few “Model” organisms to form the basis for our understanding of all Life…
The “Central Dogma”  of Molecular Biology: DNA RNA PROTEIN START STOP TRANSCRIPTION TRANSLATION REPLICATION GENE CODONS AMINO ACIDS
The “Central Dogma” in Action: http:// www.youtube.com/watch?v = NJxobgkPEAo
Molecular Biology's Central Dogma- The Movie! (everything to scale)! http:// www.youtube.com/watch?v =GkdRdik73kU
Take Home IV ,[object Object],All known Earth organisms use DNA, RNA and Proteins.  These “parts” function according to the so called “Central Dogma” of Molecular Biology… DNA>RNA>PROTEIN
Proteins act as Enzymes: http:// www.youtube.com/watch?v = cbZsXjgPDLQ
Proteins act as Machines: http:// www.youtube.com/watch?v =InIha7bCTjM&feature=related
Take Home V ,[object Object],All known Earth organisms use proteins to accomplish such basic functions as metabolism and movement, and as such all biological activity can be understood in chemical terms
Next Week: Biomolecules, Viruses and Cells More details on the chemicals and molecules that make up cells and viruses…what they look like and how they work…
Instructor Mark E Minie PhD [email_address]

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