1) Lateral lymph nodes are an important consideration in rectal cancer as they can indicate regional or metastatic disease.
2) Preoperative identification of lateral lymph node involvement varies widely between studies but incidence of post-operative involvement is 17-40%.
3) While MRI is the primary staging tool, identification of lateral lymph node metastases remains challenging. Size criteria for involvement varies.
4) Management approaches differ between Western and Japanese guidelines but generally involve neoadjuvant chemoradiation followed by total mesorectal excision with or without lateral lymph node dissection depending on response.
Tried to summarise all landmark trials in carcinoma breast in radiation oncology,medical oncology as well in surgical oncology.
References taken from Devita Book,Breast Disease book from Springer,journals like NEJM,JAMA,LANCET,ANNL ONCOLOGY etc,internet,Perez book,Practical Clinical Oncology by Hanna etc textbooks.
Thanks.
advancements in the diagnostics help detect states like oligometastasis ,which can lead to selection of patients for local and MDT and prolong the time to adjuvant therapy, at present There is no consensus on the treatment of oligometastatic cancer and clinical trials can help in evidence formation.
Artery first approach For Pancreatic Head tumours by Dr Harsh Shah (www.gastr...Dr Harsh Shah
Artery first approach to Pancreatic head tumour. There are various approaches as described in this presentation. Pros & Cons of all approaches are discussed.
Tried to summarise all landmark trials in carcinoma breast in radiation oncology,medical oncology as well in surgical oncology.
References taken from Devita Book,Breast Disease book from Springer,journals like NEJM,JAMA,LANCET,ANNL ONCOLOGY etc,internet,Perez book,Practical Clinical Oncology by Hanna etc textbooks.
Thanks.
advancements in the diagnostics help detect states like oligometastasis ,which can lead to selection of patients for local and MDT and prolong the time to adjuvant therapy, at present There is no consensus on the treatment of oligometastatic cancer and clinical trials can help in evidence formation.
Artery first approach For Pancreatic Head tumours by Dr Harsh Shah (www.gastr...Dr Harsh Shah
Artery first approach to Pancreatic head tumour. There are various approaches as described in this presentation. Pros & Cons of all approaches are discussed.
While the role of radiation therapy in carcinoma cervix management is undauntable for all stages. Recurrent carcinoma cervix need a lot of personalisation
Soft tissue sarcomas, treatment (surgical, radiation, chemotherapy)Joseph A. Di Como MD
A PowerPoint presentation for medical professionals regarding soft tissue sarcomas, likely most helpful to surgical residents and medical students. Gist tumors, liposarcomas, retroperitoneal sarcomas extremity, breast sarcoma and vascular sarcomas
Similar to Lateral lymph nodes in rectal cancer.pptx (20)
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists
Lateral lymph nodes in rectal cancer.pptx
1. Lateral lymph nodes in
rectal cancer
Pushpa Lal Bhadel
Department of Surgical oncology
BCH
2. Surgical anatomy
Lymph nodes draining the rectum below
the peritoneal reflection:
o Along superior rectal artery & inferior
mesenteric artery into para-aortic nodes
o Along middle and inferior rectal artery into
obturator, internal iliac and external iliac
nodes
TNM:
o Involvement of internal iliac LN: regional
disease
o External iliac nodes : metastatic disease
Japanese classification: all lateral LN as
regional nodes Figure 1. Lymphatic drainage of the rectum highlighting the lateral LN
4. Incidence
Pre-operative LLN involvement (Based on MRI)
Dharmarajan S et al 57 %
Ishibe et al 19.9%
MERCURY study group 11.7%
Ishihara et al 8.1%
Incidence based on post-operative histopathology
Akiyoshi et al 40.3%
Moriya Y 23%
Ueno et at 17.3%
Quadros et al 17%
Significance of LLN metastasis
Synchronous LLN disease in locally advanced tumors: 10-25% 1
According to Japanese society- incidence of LLN in tumors below peritoneal
reflection: 27% 2
1 Wei M, Wu Q, Fan C, Li Y, Chen X, et al. (2016) Lateral pelvic lymph node dissection after neoadjuvant chemo-radiation for preoperative enlarged lateral nodes in advanced low rectal cancer: study
protocol for a randomized controlled trial. Trials17: 561
2 Watanabe T, Muro K, Ajioka Y, Hashiguchi Y, Ito Y, et al. (2018) Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer. Int J Clin Oncol 23: 1-34
5. Diagnosis of LN mets in rectal cancer
MRI as primary staging tool:1
o Sensitivity: 55% and specificity: 78%
Morphologic criteria: irregular border, heterogeneous signal intensity and round
shape in combination with size: 2
o Sensitivity (36%-85%) and specificity (95%-100%)
Cutoff for LPLN size varies from 4 mm to 12 mm 3
Diffusion weighted MR-imaging (DWI-MRI) for LLNs: LLN have high DWI signal 4
1 Lahaye MJ, Engelen SME, Nelemans PJ, et al. Imaging for predicting the risk factors—the circumferential resection margin and nodal disease—of local recurrence in rectal cancer: a meta-analysis. Seminars in
Ultrasound, CT and MRI. 2005;26(4):259-268
2 Kim JH, Beets GL, Kim MJ, Kessels AGH, Beets-Tan RGH. High-resolution MR imaging for nodal staging in rectal cancer: are there any criteria in addition to the size? European Journal of Radiology.
2004;52(1):78-83
4 Ogawa S, Itabashi M, Hirosawa T, Hashimoto T, Bamba Y, Okamoto T. Diagnosis of lateral pelvic lymph node metastasis of T1 lower rectal cancer using diffusion-weighted magnetic resonance imaging: A case
report with lateral pelvic lymph node dissection of lower rectal cancer. Molecular and Clinical Oncology. 2016;4(5):817-820
3 Kawai K, Shiratori H, Hata K, Nozawa H, Tanaka T, Nishikawa T, Murono K, Ishihara S. Optimal Size Criteria for Lateral Lymph Node Dissection After Neoadjuvant Chemoradiotherapy for Rectal Cancer. Dis
Colon Rectum. 2021;64:274–283
6. Managing the LLNs
Advantage of LLND: 1
Decrease the intra-pelvic recurrence by 50%
Improve the 5-year survival by 8%-9%
Western concept Japanese concept
Regional nodes Internal iliac nodes Internal, external and
common iliac and obturator
nodes
Metastatic nodes Common iliac, external iliac and
obturator nodes
Not applicable
Management nCRT with RT boost to involved nodes LLN dissection
1 Watanabe T, Muro K, Ajioka Y, Hashiguchi Y, Ito Y, et al. (2018) Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer. Int J Clin Oncol 23: 1-34
7. AJCC: combination of TME with radiation therapy (RT) and
Chemoradiation therapy (CRT) – standard treatment for advanced
lower rectal cancer
Preoperative RT and CRT: partial local control effect
Reduce local recurrence to ≤10%
NCCN: recommends TME after CRT with concomitant fluorouracil
for cStage II-III rectal cancer
No specific description for LPLD
Extended dissection of LNs located outside resection region to which LPLNs
correspond is indicated for resectable LNs with suspected mets
ESMO: preoperative RT and CRT recommended depending on the
risk
LPLN mets is classified as advanced: preoperative CRT f/b surgery (TME +
extensive surgery) OR preoperative short-course RT + Folinic acid _
Fluorouracil + oxaliplatin (FOLFOX) regimen
8. Reassessment and preoperative treatment
Restaging to be performed after neoadjuvant treatment
Discussed during MDT meeting
Surgical decisions based on response of LLNs
oCurrent evidence infers: Internal iliac LLNs >4mm (SA) and obturator LLNs >6
mm (SA) after CRT benefit from LLND
Pt. with LLNs with complete clinical remission of both primary tumor
and LLNs after chemoradiation: careful assessment with MRI and
frequent f/u
12. LPLD and CRT for cLPLN(-) cases
JCOG0212 randomized controlled trial :
o Outcomes of prophylactic LPLD in cLPLN(-) cases without suspected metastasis
o Examined TME alone compared to TME + LPLD
o 5-year relapse-free survival (RFS) was 73.4% in the LPLD group and 73.3% in the ME
group
o 5-year OS was 92.6% in the LPLD group and 90.2% in the ME group
o 5-year local recurrence-free rates were 87.7% in the LPLD group and 82.4% in the
ME group
o Local recurrence rate 26 cases (7.4%) vs 44 cases (12.6%) was significantly lower in
the LPLD group
o LPLD is effective for reduction of recurrence in this lateral pelvis region
13. LPLD and CRT for cLPLN(+) cases
Kim et al:
o Local recurrence in 29 (7.9%) of 366 cases treated with TME alone without LPLD
after preoperative CRT.
o Recurrence in the lateral pelvis was found in 24 (82.7%) of these cases
o Local recurrence rates according to pretreatment LPLN size were 2.3%, 12.5% and
68.8% in cases with sizes < 5 mm, 5-10 mm and > 10 mm, showing that this rate was
high in cases with LPLN enlargement
Akiyoshi et al: 127 CRT treated cases
o Performed TME alone in 89 cases without suspected LPLN metastasis before
treatment (the TME group) and TME + LPLD in 38 suspected cases (LPLD group)
o LPLN metastasis: 25 (65.8%) cases in the LPLD group, but local recurrence: 7 (7.9%)
cases in the TME group and 1 (2.6%) case in the LPLD group.
o Lateral pelvic recurrence was found in only 3 cases (3.4%) in the TME group and
none in the LPLD group
14. Yang et al:
oFound no difference in overall local recurrence in cases
with suspected LPLN metastasis
oIncidence of local recurrence in the lateral pelvic region
was significantly lower in the TME + CRT + LPLD group
than in the TME + CRT group
15. Conclusion
Although the role of prophylactic LLND is unclear, it may have a role in
clinically positive lateral nodes and those that are resistant to CRT
The major question that remains still unanswered is whether routine
TME + LLND post CRT in stage II and stage III rectal cancer needs to be
advocated globally based on the oriental experience
The results from ongoing RCTs might provide an answer
16. Reference
Bailey short practice of surgery, 27th edition
Sabiston textbook of surgery, 20th edition
Internet sources
The majority of the first group of nodes are resected as a part of Total Mesorectal Excision (TME)
The second group of nodes, the lateral pelvic nodes, albeit being recognised long before, have triggered a significant interest in the field of rectal cancer surgery on the approach, recurrence and survival.
According to the TNM staging, involvement of the internal iliac group of nodes is considered as regional disease whereas the external and common iliac nodes are treated as metastatic disease.
In contrast, the Japanese classification considers all of the lateral lymph node groups as regional nodes. The Japanese guidelines for colorectal cancer (2016) recommend Lateral Lymph Node Dissection (LLND) for all tumors below the peritoneal reflection
Internal iliac compartment:
Cranial: bifurcation of common iliac artery
Caudal: internal iliac artery exiting the pelvis via sciatic foramen
Medial: mesorectal fascia
Lateral: lateral border of internal iliac artery
Posterior: piriformis muscle, sacrum
Obturator compartment:
Cranial: bifurcation of common iliac artery
Caudal: lateral lymphatic tissue meeting pelvic side-wall
Medial: lateral border of internal iliac artery
Lateral: internal obturator muscle and pelvis side-wall
Posterior: piriformis muscle
- LLN involvement in stage II-III rectal cancer
- LLNs are also reported to be the major cause for local recurrence following curative resection. About 50% of the local recurrences occur in the LLN basin without evidence of distant metastasis
European Society of Gastrointestinal and Abdominal Radiology (ESGAR) stated: “there is to date no solid evidence regarding specific or alternative (size) criteria for extra-mesorectal nodes and as such it was not deemed feasible to recommend any specific criteria for these nodes
MRI: large Field of view(FOV) thus broad assessment of all compartment
Increased sen and spe in determining malignancy in mesorectal lymph nodes
Diffusion-weighted MRI, Gadofosveset-enhanced MRI, and LN-specific contrast medium ultrasmall superparamagnetic iron oxide contrast agent (i.e. ‘USPIO’)-enhanced MRI have been examined for improvement of diagnosis of LN metastasis of rectal cancer
The AJCC classifies LLN involvement as metastatic disease except for the internal iliac nodes. As the LLNs apart from the internal iliac group are considered as metastatic disease, they were dealt with less aggressively. However, radiation oncologists in the US nowadays are preferring to deal with the non-regional nodes with treatment intensification, either Radiotherapy (RT) boost or Surgical LLND
The Japanese classification, on the other hand, considers all LLN involvement as regional disease, irrespective of the site. As a result, LLN dissection is routinely performed in this part of the world.
- The ESMO guidelines also do not particularly recommend prophylactic dissection for LPLNs without suspected metastasis, similar to the NCCN guidelines, and LPLD is not routinely performed in Western countries.
Current evidence supports LLND to be the most effective treatment strategy for persistently enlarged LLNs after (C)RT
A Ureter is dissected and taped.
B After the expose of the common iliac artery, the common iliac vein, and the hypogastric nerve, the lymph nodes in region 273 with adipose tissues located among them can be seen
Other institutions may only remove individual LLNs, without removing the entire compartment, known as “node-picking.” This approach does not follow general oncological principles, ignoring potential micro-metastatic involvement, extracapsular growth or (lympho-)vascular invasion that may result in tumor spillage or residual disease.
C The obturator nerve and vessels are exposed after dissecting anterior aspect of external iliac vein. The lymph nodes in region 283 with adipose tissues can be seen.
D After severing the obturator vessels, obturator LLNs of region 283 are removed with the obturator nerve being preserved.
E Umbilical artery is dissected and taped.
F The lymph nodes in region 263 are resected along the inner side of internal iliac artery using the superior vesical artery as a boundary
- 5-year relapse-free survival (RFS) was 73.4% in the LPLD group and 73.3% in the ME group, which did not demonstrate non-inferiority of TME alone; moreover, the Kaplan-Meier curve for RFS was consistent, showing no superiority of LPLD. The secondary endpoint of 5-year OS was 92.6% in the LPLD group and 90.2% in the ME group, again showing no significant difference. The 5-year local recurrence-free rates were 87.7% in the LPLD group and 82.4% in the ME group, with no significant difference, but the local recurrence rate was significantly lower in the LPLD group