Laparoscopic ovarian drilling (LOD) is a second-line treatment for infertility in polycystic ovary syndrome (PCOS) patients who do not respond to clomiphene citrate. Adjusting the number of punctures and thermal dose based on individual ovarian volume improves outcomes and reduces risks of damage to ovarian reserve compared to fixed dosing protocols. While LOD improves ovulation and pregnancy rates, it is not a first-line or permanent treatment, and repeated drilling is not recommended. Oral and gonadotropin therapies are preferable first-line options before considering LOD or in vitro fertilization.
Recurrent pregnancy loss is a significant redroductive medical problem, influencing 2%–5% of couples. ... Throughout the years, proof based medications, for example, surgical correction of uterine abnormalities or asprin and heparin for antiphospholipid syndrome have improved the results for couples with repetitive pregnancy loss.
Recurrent pregnancy loss - Uterine factorsAnu Manivannan
recurrent pregnancy loss - uterine factors based on fertility sterility journal - evidence based
Dr.Anu.M - Mch Resident - Department of Reproductive Medicine and Surgery
Investigations for iufd & sb, how to select?Wafaa Benjamin
Foetal loss is a distressing situation for the lady ,family and medical staff as well.
Investigating the cause of death has many benefits .
Meticulous history taking and clinical assessment is of at most importance.
There are routine standard tests & others arte selective directed by clinical scenarios.
Researches & recording are required to estimate main causes of foetal death at local level, so, investigations could be directed.
In presence of lack of resources, selection of investigations should be prioritized by most relevant and most informative ones.
Post-mortem examination should be re-included at least external examination & placental histopathology.
Recurrent pregnancy loss is a significant redroductive medical problem, influencing 2%–5% of couples. ... Throughout the years, proof based medications, for example, surgical correction of uterine abnormalities or asprin and heparin for antiphospholipid syndrome have improved the results for couples with repetitive pregnancy loss.
Recurrent pregnancy loss - Uterine factorsAnu Manivannan
recurrent pregnancy loss - uterine factors based on fertility sterility journal - evidence based
Dr.Anu.M - Mch Resident - Department of Reproductive Medicine and Surgery
Investigations for iufd & sb, how to select?Wafaa Benjamin
Foetal loss is a distressing situation for the lady ,family and medical staff as well.
Investigating the cause of death has many benefits .
Meticulous history taking and clinical assessment is of at most importance.
There are routine standard tests & others arte selective directed by clinical scenarios.
Researches & recording are required to estimate main causes of foetal death at local level, so, investigations could be directed.
In presence of lack of resources, selection of investigations should be prioritized by most relevant and most informative ones.
Post-mortem examination should be re-included at least external examination & placental histopathology.
Ovarian Drilling Do's & Don'ts - By Dhorepatil BharatiBharati Dhorepatil
Rotterdam Criteria 2003
The Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
March 2–3, 2007, Thessaloniki, Greece.
Human Reproduction 2008
Live birth by fallopian tube sperm perfusion in hyperprolactinemic woman afte...lukeman Joseph Ade shittu
The case presented describes a live birth following treatment of a 35-year-old woman with fallopian tube sperm perfusion (FTSP) using donor sperm after three-repeated unsuccessful courses of In-vitro fertilization (IVF) with Percutaneous Epididymal Sperm Aspiration (PESA), Testicular Sperm Extraction (TESE), and donor sperm. The indication of FTSP is hereby explored and discussed.
Current Role of Surgery in Endometriosis; Indications and ProgressCrimsonpublisherssmoaj
Endometriosis is a chronic debilitating disease , which affects women of reproductive age group, although medical therapy may be helpful in managing pain associated with Endometriosis or infertility, surgery becomes an integral part of managing this disease .Although initially surgery was limited to l aporotomy associated with ovarian cystectomy and/or TAH with BSO. Laporoscopy gradually replaced that. Though diagnostic laparoscopy is used for confirmation of endometriosis by histological examination, it is not acceptable that Laporoscopy be done in multiple steps, initially to diagnose and later for treatment. Recently a lot of advancement has come in the imaging techniques by which one can combine planning of surgery based on the imaging classification. Deep endometriosis involving bowel, genitourinary tract can be dealt by careful dissection in controlled trained hands, in a well equipped set up to achieve the optimum results .Endometriosis associated infertility may or may not warrant surgery as with multiple studies operation on ovarian endometriomas might land up in reducing ovarian reserve - while doing straight IVF may result in better pregnancy rates ,getting good oocyte retrieval in contrast to poor ovarian reserve resulting from damage to ovarian morphology. Use of laser for ovarian cystectomy helps in getting better outcomes than simple drainage and coagulation procedures. Robotic surgery is the latest addition, which aids in better dissection and management but its problem is its cost, not accessible to many patients and not many trained personnel available.
SHARE Presentation: New Developments in the Medical Treatment of Breast Cance...bkling
Dr. Cliff Hudis on the latest information on new breast cancer treatments. Dr. Hudis is Chief of Breast Cancer Medicine Service at Memorial Sloan-Kettering Cancer Center.
Recent evidence based guideline regarding Ovarian drilling very helpful for Gynaecologist, laparoscopic surgeon, Infertility specialist, Post doctoral fellows and post graduates
Similar to Laparoscopic ovarian drilling : Not too much Not too little (20)
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Laparoscopic ovarian drilling : Not too much Not too little
1. Prof. Mahmoud Zakherah
Prof of Obstetrics and Gynecology,
Women’s Health Hospital Assiut University
Egypt
mszakhera@gmail.com
22-12-17
2.
3. A “stepwise approach” to the management
of infertility in PCOS
Ovarian Drilling in PCOS: Is it Really
Useful?
4. Ovarian Drilling in PCOS: Is it
Really Useful?
RCOG,[2007] ACOG,[2009] Society of
Obstetricians and Gynecologists, Canada[2010]
and the PCOS consensus working group[2008),
All recommend LOD use in highly selected
cases, particularly in those with hypersecretion
(LH), normal body mass index, needing
laparoscopic assessment of the pelvis or who live
too far away from the hospital for the intensive
monitoring required during gonadotropin
therapy.
5. Ovarian Drilling in PCOS: Is it
Really Useful?
This implies that LOD
is a valid, but not the
sole option for CC-
resistant PCOS
Mitra et al ,2015
6. All meta-analysis confirmed
that LOD is a second-line
treatment in PCOS patients,
especially those with CC
resistance.
Mayenga et al Gynecol Obstet Fertil (2011) .
Farquhar et al Cochrane Database Syst
Rev (2012).
14. PCO not equal PCOS
Rotterdam criteria 2004 ,entails the
presence of ≥12 follicles within the
ovary with a diameter of 2-9 mm and/or
ovarian volume ≥10 cm.
Polycystic ovaries may present in
healthy women, s0 the inclusion of this
sign to the diagnostic criteria of
polycystic ovary syndrome is still
questioned.
15. PCO not equal PCOS
Sonographically diagnosed polycystic
ovaries by Rotterdam Criteria increase in
the percentage of polycystic
ovary syndrome .
Recently , 26 versus 12 follicles-is required
to distinguish among women with PCOS and
healthy women from the general population
(Lujan et al. Hum Reprod. 2013)
16. PCOS imitators
The most important step to
diagnose PCOS to exclude
other conditions of
CA/Hyperandrogenism
21. How many punctures?
The number of punctures is empirically
chosen depending on the ovarian size.
In the original procedure, 3-8
diathermy punctures (each of 3 mm
diameter and 2-4 mm depth) per ovary
were applied, using power setting of
200-300 W for 2-4 s ( Gjönnaess ,1984).
22. How many punctures?
Most surgeons perform four punctures per
ovary, each for 4 s at 40 W (rule of 4),
delivering 640 J of energy per ovary (the
lowest effective dose recommended)
(Armar et al 1990).
Rule of Four
➢40 W
➢4 seconds
➢4 puncture points
23. How many punctures?
The aim of fixed number of puncture
points regardless of ovary size (Felemban et
al,2000) or unilateral ovary cauterization to
decrease the potential risks of ovarian
failure and adnexal adhesions (Balen and
Jacob,1994).
May be too little
24. How many punctures?
In earlier studies there was an
assumption that the greater the
amount of energy, the more
effective the procedure.
(Gjonnaess,1989)
May be too much
25. How many punctures?
The clinical response is dose-dependent,
with higher ovulation and pregnancy
rates observed by increasing dose of
thermal energy up to 600 J/ovary,
irrespective of ovarian volume (Amer
2003).
Most gynecologists still perform bilateral
over unilateral drilling.
(Roy et al,2009 , Farquhar et al,2012).
26. Unilateral versus Bilateral
Unilateral as effective as bilateral (Balen
and Jacob,1994).
Contralateral ovary may ovulate first
(Al-Mizyen and Grudzinskas 2007)
28. Adjusted LOD
New terminology
Means tailoring the number of
punctures according to Ovarian Volume
(Zakherah et al ,2011)
29. Ovarian Volume
Ovarian volume is calculated by the
measurement of the length, width and
the thickness and use of the classical
formula for a prolate ellipsoid: L × W × T ×
0.5 (Adams et al ,1985 Chen et al ,2008).
The volume of each ovary was calculated as follows: length ×
width × height × 0.523 (Higgins et al ,1990).
Three-dimensional ultrasound is a recognized
diagnostic modality to assess ovarian volume
30. The antral follicle count(AFC)
➢AFC was defined as the total number of
follicles < 9 mm in diameter in both
ovaries
➢FNPO is best predictor for diagnosis
PCOS
Christ et al , Fertil Steril,. 2014
Lie Fong et al, Hum Reprod. 2017
31. Methodology of Adjusted LOD
We suggested dose was 625 J/10.8 cm3= 60
J/cm3 of ovarian tissue.
The required number of punctures then was
calculated by dividing total individual
ovarian dose with dose delivered in each
puncture point. ( e.g. 12 cm3 x60=720 j
÷150=4.8 punctures)
33. How many punctures?
Adjusting thermal dose based on
ovarian volume (60 J/cm3 ) has
better reproductive outcomes with
similar postoperative adhesion rates
than fixed dose of 600 J/ovary
(Zakherah et al ,20011)
34.
35. Is ovarian reserve diminished after
laparoscopic ovarian drilling?
✓The PCOS women both with and without
LOD had significantly greater ovarian reserve
than the age-matched controls having
normal ovulatory menstruation (Weerakiet et
al ,2007).
✓ LOD, if applied properly, normalizes the
exaggerated ovarian morphologic and
endocrinologic properties. (normalization of
ovarian function rather than a reduction of
ovarian reserve ) (Api,2009)
37. Assessment of ovarian reserve after
unilateral diathermy with thermal
doses adjusted to ovarian volume .
Dose-adjusted unilateral diathermy
(60 J/cm(3)) does not have significant and
long-term effects on ovarian reserve.
Sunj et al , Gynecol Endocrinol. 2014
38. Anti-Müllerian hormone, testosterone and free
androgen index following the dose-adjusted unilateral
diathermy in women with polycystic ovary syndrome
The value of T is the strongest and consistent
indicator of ovulatory response after
diathermy
Sunj et al .Eur J Obstet Gynecol Reprod Biol. 2014
39. Does unilateral laparoscopic
diathermy adjusted to ovarian volume increase the
chances of ovulation in women with polycystic
ovary syndrome?
The pregnancy rate was significantly
higher in patients with a larger right
ovary compared with those with a
smaller right ovary, regardless of the
treatment group
Sunj et al Hum Reprod. 2013
40. .
Conclusions :Accurate and documented
diagnosis of PCOS, appropriate surgical
training, adjusted thermal injury and
adjusted number of punctures are
essential for the avoidance of excessive
damageto the ovaries.
41. The impact of laparoscopic ovarian drilling on
AMH & ovarian reserve: a meta-analysis
LOD significantly lowers circulating AMH, but this
may not necessarily reflect a real damage to
ovarian reserve.
Given its proven efficacy and its long-term
benefits, LOD should remain as an option in the
management of anovulatory PCOS patients.
(Saad A Amer1, Tarek T El Shamy2, Cathryn James, Ali H
Yosef , Ahmed A. Mohamed, 2017)
42. How to avoid DOR
Adjust your dose ALOD
Cutting mode instead of coagulating
mode
Short time 5 seconds
Low wattage 30 watt
Lavage Before and After
Unilateral RT ovary –Adjusted
Never drill unless
43. To Avoid DOR
Avoid cauterization at
Mesovarium
Hilum
Corpus luteum
Ovarian ligament
Infudibulopelvic ligament
44. Never Drill
Ovarian volume less than 10 cm3.
FSH more than 9 IU/L
Previous ovarian drilling .except
AMH less than 5 ng/ml or more
than 8.3 ng/ml
Only used as a 2rd line therapy
45. Repeated LOD in polycystic ovary
syndrome
✓ DO NOT Repeat
✓ You will repeat failure
✓ After 1 y follow up IVF
✓ Antagonist Vs Long protocols
✓ Repeat LOD is ONLY in women
who previously responded to the
first procedure (Amer ,et al
,2003).
46. Take home messages
Lod still has a place and still
useful .
Proper diagnosis
Exclude PCOS imitators
LOS is 2nd line therapy for
clomiphene resistant cases
Adjust thermal dose
47. Take home messages
LOD is currently recommended as a safe, efficacious
and cost-effective alternative to gonadotropins for
OI in infertile, anovulatory, CC-resistant PCOS
women without the risks of OHSS or multiple
gestation.
Although iatrogenic adhesion formation and DOR
are potential complications, they are of little clinical
significance and can be minimized by adjusting the
number of punctures and energy applied.
48. Take home messages
LOD improves ovarian responsiveness to
CC and gonadotropins, these may be
considered after LOD failure instead of
repeat LOD, before proceeding to the last
resort that is, IVF.
LOD is only an alternative, not the
ultimate in management of PCOS
49. Take home messages
LOD NOT the first NOR
last line of treatment of
PCOS.
There are safe and efficacious oral alternatives
and relatively safe as low-dose step-up
regimen of gonadotropin therapy before
proceeding to the last resort that is, IVF.
50. If your only toy is a hammer
every problem will look like
a nail