This document discusses ketosis in cattle. It begins by defining ketosis as a multifactorial energy metabolism disorder that results from negative energy balance, leading to hypoglycemia and ketonemia. It then describes the three types of ketosis based on hepatic insufficiency and discusses the various causes of ketosis in cattle. The document outlines the pathogenesis, clinical findings, clinical pathology, diagnosis, necropsy findings, differential diagnosis, treatment, prevention and economic impact of ketosis in cattle.
Lecturer notes for metabolic diseases in Cattle.which is benificial for student of BVSc& AH/DVM and MVsc student. It is My first presentation need your feedback for more presentation like this.
Lecturer notes for metabolic diseases in Cattle.which is benificial for student of BVSc& AH/DVM and MVsc student. It is My first presentation need your feedback for more presentation like this.
Induction of parturition & elective termination of pregnancyMahalingeshwara Mali
this ppt briefs about induction of parturition and elective termination of pregnancy in farm and pet animals, which may be helpful for the veterinary undergraduates, field veterinarians, and farm managers to extend their knowledge in this aspect.
www.petsgroomingtips.com is one of the front-runners in providing complete digital information to the pet owners, which would guide theme through various process of grooming their beloved kids. A shabby puppy or kitten not only appears dirty but soon infested with disease if not treated properly. Our various tutorials and free PDF guides cover every aspect of the grooming process.
Induction of parturition & elective termination of pregnancyMahalingeshwara Mali
this ppt briefs about induction of parturition and elective termination of pregnancy in farm and pet animals, which may be helpful for the veterinary undergraduates, field veterinarians, and farm managers to extend their knowledge in this aspect.
www.petsgroomingtips.com is one of the front-runners in providing complete digital information to the pet owners, which would guide theme through various process of grooming their beloved kids. A shabby puppy or kitten not only appears dirty but soon infested with disease if not treated properly. Our various tutorials and free PDF guides cover every aspect of the grooming process.
This content is shared for the sake of Veterinary Medicine Awareness and to help the Veterinary Medical Professionals and Students of Veterinary Medicine. Hope this content will be very helpful.
Pregnancy Toxemia/Ketosis in Goats
Ghulam ullahMay 08, 2022
Pregnancy Toxemia/Ketosis in Goats
Presentation
This is a state of late pregnancy and early lactation most generally happening over the most recent a month and a half of growth in does with numerous embryos and in the initial a month of vigorously lactating does. Pregnancy pre-eclampsia is a more normal condition than ketosis in goats. Through acknowledgement of early signs and side effects and aversion of the inclining factors, it tends to be diminished to an irregular condition.
Inclining Factors
Factors that incline does to foster pregnancy pre-eclampsia can be partitioned into two kinds: deficient nourishment (they are not offered the right amount or nature of the expected proportion) and satisfactory wholesome contributions yet outer or creature factors (for example sickness) influencing admission.
Insufficient Nutrition
Does conveying numerous embryos require a lot more elevated level of energy than does convey singles. These expanded requirements are compounded by a diminished ability to consume. Whenever offered off the cuff adjusted takes care of, does in late pregnancy will willfully increment energy utilization yet extended uterine items limit dry matter admission, putting fertile does at considerably more serious gamble of creating pregnancy blood poisoning. To balance this, the maker should offer an apportion that is more energy and protein thick, for example, 35% grain to 65% scavenge. Productive does on the field might experience issues meeting their energy needs through nibbling.
Factors Affecting Intake
Outside factors
Sound, very much taken care of goats might endure numerous outside factors yet does constantly deprived can't redress. Nasty weather conditions (for example downpours or blizzards or outrageous intensity) may hinder admissions. Feeder space might have been determined for non-gravid does and might be insufficient for intensely pregnant does. While hand taking care of, the maker ought to be cautioned to look for the exorbitant contest. Limited water admission or low-quality water will diminish dry matter admissions.
Fast feed changes and transport may all briefly diminish admissions. Low quality scavenges that are too woody may likewise lessen dry matter admission. Preventive medicines like immunizing, and so on acted in late incubation might decrease admissions, especially assuming that they are held off fed for the strategy. The practice has been displayed to increment willful admission.
Creature factors
Factors that will diminish admissions incorporate dental sickness, advanced age, more modest body size than a bunch (see feeder space), and other attending infections like hypocalcaemia, weakness (for example CAE joint inflammation), gastrointestinal parasitism, Johne's illness, and so on. The body condition score of the doe is vital to go into late growth. Does that are exceptionally flimsy (< 2.5) have minimal fat or muscle stores to draw upon an
Easy availability for people to search about malnutrition..... Kwashiorkor and Marasmus condition heavenly disturbed child's health by the fact of under nutrition.
It is easy to read about the differences of malnutrition and protein energy malnutrition.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
2. Etiology
Etiology A multifactorial disorder of energy
metabolism.
Negative energy balance results in hypoglycemia,
ketonemia (the accumulation in blood of acetoacetate,
β-hydroxybutyrate [BHB] and their decarboxylation
products acetone and isopropanol), and ketonuria.
3. Hepatic Insufficiency in Ketosis
In type I, or “spontaneous” ketosis, the gluconeogenic
pathways are maximally stimulated, and ketosis occurs
when the demand for glucose outstrips the capacity of
the liver for gluconeogenesis because of an insufficient
supply of glucose precursors.
4. type II ketosis, manifest with fatty liver, gluconeogenic
pathways are not maximally stimulated, and
consequently mitochondrial uptake of NEFAs is not as
active, and NEFAs become esterified in the cytosol,
forming triglyceride.
The capacity of cattle to transport triglyceride from the
liver is low, resulting in accumulation and fatty liver.
The occurrence of a fatty liver can further suppress
hepatic gluconeogenic capacity.
5. In type III ketosis, cattle are fed a diet (typically a high-
maize ration) that results in a higher ruminal
production of butyrate, which is directly metabolized
by ruminal epithelial cells to butyrate.
6. Types of Bovine Ketosis
• Primary ketosis (production ketosis)
• Secondary ketosis
• Alimentary ketosis
• Starvation ketosis
• Ketosis resulting from a specific nutritional deficiency
7. Primary Ketosis (Production Ketosis)
Primary ketosis occurs in cows in good to excessive
body condition that have high lactation potential and
are being fed good-quality rations but that are in a
negative energy balance.
8. Secondary Ketosis
Secondary Ketosis Secondary ketosis occurs where the
presence of other disease results in a decreased food
intake.
9. Alimentary Ketosis
Alimentary ketosis (also called type III in some
classification systems) is a result of excessive amounts
of butyrate in silage and possibly also a result of
decreased food intake resulting from the poor
palatability of high-butyrate silage.
Silage made from succulent material may be more
highly ketogenic than other types of ensilage because
of its higher content of preformed butyric acid.
10. Starvation Ketosis
Starvation Ketosis Starvation ketosis occurs in cattle
that are in poor body condition and that are fed
poorquality feedstuffs. There is a deficiency of
propionate and protein from the diet and a limited
capacity of gluconeogenesis from body reserves.
Affected cattle recover with correct feeding.
11. Nutritional Deficiency
Ketosis Resulting From Specific Nutritional Deficiency
Specific dietary deficiencies of cobalt and possibly
phosphorus may also lead to a high incidence of
ketosis.
12. PATHOGENESIS
in early lactation, at which time negative energy
balance leads to adipose mobilization, and milk
synthesis creates a high glucose demand. Adipose
mobilization is accompanied by high blood serum
concentrations of nonesterified fatty acids (NEFAs).
During periods of intense gluconeogenesis, a large
portion of serum NEFAs is directed to ketone body
synthesis in the liver. Thus, the clinicopathologic
characterization of ketosis includes high serum
concentrations of NEFAs and ketone bodies and low
concentrations of glucose.
13. Ketone Formation Ketones arise from two major
sources: butyrate in the rumen and mobilization of fat.
14. In response to a negative energy balance and low
serum concentrations of glucose (and consequently
low serum concentrations of insulin), cows will
mobilize adipose tissue, with consequent increases in
serum concentrations of nonesterified fatty acids
(NEFA) and subsequent increases in serum
concentrations of β-hydroxybutyrate (BHB),
acetoacetate, and acetone.
15.
16.
17. CLINICAL FINDINGS
Two major clinical forms of bovine ketosis are
described—wasting and nervous present in varying
degrees of prominence.
18. Wasting form
The wasting form is the most common of the two and
is manifest with a gradual but moderate decrease in
appetite and milk yield over 2 to 4 days.
In component-fed herds, the pattern of appetite loss is
often very specific in that the cow first refuses to eat
grain, then ensilage, but may continue to eat hay. The
appetite may also be depraved.
“Woody” appearance because of the apparent wasting
and loss of cutaneous elasticity presumably resulting
from disappearance of subcutaneous fat.
19. The temperature and the pulse and respiratory rates
are normal, and although the ruminal movements may
be decreased in amplitude and number, they are
within the normal range unless the course is of long
duration,
The characteristic sweet odor of ketones is detectable
on the breath and often in the milk,
20. Nervous form (nervous ketosis)
Walking in circles
Straddling or crossing of the legs
Head pushing or leaning into the stanchion
Apparent blindness
Aimless movements and wandering
Vigorous licking of the skin and inanimate objects
Depraved appetite
Chewing movements with salivation Hyperesthesia
may be evident.
21. The nervous signs that occur in some cases of bovine
ketosis are thought to be caused by the production of
isopropanol, a breakdown product of acetone in the
rumen,1 although the requirement of nervous tissue
for glucose to maintain normal function may also be a
factor in these cases.
22. Subclinical Ketosis (Hyperketonemia)
Subclinical ketosis is defined as an increase in
blood/plasma/serum BHB above the normal reference
range or ketonuria in a cow without detectable clinical
signs of disease.
Potential milk production in cows with subclinical
ketosis is reduced by 1% to 9%.
23. CLINICAL PATHOLOGY
Hypoglycemia, ketonemia, and ketonuria are
characteristic of the disease.
Glucose Plasma glucose concentrations are reduced
from the normal of approximately 50 to 65 mg/dL to
20 to 40 mg/dL
BHB is the quantitatively highest circulating ketone
body in cattle.
24. Normal cows have plasma BHB concentrations less
than 1.0 mmol/L;
cows with subclinical ketosis have blood or
plasma/serum concentrations greater than 1.0, 1.2, or
1.4 mmol/L
Cows with clinical ketosis usually have serum/plasma
BHB concentrations in excess of 2.5 mmol/L, with
values rarely reaching 10.0 mmol/L.
25. Diagnosis
In a given animal, urine ketone body concentrations
are always higher than milk ketone body
concentrations.
Biochemical examination reveals hypoglycemia,
ketonemia and ketonuria.
ROTHERA'S TEST Test For Ketone Bodies.
Acetoacetic acid reacts with Sodium nitroprusside to
give a violet color.
26. NECROPSY FINDINGS
The disease is not usually fatal in cattle, but fatty
degeneration of the liver and secondary changes in the
anterior pituitary gland and adrenal cortex may be
present.
28. Treatment
Treatment of ketosis is aimed at reestablishing
normoglycemia and reducing serum ketone body
concentrations.
Dextrose 50% solution @ 500-800 ml should be
administered intravenously.
Dexamethasone, Predinisolone @ 10 ml I/M
Insulin @ 200 IU can be administered.
Propylene glycol administered orally (250–400 g/dose [8–14
oz]) once per day acts as a glucose precursor and is effective
as ketosis therapy.
Cyanocobalamin (vitamin B12, 1 to 4 mg daily IV)
29. Prevention and Control:
Prevention of ketosis is via nutritional management.
Body condition should be managed in late lactation,
when cows frequently become too fat. Modifying diets
of late lactation cows to increase the energy supply
from digestible fiber and reduce the energy supply
from starch may aid in partitioning dietary energy
toward milk and away from body fattening.
monensin sodium is approved for use in preventing
subclinical ketosis and its associated diseases. Where
approved, it is recommended at the rate of 200–300
mg/head/day.
30. Why Ionophores (monensin) is useful ?
Ionophores alter bacterial flora of the rumen, leading
to decreases in gram-positive bacteria, protozoa, and
fungi and increases in gram-negative bacteria.
The net effect of these changes in bacterial flora is
increased propionate production and a decrease in
acetate and butyrate production providing increased
gluconeogenic precursors.
31. Economic Significance
Economic Significance Clinical and subclinical ketosis are
major causes of loss to the dairy farmer. In rare instances
the disease is irreversible and the affected animal dies, but
the main economic loss results from the loss of production
while the disease is present, the possible failure to return
to full production after recovery, and the increased
occurrence of periparturient disease.
Decreased milk yields; lower milk protein and milk lactose;
increased risk for delayed estrus and lower first-service
conception rates; lower pregnancy rates; increased
intercalving intervals; increased risk of cystic ovarian
disease, metritis, and mastitis; and increased involuntary
culling