The liver, gallbladder, and pancreas have important roles in digestion and metabolism. The liver produces bile which aids in digestion and performs metabolic functions. The gallbladder stores and concentrates bile. The pancreas produces enzymes that break down nutrients. These organs receive blood supply from branches of the celiac trunk and have both exocrine and endocrine functions. They have complex internal anatomy organized into lobules and zones to efficiently process nutrients and waste.
01.12.09(b): Histology - Liver, Pancreas, and Gallbladder Open.Michigan
Slideshow is from the University of Michigan Medical School's M1 Gastrointestinal / Liver sequence
View additional course materials on Open.Michigan:
http://openmi.ch/med-m1gastro
This is not a substitute for Books. Let it just help you understand some concepts in liver anatomy.
Continuation of this work will depend on your feedback. Stay Blessed.
01.12.09(b): Histology - Liver, Pancreas, and Gallbladder Open.Michigan
Slideshow is from the University of Michigan Medical School's M1 Gastrointestinal / Liver sequence
View additional course materials on Open.Michigan:
http://openmi.ch/med-m1gastro
This is not a substitute for Books. Let it just help you understand some concepts in liver anatomy.
Continuation of this work will depend on your feedback. Stay Blessed.
Histology of Gall bladder and its formation which consist of mainly 3 layers which they are:
- Mucosa
- Muscularis / Fibromuscular layer
- Serosa / Adventitia
And you must note that there is no Muscularis mucosa
& Submucosa inside Gall bladder...
Prepared by Nahry Omer Muhammad, University of Sulaimany/Collage of Medicine
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Francesca Gottschalk from the OECD’s Centre for Educational Research and Innovation presents at the Ask an Expert Webinar: How can education support child empowerment?
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
BÀI TẬP BỔ TRỢ TIẾNG ANH GLOBAL SUCCESS LỚP 3 - CẢ NĂM (CÓ FILE NGHE VÀ ĐÁP Á...
Karaciğer, safra, pankreas histoloji ve anatomisi
1. Liver, Pancreas, and Gallbladder
Anatomy-Histology Correlate
By: Michael Lu, Class of ‘07
2. -The liver and gallbladder play important roles in
digestion via the production and storage of bile. The
liver is also the major organ for metabolism and
detoxification. The pancreas also produces digestive
enzymes to break down proteins, sugars, and fats.
- The processes described above are the exocrine
functions of the liver and gallbladder. But they also
have endocrine roles, secreting compounds into the
bloodstream. The hepatocytes produce albumin,
fibrinogen, and thrombin, for example. The pancreatic
islets produce insulin, glucagon, and somatostatin.
- The liver, gallbladder, and pancreas receive blood
supply from the celiac trunk. One main branch is the
common hepatic artery, leading to the hepatic artery
proper that branches into left and right hepatic
arteries to supply the liver. The right hepatic artery
gives off the cystic artery to supply the gallbladder.
- The pancreas is supplied by multiple vessels. The
body and tail are supplied by the dorsal, inferior, and
great pancreatic arteries, which all branch off the
splenic artery (another main branch of the celiac
trunk). The head, neck, and uncinate process are
supplied by anastomoses of arteries branching off the
celiac trunk and superior mesenteric artery. The
gastroduodenal artery, from the common hepatic
artery, divides into the anterior and posterior
superior pancreaticoduodenal arteries. They
anastomose with inferior branches of the inferior
pancreatico-duodenal artery from the superior
mesenteric artery. The same arteries supply the
3. -The liver has diaphragmatic and visceral surfaces which contact the diaphragm and abdominal viscera,
respectively. Note the right triangular, left triangular, and coronary ligaments that attach to the diaphragm.
Note also the bare area not covered by peritoneum. Anteriorly, there is a fold of peritoneum connecting the liver
to the umbilicus called the falciform ligament, which contains the round ligament or ligamentum teres. It is
the remnant of the umbilical vein that brought oxygenated blood from the placenta to the fetus heart. The
ligamentum venosum is the remnant of the fetal ductus venosus that shunted blood from the umbilical vein to
the inferior vena cava to bypass the liver. In the adult liver, the porta hepatis includes the hepatic arteries from
the hepatic artery proper, the hepatic portal vein, and the hepatic and cystic ducts joining to form the
common bile duct.
- The portal vein brings nutrients and other compounds absorbed by the GI tract to be stored and/or processed.
- Anatomical lobes: Note how the inferior vena cava, gallbladder, ligamentum teres, ligamentum venosum, and
porta hepatis form an “H” shape on the visceral surface. It divides the liver into 4 anatomical lobes based on outer
appearance – the right, left, caudate, and quadrate lobes.
- Functional lobes: These are based on the distribution of the hepatic arteries, portal vein, and hepatic bile duct.
4. - The liver is divided into many hepatic lobules. Inflow to the liver
involves hepatic arteries, which bring oxygenated blood to hepatic
tissue, and portal veins, which bring nutrients and other
compounds absorbed by the GI tract to be processed and/or
stored in the liver. Outflow also involves two routes – hepatic veins
which drain into the inferior vena cava and the common hepatic
duct which joins the cystic duct and empties bile into the
duodenum.
- Major characteristics of the liver are portal triads (labeled
“portal” in bottom left and shown in the middle) and central veins
(labeled in bottom left and shown in the right). Red arrows indicate
direction of blood flow within blood sinusoids flanking cords of
liver cells.
- Note the portal triad contains 1) the portal vein, 2) the hepatic
artery, and 3) the bile duct. Each has its typical appearance. The
central vein is lined with endothelial cells, with perforations into
which the sinusoids empty.
5. - The central veins lead to sublobular veins, which reach collecting veins,
hepatic veins, and finally the inferior vena cava. The venous outflow of
the liver has no regard to the organization of the lobules.
- The liver sinusoids are shown in higher magnification in the bottom left.
They are dilated, capillary-like vessels lined by fenestrated, discontinuous
epithelium (labeled “e”). Interspersed among the endothelial cells are
Kupffer cells (labeled “k”), which are fixed macrophages within the
hepatic tissue. They have distinct cytoplasm that may enter the sinusoidal
lumen and function like other macrophages within the body. They also
break down damaged red blood cell hemoglobin.
- In the bottom middle panel, there are many spaces between the
hepatocytes and sinusoidal epithelial cells marked by arrowheads. They
are referred to the space of Disse where exchange between hepatocytes
and blood flow takes place.
- Once again, in the bottom right, we review the Kupffer cell, endothelial
cell of the liver sinusoid, and the space of Disse.
6. - The liver lobules can be defined in 3 ways:
- 1) Classic lobule – centered around the central vein with the portal triads at
each corner. Shown below on the left, the classic lobule may not always be
hexagonal in shape.
- 2) Portal lobule (not shown) – centered on the portal triad, based on bile
secretion, and approximately triangular in shape.
- 3) Liver acinus of Rappaport – this is the most functionally important
classification. Shown below on the right, the acinus is roughly oval in shape
with 2 central veins and 2 portal triads on opposite ends. Based on the blood
flow within hepatic tissue, the acinus is divided into 3 zones. Cells in different
zones are specialized for different activity. Zone 1 cells, being closest to the
portal triads and hence most oxygenated blood, have the most drug-
metabolizing enzymatic activity. Following that same reasoning, zone 3
hepatocytes near the central veins are most susceptible to ischemia.
- As mentioned earlier, the liver
has both endocrine and
exocrine functions. The various
proteins that hepatocytes
secrete enter the bloodstream
via the liver sinusoids. The liver
also secretes bile in the
conventional exocrine fashion.
- The hepatocytes secrete bile
into sealed extracellular spaces
called bile canaliculi. The
typical “chicken-wire”
appearance is more easily
visualized with silver stain.
7. - Once again, inflow to the liver involves
oxygenated blood via hepatic arteries and
absorbed nutrients and compounds from
the GI tract via the hepatic portal veins.
- All venous drainage from the GI tract and
abdominal visceral organs enters the portal
system back to the liver. The overall order
is as following: arteries → capillaries →
veins → portal vein → hepatic sinusoids →
veins → vena cava → heart.
- In contrast, the caval system is as
following: arteries → capillaries → veins →
vena cava → heart. Obviously, this is the
circulatory system within the rest of the
body.
- The portal and caval system are not
exclusive from each other. There are 4 sites
of portocaval anastomoses:
- 1) esophageal veins
- 2) paraumbilical veins
- 3) rectal veins
- 4) retroperitoneal veins
- If there is liver damage or cirrhosis –
accumulation of fibrous tissue that
constricts the sinusoids – there may be
portal hypertension. This may lead to
varicose veins at the 4 sites of
8. - The gallbladder is found under the right lobe of the liver. Its
function is to store bile produced by the liver, which leaves via the
cystic duct. It also enters the gallbladder in the cystic duct,
traveling retrograde when the bile is not needed for digestion. Note
the fundus, body, neck, and infundibulum of the gallbladder.
- Note the right and left hepatic ducts coming together as the
common hepatic duct, joining the cystic duct to form the
common bile duct. This descends to the 2nd part of the
duodenum, is joined by the pancreatic duct, and empties its
contents into the duodenal lumen via the major duodenal papilla.
- The gallbladder is supplied by the cystic artery, which is
extremely important to find during a cholecystectomy. In most
people it branches off the right hepatic artery, but could also come
off the left hepatic, proper hepatic, or gastroduodenal arteries.
- Note the extensive folds of mucosa extending into the lumen,
consisting of tall, simple columnar epithelium. The underlying
connective tissue is comprised of lamina propria, with no distinctly
defined submucosa. There are scattered bundles of smooth
muscle in the muscularis. The adventitia has rather dense
connective tissue connecting the gallbladder to the liver.
9. - Finally, we will look at the pancreas. To
review: The head of the pancreas and
duodenum are supplied from both the celiac
trunk and the superior mesenteric artery.
- The body and tail of the pancreas are
mostly supplied by branches of the splenic
artery, namely the dorsal, greater, and
inferior pancreatic arteries.
- Piece of advice: It can be very confusing
when identifying these arteries. First orient
yourself, note whether the duodenum is in
anatomical position or reflected (as it is on
the bottom left), and identify where the
arteries branch from and where they lead.
10. - The pancreas contains multiple ducts, but the main pancreatic
duct runs from the tail to the head of the pancreas. There may be
a smaller accessory pancreatic duct. They join the common bile
duct to empty into the duodenum. The pancreas is retroperitoneal.
- Histologically, we can see the septa (S) between pancreatic
lobules with interlobular ducts (D). As mentioned above, the
pancreas also has both exocrine and endocrine functions. Most of
the bottom left panel is filled with exocrine pancreatic tissue.
Secretory portions are called acini. The scattered endocrine islets
of Langerhans (I) are paler staining.
- An islet is magnified in the bottom right. It is a compact mass of
epithelial cells that receive rich vascular supply (arrows). It is
typically very difficult to identify the different cell types in the islets.
Briefly, the alpha cells secrete glucagon, the beta cells secrete
insulin, and the delta cells secrete somatostatin.
11. -Once again, most of the pancreas contains exocrine acini. Pancreatic enzymes are very diverse, including
extremely efficient proteases, lipases, and amylases.
- Separate acini are shown in the left. The pancreatic acinar or secretory cells are polarized, meaning the basal
portions are filled with basophilic rough ER. The apical regions are filled with zymogen granules that contain
many stored pro-enzymes.
- Centroacinar cells, with paler staining, can be seen in the middle of some acini and mark the beginning of the
duct system (marked “A” in the middle panel). They converge at “B” to form intercalated ducts, marked as “C”.
The intercalated duct cells may be hard to identify, but they actively pump water and bicarbonate into the duct
lumen. Intercalated ducts empty into interlobular ducts, marked as “small duct” in the bottom right, which lead to
the main pancreatic duct.