Kala refers to time or period in Ayurveda. It is considered one of the nine Karana Dravyas or causative factors. Kala is described as eternal, all-pervading and responsible for past, present and future applications. It is responsible for changes in creation, maturation of tissues, and directing living beings towards life and death. Kala is divided into various units from nimesha to samvatsara and governs all physiological and pathological processes according to these time periods. Understanding Kala and its impact on drug shelf life, treatment protocols, disease management and progression is essential for Ayurvedic physicians.