Presentation made by Andy Jarvis in Kathmandu, Nepal on 14th September 2016 at the "Climate Smart Village Approach in Nepal" meeting organised by CCAFS, CIMMYT, Government of Nepal and others.
Climate Information for Mitigation and AdaptationCIFOR-ICRAF
This presentation by Walther E. Baethgen asks and answers some of the most important questions concerning climate change:
Adaptation to What?
What Can We Expect?
What Mitigation options are likely to succeed?
Also it presents many interesting scenarios all related to climate change: for example how it would affect socioeconomics and vice versa.
Presentation by Dr Sonja Vermeulen, Head of Research at CCAFS, about a study published in Nature Climate Change in March 2016, titled 'Timescales of transformational climate change adaptation in sub-Saharan African agriculture.'
Presentation made by Andy Jarvis in Kathmandu, Nepal on 14th September 2016 at the "Climate Smart Village Approach in Nepal" meeting organised by CCAFS, CIMMYT, Government of Nepal and others.
Climate Information for Mitigation and AdaptationCIFOR-ICRAF
This presentation by Walther E. Baethgen asks and answers some of the most important questions concerning climate change:
Adaptation to What?
What Can We Expect?
What Mitigation options are likely to succeed?
Also it presents many interesting scenarios all related to climate change: for example how it would affect socioeconomics and vice versa.
Presentation by Dr Sonja Vermeulen, Head of Research at CCAFS, about a study published in Nature Climate Change in March 2016, titled 'Timescales of transformational climate change adaptation in sub-Saharan African agriculture.'
Scaling up soil carbon enhancement contributing to mitigate climate changeCIAT
The 4 per 1000 Africa Symposium - Building synergies across Africa to advance on soils for food security and climate, Johannesburg, South Africa 24-26 October 2018
Rolf Sommer, Kristin Piikki, Mats Söderström, Sylvia Nyawira, Mayesse da Silva, Wuletawu Abera and
Job Kihara
Framework
Farm operators make strategic and tactic decisions based on dynamic climate and market processes. However, they do not access and use all the information enabled by powerful information technologies.
Asia Regional Program Planning Meeting- Climate Change Impacts in AsiaICRISAT
Presentation by Dr Kesavarao AVR, Scientist, Agroclimatology, ICRISAT Development Center, Asia Regional Program, International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) on 4 May 2016 at ICRISAT headquarters, Hyderabad, India. Presented at the Asia Regional Planning Meeting, ICRISAT, Patancheru
The relevance of a food systems approach based on Agroecology elements for in...Francois Stepman
Presentation of Emile Frison, International Panel of Experts on Sustainable Food Systems (IPES-Food) at the Online Forum on Building climate resilient food systems based on the 10 Agroecology elements 27 October 2020. Organized jointly by the Secretariat of the Thematic Working Group (TWG) on Agriculture, Food Security and Land Use at the Food and Agriculture Organization of the United Nations (FAO), Biovision Foundation and the World Wide Fund for Nature (WWF), this online forum was the second of a series that addressesed the adaptation and mitigation potential of agroecology in the Nationally Determined Contributions (NDCs).
How can agriculture help achieve the 2°C climate change target? Delivering food security while reducing emissions in the global food system
November 2, 2015
Event co-sponsored by the CGIAR Research Program on Climate Change, Agriculture and Food Security and the World Bank
Delivering on a transformed food sector:
Transforming cereal crop production
Martin Kropff, Director General, International Maize and Wheat Improvement Center (CIMMYT)
THE USE OF INTERNET OF THINGS FOR THE SUSTAINABILITY OF THE AGRICULTURAL SECT...IAEME Publication
Global climate change has huge effects on the agricultural system and its
productivity. Scientists report that changing climatic conditions led to a decrease in
global wheat yields by 5, 5% and corn by 3, 8% and that by 2090, climate change is
projected to lead to a loss of 8-24% of total world production of corn, soybeans,
wheat and rice. According with others Scientists, Africa is threatened with a loss of
the corn crop by 5% and wheat by 17% until 2050.Taking all of this into account
agricultural sector needs to adapt to climate change. The goal of the paper is analyze
the Climate-Smart Agriculture (CSA), verify the results of this approach in some
significant Country in terms of vulnerability to climate change and asses what are the
impacts. The paper intends responding to why should CSA be a good alternative and
how it is different from what is being practiced right now. The conclusions put
evidence on what is good in it and why it is important to pursue this practice.
Assessing the environmental impact of livestock industry development pathwaysILRI
Poster prepared by Fraval S, Lannerstad M, Herrero M, Notenbaert A, Ran Y, Paul B, Mugatha S, Barron J and Morris J for the ILRI@40 Workshop, Addis Ababa, 7 November 2014
Pressure on environmental resources must be considered in ambitions to meet nutritional and livelihood needs into the future. Human population is forecast to increase from 7.7 billion today to approximately 9.48 billion in 2050, with an increase of over one billion in Africa alone. Consumption of animal source foods in Sub-Saharan Africa is forecast to increase by 25% in 2050. Meeting increased demand for livestock products will depend on a strong environmental resource base and functioning eco-system services. Decision makers and industry advocates, therefore, will need to consider alternative development pathways and the related environmental impacts. How can such complex environmental assessments be incorporated into investment and policy decisions?
Keynote presentation by Philip Thornton, CCAFS Flagship Leader on Priorities and Policies for CSA, at the 3rd Conference on Agriculture and Climate Change in Budapest on 25 March 2019.
Yield & Climate Variability: Learning from Time Series & GCM
Presented by Amer Ahmed at the AGRODEP Workshop on Analytical Tools for Climate Change Analysis
June 6-7, 2011 • Dakar, Senegal
For more information on the workshop or to see the latest version of this presentation visit: http://www.agrodep.org/first-annual-workshop
Scaling up soil carbon enhancement contributing to mitigate climate changeCIAT
The 4 per 1000 Africa Symposium - Building synergies across Africa to advance on soils for food security and climate, Johannesburg, South Africa 24-26 October 2018
Rolf Sommer, Kristin Piikki, Mats Söderström, Sylvia Nyawira, Mayesse da Silva, Wuletawu Abera and
Job Kihara
Framework
Farm operators make strategic and tactic decisions based on dynamic climate and market processes. However, they do not access and use all the information enabled by powerful information technologies.
Asia Regional Program Planning Meeting- Climate Change Impacts in AsiaICRISAT
Presentation by Dr Kesavarao AVR, Scientist, Agroclimatology, ICRISAT Development Center, Asia Regional Program, International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) on 4 May 2016 at ICRISAT headquarters, Hyderabad, India. Presented at the Asia Regional Planning Meeting, ICRISAT, Patancheru
The relevance of a food systems approach based on Agroecology elements for in...Francois Stepman
Presentation of Emile Frison, International Panel of Experts on Sustainable Food Systems (IPES-Food) at the Online Forum on Building climate resilient food systems based on the 10 Agroecology elements 27 October 2020. Organized jointly by the Secretariat of the Thematic Working Group (TWG) on Agriculture, Food Security and Land Use at the Food and Agriculture Organization of the United Nations (FAO), Biovision Foundation and the World Wide Fund for Nature (WWF), this online forum was the second of a series that addressesed the adaptation and mitigation potential of agroecology in the Nationally Determined Contributions (NDCs).
How can agriculture help achieve the 2°C climate change target? Delivering food security while reducing emissions in the global food system
November 2, 2015
Event co-sponsored by the CGIAR Research Program on Climate Change, Agriculture and Food Security and the World Bank
Delivering on a transformed food sector:
Transforming cereal crop production
Martin Kropff, Director General, International Maize and Wheat Improvement Center (CIMMYT)
THE USE OF INTERNET OF THINGS FOR THE SUSTAINABILITY OF THE AGRICULTURAL SECT...IAEME Publication
Global climate change has huge effects on the agricultural system and its
productivity. Scientists report that changing climatic conditions led to a decrease in
global wheat yields by 5, 5% and corn by 3, 8% and that by 2090, climate change is
projected to lead to a loss of 8-24% of total world production of corn, soybeans,
wheat and rice. According with others Scientists, Africa is threatened with a loss of
the corn crop by 5% and wheat by 17% until 2050.Taking all of this into account
agricultural sector needs to adapt to climate change. The goal of the paper is analyze
the Climate-Smart Agriculture (CSA), verify the results of this approach in some
significant Country in terms of vulnerability to climate change and asses what are the
impacts. The paper intends responding to why should CSA be a good alternative and
how it is different from what is being practiced right now. The conclusions put
evidence on what is good in it and why it is important to pursue this practice.
Assessing the environmental impact of livestock industry development pathwaysILRI
Poster prepared by Fraval S, Lannerstad M, Herrero M, Notenbaert A, Ran Y, Paul B, Mugatha S, Barron J and Morris J for the ILRI@40 Workshop, Addis Ababa, 7 November 2014
Pressure on environmental resources must be considered in ambitions to meet nutritional and livelihood needs into the future. Human population is forecast to increase from 7.7 billion today to approximately 9.48 billion in 2050, with an increase of over one billion in Africa alone. Consumption of animal source foods in Sub-Saharan Africa is forecast to increase by 25% in 2050. Meeting increased demand for livestock products will depend on a strong environmental resource base and functioning eco-system services. Decision makers and industry advocates, therefore, will need to consider alternative development pathways and the related environmental impacts. How can such complex environmental assessments be incorporated into investment and policy decisions?
Keynote presentation by Philip Thornton, CCAFS Flagship Leader on Priorities and Policies for CSA, at the 3rd Conference on Agriculture and Climate Change in Budapest on 25 March 2019.
Yield & Climate Variability: Learning from Time Series & GCM
Presented by Amer Ahmed at the AGRODEP Workshop on Analytical Tools for Climate Change Analysis
June 6-7, 2011 • Dakar, Senegal
For more information on the workshop or to see the latest version of this presentation visit: http://www.agrodep.org/first-annual-workshop
Parker, L. Navarro-Racines, C. Available data for crop modelling and applications using EcoCrop. Second training in Climate vulnerability analysis using the EcoCrop model, organized by Mozambique Institute of Agricultural Research (IIAM) and the CGIAR Research Program on Climate Change, Agriculture and Food Security (CCAFS). Speaker and mentor. August – September 2014, Maputo-Mozambique.
Agroecology Practices in South China —biodiversity in rice production ExternalEvents
http://www.fao.org/about/meetings/agroecology-symposium-china/en/
Presentation of Luo Shiming, from South China Agricultural University, on agroecology practices in South China. Examples are discussed of biodiversity in rice production on field, agroecosystem and landscape scale. The presentation was prepared and delivered in occasion of the International Symposium on Agroecology in China, held in Kunming, China on 29-31 August 2016.
Solvent extraction, an innovative adaptation of existing crude oil refining technology, is being studied for its potential to upgrade used oils produced by small-scale oil treatment facilities. This report presents the design for a pilot-scale treatment plant using solvent extraction.
This report presents the design and the needed information for a pilot scale solvent treatment plant. Observations and discussion regarding the project and the design assumptions are presented along with the design.
Where is my technology going? - Mapping of adoption of technologies and asses...Sander Zwart
Brainstorming presentation for mapping of technology adoption using geospatial technologies including remote sensing and spatial modelling in geographic information systems.
3rd Africa Rice Congress
Theme 3: Rice processing and marketing
Mini symposium: improving rice processing technologies in Africa
Author: Ndindeng, et. al.
3rd Africa Rice Congress
Theme 2: Intensification and diversification
Mini symposium: determinants of agricultural productivity in Africa’s rice-based systems
Author: Dingkuhn et al.
Agriculture has been and continues to be the most important sector in Indian economy. Climate change is one of the most important environmental issues facing the world today. The impact of climate change is a reality and it cuts across all climates sensitive sectors including the Agriculture sector. In this situation this seminar focuses on the climate smart agriculture. CSA brings together practices, policies and institutions that are not necessarily new but are used in the context of climatic changes which is prime requirement in arena of climate change. Farmers possessed low level of knowledge regarding climate change, and they adopted traditional methods to mitigate the impact of climate change. Small land holdings, poor extension services and non availability of stress tolerant verities were the major problems faced by the farmers in adoption to climate change. Extension functionaries were having medium level awareness about impact of climate change on agriculture. They used electronic media, training and conferences and seminars as major sources of information for climate change. They need training on climate smart agriculture aspects. Based on the above facts this presentation focuses on analyzing the opportunities and challenges of climate smart agriculture.
Presentation at "Food Security in a World of Growing Natural Resource Scarcity" event hosted by IFPRI at Newseum on February 12, 2014. Speakers: Mark Rosegrant, Jawoo Koo, Nicola Cenacchi, Claudia Ringler, Ricky Robertson, Myles Fisher, Cindy Cox, Karen Garrett, Nicostrato Perez, and Pascale Sabbagh.
CROP MODELING IN VEGETABLES ( AABID AYOUB SKUAST-K).pptxAabidAyoub
crop modeling is future in agriculture to tackle changing environment conditions and increase food security in the world. These models incorporate various factors such as climate, soil characteristics, agronomic practices, and crop physiology to predict crop yields, water usage, nutrient uptake, and other important parameters. Crop modeling helps in understanding the complex interactions between different variables affecting crop growth and assists farmers, researchers, and policymakers in making informed decisions related to crop management, resource allocation, and risk assessment.
Role of AI in crop modeling: Artificial Intelligence (AI) plays a significant role in enhancing crop modeling by leveraging advanced computational techniques to improve model accuracy, efficiency, and scalability. One of the most important aspects of precision farming is sustainability. Using artificial neural networks (ANNs), a highly effective multilayer perceptron (MLP) model. The most common type in crop modeling is DSSAT , DSSAT (Decision Support System for Agro-technology Transfer).The Decision Support System for Agro-technology Transfer (DSSAT) is a software application program that comprises crop simulation models for over 42 crops (as of Version 4.8.2) as well as tools to facilitate effective use of the models. The tools include database management programs for soil, weather, crop management and experimental data, utilities, and application programs. The crop simulation models simulate growth, development and yield as a function of the soil-plant-atmosphere dynamics.DSSAT and its crop simulation models have been used for a wide range of applications at different spatial and temporal scales. This includes on-farm and precision management, regional assessments of the impact of climate variability and climate change, gene-based modeling and breeding selection, water use, greenhouse gas emissions, and long-term sustainability through the soil organic carbon and nitrogen balances.In conclusion, crop modeling stands as a crucial tool in modern agriculture, offering a systematic approach to understanding and predicting crop growth dynamics in diverse environmental conditions. By simulating the complex interactions between various factors influencing crop development, including climate, soil properties, agronomic practices, and genetic traits, crop models provide valuable insights for farmers, researchers, and policymakers.
Similar to JRV – Towards a groundnut genotypic adaptation strategy (20)
Fortalecimiento de capacidades para la producción, traducción, diseminación y uso efectivo de datos y perspectivas climáticas en el sector agropecuario en la región SICA.
Carlos Navarro-Racines
Evento de socialización de los logros alcanzados por CCAFS en Centroamérica en el marco de la gira del Grupo Técnico de Cambio Climático y Gestión Integral del Riesgo (GTCCGIR) del CAC.
Guatemala, diciembre 1, 2021
Servicios climáticos para la agricultura: Incorporando información agroclimática local en la toma de decisiones.
Feria Internacional del Medio Ambiente (FIMA)
Servicios climáticos para la agricultura: Incorporando información agroclimática local en la toma de decisiones
Webinar: Recursos De Información Para El Sector Agrícola En La Región De America Latina Y El Caribe.
Plataforma de Acción Climática en Agricultura de Latinoamérica y el Caribe (PLACA)
Presentación del Módulo 2 "El cambio climático, retos y desafíos para el desarrollo sostenible" del diplomado “El cambio climático y el sector agropecuario: desafíos y oportunidades para un desarrollo resiliente, con bajas emisiones y adaptado al clima en Centroamérica y República Dominicana.
Instituto Centroamericano de Administración Pública (ICAP)
En el marco del LXIV Foro del Clima de América Central y
el XLII Foro de Aplicaciones de los Pronósticos Climáticos
a la Seguridad Alimentaria y Nutricional
Academia Nacional de Servicios Climáticos - Guatemala
Diplomado en Ciencias del Clima y Servicios Climáticos del Sistema Guatemalteco de Ciencias del Cambio Climatico (SGCCC)
https://sgccc.org.gt/el-sgccc-es-el-anfitrion-del-diplomado-en-ciencias-del-clima-y-servicios-climaticos/
Navarro, C. Modelación climática; Cambio climático y agricultura
Clase para Curso de climatología de la Universidad de Ciencias Aplicadas y Ambientales (UDCA)
Abril 2021
Webinario: Modelación de cultivos para generar servicios
agroclimáticos (AquaCrop v.6)
LXI Foro del Clima de América Central
Jeferson Rodriguez Espinoza
Alejandra Esquivel
Carlos Navarro-Racines
J. Ramírez , D. Martínez, A. Martínez, J. Martínez, D. Giraldo, A. Muller, C. Bouroncle
Diplomado el enfoque territorios sostenibles adaptados al clima (TeSAC) en el corredor seco del oriente de Guatemala
Módulo 2 – Bloque 2 – Sesión 3
Carlos Navarro-Racines
E. Tünnermann, J. Ramírez, A. Martínez, J. Martínez
Diplomado “Inventario de Emisiones de Gases de Efecto Invernadero”, Universidad Nacional Agraria (UNA)
Módulo I Introducción. Procesos nacionales (políticas y convenios nacionales e internacionales)
Sesión 1 Introducción a la problemática del cambio climático global y observación de cambios
Importancia de los pronósticos aplicados al sector durante la crisis actual del COVID-19
XLI Foro de Aplicación de los Pronósticos Climáticos a la Seguridad Alimentaria y Nutricional: Perspectivas para el período Agosto - Octubre 2020 - 22 de julio del 2020
Presentación sobre las Mesas Técnicas Agroclimáticas en Centro América en el contexto de COVID-19, en el marco del webinar "Desafíos y oportunidades para alcanzar equidad de género en los servicios climáticos"
Training on Participatory Integrated Climate Services for Agriculture (PICSA) and Local Technical Agroclimatic Comittees (MTA / LTAC) to the DeRISK project team.
February 11 -19 2020, CIAT Hanoi, Vietnam
Conversatorio virtual - ¿Cómo pueden la Agricultura Sostenible Adaptada al Clima (ASAC) ayudar a mitigar los impactos en los sistemas agrícolas de América Latina debido al COVID-19?
Miércoles 20 de mayo de 2020
• ¿Qué estrategias alternativas podrían funcionar para diseminar información agroclimática? y ¿cómo estas pueden ser aprovechadas para diseminar información relacionada con el Covid -19?
• ¿Cuáles creen que serán las perspectivas a futuro en relación a la seguridad alimentaria de las comunidades rurales de América Latina dada la coyuntura de la pandemia?
• ¿Qué cultivos son clave para evitar una crisis de seguridad alimentaria en la región dada la coyuntura?
• ¿Cuáles creen que son las principales oportunidades para que los agricultores adopten prácticas de Agricultura Sostenible Adaptada al Clima? … ¿Cree que la situación actual de Covid- 19 aumenta estas oportunidades? y ¿Cómo?
• ¿Cómo asegurar que no se desvíen recursos que son fundamentales para el desarrollo de las comunidades rurales debido a la pandemia?
• ¿Cómo desde la ciencia podemos ayudar a mitigar las repercusiones económicas que enfrentan y/o enfrentarán los agricultores debido al Covid-19?
• ¿Cómo cambia la coyuntura actual la manera de hacer investigación agrícola? ¿Qué deberíamos cambiar?
• ¿Qué cambios supondrá la pandemia para la cadena de abastecimientos de alimentos de los países de América Latina?
• ¿Qué oportunidades se presentan para cambiar las relaciones de producción entre el campo y las ciudades a raíz de la pandemia?
More from Decision and Policy Analysis Program (20)
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Mammalian Pineal Body Structure and Also Functions
JRV – Towards a groundnut genotypic adaptation strategy
1. Towards a genotypic adaptation
strategy for Indian groundnut using
model ensembles
Julian Ramirez-Villegas
Andy Challinor
Ramirez-Villegas and Challinor, Climatic Change (in revision)
2. • Introduction
– Key concepts
– Climate change impacts on agriculture
– The importance of adaptation and of genotypic
adaptation
• An ensemble approach to designing
genotypic adaptation strategies
Outline
3. Adaptation
Changes in social-ecological systems in response
to actual and expected impacts of climate
change in the context of interacting nonclimatic
changes (Moser and Ekstrom, 2010 PNAS)
Genotypic adaptation
Involves the incorporation of novel traits in crop
varieties so as to enhance food productivity and
stability and, more broadly, also the design of
crop ideotypes (i.e. crop plants with ideal traits)
for future climates (Ramirez-Villegas et al. 2015
J. Exp. Bot)
4. Timing of transformational adaptation in sub-
Saharan African agriculture
Rippke, U; Ramirez-Villegas, J. et al. 2016. Nature Climate Change, doi:10.1038/nclimate2947
5. The role of adaptation
• Gains from adaptation ~7-15 %, least effective
for maize
Challinor et al. (2014) NCC
6. The importance of genotypic adaptation
Ramirez-Villegas et al. (2015) JXB, doi: 10.1093/jxb/erv014
Model-based estimates
of potential benefit
from crop improvement
7. An ensemble approach to designing
genotypic adaptation strategies
• General Large Area Model
for annual crops (GLAM)
• Projections as ensemble of:
– Parameters
– Climate models (GCMs)
– GCM bias correction
methods
– CO2 response
• One forcing scenario
(RCP4.5) and time period
(2030s)
Focus on Indian
groundnut
Traits: improved water use
efficiency, improved
partitioning, heat tolerance,
duration
8. Methodology steps
1. Calibrate and evaluate model in a historical
period.
2. Model historical and future yields (2030s,
RCP4.5) to quantify climate change impacts
3. Review and map traits onto GLAM parameter
space
4. Quantify genotypic improvement benefit
5. Understand robustness and uncertainty in
model projections
9. Errors and uncertainty in regional
scale simulations
Ramirez-Villegas et al. (2015) Eur. J. Agron., doi: 10.1016/j.eja.2015.11.021
11. Yield impacts without adaptation
Yield change to 2030
Yes! We know there is uncertainty:
but how much, and where does it
matter?
Lower Q
Mean
Upper Q
Reduction in terminal drought + potential to
capitalise with improved WUE genotypes
?? Uncertainty driven by rainfall signal.
Heat stress during reproduction relevant
to a number in simulations -models
don’t hold all answers!!
A frequent decrease in crop duration and
available water (simultaneously). Higher
partitioning? Dec. veg. + inc. grain filling
duration?
15. Robustness and uncertainties in
genotypic adaptation options
• R>0.5: moderately robust projections
• R>0.8: very robust projections
Low GLAM skill –
model
improvement
Very low cropping
intensity
16. Robustness and uncertainties in
genotypic adaptation options
• Climate (54 %) and crop (46 %)
contribute similarly to total uncertainty
• GCM structure and GLAM parameters
are main sources of variation
• CO2 a minor source
• Interactions between factors could be
important
17. Key messages
• Uncertainty analysis revealed robust model
outcomes in many situations.
• Heat stress NOT a major stressor. First
breeding cycle should keep focus on
drought. Duration traits seem key, and also
max. assimilation rate.
• Future work to focus on improving links
between simulated physiology and genetic
information.
Editor's Notes
Need to explain the types of adaptations are limited to modelling tools. But also that simulated adaptations may be limited by other factors (extremes, adoption, or factors limiting technology –e.g. infrastructure or water available in case of irrigation adaptations)
Overall increase in yield variability except for Western India