This document is a research article that assesses the impact of climate variability and change on maize yield in Gamo Zone, Southern Ethiopia using crop modeling. It uses output from 3 CMIP5 climate models under 2 climate scenarios (RCP4.5 and RCP8.5) as inputs to the APSIM crop model to simulate maize yields. The results show inconsistent temperature and rainfall trends due to climate change. Simulated maize yields match observed yields with low error. Median yields are projected to decrease by up to 36.5% by 2041-2070 due to less rainfall, but increase by up to 29.2% from 2010-2040 under both climate scenarios.