John Locke was a 17th century English philosopher who was a major proponent of empiricism. He rejected the idea of innate ideas and believed that all knowledge comes from experience received through the senses. Locke likened the mind to a blank tablet or "tabula rasa" at birth, emphasizing that knowledge is built from sensory experience and reflection, not innate ideas. He viewed sensation and reflection as the two sources of all knowledge.
Social Studies is the integrated study of Social Science and humanities to promote effective citizenry.
Social Science is the field of sciences concerned with the studies of the social life of human groups and individuals, including economics, geography, history, political science, psychology, social studies, and sociology. Social Studies is the study of man and their past. Social Science is hard to explain... the Social Sciences are the fields of scientific knowledge and academic scholarship that study social groups and, more generally ,human society.
Social Studies is the integrated study of Social Science and humanities to promote effective citizenry.
Social Science is the field of sciences concerned with the studies of the social life of human groups and individuals, including economics, geography, history, political science, psychology, social studies, and sociology. Social Studies is the study of man and their past. Social Science is hard to explain... the Social Sciences are the fields of scientific knowledge and academic scholarship that study social groups and, more generally ,human society.
An Essay Concerning Human Understanding is a work by John Locke concerning the foundation of human knowledge and understanding. It first appeared in 1689 (although dated 1690) with the printed title An Essay Concerning Human Understanding.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
2. John LockeBorn August 29, 1632
Wrington, Somerset, Englan
d
Died October 28, 1704 (aged
72)
High Laver, Essex, England
Era 17th-century philosophy
(Modern philosophy)
Region Western Philosophy
Main interests Metaphysics, epistemology,
political
philosophy, philosophy of
mind,
education, economics.
Notable ideas Tabula rasa, "government
with the consent of the
governed", state of
nature; rights of
life, liberty and property
Influences
•Cicero, Plato, Aristotle, Aquinas, Avicenna,
Grotius, Rutherford, Descartes, Hooker, Filmer,Pufendorf,
Hobbes, Polish Brethren (religious group whose ideas
were incorporated into Locke's theories)
Influenced
•Hume, Kant, Schopenhauer, Berkeley, Burke,
Paine, Smith, Voltaire, Condillac, Rousseau, La
3. JOHN LOCKE
Life and works
• A proponent of the school of Empiricism
• Reject the philosophy that man has innate ideas
• The beginning of knowledge is through sense Experience
• Gives the analogy of the man to a blank tablet or “Tabula rasa”
• The two fountains of knowledge are sensation and reflection
• There are two kinds of ideas: The simple and The complex ideas.
• There are degrees of knowledge:
a) Intuitive knowledge
b) Demonstrative knowledge
c) Sensitive knowledge
4. Empiricismis
a theory that states
that knowledge comes only or
primarily from sensory
experience.
John Locke, is the leading
philosopher of British
empiricism
5. JOHN LOCKE
Life and works
• A proponent of the school of Empiricism
• Reject the philosophy that man has innate
ideas
• The beginning of knowledge is through sense Experience
• Gives the analogy of the man to a blank tablet or “Tabula rasa”
• The two fountains of knowledge are sensation and reflection
• There are two kinds of ideas: The simple and The complex ideas.
• There are degrees of knowledge:
a) Intuitive knowledge
b) Demonstrative knowledge
c) Sensitive knowledge
6. Innate idea, in philosophy,
an idea allegedly inborn in the human
mind, as contrasted with those received
or compiled from experience.
7. JOHN LOCKE
Life and works
• A proponent of the school of Empiricism
• Reject the philosophy that man has innate ideas
• The beginning of knowledge is through sense
Experience
• Gives the analogy of the man to a blank tablet or “Tabula rasa”
• The two fountains of knowledge are sensation and reflection
• There are two kinds of ideas: The simple and The complex ideas.
• There are degrees of knowledge:
a) Intuitive knowledge
b) Demonstrative knowledge
c) Sensitive knowledge
8.
9. JOHN LOCKE
Life and works
• A proponent of the school of Empiricism
• Reject the philosophy that man has innate ideas
• The beginning of knowledge is through sense Experience
• Gives the analogy of the man to a blank tablet
or “Tabula rasa”
• The two fountains of knowledge are sensation and reflection
• There are two kinds of ideas: The simple and The complex ideas.
• There are degrees of knowledge:
a) Intuitive knowledge
b) Demonstrative knowledge
c) Sensitive knowledge
10. Tabula Rasa or Blank Slate
Tabula rasa is a
Latin word that
originates from
the
Roman tabula or
wax tablet used
for notes, which
was blanked by
heating the wax
and then
smoothing it.
The mind in it’s
hypothetical
primary empty
state before
receiving outside
12. JOHN LOCKE
Life and works
• A proponent of the school of Empiricism
• Reject the philosophy that man has innate ideas
• The beginning of knowledge is through sense Experience
• Gives the analogy of the man to a blank tablet or “Tabula rasa”
• The two fountains of knowledge are sensation
and reflection
• There are two kinds of ideas: The simple and The complex ideas.
• There are degrees of knowledge:
a) Intuitive knowledge
b) Demonstrative knowledge
c) Sensitive knowledge
13. The senses convey to the
mind whatever it requires
to produce perceptions of
sensible qualities.
Understanding conveys
the sense perception to
our sensation. Sensation
is great part source of our
ideas.
The sensation is
dependent on what the
senses perceive and as
derived from
understanding.
Perception, thinking,
doubting, believing,
reasoning, knowing and
willing follow upon
sensation. When the
ideas perceived by the
senses bounce back to
the mind that perceives
this is the activity of
reflection.
14. JOHN LOCKE
Life and works
• A proponent of the school of Empiricism
• Reject the philosophy that man has innate ideas
• The beginning of knowledge is through sense Experience
• Gives the analogy of the man to a blank tablet or “Tabula rasa”
• The two fountains of knowledge are sensation and reflection
• There are two kinds of ideas: The simple and
The complex ideas.
• There are degrees of knowledge:
a) Intuitive knowledge
b) Demonstrative knowledge
c) Sensitive knowledge