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Sex Differences in Pain
RIYADH COLLEGES
OF DENTISTRYAND PHARMACY
1
Reviewed by:
Al-Waleed F. Abushanan, BDS
Dr. Thuan Dao, DMD, MSc, Dip Prostho, PhD, FRCD
Journal of the American Dental Association
July 2012, Vol. 143:7
2
Dr. Thuan Dao, DMD, MSc, Dip Prostho, PhD, FRCD (c)
Associate Professor Prosthodontics, Department of Clinical Sciences,
Faculty of Dentistry, University of Toronto
2
• A 28-year-old female university student complained
to her dentist of recurrent pain in her face.
• Her dentist told her:
– There were no identifiable signs of disease.
– The type of pain she’s experiencing is common among
women.
– The pain “could be psychosomatic”.
3
• Allegations that some pain experienced by female
patients is psychosomatic could be because certain
complaints of pain are difficult to substantiate
quantitatively.
• Many recurrent pain disorders with higher female
prevalence are of unknown origin.
4
• Many sex-specific pains due to anatomical, and
hormonal differences, more often are non-
pathological in women.
5
• Several chronic pain conditions including
temporomandibular disorders (TMDs) are more
prevalent in women than in men.
• In addition, sex differences in orofacial pain emerge
at puberty, peak during reproductive years, and
decline at menopause.
6
• Analysis of medical records of 11,000 patients, for
several diagnoses, women's average pain score was
at least one point higher than men’s, a clinically
meaningful difference.
7
• A study involving 160 patients (89 men, 71 women)
found that the level of pain felt by patients during
endodontic treatment is "significantly correlated"
with gender and pulp status, and that practitioners
should be prepared to use supplemental local
anesthesia in women.
8
• Investigators in a large number of psychophysical
studies concluded that female participants exhibited
greater sensitivity to laboratory pain than did male
participants.
9
• While the evidence suggests that women and men
do not experience pain in the same way or to the
same degree, and that there is an overrepresentat-
tion of women with chronic orofacial pain, questions
remain as to why.
10
• Women may seek treatment more readily than men
when they have a physical problem.
11
• Men have been socialized to be more stoic, with
some societies regarding pain endurance as a sign of
virility.
12
• Differences in sex hormones, notably estrogen.
13
• Differences in the structural organization and
function of the nervous system.
14
• Distinct anatomical, physiological, and hormonal
features in women and men provide important clues
about how their pains might be modulated in a
different manner by a number of biological factors.
• These observations should help counteract
prejudicial attitudes toward female patients, which
can lead to inadequate care.
15
15
15

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Sex Differences in Pain

  • 1. Sex Differences in Pain RIYADH COLLEGES OF DENTISTRYAND PHARMACY 1 Reviewed by: Al-Waleed F. Abushanan, BDS Dr. Thuan Dao, DMD, MSc, Dip Prostho, PhD, FRCD Journal of the American Dental Association July 2012, Vol. 143:7
  • 2. 2 Dr. Thuan Dao, DMD, MSc, Dip Prostho, PhD, FRCD (c) Associate Professor Prosthodontics, Department of Clinical Sciences, Faculty of Dentistry, University of Toronto
  • 3. 2
  • 4. • A 28-year-old female university student complained to her dentist of recurrent pain in her face. • Her dentist told her: – There were no identifiable signs of disease. – The type of pain she’s experiencing is common among women. – The pain “could be psychosomatic”. 3
  • 5. • Allegations that some pain experienced by female patients is psychosomatic could be because certain complaints of pain are difficult to substantiate quantitatively. • Many recurrent pain disorders with higher female prevalence are of unknown origin. 4
  • 6. • Many sex-specific pains due to anatomical, and hormonal differences, more often are non- pathological in women. 5
  • 7. • Several chronic pain conditions including temporomandibular disorders (TMDs) are more prevalent in women than in men. • In addition, sex differences in orofacial pain emerge at puberty, peak during reproductive years, and decline at menopause. 6
  • 8. • Analysis of medical records of 11,000 patients, for several diagnoses, women's average pain score was at least one point higher than men’s, a clinically meaningful difference. 7
  • 9. • A study involving 160 patients (89 men, 71 women) found that the level of pain felt by patients during endodontic treatment is "significantly correlated" with gender and pulp status, and that practitioners should be prepared to use supplemental local anesthesia in women. 8
  • 10. • Investigators in a large number of psychophysical studies concluded that female participants exhibited greater sensitivity to laboratory pain than did male participants. 9
  • 11. • While the evidence suggests that women and men do not experience pain in the same way or to the same degree, and that there is an overrepresentat- tion of women with chronic orofacial pain, questions remain as to why. 10
  • 12. • Women may seek treatment more readily than men when they have a physical problem. 11
  • 13. • Men have been socialized to be more stoic, with some societies regarding pain endurance as a sign of virility. 12
  • 14. • Differences in sex hormones, notably estrogen. 13
  • 15. • Differences in the structural organization and function of the nervous system. 14
  • 16. • Distinct anatomical, physiological, and hormonal features in women and men provide important clues about how their pains might be modulated in a different manner by a number of biological factors. • These observations should help counteract prejudicial attitudes toward female patients, which can lead to inadequate care. 15
  • 17. 15
  • 18. 15

Editor's Notes

  1. MSc : Neuroscience PhD : Biomedical Sciences
  2. - Pain comes and goes, is more intense during fatigue and stress, in particular around school examination periods . The patient wondered whether her pain really was a “woman’s condition”, and wanted to know if her condition was of “psychological” origin.
  3. By means of any objective signs or measures. In fact..
  4. - Pains associated with menstruation, ovulation, pregnancy, and childbirth.
  5. It’s also true that .. However, painful conditions that are more predominant in men and boys and others do not have sex predilection. Some painful disorders appear to be age dependent, for instance, osteoarthritis is more prevalent in women older than 45 years, but is predominant in men younger than 45 years.
  6. The current study found a statistically significant association between gender and pain experienced during root canal treatment, with more women experiencing more pain.
  7. - Sex differences in pain perception also have been studied extensively in the laboratory.
  8. The claim that this occurs because women have a greater awareness and are more likely to perceive physical sensations as indicative of illness than are men. They may, therefore, attend to pain sooner in an effort to minimize its intrusiveness into their multiple primary role obligations.
  9. -The structural and functional differences between male and female descending pain inhibitory systems, such as those responsible for opioid and nonopioid stress-induced analgesia, also appear to be influenced by sex hormones. -For instance estrogen’s interaction with nerve growth factors, was proposed as a possible mechanism underlying sex differences in pain.
  10. -Weisenfeld-Hallin found differences between men and women in the areas of brain activation and intensity of response to acute pan. -Sprouting of sympathetic fibers into the hippocampus after a neural injury is more pronounced in female rats than in male rats.