The document discusses sutures of the human skull. It identifies the primary cranial sutures, including the coronal, sagittal, lambdoid, and metopic sutures. It also discusses the midpalatal suture and presents a classification system with 5 stages of maturation based on CBCT imaging. The classification aims to assess midpalatal suture morphology for determining candidacy for rapid maxillary expansion. The sutures most commonly affected by craniosynostosis are also identified.
Bones of Skull (Human Anatomy)
by DR RAI M. AMMAR
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Osteology, derived from the from Greek ὀστέον (ostéon) 'bones', and λόγος (logos) 'study', is the scientific study of bones, practised by osteologists. A subdiscipline of anatomy, anthropology, and paleontology, osteology is the detailed study of the structure of bones, skeletal elements, teeth, microbone morphology, function, disease, pathology, the process of ossification (from cartilaginous molds), and the resistance and hardness of bones (biophysics).[1]
Osteologists frequently work in the public and private sector as consultants for museums, scientists for research laboratories, scientists for medical investigations and/or for companies producing osteological reproductions in an academic context.
Osteology and osteologists should not be confused with osteopathy and its practitioners, osteopaths.
Bones of Skull (Human Anatomy)
by DR RAI M. AMMAR
www.facebook.com/drraiammar
www.twitter.com/drraiammar
www.instagram.com/drraiammar
www.linkedin.com/in/drraiammar
www.themedicall.com/blog/auther/drraiammar/
For Any Book or Notes Visit Our Website:
www.allmedicaldata.wordpress.com
www.drraiammar.blogspot.com
YOUTUBE CHANNEL :
https://www.youtube.com/channel/UCu-oR9V3OdFNTJW5yqXWXxA
ANY QUESTION ??
Get in touch with us at Any of the Above Social Media or Email at
drraiammar@gmail.com
allmedicaldata@gmail.com
Osteology, derived from the from Greek ὀστέον (ostéon) 'bones', and λόγος (logos) 'study', is the scientific study of bones, practised by osteologists. A subdiscipline of anatomy, anthropology, and paleontology, osteology is the detailed study of the structure of bones, skeletal elements, teeth, microbone morphology, function, disease, pathology, the process of ossification (from cartilaginous molds), and the resistance and hardness of bones (biophysics).[1]
Osteologists frequently work in the public and private sector as consultants for museums, scientists for research laboratories, scientists for medical investigations and/or for companies producing osteological reproductions in an academic context.
Osteology and osteologists should not be confused with osteopathy and its practitioners, osteopaths.
DEVELOPMENT OF PLACENTA,PLACENTA AT TERM , DECIDUA,PLACENTAL MEMBRANE , PLACENTAL CICULATION,PLACENTAL ENDOCRINE SYNTHESIS,ABNORMAL PLACENTA,FUNCTIONS.
DEVELOPMENT OF PLACENTA,PLACENTA AT TERM , DECIDUA,PLACENTAL MEMBRANE , PLACENTAL CICULATION,PLACENTAL ENDOCRINE SYNTHESIS,ABNORMAL PLACENTA,FUNCTIONS.
Mandibular fractures
Dr. Ahmed M. Adawy
Professor Emeritus, Dept. Oral & Maxillofacial Surg.
Former Dean, Faculty of Dental Medicine
Al-Azhar University
Fractures of the mandible are a common form of facial injury in adults and occur most frequently in males during the third decade of life. The main causes of mandibular fractures are road traffic accidents, interpersonal violence, falls and sport injuries. Mandibular fractures are classified according to various criteria. The three main factors to consider are the cause of the fracture, the type of fracture and the site of the fracture. Clinical diagnosis as well as radiographic examinations are presented. Treatment modalities are discussed. Moreover, treatment-related complications are given.
Forensic Anthropology* Sutures of the SkullDeepali Panwar
This topic is a part of Forensic Anthropology.
Forensic Anthropology
Sutures of the Skull
The sutures are a type of fibrous joint, found in between many of the bones that make up the skull. Today we're going to take a look at three sutures; the coronal suture, the sagittal suture and the lambdoid suture.
*There are four major sutures that connect the bones of the cranium together: the frontal or coronal, the sagittal, the lambdoid, and the squamous. The frontal suture connects the frontal bone to the two parietal bones. The sagittal suture connects the two parietal bones.
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Growth is a complex process and is not supported by a single theory but is based to a large extent on evolving concepts concerning the biological mechanisms of craniofacial development
According to J.S. HUXLEY:
“The self multiplication of living substance”
*According to KROGMAN:
Increase in size, change in proportion, and progressive complexity”
*According to TODD:
“An increase in size
Acoording to MERIDITH”
“Entire series of sequential anatomic and physiological changes taking place from the beginning of prenatal life to selenity”
*According to MOYERS:
“Quantitative aspect of biologic development per unit of time”
*According to MOSS:
“Change in any morphological parameter which is measurable”
According to TODD:
“ Development is progress towards maturity”
According to MOYERS:
“ All the naturally occurring unidirectional changes in the life of an individual from its existence as a single cell to its elaboration as a multifunctional unit terminating into death”
Growth is basically an anatomic phenomenon and is quantitative in nature.
Development is basically a physiologic phenomenon and is qualitative in nature.
It can be co-related as:
DEVELOPMENT= GROWTH + DIFFERENTIATION+ TRANSLOACTION
PATTERN: it reflects proportionality, i.e. physical arrangement of the body at any one time is a pattern of spatially proportioned parts.
# arrangement of parts, values, events, or relations among measurements.
* Growth trends
* Cephalocaudal gradient
VARIABILITY: Is the law of nature.
* Normality
* Differential growth
TIMING: Is variable and is concerned with rate and division of growth.
* Growth spurts
It is an axis of increased growth extending from the head towards the feet
A comparison of body proportion between prenatal and post- natal life reveals that postnatal growth of regions of the body that are away from the hypophysis is more.
Normal refers to that which is usually expected, or is ordinarily seen, or is typical.
Normal: range & ideal: fixed value
On comparison with normal, a variable can be measured.
CLINICAL IMPLICATIONS:
* Diagnosis of gross variations from central tendency of pathological condition or gross abnormal pattern of growth.
Not all the tissue systems in the body grow at the same rate, i.e. different tissues and in term different organs grow at different rates. This process is called differential growth.
Just before the birth
One year after the birth
Mixed dentition growth spurt:
BOYS: 8-11 years
GIRLS: 7-9 years
Pre-pubertal growth spurt:
BOYS: 14-16 years
GIRLS: 11-13 years
Pubertal growth spurt:
BOYS: till 25 years
GIRLS: 18-20 years
Growth spurts are an excellent indicator for the timing of orthodontic treatment.
Correlation of :
* Skeletal age
* Dental age
* Chronological age
with onset of puberty.
Pubertal increments offers the best time for determining the predictability, growth direction, patient management and total treatment t
IMPORTANCE OF VERTICAL JAW RELATION
METHODS OF DETERMINING VERTICAL JAW RELATION
EFFECT OF INCREASED VERTICAL DIMENSION
EFFECT OF DECREASED VERTICAL DIMENSION
PHYSIOLOGIC REST POSITION
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
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Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
2. Objectives:
Identify the different sutures in the human skull
and highlight which sutures are most commonly
affected.
Make a table of the times of suture closure for
the human skull, including the mid palatal suture
3. Sutures of the Skull
Cranial sutures are a type of joint or syndesmosis
between cranial bones composed of fibrous tissues.
The skull vault consists of five principal bones
The paired frontals and parietals
Occipital bone
Six primary sutures of the cranial vault exist, including
The paired coronal sutures (between the frontal and parietal bones)
The paired lambdoid sutures (between the parietal and interparietal bones)
The single sagittal suture (between the parietal bones)
The single metopic suture (between the paired frontal bones).
Levi, B., Wan, D. C., Wong, V. W., Nelson, E., Hyun, J., Longaker, M. T., 2012. Cranial suture biology: from pathways to patient care. J Craniofac Surg. 23, 13-9.
4. Sutures of the Skull
Levi, B., Wan, D. C., Wong, V. W., Nelson, E., Hyun, J., Longaker, M. T., 2012. Cranial suture biology: from pathways to patient care. J Craniofac Surg. 23, 13-9.
5. Origins of the calvaria – partly
neural crest cells and partly
mesoderm
The cranium develops from mesenchyme around the
developing brain and consists of:
The Neurocranium – protective case around the brain
The Viscerocranium – the face
6. Origins of the calvaria – partly
neural crest cells and partly
mesoderm
Morriss-Kay GM, Wilkie AO. Growth of the normal skull vault and its alteration in craniosynostosis: insights from human genetics and experimental studies. J Anat
2005; 207:637–653.
7. Affected Sutures
Craniosynostosis can involve any of these sutures either
alone or in multiple combinations.
Several other minor sutures, including the
temporosquamosal, frontonasal, and frontosphenoidal,
may also be involved in premature fusion but less is
comparatively known regarding these.
Levi, B., Wan, D. C., Wong, V. W., Nelson, E., Hyun, J., Longaker, M. T., 2012. Cranial suture biology: from pathways to patient care. J Craniofac Surg. 23, 13-9.
8. Affected Sutures
Can you identify the sutures affected ?
http://www.craniofacialmd.com/diagnoses/non-syndromic-craniosynostosis/
9. Suture closure
Suture Timing
Coronal 22-39 Years
Sagittal 22-39 Years
Lambdoid 22-39 Years
Metopic 3-9 months
Mid Palatal After 11 years
• Cunningham ML, Heike CL. Evaluation of the infant with an abnormal skull shape. Curr Opin Pediatr 2007;19:645–51
• Angelieri F, Cevidanes LH, Franchi L, Gonçalves JR, Benavides E, McNamara JA Jr. Midpalatal suture maturation: classification method for individual
assessment before rapid maxillary expansion. Am J Orthod Dentofacial Orthop. 2013;144:759-69..
10. Midpalatal suture maturation: Classification
method for individual assessment before rapid
maxillary expansion
The aim of this study:
was to present a novel classification method for the individual
assessment of midpalatal suture morphology using CBCT images
because RME is an unpredictable treatment for late adolescent and
young adult patients
Methods:
CBCT scans from 140 subjects (86 female, 54 male), with ages from 5.6 to
58.4 years and no history of previous orthodontic treatment, were
examined to determine the radiographic stages of midpalatal suture
maturation
• Angelieri F, Cevidanes LH, Franchi L, Gonçalves JR, Benavides E, McNamara JA Jr. Midpalatal suture maturation: classification method for individual
assessment before rapid maxillary expansion. Am J Orthod Dentofacial Orthop. 2013;144:759-69..
11. The definition of each CBCT radiographic appearance of the sutural
maturation stage followed the findings of unique morphology in the
maturation of the midpalatal suture described in previous histologic
studies.
Midpalatal suture maturation: Classification
method for individual assessment before rapid
maxillary expansion
• Angelieri F, Cevidanes LH, Franchi L, Gonçalves JR, Benavides E, McNamara JA Jr. Midpalatal suture maturation: classification method for individual
assessment before rapid maxillary expansion. Am J Orthod Dentofacial Orthop. 2013;144:759-69..
12. Stages of Maturation
A B C
ED
• Angelieri F, Cevidanes LH, Franchi L, Gonçalves JR, Benavides E, McNamara JA Jr. Midpalatal suture maturation: classification method for individual
assessment before rapid maxillary expansion. Am J Orthod Dentofacial Orthop. 2013;144:759-69..
13. Midpalatal suture maturation: Classification
method for individual assessment before rapid
maxillary expansion
• Angelieri F, Cevidanes LH, Franchi L, Gonçalves JR, Benavides E, McNamara JA Jr. Midpalatal suture maturation: classification method for individual
assessment before rapid maxillary expansion. Am J Orthod Dentofacial Orthop. 2013;144:759-69..
14. Histologic analysis is limited to assessments of small sections of the
total anteroposterior suture length only, even if several serial sections
from 1 area are available.
In histologic studies only frontal sections have been evaluated; this
restricts their clinical application, especially since midpalatal suture
maturation occurs from the posterior to the anterior region.
Histologic data do not explain why it is difficult to open the
midpalatal suture clinically with conventional RME in patients older
than 25 years of age.
Histologic Assessment
• Angelieri F, Cevidanes LH, Franchi L, Gonçalves JR, Benavides E, McNamara JA Jr. Midpalatal suture maturation: classification method for individual
assessment before rapid maxillary expansion. Am J Orthod Dentofacial Orthop. 2013;144:759-69..
15. Midpalatal Suture Fusion
RME is obtained easily up to 10 years of age, with more skeletal
effects than in later circumpubertal ages (11-18 years).
A clinical attempt of RME in most adult patients would probably fail
in the posterior region despite the interincisal opening and in the
maxillary bone portion of the suture, leading to failure of the RME
procedure.
• Angelieri F, Cevidanes LH, Franchi L, Gonçalves JR, Benavides E, McNamara JA Jr. Midpalatal suture maturation: classification method for individual
assessment before rapid maxillary expansion. Am J Orthod Dentofacial Orthop. 2013;144:759-69..
16. References
Levi, B., Wan, D. C., Wong, V. W., Nelson, E., Hyun, J., Longaker, M. T.,
2012. Cranial suture biology: from pathways to patient care. J
Craniofac Surg. 23, 13-9.
Cunningham ML, Heike CL. Evaluation of the infant with an abnormal
skull shape. Curr Opin Pediatr 2007;19:645–51
Angelieri F, Cevidanes LH, Franchi L, Gonçalves JR, Benavides E,
McNamara JA Jr. Midpalatal suture maturation: classification
method for individual assessment before rapid maxillary expansion.
Am J Orthod Dentofacial Orthop. 2013;144:759-69..
Editor's Notes
A syndesmosis is a slightly movable fibrous joint in which bones are joined together by connective tissue. (sharpey’s fibers)
Major bones and sutures of the adult human cranium. Lateral (left) and top (right) view demonstrating the bones (red line) and sutures (blue) of the calvarium. The metopic suture separating the right and left halves of the frontal bone generally closes by the second year of life
Skull vault consists of 5 flat bones – all formed from intramembranous ossification within a layer of mesenchyme
paired frontal and parietals
unpaired interparietal
The major sutures of the skull vault include the: sagittal(seperates the two parietal), coronal(frontal and parietal meet), metopic (seprates the 2 frontal bones) and lambdoidb (where the occipial and parietal bones meet) (sutures are composed of fibrous tissue)
sagittal suture – remains patent into adulthood
metopic suture- fuses within the first 2 years of life
3 of the calvarial sutures: the sagittal, metopic and lambdoid are formed by the narrowing of membraneous gaps between bones that are initially widely seperate.
coronal suture does not form in this way parietal bone overlaps the frontal bone from the start.
Growth of the sutures occurs perpendicular to the orientation of the suture and normally maintained throughout the period of growth of the brain
Most mesenchyme in the head region is derived from the neural crest. Neural crest cells migrate into the pharyngeal arches and form the bones and connective tissue of craniofacial structures. Homeobox (Hox Negative) genes regulate the migration and subsequent differentiation of the neural crest cells, which are crucial for the complex patterning of the head and face. These parts of the fetal cranium are derived from the cartilaginous skeleton of the first two pairs of pharyngeal arches
Mesodermal cells give rise to mesenchyme—a meshwork of loosely organized embryonic connective tissue. Bones first appear as condensations of mesenchymal cells that form bone models. Condensation marks the beginning of selective gene activity, which precedes cell differentiation (Figs. 14-2 and Fig. 14-3). Most flat bones develop in mesenchyme within preexisting membranous sheaths; this type of osteogenesis is called intramembranous bone formation. Mesenchymal models of most limb bones are transformed into cartilage bone models, which later become ossified by endochondral bone formation.
Neural crest and mesodermal contributions to the mouse head at E17.5.
C) Diagram showing the neural crest-derived (blue) and mesodermal (red) contributions to the skull vault at E17.5. Modified from images in Jiang et al. (2002). bo, basioccipital; e, eye; m, meninges; pn, pinna of ear; s, skin. Other labels as
Only neural crest cells of the trigeminal crest which migrate to th frontonasal and first branchial arch regions contribute to the skull
-neural crest migration begins at the 4-5 somite stage
-trigeminal cest cells also maintain separation fron the adjacement mesodermal crnail mesenchyme cells whih have migrated to the cranial region of the embryo from the primitive streak.
-migration of the cells occur
-by the 23 somite stage migration is complete and a clear boundary forms between the neural crest deriveed and mesoderm derived tissue.
https://zfin.org/zf_info/zfbook/stages/seg_stgs.html
Interparietal bone which is present in mice nut not in human
all the three main sutures of the skull starts closing earlier in females compared to males
The following descriptive stages of midpalatal suture maturation are proposed:
Stage A
The midpalatal suture is almost a straight high-density sutural line with no or little interdigitation.
Stage B
The midpalatal suture assumes an irregular shape and appears as a scalloped high-density line. Patients at stage B can also have some small areas where 2 parallel, scalloped, high-density lines close to each other and separated by small low-density spaces are seen.
Stage C
The midpalatal suture appears as 2 parallel, scalloped, high-density lines that are close to each other, separated by small low-density spaces in the maxillary and palatine bones (between the incisive foramen and the palatino-maxillary suture and posterior to the palatino-maxillary suture). The suture can be arranged in either a straight or an irregular pattern.
Stage D,
The fusion of the midpalatal suture has occurred in the palatine bone, with maturation progressing from posterior to anterior. In the palatine bone, the midpalatal suture cannot be visualized at this stage, and the parasutural bone density is increased (high-density bone) compared with the density of the maxillary parasutural bone. In the maxillary portion of the suture, fusion has not yet occurred, and the suture still can be seen as 2 high- density lines separated by small low-density spaces.
Stage E
Fusion of the midpalatal suture has occurred in the maxilla. The actual suture is not visible in at least a portion of the maxilla.The bone density is the same as in other regions of the palate.
Great variability was verified in the distribution of the mat- urational stages of the midpalatal suture regarding chro- nologic age. Stage A was noted in the early childhood period from 5 to almost 11 years of age, except for one 13-year-old boy. Stage B was present mainly up to 13 years of age, with 6 of 32 subjects (23% of boys, 15.7% of girls) from 14 to 18 years of age. Stage C was observed mainly from 11 to 18 years of age. Howev- er, two 10-year-old girls (8.3% of girls) and 4 of 32 adults (15.7% of girls, 7.7% of boys) were in stage C. No subject from 5 to almost 11 years of age had fusion of the midpalatal suture.
From 11 to almost 14 years of age, 6 of 24 girls (25%) had fusion of the midpalatal suture in palatine (stage D) or maxillary (stage E) bone. For subjects between 14 and 18 years of age, 11 of 19 girls (57.9%) had fusion of the midpalatal suture in palatine (stage D) or maxillary (stage E) bone; only 3 boys (23%) were in stage D. This variability also was observed in adults, who most frequently had fusion of the midpalatal suture (stages D and E), 4 subjects (12.5%) had no fused suture in stage C, and 1 subject (3.1%) was in stage B.
stages A and B a conventional RME approach would have less resistant forces and probably more skeletal effects than at stage C when there are many initial ossification areas along the midpalatal suture.
Patients in stages D and E might be better treated by surgically assisted RME because fusion of the midpalatal suture already has occurred partially or totally, hampering the RME forces from opening the suture.
Many studies have advocated that most of the resis- tance to midpalatal suture separation in adults is due to fusion of the circummaxillary sutures.
The overall prevalence of craniosynostosis has been estimated at between 1 in 2100 and 1 in 2500 births
Metopic Suture usually disappears by the age of eight months, with the two halves of the frontal bone being fused together. It is also called the metopic suture, although this term may also refer specifically to a persistent frontal.
If the suture is not present at birth because both frontal bones have fused (craniosynostosis), it will cause a keel-shaped deformity of the skull called "trigonocephaly.”
Sagittal synostosis (scaphocephaly) is the most common type. It affects the main suture on the very top of the head. The early closing forces the head to grow long and narrow, instead of wide. Babies with this type tend to have a broad forehead. It is more common in boys than girls.
Frontal plagiocephaly is the next most common type. It affects the suture that runs from ear to ear on the top of the head. It is more common in girls.
Metopic synostosis is a rare form that affects the suture close to the forehead. The child's head shape may be described as trigonocephaly. It may range from mild to severe.
The two most common causes for premature closure of a suture are either a change in one of the child’s genes, or from pressure on the skull.