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Introduction to
Pharmacology…
Introduction
to
pharmacology
Mohd Asad Farooqui
Introduction to pharmacology
Learning Objectives
► Define the terms Pharmacology, Pharmacokinetics,
Pharmacodynamics.
► List the various routes of administration of drugs.
Terminology
► Pharmacology – Pharmacology is the branch of
science dealing with the properties of drugs and their
effects on living system.
► Pharmacology: Is a science that studies of drug, Drug
effect on the body & body response for the drug.
Oswald Schmiedeberg ( Father of
Pharmacology)
► Drug: is a substance administered for diagnosis, cure,
treatment and prevention.
Terminology Cont …..
► The therapeutic effect: is the primary effect intended that is
the reason the drug is prescribed such as morphine sulfate is
analgesia.
► Side effect: secondary effect of the drug is one that
unintended, side effects are usually predictable and may be
either harmless
Terminology Cont …..
► Drug toxicity: harmful effect of the drug on an
organism or tissue, result from overdose or external
use.
► Drug allergy: is immunological reaction to a drug.
Terminology Cont …..
► Drug interaction: occur when administration of one
drug before or after alter effect of one or both drug.
► Drug misuse: Is the improper use of common
medications in way that lead to acute and chronic
toxicity for example laxative, antacid and vitamins.
Basic concepts of Pharmacology
► Pharmacokinetics: is how the body deal with drug.
► Pharmacodynamics: is effect of drug on the body.
► Pharmacotherapeutics: is a clinical using of drug.
Receptor
► The generic name: is given for the drug to being official name.
► The official name: is the name under which its listed in one in the
official publication.
► The chemical name: is the name by which the chemist knows it.
► The trade mark or brand name (proprietary name) : is name given
by the drug manufacture
► Example: hydrochlorothiazide (official name).
► Esidrex (brand name)
1. Plants: such as digitalis, vincristine.
2. Human and animals: such as epinphrine, insulin
and adrenocoticotrpoic hormone.
3. Minirals: as iron, iodine and zinc
4. Synthetic and chemical substance: as sodium
bicarbonate
Source of drugs
Routes Of Administration Of
Drugs
1. Oral is the most common
Advantage:
► Least expensive and most convenient route for most
clients.
► Safe, does not break the skin.
► Concoius, able to swallow.
Route of administration:
Oral medication
Oral Route
Disadvantage:
► Inappropriate for client nausea and vomiting.
► Drug may have unpleasant taste.
► May cause irritation of gastro intestinal tract.
► Drug may discolor teeth.
► Drug can be aspirated by ill client.
A drug placed under the tongue, where it dissolved.
Advantage:
► Same as oral plus
► Drug may administered for local effect.
► Drug rapidly absorbed into blood stream.
► More potent than oral.
Sublingual
Disadvantage:
► If swallowed drug may be inactive.
► Drug must remain under the tongue until dissolved.
3. Baccal: pertaining to the cheeks.
4 . Rectal: can be used when drug objectionable taste.
5. Translingual: on the tongue.
5. Subcutaneous (SC): hypodermic into subcutaneous tissue, just
below the skin.
► Advantage: onset drug action faster than oral.
► Disadvantage: SC
1. Must involve sterile technique because breaks skin barrier.
2. More expensive than oral.
3. Can administer only small doses.
4. Slower than intramuscular injection.
5. Some drug can irritate tissue and can cause pain.
6.Intramuscular (IM): into in the muscle.
Advantage:
► Pain from irritating drugs is minimized.
► Can administer large volume of drug.
► Drug rapidly absorbed.
Disadvantage:
► breaks skin barrier.
► Can be anxiety producing.
7. Intradermal (ID): is the administrating of a
drug into the dermal layer of the skin just
beneath the epidermis, usually small amount of
liquid is used for example 0.1ml.
► Advantage: absorption is slow (this advantage
test for allergy).
► Disadvantage:
❖ amount of drug administered must be small.
❖ Breaks skin barrier
8. Intravenous (IV): allow injection of drugs and another
substance directly into bloodstream through the vein.
9. Inhalation: is apply to drugs directly onto lungs.
10. Topical Route
1. Skin (including transdermal patches)
2. Eyes
3. Ears
4. Nose
5. Lungs (inhalation)
Question?

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introduction to pharmacology ( PK, PD, ROUTE OF ADM. OF DRUG)

  • 2. Learning Objectives ► Define the terms Pharmacology, Pharmacokinetics, Pharmacodynamics. ► List the various routes of administration of drugs.
  • 3. Terminology ► Pharmacology – Pharmacology is the branch of science dealing with the properties of drugs and their effects on living system. ► Pharmacology: Is a science that studies of drug, Drug effect on the body & body response for the drug. Oswald Schmiedeberg ( Father of Pharmacology) ► Drug: is a substance administered for diagnosis, cure, treatment and prevention.
  • 4. Terminology Cont ….. ► The therapeutic effect: is the primary effect intended that is the reason the drug is prescribed such as morphine sulfate is analgesia. ► Side effect: secondary effect of the drug is one that unintended, side effects are usually predictable and may be either harmless
  • 5. Terminology Cont ….. ► Drug toxicity: harmful effect of the drug on an organism or tissue, result from overdose or external use. ► Drug allergy: is immunological reaction to a drug.
  • 6. Terminology Cont ….. ► Drug interaction: occur when administration of one drug before or after alter effect of one or both drug. ► Drug misuse: Is the improper use of common medications in way that lead to acute and chronic toxicity for example laxative, antacid and vitamins.
  • 7. Basic concepts of Pharmacology ► Pharmacokinetics: is how the body deal with drug. ► Pharmacodynamics: is effect of drug on the body. ► Pharmacotherapeutics: is a clinical using of drug.
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  • 23. ► The generic name: is given for the drug to being official name. ► The official name: is the name under which its listed in one in the official publication. ► The chemical name: is the name by which the chemist knows it. ► The trade mark or brand name (proprietary name) : is name given by the drug manufacture ► Example: hydrochlorothiazide (official name). ► Esidrex (brand name)
  • 24. 1. Plants: such as digitalis, vincristine. 2. Human and animals: such as epinphrine, insulin and adrenocoticotrpoic hormone. 3. Minirals: as iron, iodine and zinc 4. Synthetic and chemical substance: as sodium bicarbonate Source of drugs
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  • 28. 1. Oral is the most common Advantage: ► Least expensive and most convenient route for most clients. ► Safe, does not break the skin. ► Concoius, able to swallow. Route of administration:
  • 30. Oral Route Disadvantage: ► Inappropriate for client nausea and vomiting. ► Drug may have unpleasant taste. ► May cause irritation of gastro intestinal tract. ► Drug may discolor teeth. ► Drug can be aspirated by ill client.
  • 31. A drug placed under the tongue, where it dissolved. Advantage: ► Same as oral plus ► Drug may administered for local effect. ► Drug rapidly absorbed into blood stream. ► More potent than oral. Sublingual
  • 32. Disadvantage: ► If swallowed drug may be inactive. ► Drug must remain under the tongue until dissolved. 3. Baccal: pertaining to the cheeks. 4 . Rectal: can be used when drug objectionable taste. 5. Translingual: on the tongue.
  • 33. 5. Subcutaneous (SC): hypodermic into subcutaneous tissue, just below the skin. ► Advantage: onset drug action faster than oral. ► Disadvantage: SC 1. Must involve sterile technique because breaks skin barrier. 2. More expensive than oral. 3. Can administer only small doses. 4. Slower than intramuscular injection. 5. Some drug can irritate tissue and can cause pain.
  • 34. 6.Intramuscular (IM): into in the muscle. Advantage: ► Pain from irritating drugs is minimized. ► Can administer large volume of drug. ► Drug rapidly absorbed. Disadvantage: ► breaks skin barrier. ► Can be anxiety producing.
  • 35. 7. Intradermal (ID): is the administrating of a drug into the dermal layer of the skin just beneath the epidermis, usually small amount of liquid is used for example 0.1ml. ► Advantage: absorption is slow (this advantage test for allergy). ► Disadvantage: ❖ amount of drug administered must be small. ❖ Breaks skin barrier
  • 36. 8. Intravenous (IV): allow injection of drugs and another substance directly into bloodstream through the vein. 9. Inhalation: is apply to drugs directly onto lungs.
  • 37. 10. Topical Route 1. Skin (including transdermal patches) 2. Eyes 3. Ears 4. Nose 5. Lungs (inhalation)
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