Methods: Cercariae are released by infected water snails. To determine the occurrence of cercariae-emitting snails in SchleswigHolstein, 155 public bathing places were visited and searched for fresh water snails. Family and genus of the collected snails were determined and the snails were examined for the shedding of cercariae, using a standard method and a newly developed method.
This presentation is dedicated to the eradication project undertaken by Carter Center of Guinea worms in tropical region and propose some longtime solutions for this disease which has no cure.
This presentation is dedicated to the eradication project undertaken by Carter Center of Guinea worms in tropical region and propose some longtime solutions for this disease which has no cure.
what is waterborne diseases? example,types of water borne diseases,disease pathway,route of infection,how climate control water borne disease trends,case study of cholera in south asia,application of remote sensing on study of waterborne diseases
Epidemiology and Control Measures for CholeraAB Rajar
It is an acute diarrheal disease caused by Vibrio Cholera typically characterized by sudden onset of profuse,effortless,watery diarrhea followed by vomiting, rapid dehydration, muscular cramps and suppression of urine.
what is waterborne diseases? example,types of water borne diseases,disease pathway,route of infection,how climate control water borne disease trends,case study of cholera in south asia,application of remote sensing on study of waterborne diseases
Epidemiology and Control Measures for CholeraAB Rajar
It is an acute diarrheal disease caused by Vibrio Cholera typically characterized by sudden onset of profuse,effortless,watery diarrhea followed by vomiting, rapid dehydration, muscular cramps and suppression of urine.
Study of parasites Hymenolepis nana, Taenia Echinococcus(), & Pneumocystis carinii
Treatment
Morphology
Life cycle
Pathogenesis
Laboratory diagnosis
Parasites
Hymenolepis nana – Cestode (Dwarf Tapeworm)
Taenia Echinococcus – Cestode (Dog Tapeworm)
Pneumocystis carinii - Sporozoan parasite
Hymenolepis nana
Geographical Distribution
Habitat
Morphology of Hymenolepis nana
Adult Worm
Eggs
Larva
Life cycle of Hymenolepis nana
Direct Cycle
Indirect Cycle
Hymenolepis nana - Life cycle
Life cycle of Hymenolepis nana
Pathogenesis of Hymenolepis nana
Laboratory diagnosis of Hymenolepis nana
Treatment of Hymenolepis nana
Prevention (Prophylaxis) of H. nana
Taenia Echinococcus
Echinococcus Genus: Tapeworm with carnivorous and herbivorous hosts.
Morphology of Taenia Echinococcus
Life Cycle of Taenia Echinococcus
The flesh-fly-sarcophaga-(liopygia)-crassipalpis-macquart-1839-as-an-invader-...Annex Publishers
Abstract
We present an indoor forensic case that occurred in spring 2013 in Cosenza (southern Italy). The entomological evidence collected at the scene consisted of Calliphoridae (Calliphora vicina, Lucilia sericata), Sarcophagidae (Sarcophaga crassipalpis), Fanniidae (Fannia scalaris) and Muscidae (Hydrotaea ignava). The minimum Post Mortem Interval (mPMI) was calculated by relating the entomological evidence to data available for Diptera species in the area and to our knowledge of the development of flies used as forensic indicators in Calabria. We report S. crassipalpis as a corpse invader for the first time in Italy.
Keywords: Forensic case; Flies; S. crassipalpis; mPMI; Southern Italy
Development of best practice and new technology for grading, handling, transp...Sara Barrento
The Deliverable 4.1 Report on Best Practice Handling and Transportation of Live Mussels, is an overview of the existing knowledge of the trade chains of mussels produced in Scotland, Ireland and Norway and provides a detailed description of best practice for handling and transportation of blue mussels. This protocol was tailored to participating SME AGs and SMEs. The methodology used to collect the information for this report was based on available literature, data collected from WP1 and also from personal and phone call interviews to traders of mussels in Scotland, Ireland and Norway.
The main purpose of these slides is to convey information to the Professors, Lecturers, and Students. These slides contain authentic information about this topic which is mentioned in that.
Life cycle of Protozoan parasite
fish parasite
parasitologyClinostomum compalanatum and Clinostomum marginatum are unsegmented flatworms of the class Trematoda and the order Digenea.
They are also called as yellow grub
They occur frequently in the skin and the muscle of the freshwater fish.
Small cream coloured nodules or cysts ranging from pinhead size up to 2.5 mm depending on their age
The number of cysts may vary from 1-100 or more than
They have an oval or round shape.
The skin of the fish in reaction to the infection produces the cysts, which contain worms.
It may take 3 weeks to make clearly visible cysts after the infection and 7 weeks to reach full size
A 5-year old boy, with an established diagnosis of a topic
dermatitis, previously treated by topical corticosteroids and emollient cream with a good improvement, developed widespread papules on his legs, hands and forearm that appeared 5 months ago.
Methods: Retrospectively, the file records of the patients who underwent sleeve gastrectomy were examined. Demographic features, Body Mass Index (BMI), the mouth opening, Mallampati score, thyromental distance, sternomental distance, neck circumference measurements and videolaryngoscopic examination results were recorded Results: In a total of 140 consecutive patients (58 male, 82 female) were included in the study. The mean age of the study participants was 35.40 ± 9.78 and the mean BMI of the patients was 44.33 ± 7.52 kg/m2
. The mean mouth opening of the patients was 4.82 ± 0.54 cm
and the mean neck circumference was 43.52 ± 4.66 cm. The mean thyromental distance was 8.02 ± 1.00 cm and the mean sternomental distance was16.58 ± 1.53 cm. Difficult intubation was determined in 8 (5.7%) patients. In logistic regression analysis, age (p : 0.446), gender (p : 0.371), BMI (p : 0.947), snoring (p : 0.567), sleep apnea (p : 0.218), mouth opening (p : 0.687), thyromental distance (p :0.557), sternomental (p : 0.596) and neck circumference (p : 0.838) were not the independent predictors of difficult intubation. However, Mallampati score (p : 0.001) and preoperative direct laryngoscopy findings (p : 0.037) performed in outpatient clinic were the significant
predictors of difficult intubation. Interestingly, all patients with grade 4 laryngoscopy findings had difficult intubation.
Introduction: Laparoscopic surgery has been performed in Mexico since 1989, but no reports about training tendencies exist. We conducted a national survey in 2015, and here we report the results concerning training characteristics during the surgical residence of the respondents. Materials and Methods: A prospective study was conducted through a survey questioning demographic data, laparoscopic training during pre and post surgical residency and other of areas of laparoscopic practice. The sample was calculated and survey piloted before
application. Special interest in this report was placed on type and quality of training received. Data are reported in percentages.
Heterotopic Ossification (HO) is defined as pathological bone formation at locations where bone normally does not exist. The
presence of HO has been found to be a rare complication after stroke in several studies, whereas there are only sporadic references relating HO to Cerebral Palsy (CP) and few for CP and stroke. No effective treatment for HO has yet been found, whereas the cellular and molecular mechanisms have not been completely understood. Therefore, increased awareness among physicians is required, as a challenge for early diagnosis and treatment. A case of a male patient with CP, who developed HO on the paretichip joint following an ischemic stroke is presented.
Objectives: To assess the practice of food hygiene and safety, and its associated factors among street food vendors in urban areas of Shashemane, West Arsi Zone, Oromia Ethiopia, 2019.
Methods: Cross-sectional study design was applied from December 28, 2019 to January 27, 2020. Data was collected from 120 food handlers, which were selected by purposive sampling techniques. Information was gathered from interview and field observation by conducting food safety survey and using questionnaires via face to face interview. The collected data was entered using Epi Data 3.1 and finally, it was analyzed using SPSS VERSION 20.
A Division I football athlete experienced acute posterior leg pain while pushing off on the line of scrimmage. Ultrasound (US) showed a midsubstance plantaris tendon rupture, an injury that, to our knowledge, has only been described once before in the medical literature [1]. US was also used to assist with rehab progression and return to previous level of activity, which was achieved three weeks after the injury. While there currently are no guidelines regarding return to sport after this injury, this case demonstrates that once pain is controlled and ROM restored, progression through rehabilitation and return to elite level sport is simply based on symptoms.
Type 1 Diabetes (T1D), is a severe disease, representing 5-10% of all reported cases of diabetes worldwide. Fulminant Type 1 Diabetes Mellitus (FT1D) is a subtype of type 1 diabetes mellitus that is largely characterized by the abrupt onset of Diabetic Ketoacidosis (DKA) and severe hyperglycemia without insulin defi ciency. Viral infections have been hypothesized to play a major role in the pathogenesis of Fulminant Type 1 Diabetes Mellitus (FT1D) through the complete and rapid destruction of pancreatic beta cells. Coxsackie viral infection has been detected in islets of 50% of the pancreatic tissue recovered from recent-onset Type 1 Diabetes (T1D) patients. In this report we have highlighted a case where the patient developed a Group B Coxsackie virus infection culminating in the development of Fulminant Type 1 Diabetes Mellitus (FT1D).
Objective: To generate preliminary information about of enteroviruses and Enterovirus 71 (EV71) in patients with aseptic meningitis in Khartoum State, Sudan.
Method: Cerebrospinal fluid specimens were collected from 89 aseptic meningitis patients from different Khartoum Hospitals
(Mohammed Alamin Hamid Hospital, Soba Teaching Hospital, Omdurman Military Hospital, Alban Gadeed Teaching Hospital and Police Hospital) within February to May 2015. Among these 89 patients, 43 (48%) were males and 46 (52%) were females. The patient’s age ranged between 1 day and 30 years old. The collected specimens were assayed to detect enteroviruses and EV71 RNA using Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) technique
Femoral hernias, comprise 2% to 4% of all hernias in the inguinal region, and occur most commonly in women. Th ey present typically with a mass below the level of the inguinal ligament. The sac may contain preperitoneal fat, omentum, small bowel, or other structures and have a high rate of incarceration and strangulation due to the small size of the hernia neck orifice, requiring emergency surgery. We present the case of a 54-year-old female patient with intestinal occlusion due to incarcerated femoral hernia, repaired by laparoscopic approach, that gave the patient the opportunity to attend her daughter’s wedding the same day.
Small Supernumerary Marker Chromosome (sSMC) is a rare genetic condition marked by the presence of an extra chromosome to the 46 human chromosomes. This case report describes a 4 year old child with SSMC on the 46th chromosome. The child presented with delayed speech and language development, seizures and mild developmental delay. Speech and Language evaluation was carried out and management options are discussed.
A catheter is a thin tube made from medical grade materials that serve a broad range of functions, but mainly catheters are medical devices that can be inserted in the body to treat disease or perform surgical procedures. Catheters have been inserted into body cavities, ducts, or vessels to allow for drainage, administration of therapeutic fluids or gases, operational access for surgery. Catheters help perform tasks in various systems such as cardiovascular, urological, gastrointestinal, neurovascular, and ophthalmic systems. A dataset of 12 patients with varying “weights” and “heights” was recorded along with the lengths of their catheter tubes. This data set was found from two revered statistical textbooks on linear regression and the Department of Scientific Computing at Florida State University. This data set was not able to be linked to any particular clinical or experimental research studies, but the data set can be used to help catheter manufacturers and medical professionals better decide on what particular catheter lengths to use for patients knowing only their height & weight. These research insights could be helpful to healthcare professionals that have patients with incomplete or no healthcare records
to decide what catheter length to use. The main investigative inquiry that needed to be answered was how does patient weight & height influence catheter length together and separately? We conducted linear regression and other statistical analysis procedures in R program & Microsoft Excel and discovered that this data exhibited a quality called multi collinearity. With multi collinearity, all predictors (2 or more
independent variables) are not significant in an all encompassing linear aggression, but the predictors might be significant in their own individual linear regressions. Individual linear regression analyses were conducted for both patient height & weight to see how much they both contribute to varying catheter length. Patient weight was found to be more impatful than patient height in relationship to catheter length, even though height and weight are a classical example of multi collinearity predictors.
Bovine mastitis has a negative impact through economic losses in the dairy sector across the globe. A cross sectional study was carried out from September 2015 to July 2016 to determine the prevalence of bovine mastitis, associated risk factors and isolation of major causative bacteria in lactating dairy cows in selected districts of central highland of Ethiopia. A total of 304 lactating cows selected randomly from five districts were screened by California Mastitis Test (CMT) for subclinical mastitis. Based on CMT result and clinical examination, over all prevalence of mastitis at cow level was 70.62% (214/304).
Two hundred fourteen milk samples collected from CMT positive cows were cultured for isolation of major causative bacteria. From 214 milk samples,187 were culture positive and the most prevalent isolates were Staphylococcus aureus 42.25% (79/187) followed by Streptococcus agalactiae 14.43%
(27/187). Other bacterial isolates were included Coagulase Negative Staphylococcus species 12.83% (24/187), Streptococcus dysgalactiae 5.88% (11/187), Escherichia coli 13.38% (25/187) and Entrococcus feacalis 11.23% (21/187) were also isolated. Moreover, age, parity number, visible teat abnormalities,husbandry practice, barn fl oor status and milking hygiene were considered as risk factors for the occurrence of bovine mastitis and they were found significantly associated with the occurrence of mastitis (p < 0.05). The findings of this study warrants the need for strategic approach including dairy extension that focus on enhancing dairy farmers’ awareness and practice of hygienic milking, regular screening for subclinical mastitis, dry cow therapy and culling of chronically infected cows.
Kratom is an herbal product that is derived from Southeast Asian Mitragyna speciose tree leaves [1-10]. This compound is used for many purposes such as stimulation, euphoria, or analgesia [1-10]. It has been recently identified as a drug of abuse by the United States Drug Enforcement Administration [2,8]. Side-effects from this compound have not been well documented. We describe a case of a 36-year-old female who develop nephrotoxicity after taking an herbal supplement. She took kratom as an adjunctive therapy for back pain management. She developed right upper quadrant pain and nausea. Laboratory tests showed elevated liver enzymes without evidence of bile duct obstruction. Liver enzymes normalized several weeks after Kratom discontinuation. We advise clinicians to be vigilant about Kratom’s hepatotoxic potential on patient health.
The assessment, diagnosis and treatment of critically ill patients is extremely challenging. Patients often deteriorate whilst being
reviewed and their rapidly changing pathophysiology barrages healthcare professionals with new data. Furthermore, comprehensive assessments must be postponed until the patient has been stabilised. So, important data and interventions are often missed in the heat of the moment. In emergency situations, suboptimal management decisions may cause signifi cant morbidity and mortality. Fortunately, standardisation and careful design of documentation (i.e. proformas and checklists) can enhance patient safety. So, I have developed a series of checklist proformas to guide the assessment of critically ill patients. These proformas also promote the systematic recording and presentation of information to facilitate the retrieval of the precise data required for the management for critically ill patients. The proformas have been modifi ed extensively over the last twenty years based on my personal experience and extensive consultation with colleagues in several world-renowned centres of excellence. The proformas were originally developed for use in the intensive therapy unit
or high dependency unit. However, they have been adapted for use by outreach teams reviewing patients admitted outside of critical care areas. The use of these tools can direct eff orts to provide appropriate organ support and provides a framework for diagnostic reasoning.
Systemic Hypertension (HTN) accounts for the largest amount of attributable Cardiovascular (CV) mortality worldwide. There are several factors responsible for the development of HTN and its CV complications. Multicenter trials revealed that risk factors responsible for Micro Vascular Disease (MVD) are similar for those attributable to Coronary Artery Disease (CAD) which include tobacco use, unhealthy cholesterol levels, HTN, obesity and overweight, physical inactivity, unhealthy diet, diabetes, insulin resistance, increasing age and genetic predisposition. In addition, the defective release of Nitric Oxide (NO) could be a putative candidate for HTN and MVD. This study reviewed the risk stratification of hypertensive population employing cardiac imaging modalities which are of crucial importance
in diagnosis. It further emphasized the proper used of cardiac imaging to determine patients at increased CV risk and identify the management strategy. It is now known that NO has an important effect on blood pressure, and the basal release of endothelial Nitric Oxide (eNOS) in HTN may be reduced. Although there are different forms of eNOS gene allele, there is no solid data revealing the potential role of the polymorphism of the eNOS in patients with HTN and coronary vascular diseases. In the present article, the prevalence of eNOS G298 allele in hypertensive patients with micro vascular angina will be demonstrated. This review provides an update on appropriate and justified use of non-invasive imaging tests in hypertensive patients and its important role in proper diagnosis of MVD and CAD. Second, eNOS gene allele and its relation to essential hypertension and angina pectoris are also highlighted.
Methods: Two groups were selected by non-probability random sampling technique including case group of 154 patients with
suspected dengue (fever>2days and <10days) and control group of 146 patients with febrile illness other than dengue. Clinical,hematological and serologic markers of cases and control groups were analyzed. The frequency distribution was used to compare categorical serologic markers and paired sample T test was applied for hematologic variables before and after treatment of dengue using SPSS version 21.
Researchers from Utrecht recently published yet another paper on the use of Magnetic Resonance Imaging (MRI)demonstrating an additional failed attempt to understand the importance of qualitative versus quantitative imaging, and anatomic versus physiologic imaging. Th e implications of this failure here cannot be overstated.
Introduction: Stroke is an even more dramatic major public health problem in young people. Goal of the study: Contribute to the knowledge of strokes in young people. Methodology: This was a retrospective study carried out over a period of 02 years (January 2017 to December 2018) including the files of patients aged 18 to 49 years hospitalized for any suspected case of stroke in the Neurology department of the University Hospital
Center of the Sino-Central African Friendship (CHUSCA) of Bangui.
Background: This report describes a unique case of a patient that developed psychotic symptoms believed to be secondary
to a tentorial meningioma with associated hydrocephalus. These psychotic symptoms subsequently abated with placement of a
ventriculoperitoneal shunt. Case description: 60-year-old female was admitted to an inpatient psychiatric facility on a psychiatric involuntary commitment petition due to progressive paranoia, homicidal ideation and psychosis. The work up showed a calcified six cm tentorial meningioma with associated hydrocephalus. The patient initially rejected treatment but later became amenable to placement of Ventriculoperitoneal Shunt
(VPS).
Introduction: Adjuvant chemotherapy such as S-I is thought to prolong the life expectancy of patients with gastric cancer. The
number of older patients with gastric cancer has recently been increasing. Here we examined the prognosis of older patients with stage II or III gastric cancer.
Methods: The study cohort comprises 658 patients with stage II or III gastric cancer who underwent curative surgery from 1994 to 2014 in our institution. From 1994 to 2003 was considered the early phase, whereas from 2004 to 2014 was considered the late phase. The patients were classifi ed by age into under 65 years (Non-Elderly [NE]); 65-74 years (Early Elderly [EE]); and over 74 years (Late Elderly [LE] groups.
More from SciRes Literature LLC. | Open Access Journals (20)
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
2. International Journal of Virology & Infectious Diseases
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INTRODUCTION
Cercarial dermatitis (also called swimmer’s itch) is a neglected
parasitic disease with distribution all over the world’s temperate
zones. It is caused by cercariae of flukes of the family Schistosomatidae
that normally parasitize waterfowl, such as ducks and geese [1]. The
cercariae are released by infected freshwater snails, the intermediate
host, and then attempt to penetrate into a final host. After successful
penetration of the skin of a suitable host, cercariae transform into
schistosomulae and later into adult flukes, eventually leading to
waterfowl schistosomiasis, a systemic disease [2,3]. Occasionally,
cercariae of the genus Trichobilharzia mistake the skin of humans or
pets for the skin of waterfowl and then penetrate into the skin of a
wrong host. However, in the skin of a wrong host the cercariae are in a
biological impasse and get trapped, hence they cannot transform into
schistosomula. This results in a local inflammation named cercarial
dermatitis which starts with a tingling or burning sensation and then
develops into itching maculae and papules [4-6].
Typically, cercarial dermatitis resolves within a couple of weeks
[4,5]. Very rarely cercarial dermatitis develops into an abscess or
circumscribed necrosis, presumably due to bacterial superinfection
as a consequence of scratching the itchy lesion [7-9].
In Northern Germany cercarial dermatitis is commonly caused
by cercariae of the genus Trichobilharzia, such as T. szidati, T.
regenti and T. franki [10]. The cercariae appear in warm summer
months in stagnant freshwater in great numbers. They show a typical
microscopic appearance with a forked tail and two eye spots (Figure
1). Correct and specific determination of the species is only possible
by molecular analysis [11-14].
Since cercarial dermatitis is not a notifiable disease there is no
systematic recording of cases. Therefore appropriate information is
sparse and mainly about certain regions or single water bodies. In
such studies, a high prevalence of cercariae up to 44.9% has been
found [15]. For Schleswig-Holstein there is no study of this kind this
far.
In a warm summer day, a single water snail can release up
to 100.000 cercariae [16]. These swim around searching for a
compatible host. Hosts are found by sensing of light and shade,
temperature gradient and chemotaxis [17]. Fatty components of skin,
especially ceramides seem to attract cercariae [17]. When cercariae
have identified a suitable skin, they start the penetration process by
emptying special secretion glands to make the corneal layer of the
skin permeable [17-20]. Once inside the skin the cercariae penetrate
into a small blood vessel. After reaching the bloodstream cercariae of
T. szidati and T. franki travel to the digestive organs and the liver of
waterfowl, whereas cercariae of T. regenti travel to the central nervous
system [21,22]. Here, the larvae develop to adult worms and begin the
production of eggs that are dispersed into water. Once in the water,
miracidiae hatch from the eggs and search for a suitable freshwater
snail [3,20,23]. The life circle is shown in figure 2.
In Central and Northern Europe cercarial dermatitis occurs from
May to August when peak shedding of cercariae and the bathing
season coincide [13,14,24]. Previous studies indicate that the density
of Trichobilharzia cercariae is particularly high in shallow water
during warm summer days indicating that the release of cercariae
from intermediate hosts depends on water temperature [25]. As the
snails’ species acting as intermediate hosts concentrate at the margin
of natural water bodies where the water is shallow, public bathing
places and the habitat of intermediate hosts overlap, posing bathers at
risk to get infected [26,27].
The objective of the study was to determine the prevalence of the
cercarial dermatitis in correlation to the Trichobilharzia cercariae at
the fresh water bathing places of Schleswig-Holstein in 2014. To do
so, we have sent questionnaires to the doctors of Schleswig-Holstein,
ABSTRACT
Background and Objective: Cercarial dermatitis is a parasitic disease occurring in temperate zones. In Central Europe it is caused
by cercariae of the genus Trichobilharzia. These cercariae parasitize waterfowl, but sometimes penetrate into human skin and cause
an allergic reaction. Reliable data on the occurrence of cercarial dermatitis does not exist. So the primary objective of this study was to
determine the occurrence of cercariae that can cause cercarial dermatitis in humans in the public bathing places of Schleswig-Holstein.
Methods: Cercariae are released by infected water snails. To determine the occurrence of cercariae-emitting snails in Schleswig-
Holstein, 155 public bathing places were visited and searched for fresh water snails. Family and genus of the collected snails were
determined and the snails were examined for the shedding of cercariae, using a standard method and a newly developed method.
Results: In total, eight different families/genera of water snails were found. Overall at 55% of the bathing places cercariae-emitting
snails were identified. The new detection method yielded more positive results compared to the standard method. Besides, the number
of cercariae recovered by the new method was higher.
Conclusion: Since cercarial dermatitis is no notifiable disease, data about the prevalence is sparse. Overall cercariae occur in a
great number of fresh water lakes in Schleswig-Holstein. They can be detected by standard method or in a shorter amount of time by
the newly developed method. Nevertheless further studies will be necessary to evaluate possible advantages and disadvantages of the
new method.
Keywords: Cercariae; Schleswig-Holstein; water snails
Figure 1: Schematic drawing of a Trichobilharzia cercaria (Elbnik 2016).
3. International Journal of Virology & Infectious Diseases
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Wrong
inal host
Cercaria
Egg
Miracidium
Water Water
Suitable
inal host
Intermediate
host
Figure 2: Life cycle of Trichobilharzia cercariae, modified according to [34].
including dermatologist, pediatricians and general practitioners.
Furthermore all public bathing places were surveyed for snails
and collected snails were examined for shedding cercariae using a
standard procedure as well as a newly developed method.
MATERIALS AND METHODS
To get information on reported cases of cercarial dermatitis in the
past years, all public health district offices of Schleswig-Holstein were
contacted. Additionally questionnaires were sent via the medical
association to dermatologists, pediatricians and general practitioners.
Also health insurances were contacted for data.
To get an overview of the prevalence of cercariae anyway, every
bathing place in Schleswig-Holstein was surveyed for cercariae in
2014. There are 104 lakes with a total number of 155 public bathing
places, distributed over eleven rural districts. The exact location of
the bathing places were provided by the Ministry of Health and Social
Services in Kiel. Data on weather, wind, presence of plants and soil
were registered at every bathing place. Bathing places were visited
between 8 a.m. and 6 p.m. and examined systematically. In Schleswig-
Holstein public bathing zones are marked by floating chains of buoys.
Snails were collected within these limits. Starting at one side, the
entire bathing place was searched in a meandering pattern until the
other side was reached.
When the water was clear, snails were collected by hand from
plants, floating leaves, stones and wood, or were caught off the ground
with a scoop. If visibility was limited by algae or sediment, plants were
striped from the ground to the surface by hand and the scoop was
used blindly. Collected soil was rinsed with clear water and searched
for snails.
To allow comparison between bathing places, search time was
limited deliberately. After the first snail was found the search was
continued for exactly 15 minutes and every snail found was collected.
If no snail was found within 30 minutes, the search was stopped and
classified as not successful.
All snails were placed in plastic bags containing water from the
corresponding bathing place and a few water plants. The bags were
labeled with date, hour, identification number of bathing place and
lake. A sufficient air circulation was ensured by leaving the bag open
and putting them into stable basins to keep the content from spilling.
The bags were kept in shade and at environmental temperature.
Allsnailswereexaminedwithineighthoursaftercollection,butalways
on the day of collection. Snails which were kept for several days were
fed with lettuce and customary forage for freshwater fish. Then they
were released at the bathing place they had been collected.
The genus and species of every snail were determined using
identification schemes provided by Jekel and Zick [28], Sturm [29]
and Zettler [30].
To identify shedding of cercariae each snail was put into a glass
bowl with a diameter of 7 cm filled with 15 ml of 25°
C warm tap water
[31]. The bowls were placed in sunlight for 15 minutes to provoke
the shedding of cercariae (method modified after [11]). Then one
milliliter of water was taken and put on a glass slide and examined
through a microscope at tenfold magnification.
Cercariae were classified by the existence of eye spots and the
shape of the tail according to Neuhaus [20], Jekel and Zick [28]
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and Faltynkova [8,32] (Figure 1). Only water samples containing
cercariae with two eye spots and a forked tail were considered to
contain Trichobilharzia cercariae.
Since the conventional method of detecting cercariae is time
consuming and obviously not very sensitive, a new method was
developed. As soon as snails begin to move around at the bottom of
a glass bowl they produce a trail of slime to glide on. The slime was
removed with a small wooden stick and transferred with a pipette to
a slide and examined under tenfold magnification for the presence of
cercariae.
RESULTS
Since cercarial dermatitis is not a notifiable disease, the
documented cases of cercarial dermatitis retrieved from the public
health district offices of Schleswig-Holstein were fragmentary and
not conclusive. The questionnaires designed for this study were sent
to all resident dermatologists, resident pediatricians and general
practitioners. Although they were sent via the medical association
of Schleswig-Holstein, only two questionnaires were returned. The
health insurances did also not provide any utilizable information.
All 155 official bathing places that were registered by the Ministry
of Health and Social Services in Kiel were sampled. Snails could
be found at 148 bathing places. In total 2311 snails were collected.
Trichobilharzia cercariae were recovered from 341 snails (14.8%)
from 85 bathing places (55%).
The spatial distribution of lakes with Trichobilharzia cercariae
shedding snails is shown in figure 3. The collected snails belonged
to the family of Lymnaeidae (genera Lymnaea sp. and Radix sp.), the
family of Planorbidae (genera Planorbarius sp. and Planorbis sp.), the
families of Bithynidae, Viviparidae and Physidae as well as the family
of Nerthidae (Theodoxus sp.). Table 1 shows the different families and
genera and their shedding of Trichobilharzia cercariae.
Most common were snails of the genus Lymnaea sp. (931out of
2211 snails, 40.3%). 249 of the Lymnaea sp shed cercariae (26.7%). So
this genus of snails was the most common host for cercariae in this
survey. 682 (73.2%) of Lymnaea sp. did not shed cercariae.
487 specimens of snails of the genus Radix sp. were found which
equals 21.1% of all collected water snails. 69 (14.2%) of the tested
Radix sp. shed cercariae what makes these snails the second leading
genus. 418 (85.5%) of the collected Radix sp. did not shed cercariae.
In total 10.7% of the found water snails were Radix sp.
Snails of the genus Planorbarius sp. were occasionally found.
In total 127 specimens were collected. They contributed 5.5% of all
water snails. 18 (14.2%) of the Planorbarius sp. shed cercariae. In 109
samples (85.8%) no cercariae could be found.
Table 1 also shows further snail species found and their shedding
of cercariae. To verify whether the standard procedure yielded false
negative results, for a couple of bathing places, shedding of cercariae
was determined by the standard procedure and a method based on the
examination of slime. Cercariae sticking in the slime could be easily
identified (Figure 4). Cercariae tried to free themselves from the slime
by abrupt movements of their tails. Despite of intense movement in
some cases cercariae needed more than 20 minutes to escape from the
slime. Table 2 compares both methods for the snails collected at the
bathing place at the Lanker See.
DISCUSSION
Trichobilharzia cercariae are the cause for cercarial dermatitis
all over the world. The purpose of this research was to assess the
prevalence of cercarial dermatitis in Schleswig-Holstein and correlate
the prevalence with the distribution of cercariae in freshwater lakes
used as bathing places in Schleswig-Holstein.
To evaluate the prevalence of cercarial dermatitis in Schleswig-
Holstein, we retrieved existing data about cercarial dermatitis from
every public health district office in Schleswig-Holstein. Furthermore
we sent a questionnaire via the medical association to dermatologists,
pediatricians and general practitioners. The data of the health district
offices was fragmentary and therefore not conclusive. Only two
questionnaires were returned, so this data also was not utilizable. Also
there was no data provided by health insurances.
All 155 public bathing places were visited in 2014 and searched
for fresh water snails in the peak bathing season. Different families/
genera of water snails were found to shed cercariae. Snails of the
family of Lymnaeidae most frequently shed cercariae, counting up to
a total of 1418 specimen, 62.5% of all found snails. Snails of this family
are known to be hosts for many different types of cercariae [8,15]. In
Figure 3: Geographic distribution of lakes and bathing places in Schleswig-
Holstein as well as occurrence of snails and shedding of cercariae
• Cercariae emitted from snails collected at bathing places
• No cercariae emitted from snails collected at bathing places
• No snails found at bathing places
Table 1: Families and genera of water snails and shedding of cercariae.
Family Genus
Total
Number
of Snails
Examined
Snails
Shedding
Cercariae n
(%)
Snails
Shedding
No
Cercariae
n (%)
Lymnaeidae
Lymnaea sp. 931 249(26.7) 682(73.3)
Radix sp. 487 69(14.2) 418(85.8)
Planorbidae
Planorbarius sp. 127 18(14.2) 109(85.8)
Planorbis sp. 127 0 127(100)
Bithynidae 475 0 475(100)
Viviparidae 15 5(33.3) 10(66.7)
Physidae 38 0 38(100)
Nerthidae Theodoxus sp. 111 0 111(100)
Total 2311 341(14.8) 1970(85.2)
5. International Journal of Virology & Infectious Diseases
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will be free of cercariae in the future [11,26]. Hence, our results
should be seen as a snapshot taken at the peak season of cercarial
dermatitis in 2014.
DATA AVAILABILITY
The GPS coordinates and identification codes of the bathing
places were provided by the “Amt für Soziale Dienste” Kiel and
are included in table 1. Further geographical data used in Figure 3
were supplied by the Institute of Geology, University of Kiel, under
license. Requests for access to these data should be made to www.
LVermGeoAH.schleswig-holstein.de
DECLARATION
No previously published material was used for this article.
Contents of the manuscript have not been previously published and
are not currently submitted elsewhere. I accept responsibility for the
scientific integrity of this work. All previously listed authors have seen
and approved of the manuscript and will sign off on any subsequent
manuscript revisions.
ACKNOWLEDGEMENT
We thank the department “Amt fur Soziale Dienste” Kiel and
the Institute of Geology, University of Kiel for providing valuable
geographical data and coordinates. Furthermore we thank the
Department of Dermatology, Venerology and Allergology of the
Christian-Albrechts University, Kiel for enabling us to do this field
research.
Special thanks go to our friends and families for their constant
support.
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