This document is Scott Shermer's master's thesis on instantons and perturbation theory in the 1-D quantum mechanical quartic oscillator. It begins by reviewing the harmonic oscillator and perturbation theory. It then discusses non-perturbative phenomena like instantons and Borel resummation. The focus is on obtaining the ground state energy of the quartic oscillator Hamiltonian using both perturbative and non-perturbative techniques, and addressing ambiguities that arise for negative coupling.