The document describes a liquid vial filling line solution for sterile filling of vials for parenteral purposes. The major components of the line include an ultrasonic vial washing machine, sterilization tunnel, liquid filling and stoppering machine, capping machine, and visual inspection conveyor. The filling machine uses a peristaltic pump to fill vials with liquid through nozzles while purging with nitrogen before and after filling. Stoppers are fed into the machine using a vacuum suction mechanism. The line offers high precision filling accuracy, low breakage rates, and is a cost-effective solution customizable to client needs.

1. Liquid Vial Filling Line
Product Presentation
Rahmatul Alam
Senior Sales Engineer
Business Division 1

2. Contents
• Introduction of Iiquid Vial Filling Machine
• Major Components & Discussion
• High Fine Liquid Vial Filling Line Technology & Benefits
• Principals For Liquid Vial Filling Line
• Competitors In The Market

3. Liquid Vial Filling Line Solution
 Sterile Filling Process of vial for Parenteral Purposes.
 Consists of Several Machines and Assembly to
prepare the Filled and Capped Vial
 Depending Upon the fill volume, it can be
segregrated into 2 Sections:
>>Large Volume Parenteral Liquid Filling(50-500ml)
>>Small Volume Parenteral Liquid Filling(2-30ml)

4. Major Components:
1. Ultrasonic Vial Washing Machine
2. Sterilization Tunnel
3. Liquid Vial Filling and Stoppering Machine
4. Capping Machine
5. Visual Inspection Conveyor Table
6. Labelling Machine

5. Ultrasonic Vial Washing Machine
Process:
1. Ultrasonic Vibration to remove Dirt and
Particles which adhered to the body of the vial.
2. 3 Stage Recycled water and WFI water wash,
followed by
3. Sterile Compressed Air wash after each water
washing.
Feed into: Turn Table/Sterilization Tunnel

6. Sterilization & Depyrogenation Tunnel
Process:
1. Charging of vials from the Washing
Machine/Turn Table, feed into the tunnelconveyor
2. Preheating: Preheat the vials to withstand
temperature effectively in the heating zone
3. Heating and Sterilization: 340 Degree
Centigrade, Time Depending upon the Log
Reduction
4. Cooling: Cooling the Vials and Feed into Filling
Machine.

7. Liquid Filling & Stoppering Machine

8. Liquid Filling & Stoppering Machine
• Process:
• Vials fed into Filling Machine Directly for filling through a V belt conveyor
Drive.
• Using a Filling Peristaltic Pump, the Liquid charged in a Distributor
module and through this liquid go to nozzles and nozzles fills up the vial
• N2 Purging Method to Remove Oxygen(Before and After Filling)
• Vacuum before Stoppering for O2 sensative Product.
• Stoppering/Half Stoppering using Vacuum Suction Mechanism. Stoppers
Charged into Machine through a oscillating Hopper.
• Feed in to Turn Table/ Capping Machine

9. Solution Range:

10. Features & Benefits:
1. Only 0.1% Breakage Rate
2. High Precsion, Upto 1% Filling Accuracy
3. Compact and Cost effective Solutions for Both LVP & SVP
4. Stoppering Accuracy upto 99.99%
5. Synchronus V belt Transfer drive for Stable Filling.
6. Documentations & Certifications Support
7. Customizable Solution as per Client requirement