This document discusses inductive effect and mesomeric (or resonance) effect, including their definitions, types, and applications. The key points are:
1. Inductive effect is the polarization of a sigma bond due to electron donating or withdrawing groups, transmitted through sigma bonds. It influences chemical and physical properties.
2. Mesomeric effect is polarity produced between pi bonds or a pi bond and lone pair, leading to electron delocalization. Groups like -NO2 show negative mesomeric effect while -OH shows positive effect.
3. Applications include reactivity patterns of aromatic compounds affected by activating or deactivating groups, stability of carbocations/carbanions, and acid/base
This presentaion describes about the basic principle effects in organic chemistry like inductive,mesomeric,electromeric, resonance and hyperconjugation. this presentation contains some JAM competitive questions.
Hyperconjugation is the donation of a sigma bond into an adjacent empty or partially filled p orbital, which results in an increased stability of the molecule.
Contributed by: Samuel Redstone (Undergraduate), University of Utah, 2016
This is a presentation file on Inductive Effect, Bond Length, Bond Energy, Bond Angle for the course Organic Pharmacy I, course code is PHAR-1105 specially for the pharmacy students. Also it can be used for the Biochemistry students and other like as HSC level in Bangladesh or another country. We are the students of Mawlana Bhashani Science and Technology University, department of pharmacy which is located in Tangail.
Thank you for your patient.
This presentaion describes about the basic principle effects in organic chemistry like inductive,mesomeric,electromeric, resonance and hyperconjugation. this presentation contains some JAM competitive questions.
Hyperconjugation is the donation of a sigma bond into an adjacent empty or partially filled p orbital, which results in an increased stability of the molecule.
Contributed by: Samuel Redstone (Undergraduate), University of Utah, 2016
This is a presentation file on Inductive Effect, Bond Length, Bond Energy, Bond Angle for the course Organic Pharmacy I, course code is PHAR-1105 specially for the pharmacy students. Also it can be used for the Biochemistry students and other like as HSC level in Bangladesh or another country. We are the students of Mawlana Bhashani Science and Technology University, department of pharmacy which is located in Tangail.
Thank you for your patient.
Inductive Effect is the important topic in organic chemistry that gives us idea about electron withdrawing and accepting module of the specific group that determines the reactivity of the molecule or compound.
The homolytic cleavage of covalent bonds in carbonyl compound under photochemical conditions known as Norrish Type Reactions
They are divided into two types
Norrish Type I
Norrish Type II reaction
This presentation describes the concept of Hyperconjugation in simple words, gives definition of hyperconjugation, explains why it is called as 'No bond Resonance' and gives the effects of hyperconjugation on the chemical properties of compounds: alkyl cations and their relative stability, alkyl radicals and their relative stability, alkenes and their relative stability, bond length, anomeric effect and Baker - Nathan effect.
Inductive Effect is the important topic in organic chemistry that gives us idea about electron withdrawing and accepting module of the specific group that determines the reactivity of the molecule or compound.
The homolytic cleavage of covalent bonds in carbonyl compound under photochemical conditions known as Norrish Type Reactions
They are divided into two types
Norrish Type I
Norrish Type II reaction
This presentation describes the concept of Hyperconjugation in simple words, gives definition of hyperconjugation, explains why it is called as 'No bond Resonance' and gives the effects of hyperconjugation on the chemical properties of compounds: alkyl cations and their relative stability, alkyl radicals and their relative stability, alkenes and their relative stability, bond length, anomeric effect and Baker - Nathan effect.
ORGANIC CHEMISTRY 2
AROMATIC COMPAOUNDS (ARENES)
These are organic compounds with benzene ring as functional group.
Molecular formula of benzene is C6 H6.
-It is highly unsaturated molecule but it does not undergo reaction readily and it tends to undergo substitution reaction.
STRUCTURES OF BENZENE
Organic chemistry has two main divisions. One division deals with aliphatic (fatty) compounds, the first compounds you encountered in Organic Chemistry I. The second division includes the aromatic (fragrant) compounds, of which benzene is a typical example.
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Inductive & mesomeric effect s k katoch
1. Inductive Effect & Mesomeric
Effect and applications
Presented By: Sanjeev Kumar Katoch
(PGT Chemistry)
KV Misa Cantt
Guwahati Region
2. INDUCTIVE EFFECT
The polarization of a σ bond due to electron
withdrawing or electron donating effect of
adjacent groups or atoms is called inductive
effect.
3. • Salient features of inductive effect
* It arises due to electronegativity difference
between two atoms forming a sigma bond.
* It is transmitted through the sigma bonds.
* The magnitude of inductive effect decreases
while moving away from the groups causing it.
* It is a permanent effect.
* It influences the chemical and physical properties
of compounds.
4. • Inductive effect weakens away along the
chain and is not significant beyond 3rd
carbon atom
5. TYPES OF INDUCTIVE EFFECT
1) Negative inductive effect (-I):
The electron withdrawing nature of groups
or atoms is called as negative inductive
effect. It is indicated by -I. Following are the
examples of groups in the decreasing order
of their -I effect:
NH3
+ > NO2 > CN > SO3H > CHO > CO >
COOH > COCl > CONH2 > F > Cl > Br > I >
OH > OR > NH2 > C6H5 > H
6. 2) Positive inductive effect (+I):
It refers to the electron releasing nature of
the groups or atoms and is denoted by +I.
Following are the examples of groups in the
decreasing order of their +I effect.
C(CH3)3 > CH(CH3)2 > CH2CH3 > CH3 > H
7. • Why alkyl groups are showing positive
inductive effect?
• Though the C-H bond is practically considered as non-
polar, there is partial positive charge on hydrogen atom
and partial negative charge on carbon atom. Therefore
each hydrogen atom acts as electron donating group.
This cumulative donation turns the alkyl moiety into an
electron donating group.
8. • APPLICATIONS OF INDUCTIVE EFFECT
1.Stability of carbocations:
The stability of carbocations increases with increase in
number of alkyl groups due to their +I effect. The alkyl
groups release electrons to carbon, bearing positive charge
and thus stabilizes the ion.
The order of stability of carbocations is :
9. 2.Stability of carbanions:
However the stability of carbanions decreases with
increase in the number of alkyl groups since the electron
donating alkyl groups destabilize the carbanions by
increasing the electron density.
Thus the order of stability of carbanions is:
10. 3.Acidic strength of carboxylic acids and
phenols:
The electron withdrawing groups (-I) decrease the negative
charge on the carboxylate ion and thus by stabilizing it.
Hence the acidic strength increases when -I groups are
present.
However the +I groups decrease the acidic strength.
E.g.
i) The acidic strength increases with increase in the number
of electron withdrawing Fluorine atoms as shown below.
CH3COOH < CH2FCOOH < CHF2COOH < CF3COOH
ii) Formic acid is stronger acid than acetic acid since the
–CH3 group destabilizes the carboxylate ion.
11. The p-nitrophenol is stronger acid than phenol
since the -NO2 group is a -I group and withdraws
electron density. Whereas the para-cresol is
weaker acid than phenol since the -CH3 group
shows positive (+I) inductive effect.
Therefore the decreasing order of acidic strength
is:
12. 4.Basic strength of amines: The electron
donating groups like alkyl groups increase the
basic strength of amines whereas the electron
withdrawing groups like aryl groups decrease the
basic nature. Therefore alkyl amines are stronger
Lewis bases than ammonia, whereas aryl amines
are weaker than ammonia.
Thus the order of basic strength of alkyl and aryl
amines with respect to ammonia is :
CH3NH2 > NH3 > C6H5NH2
13. 5.Reactivity of carbonyl compounds:
The +I groups increase the electron density at
carbonyl carbon. Hence their reactivity towards
nucleophiles decreases. Thus formaldehyde is
more reactive than acetaldehyde and acetone
towards nucleophilic addition reactions.
Thus the order of reactivity follows:
14. 6.Stability of free radicals:
In the same way the stability of free radicals
increases with increase in the number of alkyl
groups.
Thus the stability of different free radicals is:
15. RESONANCE EFFECT OR MESOMERIC
EFFECT :
The mesomeric effect is defined as the
polarity produced in the molecule by the
interaction of two π bonds or between a π
bond and lone pair of electrons present on
an adjacent atom. It is symbolized by M or
R.
16. 1.Negative resonance or mesomeric
effect (-M or -R): It is shown by substituents
or groups that withdraw electrons by
delocalization mechanism from rest of the
molecule and are denoted by -M or -R. The
electron density on rest of the molecular
entity is decreased due to this effect.
E.g. -NO2, Carbony group (C=O), -C≡N, -
COOH, -SO3H etc.
17. 2.Positive resonance or mesomeric effect
(+M or +R): The groups show positive
mesomeric effect when they release
electrons to the rest of the molecule by
delocalization. These groups are denoted by
+M or +R. Due to this effect, the electron
density on rest of the molecular entity is
increased.
E.g. -OH, -OR, -SH, -SR, -NH2, -NR2 etc.
19. 1. The nitro group, -NO2, in nitrobenzene shows
-M effect due to delocalization of conjugated π
electrons as shown below. Note that the electron
density on benzene ring is decreased particularly
on ortho and para positions.
• This is the reason for why nitro group deactivates the
benzene ring towards electrophilic substitution reaction.
20. 2) In phenol, the -OH group shows +M effect due
to delocalization of lone pair on oxygen atom
towards the ring. Thus the electron density on
benzene ring is increased particularly on ortho and
para positions.
Hence phenol is more reactive towards electrophilic
substitution reactions. The substitution is favored more at
ortho and para positions.
21. 3) The -NH2 group in aniline also exhibits +R effect. It
releases electrons towards benzene ring through
delocalization. As a result, the electron density on benzene
ring increases particularly at ortho and para positions. Thus
aniline activates the ring towards electrophilic substitution.
It is also worth mentioning that the electron density on
nitrogen in aniline decreases due to delocalization which is
the reason for its less basic strength when compared to
ammonia and alkyl amines.
22. INDUCTIVE EFFECT Vs RESONANCE EFFECT
• In most of the cases, resonance effect is
stronger and outweighs inductive effect.
• For example, the -OH and -NH2 groups withdraw
electrons by inductive effect (-I). However they
also release electrons by delocalization of lone
pairs (+R effect). Since the resonance effect is
more stronger than inductive effect the net result
is electron releasing to rest of the molecule. This
is clearly observed in phenol and aniline, which
are more reacting than benzene towards
electrophilic substitution
23. • Whereas the inductive effect is stronger than the
resonance effect in case of halogen atoms. These are
electronegative and hence exhibit -I effect. However at
the same time they also release electrons by
delocalization (+R effect) of lone pair.
• This is evident in case of reactivity of halobenzenes,
which are less reactive than benzene towards
electrophilic substitution due to -I effect of halogens.
• But it interesting to note that the substitution is directed
at ortho and para positions rather than meta position. It
can be ascribed to the fact that the electron density is
increased at ortho and para positions due to +R effect of
halogens as shown below.
28. CH2 ClCH
H
H3C
d+
d+
d+
d+ d-
The polarised C-Cl bond transmits further
polarisation through the s-bond framework,
But effect drops off quickly…
This proton is acidic.
See Elimination reactions and
alkene formation.