This document discusses labor induction, including its definition, reasons it may be done, risks, preparation, methods, duration, and outcomes. Labor induction is a procedure used to stimulate uterine contractions before spontaneous labor begins. It carries some risks but may be recommended if the mother or baby's health is at risk late in pregnancy. Common induction methods include stripping the membranes, dilating the cervix, intravenous oxytocin, or rupturing the amniotic sac. The duration of induction can vary from a few hours to a few days depending on the individual case. Outcomes include successful vaginal birth in most cases but may require a C-section in some situations.
This topic contains definition, incidence, varieties, causes, risk factors, dangers, diagnosis, prognosis, prevention and management of inversion of uterus.
This topic contains definition, incidence, varieties, causes, risk factors, dangers, diagnosis, prognosis, prevention and management of inversion of uterus.
5.1 Placenta, membranes and amniotic fluid.pdfChantal Settley
Allows gas exchange so the fetus gets enough oxygen
Helps the fetus get sufficient nutrition (folate, vitamins, glucose, etc)
Helps regulate the fetus’ body temperature
Removes waste from the fetus for processing by the mother’s body (excretion)
Filters out some microbes that could cause infection
Transfers antibodies from the mother to the fetus, conferring some immune protection (immunity function).
Produces hormones that keep the mother’s body primed to support pregnancy (endocrine function)
Series of events that takes place in the genital organ in an effort to expel the viable products of conception out of the womb through the vagina into the outer world is called labour.
there are four stages of labour.
Non pharmacological approaches to manage labour painVanithaCh
This is Vanitha, Non- pharmacological approaches helps in managing labour pain...there are a different techniques like water birth, music, hypnosis, exercises which helpful in managing labour pain and for safe birth. It is there in the syllabus of MSc nursing and BSc nursing syllabus and it will helpful for the students to enhance their knowledge.
Parturition, commonly known as childbirth or labor, is a natural and complex process through which a pregnant mammal gives birth to her offspring. This transformative event marks the culmination of the pregnancy journey, as the developing fetus is ready to transition from the safety of the mother's womb to the outside world. It is a remarkable phenomenon that involves intricate hormonal, physiological, and behavioral changes in both the mother and the fetus. In this essay, we will delve into the fascinating process of parturition, exploring its stages, hormonal influences, and the significance of this event in the continuation of species.
Parturition is a highly regulated process orchestrated by the intricate interplay of hormones. During pregnancy, the uterus provides a nurturing environment for the developing fetus, surrounded by the amniotic fluid. As the pregnancy reaches full term, the fetus secretes a hormone called cortisol, which stimulates the placenta to produce another hormone called prostaglandins. Prostaglandins play a crucial role in softening and thinning the cervix, the lower part of the uterus, preparing it for dilation. Additionally, the secretion of oxytocin, commonly referred to as the "love hormone" due to its role in bonding and social behavior, increases in response to fetal cortisol levels. Oxytocin triggers uterine contractions, initiating the labor process.
Parturition can be divided into three distinct stages: the latent phase, the active phase, and the placental phase. The latent phase is often the longest and least intense, characterized by irregular contractions that help in the gradual dilation and effacement of the cervix. During this phase, the expectant mother may experience a release of the mucus plug, known as the "show," indicating the progress of the cervical changes.
The active phase marks the onset of more intense and regular contractions. Oxytocin levels surge, and the contractions become stronger, more prolonged, and closer together. This stage leads to rapid cervical dilation and the eventual transition of the fetus into the birth canal. As the contractions intensify, the mother may experience increased discomfort and a strong urge to bear down and push. The amniotic sac may rupture, leading to the release of amniotic fluid, commonly referred to as the "breaking of water." This rupture also serves to facilitate the descent of the fetus.
The fetus's position and presentation are essential during childbirth. Ideally, the baby's head presents first as it is the largest and most efficient part to pass through the birth canal. In some cases, the baby may present in a breech position (feet or buttocks first) or in other less common positions, requiring additional medical attention and possibly a cesarean section.
During the active phase, the mother's body releases endorphins, which act as natural painkillers and help the mother cope with the increasing intensity of contractions.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
2. Objectives: * Definition of labor induction. * Why labor induction is done. * Risks of labor induction. * Preparing for the procedure. * Methods for inducing labor. How long dose the procedure need. * * It’s out comes. * References.
3. Definition of induction of labor: Labor induction — also known as inducing labor — is a procedure used to stimulate uterine contractions during pregnancybefore labor begins spontaneously. But it isn't appropriate if the placenta blocks the cervix (placenta previa), the baby is lying crosswise in the uterus (transverse fetal lie), or mother is having an active genital herpes infection.
4. Why labor induction is done: Health care provider may recommend labor induction for various reasons, primarily when there's concern for mother’s health or baby's health. For example: * Mother at least 10 days beyond her due date, and labor hasn't started naturally. * Water has broken, but mother not having contractions. * There's an infection in uterus. * Baby has stopped growing at the expected pace. * There's not enough amniotic fluid surrounding the baby. * Placenta has begun to deteriorate. * Having a medical condition that may put mother or baby at risk, such as high blood pressure or diabetes.
5. Risks of labor induction: Labor induction carries various risks, including: Premature birth. Inducing labor too early may result in a premature birth, which poses risks for the baby — including difficulty breathing, yellowing of the skin and whites of the eyes (jaundice), and other problems. Even inductions close to term may cause these problems. Low heart rate. The medication used to induce labor (oxytocin) may provoke too many contractions, which can diminish baby's oxygen supply and lower baby's heart rate. Infection. Labor induction increases the risk of infection for both mother and baby. Umbilical cord problems. Labor induction increases the risk of the umbilical cord slipping into the vagina before delivery, which may compress the cord and decrease the baby's oxygen supply.
6. The need for a C-section. By definition, induction promotes delivery before the body is ready for labor — which may lead to poor labor progress and the need for a C-section. An increased risk of uterine rupture if mother had a prior C-section. Uterine rupture is a rare but serious complication in which the uterus tears open along the scar line from a prior C-section. An emergency C-section is needed to prevent life-threatening complications
7. Preparing for labor induction: health care provider will tell the patient when to report to the hospital for the induction. Because the medications used to induce labor may upset her stomach, she may be asked to eat only light foods — such as soup — before arrival.
9. :Methods for inducing labor There are various methods for inducing labor. Depending on the circumstances, health care provider may: Separate the amniotic sac from the wall of uterus. This technique is also known as stripping or sweeping the membranes. It can be done during an office visit and may speed the beginning of spontaneous labor — especially if mother’s cervix has already begun to dilate. Dilate your cervix. Sometimes synthetic prostaglandins, which can be taken by mouth or placed inside the vagina, are used to dilate the cervix. In other cases, a small balloon-tipped catheter or laminaria — a small rod made of dried seaweed — is used instead. Water injected through the catheter expands the balloon, irritating the uterus and causing it to soften and open the cervix. With laminaria, the seaweed draws in water and gets thicker, which slightly dilates the cervix.
10. Use an intravenous medication. health care provider may give the mother a synthetic version of oxytocin, a hormone that causes the uterus to contract. Break mother’s water. With this technique, also known as an amniotomy or rupturing the membranes, health care provider makes a small opening in the amniotic sac with a thin plastic hook. Mother may feel a warm gush of fluid when the sac opens. An amniotomy is typically done in the hospital, and only if the cervix is partially dilated and the baby's head is deep in the pelvis. If the amniotic fluid contains traces of fecal waste (meconium), labor may be monitored more closely.
11. How long dose the procedure need: induce labor depends on how mother’s body responds to the induction techniques. If her cervix needs time to ripen, the induction may take two to three days. If she simply need a little push, she may be holding her baby in her arms in a matter of hours. Labor induction typically takes longer for first-time moms and pregnancies that aren't full term.
12. Out comes of inducing labor: In most cases, labor induction leads to a successful vaginal birth. Rarely, an induction may be discontinued and attempted again in a few days — but once water has broken, there's no turning back. If mother health or her baby's health is at risk, a C-section may be needed. The issues that led to an induction may require special care during recovery. If successful vaginal delivery is done , there may be no implications for future pregnancies. If the induction leads to a C-section, health care provider can help mother decide whether to attempt a vaginal delivery with a subsequent pregnancy or to schedule a repeat C-section.