Dear students, in this ppt you will able to understand about the Incomplete dominance. Incomplete dominance is an allelic interaction. In incomplete dominance, both alleles of a character express their character in the F1 generation.
GENETICS
CYTOGENETICS
Definition of Linkage, Coupling and Repulsion hypothesis, Linkage group- Drosophila, maize and man, Types of linkage-complete linkage and incomplete linkage, Factors affecting linkage- distance between genes, age, temperature, radiation, sex, chemicals and nutrition, Significance of linkage.
The tendency of two or more genes to stay together (i.e., the co-existence of two or more genes) in the same chromosome during inheritance is known as LINKAGE. The linked genes are present on the same chromosome are said to be SYNTENIC. The linked genes do not show independent assortment.
LINKAGE v/s INDEPENDENT ASSORTMENT
The frequency of linkage or the strength recombination is influenced by several factors (agents).
Basics of Undergraduate/university fellows
Epistasis is a Greek word that means standing over.
BATESON used term epistasis to describe the masking effect in 1909
The term epistasis describes a certain relationship between genes, where an allele of
one gene hides or masks the visible output or phenotype of another gene.
When two different genes which are not alleles, both affect the same character in such
a way that the expression of one masks (inhibits or suppresses) the expression of the
other gene, the phenomenon is said to be epistasis.
The gene that suppresses other gene expression is known as Epistatic gene.
The gene that is suppressed or remain obscure is called Hypostatic gene
The classical phenotypic ratio of 9:3:3:1 F2 ratio becomes modified by epistasis.
Dear students, in this ppt you will able to understand about the Incomplete dominance. Incomplete dominance is an allelic interaction. In incomplete dominance, both alleles of a character express their character in the F1 generation.
GENETICS
CYTOGENETICS
Definition of Linkage, Coupling and Repulsion hypothesis, Linkage group- Drosophila, maize and man, Types of linkage-complete linkage and incomplete linkage, Factors affecting linkage- distance between genes, age, temperature, radiation, sex, chemicals and nutrition, Significance of linkage.
The tendency of two or more genes to stay together (i.e., the co-existence of two or more genes) in the same chromosome during inheritance is known as LINKAGE. The linked genes are present on the same chromosome are said to be SYNTENIC. The linked genes do not show independent assortment.
LINKAGE v/s INDEPENDENT ASSORTMENT
The frequency of linkage or the strength recombination is influenced by several factors (agents).
Basics of Undergraduate/university fellows
Epistasis is a Greek word that means standing over.
BATESON used term epistasis to describe the masking effect in 1909
The term epistasis describes a certain relationship between genes, where an allele of
one gene hides or masks the visible output or phenotype of another gene.
When two different genes which are not alleles, both affect the same character in such
a way that the expression of one masks (inhibits or suppresses) the expression of the
other gene, the phenomenon is said to be epistasis.
The gene that suppresses other gene expression is known as Epistatic gene.
The gene that is suppressed or remain obscure is called Hypostatic gene
The classical phenotypic ratio of 9:3:3:1 F2 ratio becomes modified by epistasis.
Epistasis is a Greek word that means standing over .Bateson used it to describe the masking effect in 1909.
An interaction between a pair of loci in which the phenotype effect of one locus depends on the genotype at the second locus.
Genes whose phenotypes are ;
Expressed,epistatic.
Altered or suppressed hypostatic.
Linkage
Genes far apart on the same assort independently are not linked
The position of the gene – locus
Occurs in the prophase of meiosis 1 where homologous chromosomes break at identical locations and rejoin with each other
Two genes are said to be under linkage, or linked, when they are located on the same chromosome.
Example: peas T=tall; t=short R=red; r=white
Crossing Over
Crossing over is a recombination of genes due to exchange of genetic material between two homologous chromosomes
It is the mutual exchange of segments of genetic material between non-sister chromatids of two homologous chromosomes, so as to produce re-combinations or new combinations of genes.
It occurs in the pachytene stage, at four strand stage with the help of enzymes (endonuclease, exo-nuclease, R-protein or recombinase;
Stern and Hotta,(1969, 1978).
There is breakage of chromatid segments, exchange of nonsister chromatid segments and later their fusion in new places.
It's about for some interactions occurs between two genes and within a gene and how these interactions changed the phenotypic ratios of Mendelian phenotypic ratios.
Linkage refers to the presence of two different genes on the same chromosome . Two genes that occur on the same chromosome are said to be linked, and those that occur very close together are tightly linked.
A general account of Quantitative (Multiple factor or Polygenic) Inheritance; Examples : Kernel colour in Wheat, Ear size (Cob length ) in Maize(Zea mays) ; Differences between Qualitative and Quantitative Inheritance
This presentation explains the basics of crossing over, theories or mechanisms behind it, types, salient features, factors affecting crossing over and its significance.
Introduction :
Mendel and subsequent workers assumed that a character was governed by a single gene.
But it was later discovered that many characters in almost all the organisms are governed by two or more genes. Such gene affect the development of concerned characters in various ways.
The phenomenon of two or more gene affecting the expression of each other in various ways in the development of a single character of on organism is known as gene interaction.
Allelic and Non-allelic interactions : Complete dominance; Incomplete dominance-in Four O'clock plant, Mirabilis jalapa and Snapdragon, Antirrhinum majus ; Co-dominance- MN blood group, AB blood group, Roan coat colour in shorthorn breed of cattle; Inheritance of Comb pattern in Poultry; Epistasis -Dominant - Fruit colour in Summer squash, Recessive - Coat colour in mice; Complementary gene interaction -Purple flower colour in Sweet pea (Lathyrus odoratus)
Epistasis is a Greek word that means standing over .Bateson used it to describe the masking effect in 1909.
An interaction between a pair of loci in which the phenotype effect of one locus depends on the genotype at the second locus.
Genes whose phenotypes are ;
Expressed,epistatic.
Altered or suppressed hypostatic.
Linkage
Genes far apart on the same assort independently are not linked
The position of the gene – locus
Occurs in the prophase of meiosis 1 where homologous chromosomes break at identical locations and rejoin with each other
Two genes are said to be under linkage, or linked, when they are located on the same chromosome.
Example: peas T=tall; t=short R=red; r=white
Crossing Over
Crossing over is a recombination of genes due to exchange of genetic material between two homologous chromosomes
It is the mutual exchange of segments of genetic material between non-sister chromatids of two homologous chromosomes, so as to produce re-combinations or new combinations of genes.
It occurs in the pachytene stage, at four strand stage with the help of enzymes (endonuclease, exo-nuclease, R-protein or recombinase;
Stern and Hotta,(1969, 1978).
There is breakage of chromatid segments, exchange of nonsister chromatid segments and later their fusion in new places.
It's about for some interactions occurs between two genes and within a gene and how these interactions changed the phenotypic ratios of Mendelian phenotypic ratios.
Linkage refers to the presence of two different genes on the same chromosome . Two genes that occur on the same chromosome are said to be linked, and those that occur very close together are tightly linked.
A general account of Quantitative (Multiple factor or Polygenic) Inheritance; Examples : Kernel colour in Wheat, Ear size (Cob length ) in Maize(Zea mays) ; Differences between Qualitative and Quantitative Inheritance
This presentation explains the basics of crossing over, theories or mechanisms behind it, types, salient features, factors affecting crossing over and its significance.
Introduction :
Mendel and subsequent workers assumed that a character was governed by a single gene.
But it was later discovered that many characters in almost all the organisms are governed by two or more genes. Such gene affect the development of concerned characters in various ways.
The phenomenon of two or more gene affecting the expression of each other in various ways in the development of a single character of on organism is known as gene interaction.
Allelic and Non-allelic interactions : Complete dominance; Incomplete dominance-in Four O'clock plant, Mirabilis jalapa and Snapdragon, Antirrhinum majus ; Co-dominance- MN blood group, AB blood group, Roan coat colour in shorthorn breed of cattle; Inheritance of Comb pattern in Poultry; Epistasis -Dominant - Fruit colour in Summer squash, Recessive - Coat colour in mice; Complementary gene interaction -Purple flower colour in Sweet pea (Lathyrus odoratus)
The expression of a single character by the interaction of more than one pair of genes is called the Interaction of genes.
Bateson and Punnet proposed factor hypothesis to explain the Interaction of genes.
The genic interaction is of two types, namely
Non-allelic gene interaction.
Allelic gene interaction.
Genetics is a branch of biology concerned with the study of genes, genetic variation, and heredity in organisms. Though heredity had been observed for millennia, Gregor Mendel, Moravian scientist and Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene.
Trait inheritance and molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded beyond inheritance to studying the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the cell, the organism (e.g. dominance), and within the context of a population. In science and especially in mathematical studies, a variational principle is one that enables a problem to be solved using calculus of variations, which concerns finding functions that optimize the values of quantities that depend on those functions.
Genetics- Chapter 5 - Principles of inheritance and variation.docxAjay Kumar Gautam
Genetics is a branch of biology concerned with the study of genes, genetic variation, and heredity in organisms. Though heredity had been observed for millennia, Gregor Mendel, Moravian scientist and Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene.
Describe the differences among dominance, incomplete dominance, codo.pdfarchigallery1298
Describe the differences among dominance, incomplete dominance, codominance, and
overdominance.
Solution
Dominant character: A character that expresses itself even in the heterozygous state in F1
generation is known as a dominant character. With such a character, the F2 ratio is a 1:2:1 and
F1 is a 3:1 ratio in case of mono hybrid cross.
Incomplete dominance: It is also known as incomplete or partial or a semi dominant condition ,
where none of the alleles are dominant or recessive over the other. This condition is
characterised where the F1 heterozygous do not show a single colour/ trait relative to one parent,
but express a phenotype that is intermediate to both the parents. For eg: if a red flower plant of
Mirabilis jalapa is crossed with the white ones, then the F1 will not be red or white but pink in
colour. In case where the pink F1 is crossed to obtain F2 a ratio of 1:2:1 is obtained with
red:pink:white in both genotypic and phenotypic ratios.
Codominance : the co dominant alleles do not have a a dominant or recessive effect from one
another. Here, the heterozygous genotype gives rise to a phenotype that is very much different
from either of the parents. This can very well be seen in the ABO blood grouping system . The
chemical glycoproteins are controlled by three alleles out o which two IA and IB are co
dominant where as i is recessive to the other two at the ABO locus. The IAIA and IAi
individuals produce type A blood, and IBIB and IBi individuals produce type B blood, but IAIB
individuals show modifications on their blood cells and thus show type AB blood, so the IA and
IB alleles are said to be co-dominant.
Overdominance : this is the condition where the heterozygote phenotype does not lie in the range
of any of the homozygotes. For eg the sickle cell anaemic condition in humans. The individual
with this effect will have a partial resistance to malaria but the homozygotes do not show any
such kind of effects..
Double fertilization is the process found in angiosperms in which out of the two male gametes released inside the embryo sac, one fuses with the egg cell (syngamy) and another fuse with secondary nucleus (triple fusion).
Photosynthesis is an anabolic process by which simple inorganic substances like CO2 and H2O are converted into a complex substance like a carbohydrate in the presence of light and chlorophyll.
Genetics (Greek word ‘genesis’ = to grow into)
i. The branch of biology which deals with the study of heredity and variation is known as genetics.
ii. The term genetics were coined by Bateson (1906).
2. Heredity :
The transmission of character from one generation to the others is called as heredity.
Gregor Johann Mendel (July 20, 1822 – January 6, 1884) was a Czech-German Augustinian friar and scientist, who gained posthumous fame as the founder of the new science of genetics for his study of the inheritance of certain traits in pea plants. Mendel showed that the inheritance of these traits follows particular laws, which were later named after him. The significance of Mendel’s work was not recognized until the turn of the 20th century. The independent rediscovery of these laws formed the foundation of the modern science of genetics.
In incomplete dominance the genes of an allelomorphic pair are not expressed as dominant or recessive.
ii. They express them self partially when present together in hybrid.
iii. One gene cannot suppress the expression of the other completely.
iv. As a result F1, hybrid shows characters intermediate to the effect of two genes of the parent.
v. In such cases both the alleles of contrasting characters express as blend or mixing.
DNA (Deoxyribo nucleic acid) is the principal genetic material of all organisms, except some viruses.
In 1953, James Watson and Francis Crick proposed the structural model of DNA for which they received the Nobel Prize in 1962.
Mitosis is an equational division, dividing the mother cell into two daughter cells which are identical to one another and also to the mother cell in having the same number and kind of chromosome.
Meiosis is reductional division in which the chromosome number is reduced to half. During meiosis, four haploid daughter cells are formed from one parental cell.
It is a process in which the chromosomes duplicate only once but the cell divides twice.
It results in formation of four haploid cells. Hence, it is also called reduction division.
The lichens are slow growing, long living organisms.
Theophrastus was first to use the word lichen.
Lichens are formed by close association of two different partners,
A) Phycobiont or photobiont: The algal component of lichens is called phycobiont.
It mostly belong to Chlorophyceae(green algae)
Or cyanobacteria ( blue green algae)
B) Mycobiont: The fungal component of the lichens is called mycobiont. It belongs to ascomycetes and rearly Basidomycetes or Deuteromycetes.
Kingdom Fungi includes Unicellular ( Yeast) or multicellular and filamentous (Penicillium) organisms.
Unicellular organisms have a protoplast with many nuclei e.g. Rhizopus or with a single nucleus e.g. Yeast.
Filamentous organisms consist of a body called Mycelium in which a number of thread like structures called Hypae are present.
What is cell division?
Ans: Cell division is a process by which a cell divides into two or more daughter cells.
Every cell arises from the pre-existing cell by the process of cell division.
Q. What is generation time?
Ans: The period between two successive divisions is called generation time.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
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This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
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Mammalian Pineal Body Structure and Also Functions
Incomplete dominance
1. Incomplete dominance
Deparment Of Botany
Preapared by
Dr. P. B.Cholke
(Assistant Professor in Botany)
Pune District Education Association’s
Anantrao Pawar College ,Pirangut,
Tal-Mulshi, Dist-Pune- 412115
2. Incomplete dominance
• i. In incomplete dominance the genes of an
allelomorphic pair are not expressed as dominant or
recessive.
• ii. They express them self partially when present
together in hybrid.
• iii. One gene cannot suppress the expression of the
other completely.
• iv. As a result F1, hybrid shows characters
intermediate to the effect of two genes of the parent.
• v. In such cases both the alleles of contrasting
characters express as blend or mixing.
3. • Examples :
• Incomplete dominance is found in both
plants and animals.
• Good examples are Mirabilies jalapa.
(Four ‘o’ clock plant) and Anterrihinum majus
(snapdragon)
4. • e.g Four ‘O’clock plant (Mirabilis jalapa)
• i) When pure breeding red flowered plants (RR)
are crossed with pure breeding white flowered
plants (rr) then the F1 progeny shows pink flower
(Rr)
• ii) Both alleles express themselves to produce an
intermediate colour i.e. pink such alleles are said
to be incomplete dominance.
• iii) When pink flowered F1 plants are inbreeded
the F2 - phenotype ratio is 1 : 2 : 1
• In Incomplete dominance both genotypic and
phenotypic ratio are identical or equal or similar
i.e. 1:2:1
5.
6. Co-dominance
• i. Co-dominance is a phenomenon of two
contrasting alleles of same gene lacking dominant
recessive relationship.
• ii. Both the alleles when present together in
heterozygous individuals, express their two traits
independently.
• iii. The dominant allele is not able to suppress or
incompletely dominate the recessive character.
• iv. Both the genes of allelomorphic pair express
themselves equally in F1 hybrid.
7. • e.g. Roan coat colour in cattle.
• For example, when a cattle with black coat is
crossed to a bull with white coat.
• F1 hybrids possess roan coat. In roan coat,
both black and white patches appear separately.
So, the alleles which are able to express
themselves independently when present
together are called co-dominant alleles.
• In Co-dominance both genotypic and phenotypic
ratio are identical or equal or similar i.e. 1:2:1