This document provides information on impotence, including its definition, causes, examinations, investigations, and treatments. It begins by defining impotence as the inability to perform or engage in sexual intercourse. It then discusses various clinical definitions and perspectives from medicine and law. The document outlines many potential causes of impotence including physical, psychological, drug-related factors and various medical conditions. It describes examinations, tests, and evaluations used to assess impotence involving medical history, physical exams, blood tests, imaging, and more. Finally, it discusses treatment options for impotence ranging from lifestyle changes and counseling to oral medications, injections, and other therapies.
infanticide are quite common in India because of illiteracy as well as the female child unwanted . Now a days female sexual assault and murder is getting common in north Indian society
infanticide are quite common in India because of illiteracy as well as the female child unwanted . Now a days female sexual assault and murder is getting common in north Indian society
Criminal abortion is commonly practiced in India as access to legal abortion and society fear are still great barrier. Approach of the physician and government should favorable.
A POWER POINT PRESENTATION BY DR.SANGEETA CHOWDHRY & DR.SUNIL SHARMA, DEPARTMENT OF FORENSIC MEDICINE & TOXICOLOGY, GOVT. MEDICAL COLLEGE, JAMMU (JAMMU AND KASHMIR)
Bacterial Vaginosis
Dr. Yashika
Causative agent : Gardnerella vaginalis
Clinical features:
Malodorous vaginal discharge.
(Homogenous, greyish white, adherent to vaginal wall)
No vaginal inflammation.
During pregnancy
preterm membrane rupture,
preterm labour,
chorioamnionitis.
Complications:
Recurrent infection leads to PID.
Development of PID following abortion.
Vaginal cuff cellulitis following hysterectomy.
Pregnancy complications.
Diagnosis
Amsel’s criteria :
Homogenous vaginal discharge
Vaginal discharge > 4.5
Positive whiff’s test
Presence of clue cells > 20% of cells.
Whiffs test:
Appearance of fishy (amine) odour when a drop of discharge is mixed with 10% solution of KOH.
Clue cells:
Presence of stippled epithelial cells.
Treatment:
Metronidazole 200 mg TDS x 7 days.
Clindamycin cream.
Metronidazole gel.
A POWER POINT PRESENTATION BY DR.SANGEETA CHOWDHRY & DR.SUNIL SHARMA, DEPARTMENT OF FORENSIC MEDICINE & TOXICOLOGY, GOVT. MEDICAL COLLEGE, JAMMU (JAMMU AND KASHMIR)
IDENTIFICATION OF THE LIVING AND THE DEAD.pptBalinainejoseph
This is a part of forensic medicine that describes the indentification of the living and the dead
It explains both scientific and non scientific methods
A POWER POINT PRESENTATION BY DR.SANGEETA CHOWDHRY & DR.SUNIL SHARMA, DEPARTMENT OF FORENSIC MEDICINE & TOXICOLOGY, GOVT. MEDICAL COLLEGE, JAMMU (JAMMU AND KASHMIR)
includes the recent guidelines & methodology for exaamination of rape victim in india. very helpful for medical students, practising doctos, esp Govt doctors.
Criminal abortion is commonly practiced in India as access to legal abortion and society fear are still great barrier. Approach of the physician and government should favorable.
A POWER POINT PRESENTATION BY DR.SANGEETA CHOWDHRY & DR.SUNIL SHARMA, DEPARTMENT OF FORENSIC MEDICINE & TOXICOLOGY, GOVT. MEDICAL COLLEGE, JAMMU (JAMMU AND KASHMIR)
Bacterial Vaginosis
Dr. Yashika
Causative agent : Gardnerella vaginalis
Clinical features:
Malodorous vaginal discharge.
(Homogenous, greyish white, adherent to vaginal wall)
No vaginal inflammation.
During pregnancy
preterm membrane rupture,
preterm labour,
chorioamnionitis.
Complications:
Recurrent infection leads to PID.
Development of PID following abortion.
Vaginal cuff cellulitis following hysterectomy.
Pregnancy complications.
Diagnosis
Amsel’s criteria :
Homogenous vaginal discharge
Vaginal discharge > 4.5
Positive whiff’s test
Presence of clue cells > 20% of cells.
Whiffs test:
Appearance of fishy (amine) odour when a drop of discharge is mixed with 10% solution of KOH.
Clue cells:
Presence of stippled epithelial cells.
Treatment:
Metronidazole 200 mg TDS x 7 days.
Clindamycin cream.
Metronidazole gel.
A POWER POINT PRESENTATION BY DR.SANGEETA CHOWDHRY & DR.SUNIL SHARMA, DEPARTMENT OF FORENSIC MEDICINE & TOXICOLOGY, GOVT. MEDICAL COLLEGE, JAMMU (JAMMU AND KASHMIR)
IDENTIFICATION OF THE LIVING AND THE DEAD.pptBalinainejoseph
This is a part of forensic medicine that describes the indentification of the living and the dead
It explains both scientific and non scientific methods
A POWER POINT PRESENTATION BY DR.SANGEETA CHOWDHRY & DR.SUNIL SHARMA, DEPARTMENT OF FORENSIC MEDICINE & TOXICOLOGY, GOVT. MEDICAL COLLEGE, JAMMU (JAMMU AND KASHMIR)
includes the recent guidelines & methodology for exaamination of rape victim in india. very helpful for medical students, practising doctos, esp Govt doctors.
Different kinds of sexual dysfunction and their management.
Sexual difficulties in Spinal cord injury patients
Evaluation of sexual problems and differentials
New pharmacologic agents in management of sexual dysfunctions
HUMAN SEXUALITY AND SEXUAL DYSFUNCTIONS (1).pptxIshneetKaur41
Human Sexuality - Normal sexuality, normal sexual response, sexual identity and orientation and sexual dysfunctions with treatment - female sexual arousal disorder, anorgasmia, ejaculatory dysfunction, male hypoactive sexual desire disorder
Andrology (an-drol’-uh-jee): The study of the functions and diseases specific to males, especially of the reproductive organs.
It is an equivalent to Gynaecology for women meaning gynaecologists deal with female reproductive health problems
Despite common origins of both Andrology and Gynaecology from Greek language, the branch of Andrology has not become a mainstream medical branch as opposed to Gynaecology.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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1. Dr M Balaji Singh
ACS medical college and Hospital, Chennai
Courtesy :DR. Krishna Govind Lodha ( slideshare)
Dr Priyatham kasaraneni ( slideshare)
IMPOTENCY – clinical and
forensic aspects
3. Clinical definition
Impotency :
The consistent inability to obtain and
maintain penile erection sufficient to
complete satisfactory sexual
performance
4. Supreme court – definition on
impotency
Consummation ;the action of making a marriage or relationship
complete by having sexual intercourse.
5. SEXUAL DYSFUNCTION
Is an impairment either in desire for sexual
gratification or in the ability to achieve it.
In sexual intercourse
the male partner- active partner
female partner - passive partner.
Male - develops and maintain penile erection
sufficient enough to accomplish the act.
impotence refers to male
and sexual dysfunction to female.
6. Marriage and sex
Marriage without sex is an anathema (something dislikes).
Sex is the foundation of marriage
A harmonious sexual activity it necessary for any marriage to
continue for long.
sexual activity in marriage has an extremely favorable influence on a
women's mind and body.
The result being that if she does not get proper sexual satisfaction,
it will lead to depression and frustration."
7. Impotency and Law
Impotency is a ground for matrimonial relief under all
personal laws. ...
Similar provisions are there under the Indian Divorce
Act & Parsi and Muslim Marriage Acts.
In all marriage acts, impotency can be a ground of
annulment.
It has to be understood that imperfect and partial
intercourse is not consummation.
Jul 25, 2017
8. Bride gets divorce on impotence plaint
Read more at:
http://timesofindia.indiatimes.com/articleshow/
51502776.cms?utm_source=contentofinterest&
utm_medium=text&utm_campaign=cppst
9.
10. Woman in Noida alleges husband is
impotent, seeks divorce
The woman, who filed a complaint with the women’s police, said that she got married
on November 19, 2015, in Noida and went on a honeymoon trip to Goa, when she
discovered that her husband was ‘impotent’.
She had advised her husband to consult a doctor and she was assured by him and his
family members.
The woman has also mentioned that she was tense for almost six months, as her
husband avoided a physical relationship.
The matter will be forwarded to court for counselling.
The case was registered on the basis of a complaint filed by the woman.”
A case has been registered under sections 498A (husband or relative of husband of a
woman subjecting her to cruelty) and 420 (cheating) of IPC have been registered.
11. No criminal case on impotent husband
Where it is proved that a husband has not refused or neglected to
maintain his wife, a criminal Court, acting under the section, has no
jurisdiction to make an order upon the husband for her maintenance on
the ground that the husband has been guilty of cruelty to her.
But that is a very different thing from holding that no evidence of cruelty
can be admitted in a proceeding under the section to prove, not indeed
cruelty as a ground for separate maintenance, but the conduct and acts of
the husband from which the Court may draw the inference of neglect or
refusal to maintain the wife.
12.
13. medico legal importance of
IMPOTENCY AND STERILITY:-
civil
Nullity of marriage and
divorce.
Adultery
Contested paternity and
legitimacy
Suit for adoption-
where the alleged father
pleads impotency or sterility as
his defense
Claim for damages
where loss of the sexual
function is claimed as the
result of assault or accident.
Criminal
Adultery
Rape
Un-natural sexual offences
for the want of property
In cases where a sterile women
puts forward a suppositious child,
as her own to claim property
14. Other related terms
FRIGIDITY :-Refers to women who are sexually
nonreactive i.e.. the inability to initiate or maintain
the sexual arousal.
PREMATURE EJACULATION:-Means ejaculation
occurs immediately after penetration or even before
penetrative sexual inter course.
15. Epidemiology
Estimated to affect 152millions men worldwide
Non-diabetic men 0.1-18.4% prevalence
In a study of 541 diabetic males
35% in diabetic men
5.7% in 20-24 year olds
52.4% in 55-59 years olds
27. CAUSES OF IMPOTENCY IN MALE
1.AGE:- earlier than puberty - spermatozoa are not usually found- a boy is
sterile but not impotent before puberty.
II.MALFORMATION:- Absence or non development of penis constitutes
absolute impotence.
Certain malformation - intersexuality – cause impotency.
hypospadias and epispadias- result in sterility.
III. LOCAL& GENERAL DISEASES:- gonorrhea ,syphilis etc. may cause
temporary impotence.
Large hernia, elephantiasis or large hydrocele - mechanical obstacle-
temporary impotence.
mumps, testicular atrophy, diseases of testes, epididymis- sterility.
28. Impotency………causes
IV. INJURIES :-Injury to head, spinal cord, cauda equina may result in impotence.
Injuries to testicles will in time cause sterility.
Exposure to X-RAYS, without proper protection, may lead to sterility
Chronic alcoholisim & addiction to narcotics like opium cause impotence.
V. PSYCHIC CAUSES:-
Fear of impotence or fear of inability to complete the act may also cause
temporary impotence but soon is overcome.
Eg.- First night impotence Emotional disturbance Hypocondriasis Timidity
29. VI. OPERATIONS: amputation of the penis renders impotency
Vasectomy renders a male sterile but not impotent.
Lithotomy may cause sterility from injury to ejaculatory ducts.
Other causes
Varicocele:- local rise of temperature- temporary sterility.
Endocrine disorders :-rare, treatable. hyperprolactinemia is readily treatable.
Infections - Acute and chronic genital tract infections
acute orchitis or epididymitis - obstruction in the efferent ejaculatory ducts.
Chlamydia trachomatis - Unilateral epididymal obstruction
antibodies to sperm, a potential cause of male infertility.
Appropriate assessment of a semen sample including tests like presence of seminal
Fructose, neutral alpha-glucosidase and pH go a long way in differentiating between
obstructive and non-obstructive azoospermia.
36. Indications for referral
Indications are failure of initial treatment,
Urologist;
younger patients with a history of pelvic or perineal trauma,
significant penile deformity (e.g., Peyronie disease,
congenital chordee),
Endocrinologist;
complicated endocrinopathies (e.g., secondary hypogonadism,
pituitary adenoma),
Psychiatrist;
complicated psychiatric hypoactive sexual desire),
Vascular surgeon or neurosurgeon,: vascular or neurosurgical
intervention (e.g., aortic aneurysm, lumbosacral disc disease.
37. EXAMINATION IN CASE OF IMPOTENCY
Before examination, informed consent is obtained.
The following things are done,
1. Complete history of previous illness especially with reference to nervous
and mental condition and sexual history should be obtained.
2. The general examination followed by systemic examination should be
done.
3. The private parts must be examined for injuries or malformations. 4.
The condition of testes, epididymis, cord & penis should be noted and
private parts tested for sensation .
OTHER EXAMINATION
Duplex USG
Chemical stimulation
Ateriography
38. History taking
Patient’s description of the problem
Patient’s and partners expectations
Duration
Speed of onset
Intermittent/progressive?
History of sexual partners
Nocturnal erections?
Libido
39. History…..
Personal Medical History
Glycaemic control
Vascular/neurological disease
Urological
Pelvic surgery and trauma
Drug history
Anti- hypertensive's
Androgen antagonists
Sedatives
Drugs that cause hyperprolactinaemia (phenolthiazides)
Alcohol
Psychological assessment
44. Nocturnal Penile Tumescence (NPT)
Five to six erections during sleep ( during rapid
eye movement sleep (REM). – normal.
Their absence may indicate defective nerve
function or blood supply in the penis.
measuring changes in penile rigidity and
circumference during nocturnal erection: by
a). Snap gauge and ; b ) strain gauge.
Significant proportion of men who do not have
sexual dysfunction , with the absence of regular
nocturnal erections.
Positive results are more important.
48. Penile Biothesiometry
This test uses electromagnetic
vibration to
evaluate sensitivity and nerve
function in the
glans and shaft of the penis.
49. Tests for penile blood flow
arterial impairment and veno occlusive dysfunction.
Combined intra cavernous injection and stimulation
(CIS): for evaluation of penile blood flow.
intra cavernous injection of a vasodilator drug + genital or audiovisual
sexual stimulation
- erectile response is observed and rated by an independent
assessor.
50. C I S ……..
The test is designed to bypass neurologic and hormonal
influences
It allows the clinician to evaluate the vascular status of
the penis directly and objectively.
It is the most reliable and least invasive diagnostic
modality for assess
53. Duplex ultrasonography
Cavernous arterial
insufficiency is suggested
when PSV[peak systolic
velocity] is less than 25
cm/sec;
PSV consistently greater
than 35 cm/sec defines
normal cavernous arterial
inflow.
55. Indicated for
1. site-specific vasculogenic leak due to perineal or
pelvic trauma
2. who have had life-long ED (primary ED)
Test results interpreted by ;
failure to increase intracavernous pressure to the level of
the mean systolic blood pressure with saline
infusion
or the demonstration of a rapid drop of intracavernous
58. Penile Nerves Function
Tests such as the bulbocavernosus reflex test
are used to determine if there is sufficient
nerve sensation in the penis.
The physician squeezes the glans of the penis,
which immediately causes the anus to contract
if nerve function is normal.
Physician assess the latency between squeeze
and contraction by observing the anal
sphincter or by per anal finger palpation.
59. Psycho physiological evaluation
Penile Tumescence and Rigidity Monitor:
Nocturnal penile tumescence and rigidity (NPTR)
Recommended criteria for normal NPTR include four to five erectile
episodes per night, mean duration longer than 30 minutes, an increase
in circumference of more than 3 cm at the base and more than 2 cm at
the tip, and maximal rigidity above 70% at both base and TIP.
Rigiscan: An automated, portable device used for NPTR,
60. Psychological evaluation
ED is associated with anxiety, depression, low degrees of self-esteem,
negative outlook on life, self-reported emotional stress, and a history of
sexual coercion.
In the absence of organic risk factors, a primary psychogenic ED causation
may be suspected. Further support for the diagnosis may follow the
confirmation of noncoital erections (i.e., masturbatory, nocturnal or on
awakening)
61. Neurological evaluation
Target sites for evaluation include peripheral, spinal, and supraspinal centers,
as well as both somatic and autonomic pathways involved in this biologic
response.
Tests : SOMATIC Nervous system;
Biothesiometery : affrent sensory function
Evoked Response-Bulbocavernosus reflux latency: >30-40msec indicate
neuropathology.
Dorsal nerve conduction velocity
Genito cerebral evoked potential
63. Hormonal evaluation
Serum testosterone measurement : The best indicator of androgen status ( The typical
reference range is 280 to 1000 ng/dl).
Serum Gonadotropin : help to localize the source of the hypogonadism
Hyperprolactinaemia causes hypogonadism by suppression of gonadotropins-
releasing hormone from the hypothalamus, which impairs pulsatile LH secretion required for serum
testosterone production by the gonads.
Hyperthyroidism is associated with ED, possibly by increasing aromatization of
testosterone into estrogen or by increasing adrenergic tone (which causes smooth muscle
contractile effects or exerts psycho-behavioral effects
64. Teatment
Life style modification:
Quit smoking
Regular exercise
Weight control
Medication change:
Psychosexual therapy: A variety of interventions are used:
systematic anxiety reduction/ desensitization,
sensate focus,
inter personal therapy,
cognitive behavioural therapy,
sex education,
couples’ communication and sexual skills training.
67. Intra cavernosal injections
with prostaglandins
Alprostadil (prostaglandin E1),PHENTOLAMINE,
PAPAVERIN
One large RCT found increased rate of satisfactory
erections when Alprostadil injected compared to
placebo .
Side effects – pain, priapism
68. Alprostadil via urethral channel
Response rate ~50%
side effects- local urogenital pain ,
urethral bleed ,hypotension
dizziness
Effective, but requires sufficient
training
Nitroglycerin, papevarin, alprostadil etc –
topical use/ trans dermal.
69.
70.
71.
72.
73. PDE5 inhibitors (phosphodiesterase type 5
inhibitor: increases cGMP in the smooth muscle of
the corpuscavernosum, causing prolonged
vasodilation and a firmer, longer-lasting erection
Unlike injection therapy, PDE5 inhibitors
require sexual stimulation for an erection
to occur.
74. Precautions during prescribing
concomitant use of nitrates is an absolute contraindication PDE5
inhibition potentiates the hypotensive effects of nitrates.
The use of alpha adrenergic blockers also increases the risk for
hypotension and generally should be avoided.
Relative contraindications include MI, stroke, or dysrhythmia within the
past 6 months; poorly controlled hypertension or hypotension;
uncompensated cardiac failure; unstable angina; a predisposition to
priapism; and retinitis pigmentosa.
75. The most common side effects
headache,
flushing,
dyspepsia,
and nasal congestion.
The inhibition of phosphodiesterase 6 in the retina by sildenafil may cause
altered color vision–usually a blue tinge—or increased sensitivity to light in
some men.
76. Other Oral Agent
Yohimbine is an oral alpha-2 adrenergicreceptor blocker that may
improve erectile function better than placebo, particularly in psychogenic
impotence.
Studies remain ongoing for the use of phentolamine, apomorphine,
dopaminergic, and many other agents.
77. Testosterone replacement
Improves erectile function and libido
Preparations
◦ Topical (testim gel)
◦ Im testosterone
◦ Long-acting depots