Presentation on Immune Based Therapies and their implications for HIV treatment presented at the Fenway Health Center, Boston, MA for the public education conference An End To AIDS - How A State Bill Can Change Everything conducted by SearchForACure.org, the Fenway Health Center, and the MA Dept. of Public Health

1. AN .END . TO.AIDS Immune Based Therapy For The Treatment Of HIV Infection Past, Preset and Future Richard Trauger, PhD

3. Evolution of an immune response Innate immunity is characterized by an Inflammatory response that precedes adaptive immunity

4. Adaptive Immunity Increase Titer Increase CD4 Effectors (helpers) Increase CD8 effectors (killers) Vaccines

10. Inflammation

12. Elite Controllers HIV/AIDS • CID 2005:41 Walker Topics in HIV Medicine 2007

13. Elite control and the Immune Response Elite controllers provide a unique opportunity to examine the relationship between viral characteristics and host genetics/immune responses in a successful model of durable HIV control without the use of antiretroviral therapy. Insight gained from these individuals could be used as a platform for studies aimed at therapeutic vaccines and the eradication of HIV.

17. ERAMUNE 01: Enrolling people with HIV who are on a fully suppressive ARV regimen and who are judged to have a very small reservoir of infected cells based on a measurement of HIV DNA in the blood. The study will enroll 28 people living with HIV in Paris, Milan, Barcelona and London. Katlama and her colleagues will add Isentress and Selzentry to everyones regimen, an approach known as treatment intensification, to help maximize control of HIV replication. Eight weeks after people add Isentress and Selzentry, the research team will give them two cycles of IL-7 injections . The primary aim is to simply decrease the size of the HIV reservoir. ERAMUNE 02: Overall, 28 HIV-positive patients will have their antiretroviral treatment intensified and will be randomly assigned to either a control or an experimental group. The experimental group will receive an additional vaccine treatment , in the hopes that this new combination will completely eradicate HIV from the infected individual’s body. HAART plus Treatment Intensification and IBT