The diaphragm attaches anteriorly and laterally to the inferior sternum, xiphoid process, lower ribs, and costal cartilage. Posterior attachments include the crura and arcuate ligaments connecting to the lumbar vertebrae. Diaphragmatic rupture often results from blunt trauma, presenting with dyspnea, chest pain, and herniated abdominal organs into the thorax seen on imaging as dependent viscera or the collar sign. Delayed presentations can lead to bowel strangulation. CT is the most sensitive imaging method to detect discontinuity of the hemidiaphragm and intrathoracic herniation of abdominal contents. Surgical repair is usually required to correct diaph
Imaging plays an important role in diagnosis and formulating differential diagnosis in case of Solitary pulmonary nodule. It helps in differentiating and predicting benign and malignant nodules.
Imaging plays an important role in diagnosis and formulating differential diagnosis in case of Solitary pulmonary nodule. It helps in differentiating and predicting benign and malignant nodules.
Congenital neck mass radiology pk final is very good power point presentation for radiologist, radiology resident, student and even ent surgeon or resident doctor.. Every disease of neck lesion is properly describe with multi usg, ct and MRI images. this will help a lot. thanks.
About traumatic diaphragmatic hernias
Incidence in the foothills of the Himalayas may be higher than the plains- relation to climbing trees for animal fodder or falls from roads in hills onto trees or slopes
Every blunting of CP Angle in trauma pts must raise the possibility
Varied clinical spectrum.
Can be repaired by general surgeons themselves with good results
Associated injuries often influence the eventual outcome
MRI imaging of knee joint -- from radiological anatomy to pathology. inspired from my dear professor Mamdouh Mahfouz, professor of radio diagnosis - Cairo university.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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NVBDCP.pptx Nation vector borne disease control programSapna Thakur
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
2. Drawing (view from below) shows the large central tendon, which is formed by the transverse
septum.
3. Anterior and lateral attachments
• Inferior sternum, xiphoid process, lower six ribs, and
costal cartilage.
Posterior attachments
• The two diaphragmatic crura
• The medial arcuate ligaments
• The lateral arcuate ligaments
upper lumbar vertebral
bodies
b/n the L1 or L2 VB
and the
TPs of L1.
TPs of T12 laterally to
midportion of the
12th ribs.
4. DIAPHRAGMATIC RUPTURE
• Post-traumatic laceration of hemidiaphragm, frequently
resulting in herniation of abdominal viscera into thorax.
Etiology:
• Trauma (M.C) -Blunt trauma more common than
penetrating trauma.
• Less commonly idiopathic or related to previous surgery.
Location:
• Occur more on the left.
• Clinical manifestation (visceral herniation) much more
common on left side (70-90%).
5.
6. Morphology:
• Tears are usually >10 cm in length, are radially orientated
and occur at the weakest part of the diaphragm, the
musculotendinous junction in a posterolateral location.
• Prevalence of visceral herniation increases with larger
tears
7. • Presentation:
• Acute
• Multiple associated injuries- pelvic fractures, splenic injuries and
renal injuries
• Symptoms may be nonspecific and include dyspnea, chest pain,
shoulder pain, and cyanosis
• Diagnosis delayed when
• Often other more compelling injuries such as aortic laceration
• Intubated patient on positive pressure may prevent herniation
• Clinical diagnosis of acute diaphragm injury can be challenging.
Consequently, a high index of suspicion is required.
• Delayed/Obstructive
• In delayed presentation often Strangulation of bowel occurs
8. • Radiographic Findings• Chest radiography usually abnormal but often nonspecific
• Specific signs:
1. Air-filled viscus in hemithorax with or without focal constriction of
the viscus at the site of the tear (collar sign).
2. Tip of NG tube in hemithorax
• Abnormal diaphragmatic contour and changes in shape
with change in position.
• Elevated diaphragm > 7 cm.
• Contralateral mediastinal shift.
• Strangulation of bowel.
9.
10.
11.
12. CT Findings• More specific
1.
Direct discontinuity of the hemidiaphragm- most sensitive sign of
rupture
2.
Intrathoracic herniation of abdominal contents1.
2.
left side - The stomach and colon
right side -liver
Collar sign - Visceral herniation with focal constriction of bowel or liver
3.
• Hump and Band -The hump and band signs both result from herniation of the liver
through a right-sided diaphragmatic rupture .
Dependent viscera sign is very accurate.
1.
1.
2.
Visualization of abdominal viscera against posterior chest wall.
Diaphragmatic thickening, segmental absence, and combined
hemothorax and hemoperitoneum are strong predictors of blunt
diaphragmatic rupture
26. MRI:
MR imaging is less readily adapted to the acute trauma setting
and should be reserved for patients with an uncertain CT
diagnosis or delayed signs of diaphragmatic tear.
USG:
Bedside emergency ultrasonography can be safe and accurate.
But it can be compromised by pulmonary aeration, gastric and
colonic gas, subcutaneous emphysema, bandages, abdominal
pain and obesity.
Other Modalities• Barium gastrointestinal findings
Approximation and narrowing of afferent and efferent bowel loops
(pinched limbs) through the diaphragmatic defect (collar sign or kissing
birds sign).
28. DIFFERENTIAL DIAGNOSIS1. Eventration of Diaphragm
• No dependent viscera sign
• Hemidiaphragm should appear intact
• No associated injuries
• Typically seen in elderly females without a history of recent trauma
2. Diaphragm Paralysis
• Paradoxical motion at fluoroscopy (sniff test)
• No recent history of trauma
3. Sub-pulmonic or loculated Pleural Effusion• No abnormally positioned air-filled bowel
• Crus intact
4. Paraesophageal Hernia
• Tear rare at esophageal hiatus.
Sites of injuries. Drawing shows radial (A), transverse (B), and central (C) ruptures and a peripheral detachment (D). Radial tears appear to be the most frequently found injury at surgery, whereas peripheral detachments are the least frequent.
Diaphragmatic rupture. Chest radiograph showing a left-sided diaphragmatic rupture. Bowel can be seen herniating into the left hemithorax, the mediastinum is displaced to the right and there is a nasogastric tube seen coiled within an intrathoracic stomach.
Tear usually spares esophageal hiatus. So, NG tube will course normally into abdomen and then traverse into hemithorax if stomach herniated.chest radiograph shows a gas-filled viscus above the left hemidiaphragm that corresponds to the colon (C). A nasogastric tube is clearly seen in the thoracic cavity (arrow).
CTscan obtained at the level of the hepatic hilum showsa defect in the continuity of the anterolateral lefthemidiaphragm (arrows).Ccolon.(b)CT scan ofthe midthoracic region shows intrathoracic herniation of the stomach
.(c, d)Sagittal(c)and coronal(d)reformatted images show the intrathoracic herniation of the stomach more clearly
Rupture of the left hemidiaphragm following blunt trauma due to a road accident. (A) Chest radiograph reveals left mid zone contusion. (B) Axial and (C) sagittal reformatted CT images reveal a ruptured diaphragm on the left side with the stomach herniating through into the thorax. The stomach is constricted as it passes through the diaphragmatic tear—the so-called ‘collar sign’
CT scan shows a subtle sign of a right diaphragmatic tear: a focal indentation in the posterolateral aspect of the liver with a contusion (arrow).
(b) Coronal reformatted image clearly shows a waistlike constriction of the liver
Right-sided BDR in a 35-year-old man after a motor vehicle accident. (a)Coronal maximum intensity projection image from contrast-enhanced CT shows herniation of the liver dome through a diaphragmatic rupture (hump sign), with a smooth collar sign (arrows) and a linear area of subtle hypoattenuation (band sign) (arrowhead) extending across the base of the defect. (b)Axial contrast-enhanced CT image shows an area of hypoattenuation (arrowheads) in the dome of the liver, a finding that might correspond to the band visible in a.
C+ ct Left-sided BDR in a 42-year-old man after a motor vehicle accident. Axial contrast-enhanced CT scan shows a curvilinear flap extending away from the chest wall toward the center of the abdomen (dangling diaphragm sign) (arrow), a finding that represents the torn free edge of the left hemidiaphragm, the distal part of which appears thickened (thickening of the diaphragm sign). An air-filled bowel loop is seen peripheral to the diaphragm, within the pleural cavity (abdominal content peripheral to the diaphragm or lung sign) (arrowheads).
Axial c+ct stomach lying adjacent to posterior ribs
ransverse CT scan with oral and intravenous contrast material demonstrates dependent viscera sign on the left side of a 32-year-old man. The stomach (arrow), which contains food and oral contrast material, abuts the posteriorribs on the left side and is posterior to the top of the spleen (arrowhead)
ransverse CT scan with oral and intravenous contrast material demonstrates dependent viscera sign on the left side of a 40-year-old man. The colon(arrow) abuts the posterior ribs on the left side
Multiple signs of blunt diaphragm rupture.Coronal MPR CT demonstrates intrathoracic herniationof stomach (black arrow)andcolon(white arrow), gastric collar sign (curved arrow), and free edge of ruptured left hemidiaphragm (arrowhead).
Coronal contrast-enhanced reformatted CT image at the level of the spleen shows thickening of the left crus (arrow). Parts of the stomach (ST), small bowel (SB), and omental fat (F)have herniated into the thorax and directly contact the collapsed lung (L)(herniation through a defect sign, abdominal viscera abutting thoracic fluid or a thoracic organ sign).
Sonographic signs of injury include herniation of viscera through the diaphragm[47,48], diaphragm disruption, diaphragmnonvisualization [48], and absent diaphragmexcursion during the respiratory cycle