The document describes the work of Ignacio Larrayoz Roldan and his Biomarkers and Molecular Signaling Group at CIBIR in Logroño, Spain. The group uses bioinformatics, molecular biology techniques like RNA-seq on tissue samples, and develops 3D/VR technologies. Specific projects include studying colorectal cancer and melanoma biomarkers, blood-based biomarkers for age-related macular degeneration, and using VR for stroke patient rehabilitation. The group has also created software for 3D visualization of medical images like PET scans and confocal microscopy images.

1. Refbio Fase IIRefbio Fase II
Ignacio Larrayoz Roldan
CIBIR (Logroño)
Group Leader, Biomarkers and Molecular Signaling
Biomarkers,
Virtual Reality and
Neurorehabilitation

2. Refbio Fase IIRefbio Fase II
Biomarkers and Molecular Signaling Group
Bioinformatics,
-omics
3D/VR
technologies
Molecular Biology,
Cell culture,
animal model,
clinical trials

3. Refbio Fase IIRefbio Fase II
• Colorectal cancer:
FFPE, RNA-Seq, Biomarkers (Survival,…)
• Locally advanced Melanoma:
FFPE, RNA-Seq, Biomarkers (Survival,…)
• Blood-based Predictive Biomarkers for Age-related Macular
Degeneration and New Therapeutic Opportunities
• Retinal Cells
• Animal Models of AMD
• Patients
Molecular Biology and Biomarkers (using –omics)

4. Refbio Fase IIRefbio Fase II
3D Image Visualization Device
Medical Image
• Automatic generic
PET/TAC image 3D
reconstruction
• Section and tissue
isolation tools
• Not-invasive gesture
control for image
exploring
Confocal microscopy
• Channel separated
semi-automatized
reconstructions
• Solid 3D models,
not only rendered
• Full channel and
image interaction
Generic 3D
visualization system
+
Specific image
treatment software for
3D image building.
Specialized in
biomedical images.
Next step: Clinical validation

5. Refbio Fase IIRefbio Fase II
• HTC Vive platform
• Stroke patients
• Occupational therapy / VR
Virtual Reality and
Neurorehabilitation

6. Merci!
Gracias!
www.refbio.eu
Ignacio Larrayoz Roldan
ilarrayoz@riojasalud.es
Cibir, Logroño, Spain
Programa financiado por el FEDER