SlideShare a Scribd company logo
HYPOTHYROIDISM
DHANYA VJ
ASSISTANT PROFESSOR
SUM NURSING COLLEGE
HYPOTHYROIDISM
• It is a condition in which thyroxin hormone
level is decreased.
2 types
• 1.Congenital hypothyroidism- is a common
type associated with down syndrome.
• 2.Acquired hypothyroidism – occurs after the
age of 1 year and late onset hypothyroidism.
INCIDENCE
• World wide prevalence is 1: 4000 newborns
• If untreated after birth severe congenital
hypothyroidism can lead growth failure
condition known as cretinism.
ETIOLOGY
CONGENITAL
• Gene mutation
• Failure of CNS
• Iodine deficiency
ACQUIRED
• Thyroid
dysfunction
• Deficiency of TSH
ETIOLOGY
Primary hypothyroidism
Congenital
• Thyroid gland
aplasia,hypoplasia
• Inborn error of thyoid
hormone
• Inherited defect of
thyroid hormone
receptors
• Maternal drugs like
carbimazole, radioiodine
acquired
• Iodine deficiency
• Autoimmune chronic
lymphocytic thyroiditis
• Irradiation
• Ingestion of goitrogen
• Drug induced
PATHOPHYSIOLOGY
The hypothyroid fetus does nit get maternal thyroid hormone to meet
its metabolic requirement to protect from congenital hypothyroidsm
Neonatal period thyroid functioning is completely
independent from the mother
At the 8th week gestation thyroid gland normally occupies its
permanent anatomic site and at term reaches its maximum
functioning
PATHOPHYSIOLOGY
Baby of mother with hyperthyroidism is born with
hypothyroidism and fetal goiter
However allows the passage of antithyroid drugs if
mother is taking them
Placenta does not allow passage of maternal thyroid
hormone
CLINICAL MANIFESTATION
• One of the earliest signs is patent fontanels
and widely opened cranial sutures due to
utero lag in skeletal maturation
• Another early indication of congenital
hypothyroidism is prolonged physiologic
jaundice due to delayed maturation of
glucuronide conjugation
• Birth weight more than average
CLINICAL MANIFESTATION
• Babies are dull ,flaccid and good natured as
they cry less and sleep most of the time.
• Pallor due to anemia
• Feeding difficulties
• constipation
CLINICAL MANIFESTATION
CONGENITAL (CRETINISM)
• Thickened protruded
tongue,thick lip
• Anemia,rough and thick skin
• Over sleeping
• Hypotonia
• Bradycardia,cool
extrimities,wide posterior
fontanel
• Difficulty in feeding
• Horse cry
ACQUIRED
• Decrease appetite,dry
skin,coarse hair,depressed
reflex
• Constipation ,enlarged
thyroid gland,Delayed bone
age
• Muscle weakness
• Delayed puberty,bradycardia
• Growth retardation ,short
stature,short appearance
with large heat.
CLINICAL MANIFESTATION
• Skin
-yellow discoloration due to prolonged jaundice
-skin is dry ,thick,coarse,cool and mottled
CLINICAL MANIFESTATION
• Head and face
-puffy face
-swollen eyelids
-widely separated eyes
-narrow palpebral fissures
-broad nose with depressed bridge
-open mouth with large protruding tongue
-sparse ,coarse and brittle hair
-delayed dentition and tooth decay
-neck short
-voice is hoarse
CLINICAL MANIFESTATION
• Trunk and extremities
-retarded skeletal development and
maturation
-short stature
-extremities appear short in relation to trunk
-hands are broad and fingers are short
-protruding abdomen
-umbilical hernia may be present
CLINICAL MANIFESTATION
• Vital signs
-temperature is usually subnormal below 35
degree celsius because of decreased
metabolic rate
-pulse is slow with reduced pulse pressure
-dyspnoea ,noisy breath ,nasal obstruction and
apnoea
-heart murmur and cardiomegaly
DIAGNOSIS
• X ray study of bone age
• Screening of thyroid hormone
• Examination of serum T 3 ,T4
• Test for TSH level
• Thyroid antibody study
MANAGEMENT
• Normalize the level TSH
• Thyroid hormone levothyroxin is prescribed
• For neonate 10-15microgram /kg/day
• Monitor the serum thyroid level regularly
•
MANAGEMENT
• Growth monitoring during therapies is
important.
• Educate the parents about the disease,and
management
• Adequacy of replacement therapy – control
of constipation correction of feeding problem
,improvement in appetite.
NURSING MANAGEMENT
• Early identification of infant having
hypothyroidism
• Collect the infant history and assist in lab test
and radiographic examination
• Administer the drug daily
• Nurse must tell about the manifestation of
overdose of drug
• Parents are told to withhold the drug if pulse
rate is high
• Teach the importance of follow up
Hypothyroidism in children

More Related Content

What's hot

Convulsive disorder
Convulsive disorderConvulsive disorder
Convulsive disorder
manoj922
 
Nephrotic syndrome
Nephrotic syndromeNephrotic syndrome
Nephrotic syndrome
manisha21486
 
diabetes mellitus in children
diabetes mellitus in childrendiabetes mellitus in children
diabetes mellitus in children
Azad Haleem
 
Failure to Thrive
Failure to ThriveFailure to Thrive
Failure to Thrive
CSN Vittal
 
DIABETES MELLITUS IN CHILDREN
DIABETES MELLITUS IN CHILDRENDIABETES MELLITUS IN CHILDREN
DIABETES MELLITUS IN CHILDREN
Arifa T N
 
Neonatal Jaundice
Neonatal JaundiceNeonatal Jaundice
Neonatal Jaundice
Rosetta Davis
 
Convulsion disorder
Convulsion disorderConvulsion disorder
Convulsion disorder
manisha21486
 
JUVENILE DIABETES MELLITUS.pptx
JUVENILE DIABETES MELLITUS.pptxJUVENILE DIABETES MELLITUS.pptx
JUVENILE DIABETES MELLITUS.pptx
VIJI.V.S
 
disorders of Endocrine in Children
disorders of Endocrine in Childrendisorders of Endocrine in Children
disorders of Endocrine in Children
Ramya Deepthi P
 
Tonsillitis.in children
Tonsillitis.in childrenTonsillitis.in children
Tonsillitis.in children
Amrutha Ramakrishnan Nair
 
Neonatal seizures
Neonatal seizuresNeonatal seizures
Neonatal seizures
Rahul Dhaker
 
Anaemia in children
Anaemia in childrenAnaemia in children
Anaemia in children
giridharkv
 
Meconium aspiration syndrome_
Meconium aspiration syndrome_Meconium aspiration syndrome_
Meconium aspiration syndrome_
Amlendra Yadav
 
Nephrotic Syndrome in Pediatrics
Nephrotic Syndrome in PediatricsNephrotic Syndrome in Pediatrics
Nephrotic Syndrome in Pediatrics
Julius P. Kessy
 
Pediatric burns
Pediatric burnsPediatric burns
Pediatric burns
Wahid altaf Sheeba hakak
 
Failure to thrive
Failure to thriveFailure to thrive
Failure to thrive
Dr,Kaushik Barot
 
Neonatal sepsis
Neonatal sepsis Neonatal sepsis
Neonatal sepsis
Azad Haleem
 
Nephrotic Syndrome
Nephrotic SyndromeNephrotic Syndrome
Nephrotic Syndrome
HIRANGER
 
Dehydration in children
Dehydration in childrenDehydration in children
Dehydration in children
Naz Mayi
 
Breath Holding Spells
Breath Holding SpellsBreath Holding Spells
Breath Holding Spells
Ravi Kumar
 

What's hot (20)

Convulsive disorder
Convulsive disorderConvulsive disorder
Convulsive disorder
 
Nephrotic syndrome
Nephrotic syndromeNephrotic syndrome
Nephrotic syndrome
 
diabetes mellitus in children
diabetes mellitus in childrendiabetes mellitus in children
diabetes mellitus in children
 
Failure to Thrive
Failure to ThriveFailure to Thrive
Failure to Thrive
 
DIABETES MELLITUS IN CHILDREN
DIABETES MELLITUS IN CHILDRENDIABETES MELLITUS IN CHILDREN
DIABETES MELLITUS IN CHILDREN
 
Neonatal Jaundice
Neonatal JaundiceNeonatal Jaundice
Neonatal Jaundice
 
Convulsion disorder
Convulsion disorderConvulsion disorder
Convulsion disorder
 
JUVENILE DIABETES MELLITUS.pptx
JUVENILE DIABETES MELLITUS.pptxJUVENILE DIABETES MELLITUS.pptx
JUVENILE DIABETES MELLITUS.pptx
 
disorders of Endocrine in Children
disorders of Endocrine in Childrendisorders of Endocrine in Children
disorders of Endocrine in Children
 
Tonsillitis.in children
Tonsillitis.in childrenTonsillitis.in children
Tonsillitis.in children
 
Neonatal seizures
Neonatal seizuresNeonatal seizures
Neonatal seizures
 
Anaemia in children
Anaemia in childrenAnaemia in children
Anaemia in children
 
Meconium aspiration syndrome_
Meconium aspiration syndrome_Meconium aspiration syndrome_
Meconium aspiration syndrome_
 
Nephrotic Syndrome in Pediatrics
Nephrotic Syndrome in PediatricsNephrotic Syndrome in Pediatrics
Nephrotic Syndrome in Pediatrics
 
Pediatric burns
Pediatric burnsPediatric burns
Pediatric burns
 
Failure to thrive
Failure to thriveFailure to thrive
Failure to thrive
 
Neonatal sepsis
Neonatal sepsis Neonatal sepsis
Neonatal sepsis
 
Nephrotic Syndrome
Nephrotic SyndromeNephrotic Syndrome
Nephrotic Syndrome
 
Dehydration in children
Dehydration in childrenDehydration in children
Dehydration in children
 
Breath Holding Spells
Breath Holding SpellsBreath Holding Spells
Breath Holding Spells
 

Similar to Hypothyroidism in children

Patho2 chapter40 student1
Patho2 chapter40 student1Patho2 chapter40 student1
Patho2 chapter40 student1
btruong1
 
hypothyroidisminchildren2023 sahiwal.pptx
hypothyroidisminchildren2023 sahiwal.pptxhypothyroidisminchildren2023 sahiwal.pptx
hypothyroidisminchildren2023 sahiwal.pptx
SumeraAhmad5
 
Thyroid disorders
Thyroid disordersThyroid disorders
Thyroid disorders
Gagan Velayudhan
 
ORAL MANIFESTATIONS OF ENDOCRINE DISORDERS.ppt
ORAL MANIFESTATIONS OF ENDOCRINE DISORDERS.pptORAL MANIFESTATIONS OF ENDOCRINE DISORDERS.ppt
ORAL MANIFESTATIONS OF ENDOCRINE DISORDERS.ppt
drpriyanka8
 
Endocrine chart by Pandian M
Endocrine chart by Pandian MEndocrine chart by Pandian M
Endocrine chart by Pandian M
Pandian M
 
Congenital hypothyroidism
Congenital  hypothyroidism Congenital  hypothyroidism
NGRTCI Endocrine System Disorders Lecture
NGRTCI Endocrine System Disorders LectureNGRTCI Endocrine System Disorders Lecture
NGRTCI Endocrine System Disorders Lecture
Jofred Martinez
 
Endocrinology
EndocrinologyEndocrinology
Endocrinology
Indian dental academy
 
Endocrinology/ dental crown & bridge courses
Endocrinology/ dental crown & bridge coursesEndocrinology/ dental crown & bridge courses
Endocrinology/ dental crown & bridge courses
Indian dental academy
 
Hypothyroidism.pptx
Hypothyroidism.pptxHypothyroidism.pptx
Hypothyroidism.pptx
Pradeep Pande
 
Disturbances in hormone metabolism
Disturbances in hormone metabolismDisturbances in hormone metabolism
Disturbances in hormone metabolism
DR SUNITA PATHAK
 
Hyperthyroidism
HyperthyroidismHyperthyroidism
Hyperthyroidism
Ganesh naik
 
hypothyroidism for MBBS first year students
hypothyroidism for MBBS first year studentshypothyroidism for MBBS first year students
hypothyroidism for MBBS first year students
drrevanthesic
 
Thyroid disorders
Thyroid disorders Thyroid disorders
Thyroid disorders
Dr.Nusrat Tariq
 
Session 9: Chapter 11 PowerPoint Presentation
Session 9: Chapter 11 PowerPoint PresentationSession 9: Chapter 11 PowerPoint Presentation
Session 9: Chapter 11 PowerPoint Presentation
ITCC/ pb
 
Pituitary gland disorders
Pituitary gland disordersPituitary gland disorders
Pituitary gland disorders
loritacaroline
 
Endocrine disorders
Endocrine disorders Endocrine disorders
Endocrine disorders
Firdous Ansari
 
Endocrine lecture +spring+2012+student+copy
Endocrine lecture +spring+2012+student+copyEndocrine lecture +spring+2012+student+copy
Endocrine lecture +spring+2012+student+copy
NancyHarrison16
 
Congenital malformations
Congenital malformationsCongenital malformations
Congenital malformations
Nkeramahame Juvenal
 
Endocrine Diseases and its Dental Management
Endocrine Diseases and its Dental ManagementEndocrine Diseases and its Dental Management
Endocrine Diseases and its Dental Management
letsgogaga
 

Similar to Hypothyroidism in children (20)

Patho2 chapter40 student1
Patho2 chapter40 student1Patho2 chapter40 student1
Patho2 chapter40 student1
 
hypothyroidisminchildren2023 sahiwal.pptx
hypothyroidisminchildren2023 sahiwal.pptxhypothyroidisminchildren2023 sahiwal.pptx
hypothyroidisminchildren2023 sahiwal.pptx
 
Thyroid disorders
Thyroid disordersThyroid disorders
Thyroid disorders
 
ORAL MANIFESTATIONS OF ENDOCRINE DISORDERS.ppt
ORAL MANIFESTATIONS OF ENDOCRINE DISORDERS.pptORAL MANIFESTATIONS OF ENDOCRINE DISORDERS.ppt
ORAL MANIFESTATIONS OF ENDOCRINE DISORDERS.ppt
 
Endocrine chart by Pandian M
Endocrine chart by Pandian MEndocrine chart by Pandian M
Endocrine chart by Pandian M
 
Congenital hypothyroidism
Congenital  hypothyroidism Congenital  hypothyroidism
Congenital hypothyroidism
 
NGRTCI Endocrine System Disorders Lecture
NGRTCI Endocrine System Disorders LectureNGRTCI Endocrine System Disorders Lecture
NGRTCI Endocrine System Disorders Lecture
 
Endocrinology
EndocrinologyEndocrinology
Endocrinology
 
Endocrinology/ dental crown & bridge courses
Endocrinology/ dental crown & bridge coursesEndocrinology/ dental crown & bridge courses
Endocrinology/ dental crown & bridge courses
 
Hypothyroidism.pptx
Hypothyroidism.pptxHypothyroidism.pptx
Hypothyroidism.pptx
 
Disturbances in hormone metabolism
Disturbances in hormone metabolismDisturbances in hormone metabolism
Disturbances in hormone metabolism
 
Hyperthyroidism
HyperthyroidismHyperthyroidism
Hyperthyroidism
 
hypothyroidism for MBBS first year students
hypothyroidism for MBBS first year studentshypothyroidism for MBBS first year students
hypothyroidism for MBBS first year students
 
Thyroid disorders
Thyroid disorders Thyroid disorders
Thyroid disorders
 
Session 9: Chapter 11 PowerPoint Presentation
Session 9: Chapter 11 PowerPoint PresentationSession 9: Chapter 11 PowerPoint Presentation
Session 9: Chapter 11 PowerPoint Presentation
 
Pituitary gland disorders
Pituitary gland disordersPituitary gland disorders
Pituitary gland disorders
 
Endocrine disorders
Endocrine disorders Endocrine disorders
Endocrine disorders
 
Endocrine lecture +spring+2012+student+copy
Endocrine lecture +spring+2012+student+copyEndocrine lecture +spring+2012+student+copy
Endocrine lecture +spring+2012+student+copy
 
Congenital malformations
Congenital malformationsCongenital malformations
Congenital malformations
 
Endocrine Diseases and its Dental Management
Endocrine Diseases and its Dental ManagementEndocrine Diseases and its Dental Management
Endocrine Diseases and its Dental Management
 

Recently uploaded

Time line.ppQAWSDRFTGYUIOPÑLKIUYTREWASDFTGY
Time line.ppQAWSDRFTGYUIOPÑLKIUYTREWASDFTGYTime line.ppQAWSDRFTGYUIOPÑLKIUYTREWASDFTGY
Time line.ppQAWSDRFTGYUIOPÑLKIUYTREWASDFTGY
DianaRodriguez639773
 
Luxurious Spa In Ajman Chandrima Massage Center
Luxurious Spa In Ajman Chandrima Massage CenterLuxurious Spa In Ajman Chandrima Massage Center
Luxurious Spa In Ajman Chandrima Massage Center
Chandrima Spa Ajman
 
Professional Secrecy: Forensic Medicine Lecture
Professional Secrecy: Forensic Medicine LectureProfessional Secrecy: Forensic Medicine Lecture
Professional Secrecy: Forensic Medicine Lecture
DIVYANSHU740006
 
Michigan HealthTech Market Map 2024 with Policy Makers, Academic Innovation C...
Michigan HealthTech Market Map 2024 with Policy Makers, Academic Innovation C...Michigan HealthTech Market Map 2024 with Policy Makers, Academic Innovation C...
Michigan HealthTech Market Map 2024 with Policy Makers, Academic Innovation C...
Levi Shapiro
 
Hypertension and it's role of physiotherapy in it.
Hypertension and it's role of physiotherapy in it.Hypertension and it's role of physiotherapy in it.
Hypertension and it's role of physiotherapy in it.
Vishal kr Thakur
 
Tips for Pet Care in winters How to take care of pets.
Tips for Pet Care in winters How to take care of pets.Tips for Pet Care in winters How to take care of pets.
Tips for Pet Care in winters How to take care of pets.
Dinesh Chauhan
 
NEEDLE STICK INJURY - JOURNAL CLUB PRESENTATION - DR SHAMIN EABENSON
NEEDLE STICK INJURY - JOURNAL CLUB PRESENTATION - DR SHAMIN EABENSONNEEDLE STICK INJURY - JOURNAL CLUB PRESENTATION - DR SHAMIN EABENSON
NEEDLE STICK INJURY - JOURNAL CLUB PRESENTATION - DR SHAMIN EABENSON
SHAMIN EABENSON
 
Can coffee help me lose weight? Yes, 25,422 users in the USA use it for that ...
Can coffee help me lose weight? Yes, 25,422 users in the USA use it for that ...Can coffee help me lose weight? Yes, 25,422 users in the USA use it for that ...
Can coffee help me lose weight? Yes, 25,422 users in the USA use it for that ...
nirahealhty
 
Pediatric Emergency Care for Children | Apollo Hospital
Pediatric Emergency Care for Children | Apollo HospitalPediatric Emergency Care for Children | Apollo Hospital
Pediatric Emergency Care for Children | Apollo Hospital
Apollo 24/7 Adult & Paediatric Emergency Services
 
HUMAN BRAIN.pptx.PRIYA BHOJWANI@GAMIL.COM
HUMAN BRAIN.pptx.PRIYA BHOJWANI@GAMIL.COMHUMAN BRAIN.pptx.PRIYA BHOJWANI@GAMIL.COM
HUMAN BRAIN.pptx.PRIYA BHOJWANI@GAMIL.COM
priyabhojwani1200
 
Gemma Wean- Nutritional solution for Artemia
Gemma Wean- Nutritional solution for ArtemiaGemma Wean- Nutritional solution for Artemia
Gemma Wean- Nutritional solution for Artemia
smuskaan0008
 
R3 Stem Cell Therapy: A New Hope for Women with Ovarian Failure
R3 Stem Cell Therapy: A New Hope for Women with Ovarian FailureR3 Stem Cell Therapy: A New Hope for Women with Ovarian Failure
R3 Stem Cell Therapy: A New Hope for Women with Ovarian Failure
R3 Stem Cell
 
PrudentRx: A Resource for Patient Education and Engagement
PrudentRx: A Resource for Patient Education and EngagementPrudentRx: A Resource for Patient Education and Engagement
PrudentRx: A Resource for Patient Education and Engagement
PrudentRx Program
 
FACIAL NERVE
FACIAL NERVEFACIAL NERVE
FACIAL NERVE
aditigupta1117
 
LGBTQ+ Adults: Unique Opportunities and Inclusive Approaches to Care
LGBTQ+ Adults: Unique Opportunities and Inclusive Approaches to CareLGBTQ+ Adults: Unique Opportunities and Inclusive Approaches to Care
LGBTQ+ Adults: Unique Opportunities and Inclusive Approaches to Care
VITASAuthor
 
Champions of Health Spotlight On Leaders Shaping Germany's Healthcare.pdf
Champions of Health Spotlight On Leaders Shaping Germany's Healthcare.pdfChampions of Health Spotlight On Leaders Shaping Germany's Healthcare.pdf
Champions of Health Spotlight On Leaders Shaping Germany's Healthcare.pdf
eurohealthleaders
 
Unlocking the Secrets to Safe Patient Handling.pdf
Unlocking the Secrets to Safe Patient Handling.pdfUnlocking the Secrets to Safe Patient Handling.pdf
Unlocking the Secrets to Safe Patient Handling.pdf
Lift Ability
 
Hypotension and role of physiotherapy in it
Hypotension and role of physiotherapy in itHypotension and role of physiotherapy in it
Hypotension and role of physiotherapy in it
Vishal kr Thakur
 
Letter to MREC - application to conduct study
Letter to MREC - application to conduct studyLetter to MREC - application to conduct study
Letter to MREC - application to conduct study
Azreen Aj
 
Innovative Minds France's Most Impactful Healthcare Leaders.pdf
Innovative Minds France's Most Impactful Healthcare Leaders.pdfInnovative Minds France's Most Impactful Healthcare Leaders.pdf
Innovative Minds France's Most Impactful Healthcare Leaders.pdf
eurohealthleaders
 

Recently uploaded (20)

Time line.ppQAWSDRFTGYUIOPÑLKIUYTREWASDFTGY
Time line.ppQAWSDRFTGYUIOPÑLKIUYTREWASDFTGYTime line.ppQAWSDRFTGYUIOPÑLKIUYTREWASDFTGY
Time line.ppQAWSDRFTGYUIOPÑLKIUYTREWASDFTGY
 
Luxurious Spa In Ajman Chandrima Massage Center
Luxurious Spa In Ajman Chandrima Massage CenterLuxurious Spa In Ajman Chandrima Massage Center
Luxurious Spa In Ajman Chandrima Massage Center
 
Professional Secrecy: Forensic Medicine Lecture
Professional Secrecy: Forensic Medicine LectureProfessional Secrecy: Forensic Medicine Lecture
Professional Secrecy: Forensic Medicine Lecture
 
Michigan HealthTech Market Map 2024 with Policy Makers, Academic Innovation C...
Michigan HealthTech Market Map 2024 with Policy Makers, Academic Innovation C...Michigan HealthTech Market Map 2024 with Policy Makers, Academic Innovation C...
Michigan HealthTech Market Map 2024 with Policy Makers, Academic Innovation C...
 
Hypertension and it's role of physiotherapy in it.
Hypertension and it's role of physiotherapy in it.Hypertension and it's role of physiotherapy in it.
Hypertension and it's role of physiotherapy in it.
 
Tips for Pet Care in winters How to take care of pets.
Tips for Pet Care in winters How to take care of pets.Tips for Pet Care in winters How to take care of pets.
Tips for Pet Care in winters How to take care of pets.
 
NEEDLE STICK INJURY - JOURNAL CLUB PRESENTATION - DR SHAMIN EABENSON
NEEDLE STICK INJURY - JOURNAL CLUB PRESENTATION - DR SHAMIN EABENSONNEEDLE STICK INJURY - JOURNAL CLUB PRESENTATION - DR SHAMIN EABENSON
NEEDLE STICK INJURY - JOURNAL CLUB PRESENTATION - DR SHAMIN EABENSON
 
Can coffee help me lose weight? Yes, 25,422 users in the USA use it for that ...
Can coffee help me lose weight? Yes, 25,422 users in the USA use it for that ...Can coffee help me lose weight? Yes, 25,422 users in the USA use it for that ...
Can coffee help me lose weight? Yes, 25,422 users in the USA use it for that ...
 
Pediatric Emergency Care for Children | Apollo Hospital
Pediatric Emergency Care for Children | Apollo HospitalPediatric Emergency Care for Children | Apollo Hospital
Pediatric Emergency Care for Children | Apollo Hospital
 
HUMAN BRAIN.pptx.PRIYA BHOJWANI@GAMIL.COM
HUMAN BRAIN.pptx.PRIYA BHOJWANI@GAMIL.COMHUMAN BRAIN.pptx.PRIYA BHOJWANI@GAMIL.COM
HUMAN BRAIN.pptx.PRIYA BHOJWANI@GAMIL.COM
 
Gemma Wean- Nutritional solution for Artemia
Gemma Wean- Nutritional solution for ArtemiaGemma Wean- Nutritional solution for Artemia
Gemma Wean- Nutritional solution for Artemia
 
R3 Stem Cell Therapy: A New Hope for Women with Ovarian Failure
R3 Stem Cell Therapy: A New Hope for Women with Ovarian FailureR3 Stem Cell Therapy: A New Hope for Women with Ovarian Failure
R3 Stem Cell Therapy: A New Hope for Women with Ovarian Failure
 
PrudentRx: A Resource for Patient Education and Engagement
PrudentRx: A Resource for Patient Education and EngagementPrudentRx: A Resource for Patient Education and Engagement
PrudentRx: A Resource for Patient Education and Engagement
 
FACIAL NERVE
FACIAL NERVEFACIAL NERVE
FACIAL NERVE
 
LGBTQ+ Adults: Unique Opportunities and Inclusive Approaches to Care
LGBTQ+ Adults: Unique Opportunities and Inclusive Approaches to CareLGBTQ+ Adults: Unique Opportunities and Inclusive Approaches to Care
LGBTQ+ Adults: Unique Opportunities and Inclusive Approaches to Care
 
Champions of Health Spotlight On Leaders Shaping Germany's Healthcare.pdf
Champions of Health Spotlight On Leaders Shaping Germany's Healthcare.pdfChampions of Health Spotlight On Leaders Shaping Germany's Healthcare.pdf
Champions of Health Spotlight On Leaders Shaping Germany's Healthcare.pdf
 
Unlocking the Secrets to Safe Patient Handling.pdf
Unlocking the Secrets to Safe Patient Handling.pdfUnlocking the Secrets to Safe Patient Handling.pdf
Unlocking the Secrets to Safe Patient Handling.pdf
 
Hypotension and role of physiotherapy in it
Hypotension and role of physiotherapy in itHypotension and role of physiotherapy in it
Hypotension and role of physiotherapy in it
 
Letter to MREC - application to conduct study
Letter to MREC - application to conduct studyLetter to MREC - application to conduct study
Letter to MREC - application to conduct study
 
Innovative Minds France's Most Impactful Healthcare Leaders.pdf
Innovative Minds France's Most Impactful Healthcare Leaders.pdfInnovative Minds France's Most Impactful Healthcare Leaders.pdf
Innovative Minds France's Most Impactful Healthcare Leaders.pdf
 

Hypothyroidism in children

  • 2. HYPOTHYROIDISM • It is a condition in which thyroxin hormone level is decreased. 2 types • 1.Congenital hypothyroidism- is a common type associated with down syndrome. • 2.Acquired hypothyroidism – occurs after the age of 1 year and late onset hypothyroidism.
  • 3. INCIDENCE • World wide prevalence is 1: 4000 newborns • If untreated after birth severe congenital hypothyroidism can lead growth failure condition known as cretinism.
  • 4. ETIOLOGY CONGENITAL • Gene mutation • Failure of CNS • Iodine deficiency ACQUIRED • Thyroid dysfunction • Deficiency of TSH
  • 5. ETIOLOGY Primary hypothyroidism Congenital • Thyroid gland aplasia,hypoplasia • Inborn error of thyoid hormone • Inherited defect of thyroid hormone receptors • Maternal drugs like carbimazole, radioiodine acquired • Iodine deficiency • Autoimmune chronic lymphocytic thyroiditis • Irradiation • Ingestion of goitrogen • Drug induced
  • 6. PATHOPHYSIOLOGY The hypothyroid fetus does nit get maternal thyroid hormone to meet its metabolic requirement to protect from congenital hypothyroidsm Neonatal period thyroid functioning is completely independent from the mother At the 8th week gestation thyroid gland normally occupies its permanent anatomic site and at term reaches its maximum functioning
  • 7. PATHOPHYSIOLOGY Baby of mother with hyperthyroidism is born with hypothyroidism and fetal goiter However allows the passage of antithyroid drugs if mother is taking them Placenta does not allow passage of maternal thyroid hormone
  • 8. CLINICAL MANIFESTATION • One of the earliest signs is patent fontanels and widely opened cranial sutures due to utero lag in skeletal maturation • Another early indication of congenital hypothyroidism is prolonged physiologic jaundice due to delayed maturation of glucuronide conjugation • Birth weight more than average
  • 9. CLINICAL MANIFESTATION • Babies are dull ,flaccid and good natured as they cry less and sleep most of the time. • Pallor due to anemia • Feeding difficulties • constipation
  • 10. CLINICAL MANIFESTATION CONGENITAL (CRETINISM) • Thickened protruded tongue,thick lip • Anemia,rough and thick skin • Over sleeping • Hypotonia • Bradycardia,cool extrimities,wide posterior fontanel • Difficulty in feeding • Horse cry ACQUIRED • Decrease appetite,dry skin,coarse hair,depressed reflex • Constipation ,enlarged thyroid gland,Delayed bone age • Muscle weakness • Delayed puberty,bradycardia • Growth retardation ,short stature,short appearance with large heat.
  • 11. CLINICAL MANIFESTATION • Skin -yellow discoloration due to prolonged jaundice -skin is dry ,thick,coarse,cool and mottled
  • 12. CLINICAL MANIFESTATION • Head and face -puffy face -swollen eyelids -widely separated eyes -narrow palpebral fissures -broad nose with depressed bridge -open mouth with large protruding tongue -sparse ,coarse and brittle hair -delayed dentition and tooth decay -neck short -voice is hoarse
  • 13. CLINICAL MANIFESTATION • Trunk and extremities -retarded skeletal development and maturation -short stature -extremities appear short in relation to trunk -hands are broad and fingers are short -protruding abdomen -umbilical hernia may be present
  • 14. CLINICAL MANIFESTATION • Vital signs -temperature is usually subnormal below 35 degree celsius because of decreased metabolic rate -pulse is slow with reduced pulse pressure -dyspnoea ,noisy breath ,nasal obstruction and apnoea -heart murmur and cardiomegaly
  • 15. DIAGNOSIS • X ray study of bone age • Screening of thyroid hormone • Examination of serum T 3 ,T4 • Test for TSH level • Thyroid antibody study
  • 16. MANAGEMENT • Normalize the level TSH • Thyroid hormone levothyroxin is prescribed • For neonate 10-15microgram /kg/day • Monitor the serum thyroid level regularly •
  • 17. MANAGEMENT • Growth monitoring during therapies is important. • Educate the parents about the disease,and management • Adequacy of replacement therapy – control of constipation correction of feeding problem ,improvement in appetite.
  • 18. NURSING MANAGEMENT • Early identification of infant having hypothyroidism • Collect the infant history and assist in lab test and radiographic examination • Administer the drug daily • Nurse must tell about the manifestation of overdose of drug • Parents are told to withhold the drug if pulse rate is high • Teach the importance of follow up