Human-centered AI: how can we support end-users to interact with AI?
This document discusses how to design human-centered AI systems that support end-users. It explores explaining model outcomes to increase trust and acceptance, and enabling users to interact with explanation processes. Personal characteristics like need for cognition impact how users respond to explanations. Explanations should be personalized and allow different levels of detail. Evaluations show explanations improve understanding but also increase cognitive load, so simplification is important. The goal is to preserve human control and ensure AI meets user needs.
apidays Helsinki & North 2023 - What Generative AI Really Means To Cloud Ecos...apidays
apidays Helsinki & North 2023
API Ecosystems - Connecting Physical and Digital
June 5 & 6, 2023
What Generative AI Really Means To Cloud Ecosystems
Merja Kajava, CEO at Aavista
------
Check out our conferences at https://www.apidays.global/
Do you want to sponsor or talk at one of our conferences?
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Learn more on APIscene, the global media made by the community for the community:
https://www.apiscene.io
Explore the API ecosystem with the API Landscape:
https://apilandscape.apiscene.io/
Explainable AI - making ML and DL models more interpretableAditya Bhattacharya
Abstract –
Although industries have started to adopt AI and Machine Learning in almost every sector to solve complex business problems, but are these models always trustworthy? Machine Learning models are not any oracle but rather are scientific methods and mathematical models which best describes the data. But science is all about explaining complex natural phenomena in the simplest way possible! So, can we make ML and DL models more interpretable, so that any business user can understand these models and trust the results of these models?
In order to find out the answer, please join me in this session, in which I will take about concepts of Explainable AI and discuss its necessity and principles which help us demystify black-box AI models. I will be discussing about popular approaches like Feature Importance, Key Influencers, Decomposition trees used in classical Machine Learning interpretable. We will discuss about various techniques used for Deep Learning model interpretations like Saliency Maps, Grad-CAMs, Visual Attention Maps and finally go through more details about frameworks like LIME, SHAP, ELI5, SKATER, TCAV which helps us to make Machine Learning and Deep Learning models more interpretable, trustworthy and useful!
Storytelling with Data - Approach | SkillsAmit Kapoor
The ever increasing computational capacity has enabled us to acquire, process and analyze larger data-sets and information. However, the human memory and attention required to use this data is more limited and has remained relatively constant. Data visualization can enable us to compress data and encode it visually in ways that allows us to aid perceptual and cognitive understanding.
However, data visualisation alone is not enough and often we need to try to tell stories through data. Storytelling with data can enable us to move from analysis to synthesis, from numbers to visuals, and from an argument to a story. Operating at this intersection of data, visual and story can help persuade not only through logos (logic) but also through pathos (empathy) and ethos (credibility). In trying to tell compelling data stories, we can empower our selves to engage, communicate and persuade a large and diverse audience.
In this talk, I discuss ‘why’ stories work and what we can learn about the art of storytelling from other mediums like oral storytelling, written stories, pictures, comics and movies. I will summarise basic principles that can help us in our crafting journey, as we take the data through the layers of abstraction. The focus would be on unpacking the seven dimensions of creating an engaging data story - Abstraction (data patterns), Representation (visual encoding), Framing & Transition (perspective, focus), Messaging (verbal, text annotation), Flow (arrangement) and Interactivity.
Further, creating data stories is a cross disciplinary activity that requires us to operate at the intersection of a visual designer, data scientist and storyteller. It is both a science and an art. So how does one realistically learn these multitude of skills needed to get good at it. I will also discuss ideas about the possible path that practitioners could adopt to learn this craft through sustained practice.
## About the Speaker
Amit Kapoor is interested in learning and teaching the craft of telling visual stories with data. He uses storytelling and data visualization as tools for improving communication, persuasion and leadership. He conducts workshops and trainings for corporates, non-profits, colleges, and individuals at narrativeVIZ Consulting. He also teaches storytelling with data as invited guest faculty in academia, both in management context at IIM Bangalore and IIM Ahmedabad and in design context at NID, Bangalore.
His background is in strategy consulting in using data-driven stories to drive change across organizations and businesses. He has 15 years of management consulting experience, first with AT Kearney in India, then with Booz & Company in Europe and more recently with startups in Bangalore. He did his B.Tech in Mechanical Engineering from IIT, Delhi and PGDM (MBA) from IIM, Ahmedabad. You can find more about him at amitkaps.com and tweet him at @amitkaps
MLOps Bridging the gap between Data Scientists and Ops.Knoldus Inc.
Through this session we're going to introduce the MLOps lifecycle and discuss the hidden loopholes that can affect the MLProject. Then we are going to discuss the ML Model lifecycle and discuss the problem with training. We're going to introduce the MLFlow Tracking module in order to track the experiments.
apidays Helsinki & North 2023 - What Generative AI Really Means To Cloud Ecos...apidays
apidays Helsinki & North 2023
API Ecosystems - Connecting Physical and Digital
June 5 & 6, 2023
What Generative AI Really Means To Cloud Ecosystems
Merja Kajava, CEO at Aavista
------
Check out our conferences at https://www.apidays.global/
Do you want to sponsor or talk at one of our conferences?
https://apidays.typeform.com/to/ILJeAaV8
Learn more on APIscene, the global media made by the community for the community:
https://www.apiscene.io
Explore the API ecosystem with the API Landscape:
https://apilandscape.apiscene.io/
Explainable AI - making ML and DL models more interpretableAditya Bhattacharya
Abstract –
Although industries have started to adopt AI and Machine Learning in almost every sector to solve complex business problems, but are these models always trustworthy? Machine Learning models are not any oracle but rather are scientific methods and mathematical models which best describes the data. But science is all about explaining complex natural phenomena in the simplest way possible! So, can we make ML and DL models more interpretable, so that any business user can understand these models and trust the results of these models?
In order to find out the answer, please join me in this session, in which I will take about concepts of Explainable AI and discuss its necessity and principles which help us demystify black-box AI models. I will be discussing about popular approaches like Feature Importance, Key Influencers, Decomposition trees used in classical Machine Learning interpretable. We will discuss about various techniques used for Deep Learning model interpretations like Saliency Maps, Grad-CAMs, Visual Attention Maps and finally go through more details about frameworks like LIME, SHAP, ELI5, SKATER, TCAV which helps us to make Machine Learning and Deep Learning models more interpretable, trustworthy and useful!
Storytelling with Data - Approach | SkillsAmit Kapoor
The ever increasing computational capacity has enabled us to acquire, process and analyze larger data-sets and information. However, the human memory and attention required to use this data is more limited and has remained relatively constant. Data visualization can enable us to compress data and encode it visually in ways that allows us to aid perceptual and cognitive understanding.
However, data visualisation alone is not enough and often we need to try to tell stories through data. Storytelling with data can enable us to move from analysis to synthesis, from numbers to visuals, and from an argument to a story. Operating at this intersection of data, visual and story can help persuade not only through logos (logic) but also through pathos (empathy) and ethos (credibility). In trying to tell compelling data stories, we can empower our selves to engage, communicate and persuade a large and diverse audience.
In this talk, I discuss ‘why’ stories work and what we can learn about the art of storytelling from other mediums like oral storytelling, written stories, pictures, comics and movies. I will summarise basic principles that can help us in our crafting journey, as we take the data through the layers of abstraction. The focus would be on unpacking the seven dimensions of creating an engaging data story - Abstraction (data patterns), Representation (visual encoding), Framing & Transition (perspective, focus), Messaging (verbal, text annotation), Flow (arrangement) and Interactivity.
Further, creating data stories is a cross disciplinary activity that requires us to operate at the intersection of a visual designer, data scientist and storyteller. It is both a science and an art. So how does one realistically learn these multitude of skills needed to get good at it. I will also discuss ideas about the possible path that practitioners could adopt to learn this craft through sustained practice.
## About the Speaker
Amit Kapoor is interested in learning and teaching the craft of telling visual stories with data. He uses storytelling and data visualization as tools for improving communication, persuasion and leadership. He conducts workshops and trainings for corporates, non-profits, colleges, and individuals at narrativeVIZ Consulting. He also teaches storytelling with data as invited guest faculty in academia, both in management context at IIM Bangalore and IIM Ahmedabad and in design context at NID, Bangalore.
His background is in strategy consulting in using data-driven stories to drive change across organizations and businesses. He has 15 years of management consulting experience, first with AT Kearney in India, then with Booz & Company in Europe and more recently with startups in Bangalore. He did his B.Tech in Mechanical Engineering from IIT, Delhi and PGDM (MBA) from IIM, Ahmedabad. You can find more about him at amitkaps.com and tweet him at @amitkaps
MLOps Bridging the gap between Data Scientists and Ops.Knoldus Inc.
Through this session we're going to introduce the MLOps lifecycle and discuss the hidden loopholes that can affect the MLProject. Then we are going to discuss the ML Model lifecycle and discuss the problem with training. We're going to introduce the MLFlow Tracking module in order to track the experiments.
The catalyst for the success of automobiles came not through the invention of the car but rather through the establishment of an innovative assembly line. History shows us that the ability to mass produce and distribute a product is the key to driving adoption of any innovation, and machine learning is no different. MLOps is the assembly line of Machine Learning and in this presentation we will discuss the core capabilities your organization should be focused on to implement a successful MLOps system.
The Java ecosystem is very broad, with different technologies including Java SE, Java EE/Jakarta EE, Spring, numerous application servers, and other frameworks. Wherever you are in Java, Azure supports your workload and process with an abundance of choice – from IaaS to fully managed services. You can run any application architecture, from monoliths, to containerized monoliths, all the way to completely microservices based apps.
We see three broad patterns for running Java applications in the cloud, depending on how much control or productivity you need.
The first is lift and shift with Virtual Machines:
Virtual machines provide the most flexibility, control and visibility while moving to the cloud, especially for initial lift and shift of Java workloads. Azure provides a variety of Java focused VM images and solutions templates in the Azure Marketplace to get you up and running quickly.
The second is modernization using containers:
Containers provide portability, flexibility, scalability, manageability, repeatability, and predictability.
Azure provides best of breed support for Docker and Kubernetes, especially through the Azure Kubernetes Service (AKS) and Azure Red Hat OpenShift.
Finally, Azure has the most managed hosting options for Java applications of any major cloud platform with fully managed PaaS for Spring, Tomcat, and JBoss EAP:
Managed services offer ease-of-use, ease-of-management, productivity, and lower total cost of ownership.
You can focus on building your applications, not managing infrastructure.
All of this is supported by managed databases and DevOps tooling:
Use fully managed SQL and NoSQL databases, including PostgreSQL, MySQL, Cosmos DB, and SQL.
Keep using the tools you love, with plugins for IntelliJ and Eclipse, integrations with a variety of DevOps tools like Maven, Gradle, Jenkins, and GitHub.
Introdution to Dataops and AIOps (or MLOps)Adrien Blind
This presentation introduces the audience to the DataOps and AIOps practices. It deals with organizational & tech aspects, and provide hints to start you data journey.
Feature drift monitoring as a service for machine learning models at scaleNoriaki Tatsumi
In this talk, you’ll learn about techniques used to build a feature drift detection as a service capability for your enterprise and beyond. Feature drift monitoring is a way to check volatility of machine learning model inputs. It can trigger investigations for potential model degradation as well as explain why models have shifted.
Recent Research and Developments on Recommender Systems in TELHendrik Drachsler
Presentation given at the Learning Network seminar series at CELSTEC. Special guest was Wolfgang Reinhardt who provided his view on data science in relation to awareness improvement of knowledge workers.
Evidence-based Semantic WebJust a Dream or the Way to Go?Dragan Gasevic
The Semantic Web vision emerged with a promise to collect and interlink semantically relevant data from diverse sources in order to to achieve a full potential of the Web. After more than a decade of diligent research, it is the time to start summing up what has been accomplished and how mature Semantic Web research is, so that plans for the future can be charted. One of the key trails of a mature discipline is to have well-designed research methods allowing researchers to establish evidence about the effectiveness of the research ideas. It is equally important to to have knowledge translation methods that allow for transferring the established evidence to decision makers in practice. In this talk, we will first share some experience and challenges in conducting experiments in the area of the Semantic Web. We will next discuss findings of systematic reviews conducted to estimate the level of quality of the existing research results based on the criteria well-known in medical research and recently adopted in empirical software engineering. We will conclude the talk by discussing the importance and potential milestones for the Semantic Web in order to become an evidence-based discipline (similar to medicine or education) capable of producing strong research evidence transferable to practice.
The catalyst for the success of automobiles came not through the invention of the car but rather through the establishment of an innovative assembly line. History shows us that the ability to mass produce and distribute a product is the key to driving adoption of any innovation, and machine learning is no different. MLOps is the assembly line of Machine Learning and in this presentation we will discuss the core capabilities your organization should be focused on to implement a successful MLOps system.
The Java ecosystem is very broad, with different technologies including Java SE, Java EE/Jakarta EE, Spring, numerous application servers, and other frameworks. Wherever you are in Java, Azure supports your workload and process with an abundance of choice – from IaaS to fully managed services. You can run any application architecture, from monoliths, to containerized monoliths, all the way to completely microservices based apps.
We see three broad patterns for running Java applications in the cloud, depending on how much control or productivity you need.
The first is lift and shift with Virtual Machines:
Virtual machines provide the most flexibility, control and visibility while moving to the cloud, especially for initial lift and shift of Java workloads. Azure provides a variety of Java focused VM images and solutions templates in the Azure Marketplace to get you up and running quickly.
The second is modernization using containers:
Containers provide portability, flexibility, scalability, manageability, repeatability, and predictability.
Azure provides best of breed support for Docker and Kubernetes, especially through the Azure Kubernetes Service (AKS) and Azure Red Hat OpenShift.
Finally, Azure has the most managed hosting options for Java applications of any major cloud platform with fully managed PaaS for Spring, Tomcat, and JBoss EAP:
Managed services offer ease-of-use, ease-of-management, productivity, and lower total cost of ownership.
You can focus on building your applications, not managing infrastructure.
All of this is supported by managed databases and DevOps tooling:
Use fully managed SQL and NoSQL databases, including PostgreSQL, MySQL, Cosmos DB, and SQL.
Keep using the tools you love, with plugins for IntelliJ and Eclipse, integrations with a variety of DevOps tools like Maven, Gradle, Jenkins, and GitHub.
Introdution to Dataops and AIOps (or MLOps)Adrien Blind
This presentation introduces the audience to the DataOps and AIOps practices. It deals with organizational & tech aspects, and provide hints to start you data journey.
Feature drift monitoring as a service for machine learning models at scaleNoriaki Tatsumi
In this talk, you’ll learn about techniques used to build a feature drift detection as a service capability for your enterprise and beyond. Feature drift monitoring is a way to check volatility of machine learning model inputs. It can trigger investigations for potential model degradation as well as explain why models have shifted.
Recent Research and Developments on Recommender Systems in TELHendrik Drachsler
Presentation given at the Learning Network seminar series at CELSTEC. Special guest was Wolfgang Reinhardt who provided his view on data science in relation to awareness improvement of knowledge workers.
Evidence-based Semantic WebJust a Dream or the Way to Go?Dragan Gasevic
The Semantic Web vision emerged with a promise to collect and interlink semantically relevant data from diverse sources in order to to achieve a full potential of the Web. After more than a decade of diligent research, it is the time to start summing up what has been accomplished and how mature Semantic Web research is, so that plans for the future can be charted. One of the key trails of a mature discipline is to have well-designed research methods allowing researchers to establish evidence about the effectiveness of the research ideas. It is equally important to to have knowledge translation methods that allow for transferring the established evidence to decision makers in practice. In this talk, we will first share some experience and challenges in conducting experiments in the area of the Semantic Web. We will next discuss findings of systematic reviews conducted to estimate the level of quality of the existing research results based on the criteria well-known in medical research and recently adopted in empirical software engineering. We will conclude the talk by discussing the importance and potential milestones for the Semantic Web in order to become an evidence-based discipline (similar to medicine or education) capable of producing strong research evidence transferable to practice.
User Control in AIED (Artificial Intelligence in Education)Peter Brusilovsky
Slides of my intro to "Meet the Expert" session at AIED 2021. This is a subset of slides of a longer presentation on user control in AI extended with many specific examples from AIED area.
Tutorial at UMAP 2022:
In recent years, the use of Artificial Intelligence (AI) technologies expanded to many areas where they directly affect the lives of many
people. AI-based approaches advise human decision-makers who should be released on bail, whether it is a good time to discharge a
patient from a hospital and whether a specific student is at risk to fail a course. Such an extensive use in AI in decision making came with
a range of protentional problems that have been extensively studied over the last few years. Recognition of these problems motivated a
rapid rise of research on “human-centered AI”, which attempted to address and minimize the negative effects of using AI technologies.
Among the ideas of human-centered AI is user control - engaging users in affecting AI decision making to prevent possible errors and
biases. In my talk, I will focus on the application of user control in one popular area of AI application, adaptive information access.
Adaptive information access systems such as personalized search and recommender systems attempt to model their users to help them in
finding the most relevant information. Yet, user modeling and personalization mechanisms might not always work as expected resulting
in errors, biases, and suboptimal behavior. Combining the decision power or AI with the ability of the user to guide and control it brings
together the strong sides of artificial and human intelligence and could lead to better results. This tutorial will provide a systematic review
of approaches focused on adding various kinds of user control to adaptive information access systems and discuss lessons learned,
prospects, and challenges of this direction of research.
TitleABC123 Version X1Article Analysis TopicsPSYCH.docxjuliennehar
Title
ABC/123 Version X
1
Article Analysis Topics
PSYCH/660 Version 3
1
University of Phoenix Material
Article Analysis Topics
The Article Analysis Presentation is due in Week Three.
Student
Topic
Allen, J. (2007). A multicultural assessment supervision model to guide research and practice. Professional Psychology: Research and Practice, 38(3), 248-258.
Appelbaum, P. S., & Rosenbaum, A. (1989). Tarasoff and the researcher; Does the duty to protect apply to the research setting? American Psychologist, 44(6), 885-894.
Appelbaum, P. S. (2009). Mental retardation and the death penalty: After Atkins. Psychiatric Services, 60(10), 1295-1297.
Arredondo, P., & Toporek, R. (2004). Multicultural counseling competencies = ethical practice. Journal of Mental Health Counseling, 26(1), 44-55.
Boysen, G. A., & Vogel, D. L. (2008). The relationship between level of training, implicit bias, and multicultural competency among counselor trainees. Training and Education in Professional Psychology, 2(2), 103-110.
Brabender, V. (2006) The ethical group psychotherapist. International Journal of Group Psychotherapy, 56(4), 395-414.
Dailor, A. N., & Jacob, S. (2011). Ethically challenging situations reported by school psychologists: Implications for training. Psychology in the Schools, 48(6), 619-631.
Dugbartey, A. T., & Miller, M. (2009). Review of Boundaries in psychotherapy: Ethical and clinical explorations. Canadian Psychology, 50(1), 42-43.
Gallardo, M. E., Johnson, J., Parham, T. A., & Carter, J. A. (2009). Ethics and multiculturalism: advancing cultural and clinical responsiveness. Professional Psychology: Research and Practice, 40(5), 425-435.
Hess, A. K. (1987). Psychotherapy supervision: Stages, Buber, and a theory of relationship. Professional Psychology: Research and Practice, 18(3), 251-259.
Kalmbach, K. C., & Lyons, P. M. (2006). Ethical issues in conducting forensic evaluations. Applied Psychology in Criminal Justice, 2 (3), 261-290.
Lasky, G. B., & Riva, M. T. (2006). Confidentiality and privileged communications in-group psychotherapy. International Journal of Group Psychotherapy, 56(4), 455-476.
Macvaugh III, G. S., & Cunningham, M. D. (2009). Atkins v. Virginia: Implications and recommendation for forensic practice. Journal of Psychiatry & Law, 37, 131-184.
Pepper, R. S. (2007). Confidentiality and dual relationships in group psychotherapy. International Journal of Group Psychotherapy, 54(1), 103-114.
Razza, N. J., Tomasulo, D. J., & Sobsey, D. (2011). Group psychotherapy for trauma-related disorders in people with intellectual disabilities. Advances in Mental Health and Intellectual Disabilities, 5(5), 40-45
Schank, J. A., & Skovholt, T. M. (1997). Dual-relationship dilemmas of rural and small-community psychologists. Professional Psychology: Research and Practice, 28(1), 44-49.
Vannicelli, M. (2001). Leader dilemmas and countertransference considerations in-group psychotherapy with substance abusers. International Journal ...
The Innovation Engine for Team Building – The EU Aristotele Approach From Ope...ARISTOTELE
ARISTOTELE approach has been presented at the Innovation Adoption Forum for Industry and Public Sector within the 6th IEEE International Conference on Digital Ecosystem Technologies (IEEE DEST - CEE 2012). The presentation about ARISTOTELE has been held by Paolo Ceravolo and Ernesto Damiani (University of Milan) during the keynote "The Innovation Engine for Team Building – The EU Aristotele Approach". Learn more on http://www.aristotele-ip.eu/
Similar to Human-centered AI: how can we support end-users to interact with AI? (20)
Agents vs Users: Visual Recommendation of Research Talks with Multiple Dimens...Katrien Verbert
Published in ACM TiiS: Verbert, K., Parra, D., & Brusilovsky, P. (2016). Agents Vs. Users: Visual Recommendation of Research Talks with Multiple Dimension of Relevance. ACM Transactions on Interactive Intelligent Systems (TiiS), 6(2), 11.
Presented at IUI 2017
Scalable Exploration of Relevance Prospects to Support Decision MakingKatrien Verbert
Presented at IntRS 2016 - Interfaces and Human Decision Making for Recommender Systems, workshop at RecSys 2016
Citation: Verbert, K., Seipp, K., He, C., Parra, D., Wongchokprasitti, C., & Brusilovsky, P. (2016). Scalable Exploration of Relevance Prospects to Support Decision Making. Proceedings of the Joint Workshop on Interfaces and Human Decision Making for Recommender Systems co-located with ACM Conference on Recommender Systems (RecSys 2016), Boston, MA, USA, September 16, 2016.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Predicting property prices with machine learning algorithms.pdf
Human-centered AI: how can we support end-users to interact with AI?
1. Human-centered AI: how can we support end-users to
interact with AI?
TRAIL seminar – Paris – 7 April 2023
Katrien Verbert
Augment/HCI – Department of Computer Science – KU Leuven
@katrien_v
4. Human-Computer Interaction group
Explainable AI - recommender systems – visualization – intelligent user interfaces
Augment Katrien Verbert
ARIA Adalberto Simeone
Computer
Graphics
Phil Dutré
LIIR Sien Moens
NLP Miryam de Lhoneux
E-media
Vero Vanden Abeele
Luc Geurts
5. Human-centered AI
5
Human-Centered AI (HCAI) is an emerging discipline intent on creating AI
systems that amplify and augment rather than displace human abilities.
HCAI seeks to preserve human control in a way that ensures artificial
intelligence meets our needs while also operating transparently, delivering
equitable outcomes, and respecting privacy.
https://research.ibm.com/blog/what-is-human-centered-ai
6. Explaining model outcomes to increase user trust and acceptance
Enable users to interact with the explanation process to improve the model
New forms of human-AI interactions
Models
7. Explaining prediction models
7
Gutiérrez, F., Ochoa, X., Seipp, K., Broos, T., & Verbert, K. (2019). Benefits and trade-offs of different
model representations in decision support systems for non-expert users. In Human-Computer Interaction–
INTERACT 2019
9. Explanations
9
Millecamp, M., Htun, N. N., Conati, C., & Verbert, K. (2019, March). To explain or not to explain: the
effects of personal characteristics when explaining music recommendations. In Proceedings of the 2019
Conference on Intelligent User Interface (pp. 397-407). ACM.
media
10. Personal characteristics
Need for cognition
• Measurement of the tendency for an individual to engage in, and enjoy, effortful cognitive activities
• Measured by test of Cacioppo et al. [1984]
Visualisation literacy
• Measurement of the ability to interpret and make meaning from information presented in the form of
images and graphs
• Measured by test of Boy et al. [2014]
Locus of control (LOC)
• Measurement of the extent to which people believe they have power over events in their lives
• Measured by test of Rotter et al. [1966]
Visual working memory
• Measurement of the ability to recall visual patterns [Tintarev and Mastoff, 2016]
• Measured by Corsi block-tapping test
Musical experience
• Measurement of the ability to engage with music in a flexible, effective and nuanced way
[Müllensiefen et al., 2014]
• Measured using the Goldsmiths Musical Sophistication Index (Gold-MSI)
Tech savviness
• Measured by confidence in trying out new technology
10
11. Study design
Within-subjects design: 105 participants recruited with Amazon Mechanical Turk
Baseline version (without explanations) compared with explanation interface
Pre-study questionnaire for all personal characteristics
Task: Based on a chosen scenario for creating a play-list, explore songs and rate all
songs in the final playlist
Post-study questionnaire:
Recommender effectiveness
Trust
Good understanding
Use intentions
Novelty
Satisfaction
Confidence
13. Design implications
Explanations should be personalised for different groups of end-
users.
Users should be able to choose whether or not they want to see
explanations.
Explanation components should be flexible enough to present
varying levels of details depending on a user’s preference.
13
14. User control
Users tend to be more satisfied when they have control over
how recommender systems produce suggestions for them
Control recommendations
Douban FM
Control user profile
Spotify
Control algorithm parameters
TasteWeights
media
15. Controllability Cognitive load
Additional controls may increase cognitive load
(Andjelkovic et al. 2016)
Ivana Andjelkovic, Denis Parra, andJohn O’Donovan. 2016. Moodplay: Interactive mood-based music
discovery and recommendation. In Proc. of UMAP’16. ACM, 275–279.
16. Different levels of user control
16
Level
Recommender
components
Controls
low Recommendations (REC) Rating, removing, and sorting
medium User profile (PRO)
Select which user profile data
will be considered by the
recommender
high
Algorithm parameters
(PAR)
Modify the weight of different
parameters
Jin, Y., Tintarev, N., & Verbert, K. (2018, September). Effects of personal characteristics on music recommender
systems with different levels of controllability. In Proceedings of the 12th ACM Conference on Recommender
Systems (pp. 13-21). ACM.
17. User profile (PRO) Algorithm parameters (PAR) Recommendations (REC)
8 control settings
No control
REC
PAR
PRO
REC*PRO
REC*PAR
PRO*PAR
REC*PRO*PAR
18. Study design
Between-subjects – 240 participants recruited with AMT
Independent variable: settings of user control
2x2x2 factorial design
Dependent variables:
Acceptance (ratings)
Cognitive load (NASA-TLX), Musical Sophistication, Visual Memory
Framework Knijnenburg et al. [2012]
19. Results
Main effects: from REC to PRO to PAR → higher cognitive load
Two-way interaction: does not necessarily result in higher
cognitive load. Adding an additional control component to
PAR increases the acceptance. PRO*PAR has less cognitive
load than PRO and PAR
High musical sophistication leads to higher quality, and thereby
result in higher acceptance
19
Jin, Y., Tintarev, N., & Verbert, K. (2018, September). Effects of personal characteristics on music
recommender systems with different levels of controllability. In Proceedings of the 12th ACM Conference on
Recommender Systems (pp. 13-21). ACM.
20. What if the stakes are higher?
20
Learning
analytics &
human
resources
Media
consumption
health
Precision
agriculture
FinTech &
Insurtech
22. 22
Gutiérrez Hernández F., Seipp K., Ochoa X., Chiluiza K., De Laet T., Verbert K. (2018). LADA: A learning
analytics dashboard for academic advising. Computers in Human Behavior, pp 1-13. doi:
10.1016/j.chb.2018.12.004
LADA: a learning analytics dashboard for
study advisors
24. Results
What worked
✚ valuable tool for more
accurate and efficient
decision making.
✚ Users evaluated significantly
more scenarios.
What didn’t work
− More transparency needed
increase trust.
− Model didn’t behave as
expected
− LADA didn’t meet our users
needs
24
Gutiérrez Hernández F., Seipp K., Ochoa X., Chiluiza K., De Laet T., Verbert K. (2018). LADA: A learning
analytics dashboard for academic advising. Computers in Human Behavior, pp 1-13. doi:
10.1016/j.chb.2018.12.004
26. Design science research
26
Fraefel, U. (2014, November). Professionalization of pre-service teachers through university-school partnerships. In
Conference Proceedings of WERA Focal Meeting, Edinburgh.
27. Data-centric explanations
Charleer, S., Moere, A. V., Klerkx, J., Verbert, K., & De Laet, T. (2018). Learning analytics
dashboards to support adviser-student dialogue. IEEE Transactions on Learning
Technologies, 11(3), 389-399.
28. Do not oversimplify: show uncertainty
reality is complex
measurement is limited
individual circumstances
need for nuance
trigger reflection
29. 29
Charleer S., Gutiérrez Hernández F., Verbert K. (2019). Supporting job mediator and job seeker through an actionable dashboard. In:
Proceedings of the 24th IUI conference on Intelligent User Interfaces Presented at the ACM IUI 2019
actionalable
explanations
35. Take away messages
Explanations contribute to user empowerment
Key difference between actionable and non-actionable
parameters
Need for customization and contextualization
Need for simplification
35
38. AHMoSe
Rojo, D., Htun, N. N., Parra, D., De Croon, R., & Verbert, K. (2021). AHMoSe: A knowledge-based visual
support system for selecting regression machine learning models. Computers and Electronics in Agriculture,
187, 106183.
40. Case Study – Grape Quality Prediction
40
Grape Quality Prediction Scenario [Tag14]
Data
Years 2010, 2011 (train) 2012 (test)
48 cells (Central Greece)
Knowledge-based rules
[Tag14] Tagarakis, A., et al. "A fuzzy inference system to model
grape quality in vineyards." Precision Agriculture 15.5 (2014):
555-578.
Source: [Tag14]
41. Simulation Study
AHMoSe vs full AutoML approach to support model selection.
41
RMSE (AutoML) RMSE (AHMoSe) Difference %
Scenario A
Complete
Knowledge
0.430 0.403 ▼ 6.3%
Scenario B
Incomplete
Knowledge
0.458 0.385 ▼ 16.0%
42. Qualitative Evaluation
10 open ended questions
5 viticulture experts and 4 ML experts.
Thematic Analysis: potential use cases, trust, usability, and
understandability.
43. Qualitative Evaluation - Trust
43
Showing the dis/agreement of model outputs with expert’s
knowledge can promote trust.
“The thing that makes us trust the models is the fact that most of
the time, there is a good agreement between the values
predicted by the model and the ones obtained for the knowledge
of the experts.”
– Viticulture Expert
46. Design and Evaluation
46
Gutiérrez F., Cardoso B., Verbert K. (2017). PHARA: a personal health augmented reality assistant to support
decision-making at grocery stores. In: Proceedings of the International Workshop on Health Recommender
Systems co-located with ACM RecSys 2017 (Paper No. 4) (10-13).
47. What if the stakes are really high?
Learning
analytics &
human
resources
Media
consumption
health
Precision
agriculture
FinTech &
Insurtech
50. 50
Gutiérrez Hernández, F. S., Htun, N. N., Vanden Abeele, V., De Croon, R., & Verbert, K. (2021). Explaining call
recommendations in nursing homes: a user-centered design approach for interacting with knowledge-based
health decision support systems. In Proceedings of the 27th Annual Conference on Intelligent User Interfaces.
ACM.
Explaining predictions health
51. Evaluation
12 nurses used the app for three months
Data collection
Interaction logs
Resque questions
Semi-structured interviews
51
53. Results
Iterative design process identified several important features, such as the pending
list, overview and the feedback shortcut to encourage feedback.
Explanations seem to contribute well to better support the healthcare professionals.
Results indicate a better understanding of the call notifications by being able to see the
reasons of the calls.
More trust in the recommendations and increased perceptions of transparency and control
Interaction patterns indicate that users engaged well with the interface, although some
users did not use all features to interact with the system.
Need for further simplification and personalization.
53
55. 55
Explaining recommendations
Word cloud Feature importance Feature importance+ %
Maxwell Szymanski, Vero Vanden Abeele and Katrien Verbert Explaining health
recommendations to lay users: The dos and don’ts – Apex-IUI 2022
health
59. Results
Hybrid explanations more useful compared to both the textual and
visual explanations.
Users with a higher NFC tend to score the hybrid explanations
lower in terms of trust, transparency and usefulness compared to
the unimodal explanation.
59
60. Results
Participants with low NFC have a better perception of hybrid
explanations
Participants with high NFC have a better perception of
unimodal explanations
60
62. Combining XAI methods to address different
dimensions of explainability
Increasing actionability through interactive what-if analysis
Explanations through actionable features instead of non-
actionable features
Color-coded visual indicators for easy identification of patients
with high risk
Data-centric directive explanations
62
Bhattacharya, A., Ooge, J., Stiglic, G., & Verbert, K. (2023, March). Directive Explanations for Monitoring the Risk of Diabetes
Onset: Introducing Directive Data-Centric Explanations and Combinations to Support What-If Explorations. In Proceedings of the
28th International Conference on Intelligent User Interfaces (pp. 204-219).
67. Data-centric explanation methods for fraud detection
Explanations in high-stake domains will become mandatory by EU
regulations
Transparent and interactive data matching
Insurance premium simulations
Link with external data sources
E.g. occupational accidents, absenteeism data
67
https://human-centered.ai/project/explainable-ai-fwf-32554/
68. Take-away messages
Involvement of end-users has been key to come up with
interfaces tailored to the needs of non-expert users
Actionable vs non-actionable parameters
Domain expertise of users and need for cognition important
personal characteristics
Need for personalisation and simplification
Data-centric explanations provide powerful solution
68
The prediction model shows the impact of the food product on the weight of the participant. Opacity is used to represent the uncertainty of this prediction. (POINT to third card)
“Insight vs. information overload”
Most users prefer more information (holistic overview of inputs)
However, some users experienced information overload
→ Future work - Do personal characteristics such as NFC influence this?