Human & canine atopic dermatitis: Similarities and differences

•

4 likes•5,145 views

This document summarizes similarities and differences between human and canine atopic dermatitis. Canine atopic dermatitis (CAD) is defined as a pruritic and inflammatory skin condition that is often genetically predisposed and associated with environmental allergens. CAD most commonly affects the feet, ears, and abdomen. It has been shown to run in families. Treatment focuses on glucocorticoids, calcineurin inhibitors, and allergen-specific immunotherapy, which is effective in 70% of cases. House dust mites, pollens, and molds are major allergens. An elimination diet can help identify food triggers. Human atopic dermatitis serves as a good comparative model for understanding

Zürich Universität- Vetsuisse Fakultät
Klinik für Kleintiermedizin
Dermatologie Abteilung

Human & canine atopic dermatitis:
Similarities and differences

Prof. Dr Claude Favrot, MsSc, Dip.ECVD
Vetsuisse Faculty, Zurich

Human versus canine AD
• Many similarities and some (minor)
differences

CAD: Definition (Halliwell for ICADA, 2008)
• A genetic predisposed, inflammatory and
pruritic dermatitis, that often develops in
association with environmental allergenspecific IgE

CAD: Localization
32%

58%

32%

42%

62%

75%
80%

66%

Genetic make-up
Food

Food

UV

Stress
Microbes
Stress

Impaired epidermal
barrier

+

Impaired imm.syst.
Th2 responders
High IgE responders

Climate
Irritant contact d.
Allergic contact d.

+
Allergenes:
Environmental,
food, microbes,
autoallergens

Microbes

Contactants

Atopic dermatitis,
Atopic-like dermatitis

Favrot, 2011

Diagnosis of CAD
•
•
•

Exclusion of resembling diseases
Criteria
Allergy tests:
–
–
–

IgE serology
Intradermal testing
Elimination diet

Major allergens
• House dust mites and storage mites. 90%
–
–
–
–

Dermatophagoides Farinae
DP, AC, Tyrophagus
Numerous cross reactions
Derf15 >Derf1, Derf2

• Pollens. 30%

– Cedar, Ragweed, Birch, Dandelion...

• Molds: 50%
• Epithelia: 5%

Role of food
• Food hypersensitivity
–
–

Atopic dermatitis
Urticaria, Angioedema, GI

• Elimination diet and provocation
– IgE driven?

CAD treatment
•
•
•

Glucocorticoids and Calcineurin inhibitors
Systemically rather than topically
Allergen-specific immunotherapy
– 70% success rate

• New trends:
–
–

Jak inhibitors: Oclacitinib
C kit inhibitors: Masitinib

Allergy march in atopic dogs?
• Food allergy in younger dogs?
• Pollen allergy before mites allergy?

Conclusion
• Human atopic dermatitis is a good model
for canine atopic dermatitis 

This document discusses canine atopic dermatitis (cAD) and its potential interactions with humans. It first provides background on cAD, noting its increasing prevalence which may be linked to changes in dogs' way of life. The document then examines whether cAD impacts owners' quality of life. A survey found cAD negatively impacts 48% of owners' quality of life, with effects depending on disease severity. The disease disturbed sleep for 35% of owners and treatment was considered a major burden for 32% of owners. In conclusion, changes to dogs' lifestyle may increase cAD risk, and cAD can significantly impact the quality of life of affected dogs' owners.

Molluscum-contagiosum cfuk

Dr. Faramarz Didar

Molluscum contagiosum is a viral disease with following characteristics: Benign viral infection Caused by a pox virus Double stranded DNA virus Spread by direct contact, bath towels, tattoo instruments, beauty parlour implements, swimming pools in children In adults, most commonly an STD, males>females Incubation period – 2-7 weeks but can be as long as 26 weeks More common and severe in patients with A.D. More common in certain geographic areas with warm climates (Fiji, Congo, Papua New Guinea)

مشاكل تناسلية تحدث بعد الولادة وكيفية التعامل معها

hamed attia

1. The document discusses various postpartum complications including perineal rupture, retained placenta, uterine prolapse, and uterine and vaginal rupture. 2. It provides details on the causes, symptoms, and treatments for several common postpartum infections and diseases such as puerperal bacterial intoxication, septi metritis, puerperal necrosis, puerperal tetanus, and vaginitis and vulvitis. 3. The postpartum complications covered range from physical injuries to infections caused by various bacteria that can enter the uterus and genital tract during or after birth.

Main lines of treatmentin diseased animals proff. dr hamed attia

hamed attia

This document discusses veterinary treatment guidelines for various diseases in farm animals. It provides treatment guidelines for enteritis, calf scours, pneumonia, mastitis, acidosis, ketosis, milk fever, hypo-phosphatemia, babesiosis, theileriasis, urinary tract infections, and bacterial/viral vaccines. The guidelines emphasize correct diagnosis, fluid therapy, antibiotics, anti-inflammatories, and supportive care. Causes of antibiotic treatment failure are also reviewed.

An overview of cat bond

Shuo Li

This document provides an overview of cat bonds, which offer an alternative capacity source for natural catastrophe insurance. Cat bonds transfer catastrophe risk to the capital markets through securitization. Since 1997, 141 cat bonds have been issued totaling $27 billion in risk limits. The market started growing significantly after major hurricanes and earthquakes in the 1990s. Investor interest continues to rise due to attractive yields and increased understanding of natural catastrophe risk. Cat bonds and other insurance-linked securities may prove useful for risk management in China and other parts of Asia in the future.

bitler-ve-parazitlikleri (fazlası için www.tipfakultesi.org )www.tipfakultesi. org

Therapeutic management of skin diseases in animals

Obli Rajendran VinodhKumar, ICAR- Indian Veterinary Research Institute, Bareilly

This document discusses various skin diseases affecting animals. It categorizes skin diseases as bacterial, parasitic, fungal, viral, endocrine, nutritional, inherited, and those caused by physical, chemical or unknown factors. For each category, it describes common conditions, symptoms, diagnosis involving examination and tests, and treatment options involving antibiotics, antifungals, antiparasitics, steroids, or removing the causative agent. The document provides a comprehensive overview of animal skin diseases and their management.

SISTEMAS DE GESTÃO DO CONHECIMENTO EM NUVEM: A HORA DAS PEQUENAS E MÉDIAS E...

Artur Todeschini

Este documento discute como a computação em nuvem pode fornecer às pequenas e médias empresas uma solução acessível para gerenciar seus ativos de conhecimento por meio de sistemas de gestão do conhecimento na nuvem. Primeiro, introduz conceitos de gestão do conhecimento e sistemas de gestão do conhecimento. Em seguida, descreve os benefícios da computação em nuvem para PMEs, incluindo custos reduzidos e acesso a soluções tecnológicas. Finalmente,

This is the keynote lecture given at the University of Illinois at Chicago Garden Walk event in the department of Pharmacognosy. The objectives of the talk were: ·Discuss the role of medical ethnobotany in drug discovery efforts ·Explore state-of-the-art research techniques that examine the activity of botanical natural products with next generation antibiotic discovery efforts focused on “alternative targets”, such as bacterial communication systems ·Provide examples of current research underway by her group both in the field (especially through fieldwork in the Mediterranean) and the lab (natural product research on multidrug resistant bacteria).

Allergic Rhinitis

Ramesh Parajuli

This document provides an overview of allergic rhinitis. It defines allergic rhinitis as an IgE-mediated hypersensitivity disease characterized by sneezing, nasal discharge and obstruction. The document notes that allergic rhinitis prevalence is 15-20% globally, with higher rates in children. It affects quality of life by impacting school/work performance. Risk factors include genetics, family history of atopy, environmental irritants and allergens. Diagnosis involves history, exam, skin prick tests and blood tests. Management includes environmental control, nasal irrigation, medications like antihistamines, decongestants, steroids and immunotherapy.

Biologics hypersensitivity.pdf

Chulalongkorn Allergy and Clinical Immunology Research Group

Initiate infusion at a rate of 100 mg/hr, and increase by 100 mg/hr increments every 30 minutes to a maximum of 400 mg/hr as tolerated. - In the absence of infusion reactions, a more rapid infusion can be administered within 6 hours. - Premedicate with acetaminophen and an antihistamine approximately 30-60 minutes before each infusion. - For patients with a history of infusion reactions, premedicate with corticosteroids (methylprednisolone or equivalent). Specific drug - Rituximab

Abordagem diagnóstica e terapêutica do prurido em gatos

Instituto Qualittas de Pós Graduação

Presentation allergic rhinitis madan

madan gupta

Allergen immunotherapy (AIT) involves controlled exposure to allergens to reduce symptoms of allergic diseases like rhinitis, asthma, and conjunctivitis. It was first attempted in the early 1900s by immunizing people with plant extracts. While initial attempts caused adverse reactions, later studies found controlling the dose prevented this. Today, AIT is accepted for treating respiratory allergies and insect sting reactions but not food allergies or other conditions.

Dermatology 5th year, 1st lecture (Dr. Ali El-Ethawi)

College of Medicine, Sulaymaniyah

This document provides information on various types of dermatitis and eczema. It discusses the definitions and characteristics of conditions like chronic eczema/dermatitis, acute eczema/dermatitis, irritant contact dermatitis, allergic contact dermatitis, atopic dermatitis, discoid eczema, seborrheic dermatitis, and their signs, symptoms, causes, diagnosis and treatment options. Patch testing and other laboratory examinations are mentioned as ways to identify the cause and properly diagnose different types of dermatitis. Management involves identifying and removing triggers, using topical corticosteroids and other creams or ointments, phototherapy, and occasionally systemic therapies

Fungal Research Trust 20th Anniversary Meeting June 2011 - Dr Astrid Leck (No...

Graham Atherton

Dr. Pedro Urriola - Survival And Mitigation Strategies Of PEDv & Deltacorona ...

John Blue

Common Occupational Allergies: Where Do We Stand?

Dr_Rakesh_Nair

Common occupational allergies include contact dermatitis from exposure to chemicals in various work environments like construction and healthcare. Occupational diseases can affect the skin, nose, and lungs from allergens or irritants. It is important to identify potential occupational allergens early to prevent chronic illness and support removal from exposure. Latex allergy is common in healthcare workers while contact dermatitis and rhinitis frequently occur in jobs like construction, hairdressing, and food processing due to chemicals. Preventive measures include identifying susceptible workers, controlling exposures, and using protective equipment.

Contact dermatitis

Chulalongkorn Allergy and Clinical Immunology Research Group

This document provides an overview of contact dermatitis, including its definition, classification, epidemiology, pathology, clinical presentation, investigation, and management. Contact dermatitis can be allergic, caused by an allergen-specific immune response, or irritant, caused by prolonged exposure to irritants. It is a common skin condition worldwide, with prevalence rates varying by region. Diagnosis involves a clinical examination and patch testing to identify potential allergens. Management focuses on avoiding causal allergens or irritants.

18Occupational Skin diseases and management, Dr. Dincy peter

ohscmcvellore

Occupational dermatoses, especially contact dermatitis, are common among healthcare workers due to frequent exposure to irritants and allergens. The most frequent types are irritant contact dermatitis caused by chemicals like detergents, disinfectants, and gloves, and allergic contact dermatitis triggered by substances like latex, glutaraldehyde, and antibiotics. Proper diagnosis involves a detailed history of workplace exposures and patch testing. Management focuses on eliminating exposures, using protective equipment, and treating flares with topical steroids and immunosuppressants to prevent chronicity.

Allergy- Laboratory Diagnostic Tests

Dr. Rajesh Bendre

Allergy testing is important for diagnosis of allergic conditions. Skin prick tests and blood tests like specific IgE tests can help identify triggers. Specific IgE tests like ImmunoCAP are more accurate than total IgE and are not affected by medications, skin conditions, or pregnancy. Phadiatop is a useful screening test to detect sensitization to common inhalants and foods. Positive results on screening tests should be followed up with customized allergen panels based on symptoms and environment. Reference lab data shows significant prevalence of sensitization to common allergens like dust mites, pollens, foods in the local population tested. Proper history and examination along with selection of right allergen panels is key to allergy diagnosis

Diagnosis and management of allergic rhinitis

Chulalongkorn Allergy and Clinical Immunology Research Group

Shifting The Diagnostic Paradigm For Undiagnosed Illnesses Woutrina SMITH

Human & canine atopic dermatitis: Similarities and differences

Recommended

Recommended

More Related Content

Similar to Human & canine atopic dermatitis: Similarities and differences

Similar to Human & canine atopic dermatitis: Similarities and differences (20)

More from Global Risk Forum GRFDavos

More from Global Risk Forum GRFDavos (20)

Recently uploaded

Recently uploaded (20)

Human & canine atopic dermatitis: Similarities and differences