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Histological study of 
Thyroid gland 
- Asst Prof Chetana 
.S.Kanekar 
M.Sc Zoology( SET Life sciences)
Introduction 
 Thyroid consist of two 
lateral lobes and the 
connecting part called 
isthmus. 
 Largest gland in body. 
 Endodermal in origin. 
 Gland secretes 
thyroid hormones 
called thyroxine.
Position of Thyroid gland
Microscopic structure 
 Structural unit is follicle 
or acinus. 
 Follicle consist of layer 
of simple epithelium, 
enclosing cavity called 
the follicular cavity. 
 The cavity is usually 
filled with gel-like 
viscous iodine-rich 
material called colloid. 
 Interfollicular spaces 
are filled by reticular 
connnective tissue, 
adipose tissue and 
blood vessels.
Follicular cells 
 These are cuboidal epithelial cells with their basal 
ends resting on basement membrane. 
 These cells show the changes in shape 
depending on state of gland. 
 When gland is inactive, cells exhibit squamous 
structure and columnar when hyperactive. 
 The follicular cells show central or basal round 
nucleus with one or more excentric nuclei. 
 The apical tips of cells extend microvilli in the 
cavity.
Parafollicular cells 
 In Interfollicular spaces spaces there are some 
special parafollicular cells. 
 They found in singly or in groups. 
 They secrete hormone thyrocalcitonin, which 
lowers the calcium level.
Colloid 
 Cavity of thyroid follicle is filled with semi-fluid or 
gel like substance, called thyroid colloid. 
 It is the endocrine secretion of epithelial cells and 
composed of nucleoproteins, thyroglubolin and 
proteolytic enzymes. 
 Among the endocrine glands, thyroid is unique 
because it utilizes an inorganic element iodine for 
the synthesis of its hormones.
Thyroid gland malfunctioning 
 Hypothyroidism 
 Cretinism. 
 Myxedema 
 Hyperthroidism 
 Grave’s Disease
Distinguishing features of thyroid 
 Follicle is structural unit. 
 Follicle contains follicular epithelial cells and 
parafollicular cells. 
 Follicle shows follicular cavity in which contains 
gel-like colloid. 
 Inter-follicular spaces are filled by reticular 
connective tissue and blood vessels.
Thank you

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Histology of thyroid gland

  • 1. Histological study of Thyroid gland - Asst Prof Chetana .S.Kanekar M.Sc Zoology( SET Life sciences)
  • 2. Introduction  Thyroid consist of two lateral lobes and the connecting part called isthmus.  Largest gland in body.  Endodermal in origin.  Gland secretes thyroid hormones called thyroxine.
  • 4. Microscopic structure  Structural unit is follicle or acinus.  Follicle consist of layer of simple epithelium, enclosing cavity called the follicular cavity.  The cavity is usually filled with gel-like viscous iodine-rich material called colloid.  Interfollicular spaces are filled by reticular connnective tissue, adipose tissue and blood vessels.
  • 5. Follicular cells  These are cuboidal epithelial cells with their basal ends resting on basement membrane.  These cells show the changes in shape depending on state of gland.  When gland is inactive, cells exhibit squamous structure and columnar when hyperactive.  The follicular cells show central or basal round nucleus with one or more excentric nuclei.  The apical tips of cells extend microvilli in the cavity.
  • 6. Parafollicular cells  In Interfollicular spaces spaces there are some special parafollicular cells.  They found in singly or in groups.  They secrete hormone thyrocalcitonin, which lowers the calcium level.
  • 7. Colloid  Cavity of thyroid follicle is filled with semi-fluid or gel like substance, called thyroid colloid.  It is the endocrine secretion of epithelial cells and composed of nucleoproteins, thyroglubolin and proteolytic enzymes.  Among the endocrine glands, thyroid is unique because it utilizes an inorganic element iodine for the synthesis of its hormones.
  • 8. Thyroid gland malfunctioning  Hypothyroidism  Cretinism.  Myxedema  Hyperthroidism  Grave’s Disease
  • 9. Distinguishing features of thyroid  Follicle is structural unit.  Follicle contains follicular epithelial cells and parafollicular cells.  Follicle shows follicular cavity in which contains gel-like colloid.  Inter-follicular spaces are filled by reticular connective tissue and blood vessels.