The heart is located in the center-left portion of the chest and pumps oxygen-rich blood to all cells in the body. The United States performs over 2,000 heart transplants annually, with survival rates of 81% after 1 year and around 68% after 5 years. Heart transplants may be required for severe heart failure or defects that cannot be treated otherwise. Recipients must meet health criteria and take anti-rejection drugs lifelong, while living with cardiac monitoring and dietary restrictions after transplant.